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https://www.readbyqxmd.com/read/28088129/in-vitro-eye-irritation-testing-using-the-open-source-reconstructed-hemicornea-a-ring-trial
#1
Karsten R Mewes, Maria Engelke, Michaela Zorn-Kruppa, Melinda Bartok, Rashmi Tandon, Johanna M Brandner, Dirk Petersohn
Aim of the present ring trial was to prove whether two new methodological approaches for the in vitro classification of eye irritating chemicals can be reliably transferred from the developers' laboratories to other sites.Both test methods are based on the well-established open source reconstructed 3D hemicornea models. In the first approach, the initial depth of injury in the hemicornea model after chemical treatment is derived from the quantitative analysis of histological sections. In the second approach tissue viability, as a measure for corneal damage after chemical treatment, is analyzed separately for epithelium and stroma of the hemicornea model...
January 14, 2017: ALTEX
https://www.readbyqxmd.com/read/28087395/lumbar-spinal-muscles-and-spinal-canal-study-by-mri-three-dimensional-reconstruction-in-adult-lumbar-spinal-stenosis
#2
Louis Boissière, Bertrand Moal, Olivier Gille, Elise De-Roquefeuil, Muriel Durieux, Ibrahim Obeid, Vincent Dousset, Jean-Marc Vital, Wafa Skalli
BACKGROUND: Lumbar spinal stenosis is degenerative disc disease most common manifestation. If stenosis degree seems poorly related to symptom severity, lumbar muscles role is recognized. Many studies report imaging methods, to analyze muscle volumes and fat infiltration (FI), but remain limited due to the difficulty to represent entire muscle volume variability. Recently a 3D muscle reconstruction protocol (using the deformation of a parametric specific object method (DPSO) and three point Dixon images) was reported...
January 10, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28081089/direct-comparison-of-two-dimensional-and-three-dimensional-laser-induced-fluorescence-measurements-on-highly-turbulent-flames
#3
Lin Ma, Qingchun Lei, Tyler Capil, Stephen D Hammack, Campbell D Carter
This Letter reports the first direct comparison between two-dimensional (2D) and three-dimensional (3D) laser-induced fluorescence (LIF) applied to highly turbulent flames, with the goal of experimentally illustrating the capabilities and limitations of volumetric LIF (VLIF). To accomplish these goals, planar LIF (PLIF) and VLIF measurements were simultaneously performed on turbulent flames based on the CH radical. The PLIF measurements imaged a planar cross-section of the target flames across a 2D field-of-view (FOV) of 42  mm×42  mm...
January 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28079525/a-model-based-3d-patient-specific-pre-treatment-qa-method-for-vmat-using-the-epid
#4
Peter M McCowan, Ganiyu Asuni, Timothy van Beek, Eric Van Uytven, Kaden Kujanpaa, Boyd McCurdy
This study reports the development and validation of the first model-based, 3D patient dose reconstruction method for pre-treatment quality assurance using EPID images. The method is also investigated for sensitivity to potential MLC delivery errors. Each cine-mode EPID image acquired during plan delivery was processed using a previously developed back-projection dose reconstruction model providing a 3D dose estimate on the CT simulation data. Validation was carried out using 24 SBRT-VMAT patient plans by comparing: 1) ion chamber point dose measurements in a solid water phantom, 2) the treatment planning system (TPS) predicted 3D dose to the EPID reconstructed 3D dose in a solid water phantom, and 3) the TPS predicted 3D dose to the EPID and our forward predicted reconstructed 3D dose in the patient (CT data)...
January 12, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28076415/structure-and-recognition-of-a-novel-hiv-1-gp120-gp41-interface-antibody-that-caused-mper-exposure-through-viral-escape
#5
Constantinos Kurt Wibmer, Jason Gorman, Gabriel Ozorowski, Jinal N Bhiman, Daniel J Sheward, Debra H Elliott, Julie Rouelle, Ashley Smira, M Gordon Joyce, Nonkululeko Ndabambi, Aliaksandr Druz, Mangai Asokan, Dennis R Burton, Mark Connors, Salim S Abdool Karim, John R Mascola, James E Robinson, Andrew B Ward, Carolyn Williamson, Peter D Kwong, Lynn Morris, Penny L Moore
A comprehensive understanding of the regions on HIV-1 envelope trimers targeted by broadly neutralizing antibodies may contribute to rational design of an HIV-1 vaccine. We previously identified a participant in the CAPRISA cohort, CAP248, who developed trimer-specific antibodies capable of neutralizing 60% of heterologous viruses at three years post-infection. Here, we report the isolation by B cell culture of monoclonal antibody CAP248-2B, which targets a novel membrane proximal epitope including elements of gp120 and gp41...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28076351/ultra-fine-scale-spatially-integrated-mapping-of-habitat-and-occupancy-using-structure-from-motion
#6
Philip McDowall, Heather J Lynch
Organisms respond to and often simultaneously modify their environment. While these interactions are apparent at the landscape extent, the driving mechanisms often occur at very fine spatial scales. Structure-from-Motion (SfM), a computer vision technique, allows the simultaneous mapping of organisms and fine scale habitat, and will greatly improve our understanding of habitat suitability, ecophysiology, and the bi-directional relationship between geomorphology and habitat use. SfM can be used to create high-resolution (centimeter-scale) three-dimensional (3D) habitat models at low cost...
2017: PloS One
https://www.readbyqxmd.com/read/28074963/ultrahigh-capacity-dynamic-holographic-displays-via-anisotropic-nanoholes
#7
Xiaohu Zhang, Jinjin Jin, Mingbo Pu, Xiong Li, Xiaoliang Ma, Ping Gao, Zeyu Zhao, Yanqin Wang, Changtao Wang, Xiangang Luo
For the miniaturization of optical holographic and data recording devices, large information capacity or data density is indispensable but difficult to obtain using traditional technologies. In this paper, an ultrahigh-capacity metasurface hologram is proposed by encoding information in deep-subwavelength scale nanohole arrays, which can be reconstructed via a light beam with proper designed incident angles. The imaging information capacity of the two-dimensional (2D) hologram, defined by the distortion-free region, can be increased 11...
January 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28074466/anatomical-organization-of-the-brain-of-a-diurnal-and-a-nocturnal-dung-beetle
#8
Esa-Ville Immonen, Marie Dacke, Stanley Heinze, Basil El Jundi
To avoid the fierce competition for food, South African ball-rolling dung beetles carve a piece of dung off a dung-pile, shape it into a ball and roll it away along a straight line path. For this unidirectional exit from the busy dung pile, at night and day, the beetles use a wide repertoire of celestial compass cues. This robust and relatively easily measurable orientation behavior has made ball-rolling dung beetles an attractive model organism for the study of the neuroethology behind insect orientation and sensory ecology...
January 11, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28073637/variable-angle-stereo-imaging-for-rapid-patient-position-correction-in-an-in-house-real-time-position-monitoring-system
#9
Sankar Arumugam, Mark Sidhom, Daniel Truant, Aitang Xing, Mark Udovitch, Lois Holloway
PURPOSE: To develop and validate a variable angle stereo image based position correction methodology in an X-ray based in-house online position monitoring system. MATERIALS AND METHODS: A stereo imaging module that enables 3D position determination and couch correction of the patient based on images acquired at any arbitrary angle and arbitrary angular separation was developed and incorporated to the in-house SeedTracker real-time position monitoring system. The accuracy of the developed system was studied by imaging an anthropomorphic phantom implanted with radiopaque markers set to known offset positions from its reference position in an Elekta linear accelerator (LA) and associated XVI imaging system...
January 7, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28073200/the-role-of-intraoperative-ultrasound-in-small-renal-mass-robotic-enucleation
#10
Roberta Gunelli, Massimo Fiori, Cristiano Salaris, Umberto Salomone, Marco Urbinati, Alexia Vici, Teo Zenico, Mauro Bertocco
INTRODUCTION: As a result of the growing evidence on tumor radical resection in literature, simple enucleation has become one of the best techniques associated to robotic surgery in the treatment of renal neoplasia, as it guarantees minimal invasiveness and the maximum sparing of renal tissue, facilitating the use of reduced or zero ischemia techniques during resection. The use of a robotic ultrasound probe represents a useful tool to detect and define tumor location, especially in poorly exophytic small renal mass...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28072394/three-dimensional-cascaded-system-analysis-of-a-50-%C3%A2%C2%B5m-pixel-pitch-wafer-scale-cmos-active-pixel-sensor-x-ray-detector-for-digital-breast-tomosynthesis
#11
Chumin Zhao, Nikita Vassiljev, Anastasios Konstantinidis, Robert Speller, Jerzy Kanicki
High-resolution, low-noise x-ray detectors based on the complementary metal-oxide-semiconductor (CMOS) active pixel sensor (APS) technology have been developed and proposed for digital breast tomosynthesis (DBT). In this study, we evaluated the three-dimensional (3D) imaging performance of a 50 ��m pixel pitch CMOS APS x-ray detector named DynAMITe (Dynamic Range Adjustable for Medical Imaging Technology). The two-dimensional (2D) angle-dependent modulation transfer function (MTF), normalized noise power spectrum (NNPS), and detective quantum efficiency (DQE) were experimentally characterized and modeled using the cascaded system analysis at oblique incident angles up to 30��...
January 10, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28069920/folding-but-not-surface-area-expansion-is-associated-with-cellular-morphological-maturation-in-the-fetal-cerebral-cortex
#12
Xiaojie Wang, Colin Studholme, Peta L Grigsby, Antonio E Frias, Verginia C Cuzon Carlson, Christopher D Kroenke
: Altered macroscopic anatomical characteristics of the cerebral cortex have been identified in individuals affected by various neurodevelopmental disorders. However, the cellular developmental mechanisms that give rise to these abnormalities are not understood. Recently, advances in image reconstruction of diffusion magnetic resonance imaging (diffusion MRI) have made possible high resolution in utero measurements of water diffusion anisotropy in the fetal brain. Here, diffusion anisotropy within the developing fetal cerebral cortex is longitudinally characterized in the rhesus macaque, focusing on gestation days (G) 85 through G135 of the 165 day term...
January 9, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28068971/a-comparison-of-the-shaping-ability-of-three-nickel-titanium-rotary-instruments-a-micro-computed-tomography-study-via-a-contrast-radiopaque-technique-in-vitro
#13
Zhao Wei, Zhi Cui, Ping Yan, Han Jiang
BACKGROUND: Micro-CT (μCT) studies that combine simulated canals with meglucamine diatrizoate to evaluate the shaping ability of nickel-titanium (NiTi) rotary instruments are lacking in the literature. The purpose of this study was to evaluate the shaping ability of three new different nickel-titanium rotary instruments in simulated root canals using μCT. METHODS: Thirty simulated root canals with a curvature of 60° were randomly allocated into the following 3 groups (n = 10): Group 1, ProTaper Universal (PTU) rotary system; Group 2, Reciproc single-file system; and Group 3, K3XF rotary system...
January 9, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28066840/task-based-design-of-fluence-field-modulation-in-ct-for-model-based-iterative-reconstruction
#14
Grace J Gang, Jeffrey H Siewerdsen, J Webster Stayman
A task-driven imaging framework for prospective fluence field modulation (FFM) is developed in this paper. The design approach uses a system model that includes a parameterized FFM acquisition and model-based iterative reconstruction (MBIR) for image formation. Using prior anatomical knowledge (e.g. from a low-dose 3D scout image), accurate predictions of spatial resolution and noise as a function of FFM are integrated into a task-based objective function. Specifically, detectability index (d'), a common metric for task-based image quality assessment, is computed for a specific formulation of the imaging task...
July 2016: Conference Proceedings of International Conference on Image Formation in X-Ray Computed Tomography
https://www.readbyqxmd.com/read/28066801/cell-assisted-lipotransfer-in-breast-augmentation-and-reconstruction-a-systematic-review-of-safety-efficacy-use%C3%A2-of%C3%A2-patient-reported-outcomes-and-study-quality
#15
Zeeshaan Arshad, Lindsey Karmen, Rajan Choudhary, James A Smith, Olivier A Branford, David A Brindley, David Pettitt, Benjamin M Davies
BACKGROUND: Cell assisted lipotransfer serves as a novel technique for both breast reconstruction and breast augmentation. This systematic review assesses the efficacy, safety and use of patient reported outcome measures in studies involving cell assisted lipotransfer. We also carry out an objective assessment of study quality focussing on recruitment, follow-up and provide an up-to-date clinical trial landscaping analysis. METHODS: Key electronic databases were searched according to PRISMA guidelines and pre-defined inclusion and exclusion criteria...
December 2016: JPRAS Open
https://www.readbyqxmd.com/read/28066674/three-dimensional-computed-tomography-bronchography-and-angiography-in-the-preoperative-evaluation-of-thoracoscopic-segmentectomy-and-subsegmentectomy
#16
REVIEW
Wei-Bing Wu, Xin-Feng Xu, Wei Wen, Jing Xu, Quan Zhu, Xiang-Long Pan, Yang Xia, Liang Chen
Thoracoscopic pulmonary segmentectomy is technically meticulous due to the complicated anatomical variations of segmental bronchus and vessels. Currently three dimensional-computed tomography angiography (3D-CTA) could only meet the simple requirements of segmentectomy. Our center developed a software for reconstruction, "deepinsight", which could effectively solve some key technical problems. Preoperative three-dimensional computed tomography bronchography and angiography (3D-CTBA) could reveal the anatomical structures and improve the accuracy of operation...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28065926/image-based-3d-canopy-reconstruction-to-determine-potential-productivity-in-complex-multi-species-crop-systems
#17
Alexandra J Burgess, Renata Retkute, Michael P Pound, Sean Mayes, Erik H Murchie
BACKGROUND AND AIMS: Intercropping systems contain two or more species simultaneously in close proximity. Due to contrasting features of the component crops, quantification of the light environment and photosynthetic productivity is extremely difficult. However it is an essential component of productivity. Here, a low-tech but high-resolution method is presented that can be applied to single- and multi-species cropping systems to facilitate characterization of the light environment. Different row layouts of an intercrop consisting of Bambara groundnut (Vigna subterranea) and proso millet (Panicum miliaceum) have been used as an example and the new opportunities presented by this approach have been analysed...
January 8, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28065895/automated-neuron-tracing-using-probability-hypothesis-density-filtering
#18
Miroslav Radojević, Erik Meijering
MOTIVATION: The functionality of neurons and their role in neuronal networks is tightly connected to the cell morphology. A fundamental problem in many neurobiological studies aiming to unravel this connection is the digital reconstruction of neuronal cell morphology from microscopic image data. Many methods have been developed for this, but they are far from perfect, and better methods are needed. RESULTS: Here we present a new method for tracing neuron centerlines needed for full reconstruction...
January 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28064435/3d-volume-reconstruction-from-serial-breast-specimen-radiographs-for-mapping-between-histology-and-3d-whole-specimen-imaging
#19
Thomy Mertzanidou, John H Hipwell, Sara Reis, David J Hawkes, Babak Ehteshami Bejnordi, Mehmet Dalmis, Suzan Vreemann, Bram Platel, Jeroen van der Laak, Nico Karssemeijer, Meyke Hermsen, Peter Bult, Ritse Mann
PURPOSE: In breast imaging, radiological in-vivo images, such as X-ray mammography and Magnetic Resonance Imaging (MRI), are used for tumour detection, diagnosis and size determination. After excision, the specimen is typically sliced into slabs and a small subset is sampled. Histopathological imaging of the stained samples is used as the gold standard for characterisation of the tumour microenvironment. A 3D volume reconstruction of the whole specimen from the 2D slabs could facilitate bridging the gap between histology and in-vivo radiological imaging...
January 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28063078/analysis-of-acetabular-orientation-and-femoral-anteversion-using-images-of-three-dimensional-reconstructed-bone-models
#20
Jaeyeong Park, Jun-Young Kim, Hyun Deok Kim, Young Cheol Kim, Anna Seo, Minkyu Je, Jong Uk Mun, Bia Kim, Il Hyung Park, Shin-Yoon Kim
PURPOSE: Radiographic measurements using two-dimensional (2D) plain radiographs or planes from computed tomography (CT) scans have several drawbacks, while measurements using images of three-dimensional (3D) reconstructed bone models can provide more consistent anthropometric information. We compared the consistency of results using measurements based on images of 3D reconstructed bone models (3D measurements) with those using planes from CT scans (measurements using 2D slice images)...
January 6, 2017: International Journal of Computer Assisted Radiology and Surgery
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