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https://www.readbyqxmd.com/read/29156835/indonesian-herbal-medicine-prevents-hypertension-induced-left-ventricular-hypertrophy-by-diminishing-nadph-oxidase-dependent-oxidative-stress
#1
Erna Sulistyowati, Jong-Hau Hsu, Yuan-Bin Cheng, Fang-Rong Chang, Ying-Fu Chen, Jwu-Lai Yeh
Indonesian herbal medicine Centella asiatica, Justicia gendarussa and Imperata cylindrica decoction (CJID) are known to be efficacious for hypertension. Oxidative stress plays an important role in hypertension-induced left ventricular hypertrophy (H-LVH). This study evaluated whether CJID inhibit cardiac remodeling in spontaneously hypertensive rats (SHRs) through mechanism of oxidative stress-related cardiac-NADPH oxidase (NOXs) pathway: NOX1, NOX2 and NOX4. Forty-weeks-old SHRs and normotensive-WKY rats, were both randomly divided into 2 groups: CJID and control...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156831/protective-effect-of-nsa-on-intestinal-epithelial-cells-in-a-necroptosis-model
#2
Wei Dong, Min Zhang, Yaxi Zhu, Yuanhan Chen, Xingchen Zhao, Ruizhao Li, Li Zhang, Zhiming Ye, Xingling Liang
Objective: This study aimed to investigate the protective effect of the necroptosis inhibitor necrosulfonamide (NSA) on intestinal epithelial cells using a novel in vitro necroptosis model that mimics inflammatory bowel disease (IBD). Methods: 2,4,6-trinitrobenzenesulfonic acid (TNBS) was perfused into the rectum of BALB/c mice to established a colitis model. Pathologic injury and cell death were evaluated. A novel in vitro model of necroptosis was established in Caco-2 cells using TNF-α and Z-VAD-fmk, and the cells were treated with or without NSA...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156755/escherichia-coli-nissle-1917-engineered-to-express-tum-5-can-restrain-murine-melanoma-growth
#3
Lian He, Huijun Yang, Fei Liu, Yiyan Chen, Sijia Tang, Wei Ji, Jianli Tang, Zhudong Liu, Yunjun Sun, Shengbiao Hu, Youming Zhang, Xiong Liu, Weitao Huang, Xuezhi Ding, Liqiu Xia
Tumor growth and metastasis depend on angiogenesis. Thus, inhibiting tumor angiogenesis has become promising cancer therapeutic strategy in recent years. Tumstatin is a more powerful angiogenesis inhibitor than endostatin. Anti-angiogenic active fragment encoding amino acids 45-132 (Tum-5) of tumstatin was subcloned into four different inducible expression vectors and successfully solubly expressed in Escherichia coli BL21 (DE3) in this study. Subsequently, an anaerobic inducible expression vector was constructed under Vitreoscilla hemoglobin gene promoter Pvhb in E...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156735/telomerase-reverse-transcriptase-mediates-emt-through-nf-%C3%AE%C2%BAb-signaling-in-tongue-squamous-cell-carcinoma
#4
Yan Wu, Chunxiang Bian, Chunlin Zhen, Liu Liu, Zhenghong Lin, Muhammad Farrukh Nisar, Mei Wang, Jörg W Bartsch, Enyi Huang, Ping Ji, Li Yang, Yanhong Yu, Junfeng Yang, Xuemei Jiang, Julia Li Zhong
Locoregional lymph nodes metastasis in oral tongue squamous cell carcinoma represents one of important and common prognostic factors for poor clinical outcome. The human Telomerase Reverse Transcriptase (hTERT) is one of key players in cancer metastasis and stemness, but its exact function in tongue squamous cell carcinoma remains unknown. Here, we aim to understand the role of hTERT by utilizing the CRISPR/Cas9 gene editing system to deplete hTERT in the SCC-15 cell line. Functional comparison of SCC-15 control and knockout cells (hTERT(-/-)) showed that loss of hTERT suppressed cell proliferation and migration/invasion...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156631/morphology-and-mechanical-properties-of-polyimide-films-the-effects-of-uv-irradiation-on-microscale-surface
#5
Changzi Qu, Junsong Hu, Xing Liu, Zheng Li, Yanhuai Ding
As an attractive dielectric material, polyimide has been widely used in the field of electronics, aerospace, and automobiles due to its useful mechanical properties and good chemical resistance. UV irradiation was considered to be the main factor related to the damage and failure of polyimide. Here the effects of UV irradiation on the surface morphology and microscale mechanical properties of polyimide films are characterized by atomic force microscopy (AFM). The surface roughness of the UV-irradiated samples developed and the mechanical properties degraded with the radiation dose increased...
November 20, 2017: Materials
https://www.readbyqxmd.com/read/29156600/fabrication-of-semiconductor-zno-nanostructures-for-versatile-sers-application
#6
REVIEW
Lili Yang, Yong Yang, Yunfeng Ma, Shuai Li, Yuquan Wei, Zhengren Huang, Nguyen Viet Long
Since the initial discovery of surface-enhanced Raman scattering (SERS) in the 1970s, it has exhibited a huge potential application in many fields due to its outstanding advantages. Since the ultra-sensitive noble metallic nanostructures have increasingly exposed themselves as having some problems during application, semiconductors have been gradually exploited as one of the critical SERS substrate materials due to their distinctive advantages when compared with noble metals. ZnO is one of the most representative metallic oxide semiconductors with an abundant reserve, various and cost-effective fabrication techniques, as well as special physical and chemical properties...
November 19, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29156494/comparative-analysis-of-vestibular-ecomorphology-in-birds
#7
Roger B J Benson, Ethan Starmer-Jones, Roger A Close, Stig A Walsh
The bony labyrinth of vertebrates houses the semicircular canals. These sense rotational accelerations of the head and play an essential role in gaze stabilisation during locomotion. The sizes and shapes of the semicircular canals have hypothesised relationships to agility and locomotory modes in many groups, including birds, and a burgeoning palaeontological literature seeks to make ecological interpretations from the morphology of the labyrinth in extinct species. Rigorous tests of form-function relationships for the vestibular system are required to support these interpretations...
December 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29156452/an-international-consortium-update-pathophysiology-diagnosis-and-treatment-of-polycystic-ovarian-syndrome-in-adolescence
#8
Lourdes Ibáñez, Sharon E Oberfield, Selma F Witchel, Richard J Auchus, R Jeffrey Chang, Ethel Codner, Preeti Dabadghao, Feyza Darendeliler, Nancy Samir Elbarbary, Alessandra Gambineri, Cecilia Garcia Rudaz, Kathleen M Hoeger, Abel López-Bermejo, Ken Ong, Alexia S Peña, Thomas Reinehr, Nicola Santoro, Manuel Tena-Sempere, Rachel Tao, Bulent O Yildiz, Haya Alkhayyat, Asma Deeb, Dipesalema Joel, Reiko Horikawa, Francis de Zegher, Peter A Lee
This paper represents an international collaboration of paediatric endocrine and other societies (listed in the Appendix) under the International Consortium of Paediatric Endocrinology (ICPE) aiming to improve worldwide care of adolescent girls with polycystic ovary syndrome (PCOS)1. The manuscript examines pathophysiology and guidelines for the diagnosis and management of PCOS during adolescence. The complex pathophysiology of PCOS involves the interaction of genetic and epigenetic changes, primary ovarian abnormalities, neuroendocrine alterations, and endocrine and metabolic modifiers such as anti-Müllerian hormone, hyperinsulinemia, insulin resistance, adiposity, and adiponectin levels...
November 13, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29156445/autologous-tenocyte-implantation-into-shoulder-tendon-pathology-in-an-elite-swimmer
#9
Laura M Schwab, Peter Blanch, Mark Young
INTRODUCTION: The use of novel bioengineer treatment techniques such as Autologous Tenocyte Implantation (ATI) have shown promising improvements in both pain ratings and functional outcomes in elbow, gluteal and shoulder tendon pathology. This case will review the injury timeline of ATI intervention in an elite male swimmer with subscapularis tendon pathology and investigate whether ATI has a concomitant healing effect associated with improved functional outcomes. METHODS: A palmaris longus tendon biopsy was performed and cells were expanded by in-vitro culture...
October 13, 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29156405/effective-immobilization-of-au-nanoparticles-on-tio2-loaded-graphene-for-a-novel-sandwich-type-immunosensor
#10
Ying Chen, Yu Li, Dongmei Deng, Haibo He, Xiaoxia Yan, Zhenxin Wang, Chunhai Fan, Liqiang Luo
A novel and sensitive sandwich immunosensor for amperometric determination of carcinoembryonic antigen (CEA) was designed using Au nanoparticles-titanium dioxide-graphene (AuNPs-TiO2-graphene) nanocomposites. Dopamine-functionalized graphene was firstly prepared by π-stacking interaction, and TiO2 was then attached to the surface of dopamine-graphene by the specificity and high affinity of enediol ligands to Ti (IV). Afterwards, AuNPs-TiO2-graphene nanocomposites were synthesized with photo-reduction approach under ultraviolet irradiation...
November 17, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29156398/spontaneous-hair-follicle-germ-hfg-formation-in%C3%A2-vitro-enabling-the-large-scale-production-of-hfgs-for-regenerative-medicine
#11
Tatsuto Kageyama, Chisa Yoshimura, Dina Myasnikova, Ken Kataoka, Tadashi Nittami, Shoji Maruo, Junji Fukuda
Hair follicle morphogenesis is triggered by reciprocal interactions between hair follicle germ (HFG) epithelial and mesenchymal layers. Here, we developed a method for large-scale preparation of HFGs in vitro via self-organization of cells. We mixed mouse epidermal and mouse/human mesenchymal cells in suspension and seeded them in microwells of a custom-designed array plate. Over a 3-day culture period, cells initially formed a randomly distributed single cell aggregate and then spatially separated from each other, exhibiting typical HFG morphological features...
November 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/29156341/urinary-bisphenol-a-concentrations-are-associated-with-reproductive-parameters-in-young-men
#12
Evdochia Adoamnei, Jaime Mendiola, Fernando Vela-Soria, Mariana F Fernández, Nicolás Olea, Niels Jørgensen, Shanna H Swan, Alberto M Torres-Cantero
Bisphenol A (BPA) is a pervasive environmental toxicant with known reproductive effects on sperm parameters and hormone levels. Several observational studies have investigated the associations between BPA exposure and male reproductive function, but findings are inconsistent. The objective of this study was to assess the associations between urinary BPA concentrations and semen quality and reproductive hormone levels in a cross-sectional study with 215 healthy young university students (18-23 years old), investigated between 2010 and 2011 in Southern Spain (Murcia Region)...
November 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/29156340/fabricating-hierarchical-micro-and-nano-structures-on-implantable-co-cr-mo-alloy-for-tissue-engineering-by-one-step-laser-ablation
#13
Liguo Qin, Hongxing Wu, Junde Guo, Xinan Feng, Guangneng Dong, Jinyou Shao, Qunfeng Zeng, Yali Zhang, Yuanbin Qin
Surface texturing is one of the effective strategies to improve bioactivity of implantable materials. In this study, hierarchical micro and nano structure (HMN) were fabricated on Co-Cr-Mo alloy substrate by a movable picosecond laser irradiation. Respectively, microgrooves with nano ripples and islands were produced on Co-Cr-Mo alloy by low and high laser power density. X-ray diffraction apparatus (XRD) phase analysis illustrated that substrate was in the phase of γ- face-centered cubic structure (FCC) before laser treatment, while it was in ε-hexagonal closest packing structure (HCP) phase dominant after laser treatment...
November 17, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29156338/effect-of-laminaria-japonica-polysaccharides-on-lipids-monolayers-at-the-air-water-surface
#14
Juanjuan Yang, Changchun Hao, Runguang Sun
In this paper, we examined the effect of Laminaria japonica polysaccharides (LJP) on cationic 1,2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP) and anionic 1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-1-glycerol] (DPPG) monolayers at the air-water interface by the pressure-area isotherms (π-A), adsorption curves (π-t) and morphology measurements with atomic force microscopy (AFM) technique. The π-A curves revealed that the isotherms shifted to larger mean molecular area with progressive addition of LJP into subphase for both DOTAP and DPPG monolayers...
November 17, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29156306/effect-of-microcystins-on-root-growth-oxidative-response-and-exudation-of-rice-oryza-sativa
#15
Qing Cao, Richard R Rediske, Lei Yao, Liqiang Xie
A 30 days indoor hydroponic experiment was carried out to evaluate the effect of microcystins (MCs) on rice root morphology and exudation, as well as bioaccumulation of MCs in rice. MCs were bioaccumulated in rice with the greatest concentrations being observed in the leaves (113.68μgg(-1) Fresh weight (FW)) when exposed to 500μgL(-1) MCs. Root activity at 500μgL(-1) decreased 37%, compared to the control. MCs also induced disruption of the antioxidant system and lipid peroxidation in rice roots. Root growth was significantly inhibited by MCs...
November 17, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29156282/pesticides-in-agricultural-headwater-streams-in-southwestern-germany-and-effects-on-macroinvertebrate-populations
#16
Gero Weber, Nicole Christmann, Ann-Cathrin Thiery, Dieter Martens, Jochen Kubiniok
Pesticides are a major burden for stream ecosystems in the central European cultivated landscape. The objective of the present study was to investigate the applicability of ecological indicator methods in relation to toxicity of pesticides under the specific hydro-morphological conditions in small water bodies. Thus, an association of toxicity evaluating methods with different ecological indicators was to be attempted. Based on three random samples taken within the 2016 vegetation period, 23 headwater areas in the Saarland were investigated to test for pesticides and their metabolites...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29156254/xenografted-tissue-models-for-the-study-of-human-endometrial-biology
#17
REVIEW
Satu Kuokkanen, Liyin Zhu, Jeffrey W Pollard
The human endometrium undergoes extensive morphological, biochemical and molecular changes under the influence of female sex steroid hormones. Besides the fact that estrogen stimulates endometrial cell proliferation and progesterone inhibits this proliferation and induces differentiation, there is limited knowledge about precise molecular mechanisms underlying human endometrial biology. The importance of paracrine signaling in endometrial physiology explains why in vitro culture of endometrial cells has been challenging...
November 10, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/29156202/relapsed-acute-lymphoblastic-leukemia-is-it-crucial-to-achieve-molecular-remission-prior-to-transplant
#18
REVIEW
Mary Eapen
In patients with acute lymphoblastic leukemia (ALL) the risk of recurrent leukemia influences the choice of treatment between chemotherapy and allogeneic hematopoietic cell transplantation. The evaluation of minimal residual disease (MRD) is now considered to be the greatest progress in risk stratification in regard to leukemia recurrence. Achieving molecular remission at the end of induction therapy after diagnosis or after relapse has influenced treatment choice. Failure to achieve molecular remission is considered "high risk" and allogeneic hematopoietic cell transplantation with a suitable donor, the accepted standard...
December 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29156133/harnessing-sphingosine-1-phosphate-signaling-and-nanotopographical-cues-to-regulate-skeletal-muscle-maturation-and-vascularization
#19
Jonathan Hung Tsui, Kajohnkiart Janebodin, Nicholas Ieronimakis, David Michael Patrick Yama, Hee Seok Yang, Rakchanok Chavanachat, Aislinn L Hays, Haeshin Lee, Morayma Reyes, Deok-Ho Kim
Despite possessing substantial regenerative capacity, skeletal muscle can suffer from loss of function due to catastrophic traumatic injury or degenerative disease. In such cases, engineered tissue grafts hold the potential to restore function and improve patient quality of life. Requirements for successful integration of engineered tissue grafts with the host musculature include cell alignment that mimics host tissue architecture and directional functionality, as well as vascularization to ensure tissue survival...
November 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29156051/natural-and-anthropogenic-influences-on-the-mating-system-of-the-common-morning-glory
#20
Diego F Alvarado-Serrano, Shu-Mei Chang, Regina S Baucom
Evolutionary biologists remain puzzled by the often dramatic variation of mating strategies within single species. Of particular interest is the extent to which environmental conditions shape patterns of variation of mating system components within mixed mating species, and how widespread anthropogenic manipulations may influence these associations. Here, we address this question in the common morning glory (Ipomoea purpurea) by combining a dataset of floral traits, estimates of the mating system, and relevant environmental factors compiled for 22 populations of this species distributed along a wide range of environments from the Southeast and midwest USA...
November 16, 2017: Journal of Heredity
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