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https://www.readbyqxmd.com/read/28432977/effect-of-short-term-zn-pb-or-long-term-multi-metal-stress-on-physiological-and-morphological-parameters-of-metallicolous-and-nonmetallicolous-echium-vulgare-l-populations
#1
Sławomir Dresler, Magdalena Wójciak-Kosior, Ireneusz Sowa, Grzegorz Stanisławski, Izabela Bany, Małgorzata Wójcik
The aim of the study was to determine the response of metallicolous and nonmetallicolous Echium vulgare L. populations to chronic multi-metal (Zn, Pb, Cd) and acute Zn (200, 400 μM) and Pb (30, 60 μM) stress. Three populations of E. vulgare, one from uncontaminated and two from metal-contaminated areas, were studied. Two types of experiments were performed - a short-term hydroponic experiment with acute Zn or Pb stress and a long-term manipulative soil experiment with the use of soils from the sites of origin of the three populations...
April 13, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28432957/nanoencapsulation-strategies-for-the-delivery-of-novel-bifunctional-antioxidant-%C3%AF-1-selective-ligands
#2
Claudia Carbone, Emanuela Arena, Veronica Pepe, Orazio Prezzavento, Ivana Cacciatore, Hasan Turkez, Agostino Marrazzo, Antonio Di Stefano, Giovanni Puglisi
Nowadays sigma-1 receptors are considered as new therapeutic objectives for central nervous system neurodegenerative diseases. Among different molecules, alpha lipoic acid has been identified as a natural potent antioxidant drug, whose therapeutic efficacy is limited by its many drawbacks, such as fast metabolism, poor bioavailability and high physico-chemical instability. Alfa-lipoic acid derivatives have been recently developed demonstrating their neuroprotective activity and effectiveness in different types of oxidative stress...
April 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28432956/introduction-of-n-cadherin-binding-motif-to-alginate-hydrogels-for-controlled-stem-cell-differentiation
#3
Jae Won Lee, Hyoseok An, Kuen Yong Lee
Control of stem cell fate and phenotype using biomimetic synthetic extracellular matrices (ECMs) is an important tissue engineering approach. Many studies have focused on improving cell-matrix interactions. However, proper control of cell-cell interactions using synthetic ECMs could be critical for tissue engineering, especially with undifferentiated stem cells. In this study, alginate hydrogels were modified with a peptide derived from the low-density lipoprotein receptor-related protein 5 (LRP5), which is known to bind to N-cadherin, as a cell-cell interaction motif...
April 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28432955/the-calorimetric-properties-of-liposomes-determine-the-morphology-of-dried-droplets
#4
Jorge González-Gutiérrez, Rosendo Pérez-Isidoro, M I Pérez-Camacho, J C Ruiz-Suárez
The evaporation of liquid droplets deposited on a substrate is a very complex phenomenon. Driven by capillary and Marangoni flows, particle-particle and particle-substrate interactions, the deposits they leave are vestiges of such complexity. We study the formation of patterns during the evaporation of liposome suspension droplets deposited on a hydrophobic substrate at different temperatures. We observed that as we change the temperature of the substrate, a morphological phase transition occurs at a given temperature Tm...
April 19, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28432936/the-immunosuppressive-characteristics-of-fb1-by-inhibition-of-maturation-and-function-of-bmdcs
#5
Yinhuan Li, Yanhong Fan, Bingbing Xia, Qiuping Xiao, Qingqing Wang, Weidong Sun, Haibin Zhang, Chenghua He
Fumonisin B1 (FB1) is one kind of mycotoxins that has the neurotoxicity, carcinogenicity, hepatotoxicity and immunotoxicity produced by the fungus Fusarium verticillioides, which commonly infects corn and other crops and is harmful to animal and human health upon consumption of FB1-contaminated feed or food. However, the mechanism of immunotoxicity, especially the immunosuppression induced by FB1 is still unclear. The most pivotal cells in the induction of immune responses are dendritic cells (DCs). In this study, we used murine bone marrow-derived dendritic cells (BMDCs) as a model system to elucidate the effect of FB1 on the function of BMDCs through biological methods...
April 19, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28432822/focal-liver-lesions-segmentation-and-classification-in-nonenhanced-t2-weighted-mri
#6
Ilias Gatos, Stavros Tsantis, Maria Karamesini, Stavros Spiliopoulos, Dimitris Karnabatidis, John D Hazle, George C Kagadis
PURPOSE: To automatically segment and classify focal liver lesions (FLLs) on nonenhanced T2-weighted magnetic resonance imaging (MRI) scans using a computer-aided diagnosis (CAD) algorithm. METHODS: 71 FLLs (30 benign lesions, 19 hepatocellular carcinomas, and 22 metastases) on T2-weighted MRI scans were delineated by the proposed CAD scheme. The FLL segmentation procedure involved wavelet multiscale analysis to extract accurate edge information and mean intensity values for consecutive edges computed using horizontal and vertical analysis that were fed into the subsequent fuzzy C-means algorithm for final FLL border extraction...
April 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/28432818/characterization-of-decellularized-ovine-small-intestine-submucosal-layer-as-extracellular-matrix-based-scaffold-for-tissue-engineering
#7
Morteza Rashtbar, Jamshid Hadjati, Jafar Ai, Issa Jahanzad, Mahmoud Azami, Sadegh Shirian, Somayeh Ebrahimi-Barough, Esmaeil Sadroddiny
Extracellular matrix-based scaffolds derived from mammalian tissues have been used in tissue engineering applications. Among all the tissues, decellularized small intestine submucosal layer (SIS) has been recently investigated for its exceptional characteristics and biocompatibilities. These investigations have been mainly focused on the decellularized porcine SIS; however, there has not been any report on ovine SIS (OSIS) layer. In this study, OSIS was decellularized and its physical, chemical, and morphological properties were evaluated...
April 22, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28432787/presynaptic-morphology-and-vesicular-composition-determine-vesicle-dynamics-in-mouse-central-synapses
#8
Laurent Guillaud, Dimitar Dimitrov, Tomoyuki Takahashi
Transport of synaptic vesicles (SVs) in nerve terminals is thought to play essential roles in maintenance of neurotransmission. To identify factors modulating SV movements, we performed real-time imaging analysis of fluorescently labeled SVs in giant calyceal and conventional hippocampal terminals. Compared with small hippocampal terminals, SV movements in giant calyceal terminals were faster, longer and kinetically more heterogeneous. Morphological maturation of giant calyceal terminals was associated with an overall reduction in SV mobility and displacement heterogeneity...
April 22, 2017: ELife
https://www.readbyqxmd.com/read/28432755/mitochondria-and-ageing-role-in-heart-skeletal-muscle-and-adipose-tissue
#9
REVIEW
Kerstin Boengler, Maik Kosiol, Manuel Mayr, Rainer Schulz, Susanne Rohrbach
Age is the most important risk factor for most diseases. Mitochondria play a central role in bioenergetics and metabolism. In addition, several lines of evidence indicate the impact of mitochondria in lifespan determination and ageing. The best-known hypothesis to explain ageing is the free radical theory, which proposes that cells, organs, and organisms age because they accumulate reactive oxygen species (ROS) damage over time. Mitochondria play a central role as the principle source of intracellular ROS, which are mainly formed at the level of complex I and III of the respiratory chain...
April 21, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28432731/association-between-progressive-hepatic-morphology-changes-on-serial-mr-imaging-and-clinical-outcome-in-primary-sclerosing-cholangitis
#10
Yu Xuan Kitzing, Siobhan A Whitley, Sara S Upponi, Brijesh Srivastava, Graeme Jm Alexander, David J Lomas
INTRODUCTION: Hepatic morphology changes are well described in Primary Sclerosing Cholangitis and characterised by a combination of atrophy and hypertrophy changes. This study investigates the relationship between progression of these changes over time and clinical outcome in patients with PSC. METHODS: Fifty-three patients with PSC (mean age 44, 28 males and 25 females) who underwent serial MRI liver studies at least one year apart were identified. The first and the last MRI studies were selected for the retrospective analysis...
April 22, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28432703/selective-calixarene-directed-synthesis-of-mxene-plates-crumpled-sheets-spheres-and-scrolls
#11
Arni Vaughn, Jeremy Ball, Tobias Heil, David Morgan, Giulio Lampronti, Gabija Maršalkaitė, Colin L Raston, Nicholas P Power, Suela Kellici
Fully exploiting the electronic and mechanical properties of 2D laminar materials not only requires efficient and effective means of their exfoliation into low dimensional layers, but also necessitates a means of changing their morphology so as to explore any enhancement that this may offer. MXenes are a rapidly emerging new class of such laminar materials with unique properties. However, access to other morphologies of MXenes has not yet been fully realised. To this end we have developed the synthesis of MXenes (Ti2C) as plates, crumpled sheets, spheres and scrolls, which involves selective intercalation of p-phosphonic calix[n]arenes, with control in morphology arising from the choice of the size of the macrocycle, n = 4, 5, 6 or 8...
April 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28432627/inorganic-fouling-control-in-reverse-osmosis-wastewater-reclamation-by-purging-carbon-dioxide
#12
Muhammad Kashif Shahid, Minsu Pyo, Young-Gyun Choi
Inorganic fouling on the membrane surface is one of the major prevalent issues affecting the performance and cost of reverse osmosis system. Chemical dosage is a widely adopted method for the inhibition of inorganic scale on the membrane surface. In this study, CO2 was used to control inorganic scale formation on surface of reverse osmosis (RO) membrane in wastewater reclamation. The pH of influent could be lowered by purging CO2. It caused an increase in solubility of inorganic salts in water resulting in discharge of principle ions in concentrate stream...
April 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28432566/four-new-species-of-dactylogyrus-diesing-1850-monogenea-dactylogyridae-parasitising-the-gills-of-northern-moroccan-luciobarbus-heckel-cyprinidae-morphological-and-molecular-characterisation
#13
Imane Rahmouni, Eva Řehulková, Antoine Pariselle, Ouafae Berrada Rkhami, Andrea Šimková
Four new species of Dactylogyrus Diesing, 1850 are described from the gills of three species of Luciobarbus Heckel collected from various hydrographical basins in northern Morocco: Dactylogyrus scorpius n. sp. from Luciobarbus rifensis Doadrio, Casal-Lopez & Yahyaoui; D. benhoussai n. sp. from L. moulouyensis Pellegrin; and D. varius n. sp. and D. falsiphallus n. sp. from L. maghrebensis Doadrio, Perea & Yahyaoui. The descriptions of the new species are confirmed by molecular data (partial 18S rDNA, ITS1, and partial 28S rDNA sequences)...
April 21, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28432565/parapharyngodon-hugoi-n-sp-a-new-nematode-oxyuroidea-pharyngodonidae-of-the-tree-frog-trachycephalus-typhonius-linnaeus-from-the-brazilian-pantanal-including-a-key-to-the-congeners-from-amphibians-of-the-american-continent
#14
Felipe B Pereira, Karla M Campião, José L Luque, Luiz E R Tavares
A new nematode Parapharyngodon hugoi n. sp. (Oxyuroidea: Pharyngodonidae) is described parasitising the large intestine of the tree frog Trachycephalus typhonius (Linnaeus) (Anura: Hylidae) from the wetlands of Pantanal, State of Mato Grosso do Sul, Brazil. The new species exhibits a unique structure of the posterior cloacal lip in males, which is supported by a rigid V-shaped structure. Parapharyngodon hylidae parasitic in hylid frogs, including T. typhonius, from Mexico, is the most similar congener to P...
April 21, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28432562/increased-expression-of-the-microrna-106b-25-cluster-and-its-host-gene-mcm7-in-corticotroph-pituitary-adenomas-is-associated-with-tumor-invasion-and-crooke-s-cell-morphology
#15
Filip Garbicz, Dawid Mehlich, Beata Rak, Emir Sajjad, Maria Maksymowicz, Wiktor Paskal, Grzegorz Zieliński, Paweł K Włodarski
PURPOSE: MCM7 (minichromosome maintenance complex component 7), a DNA replication licensing factor, is a host gene for the oncogenic miR-106b~25 cluster. It has been recently revealed as a relevant prognostic biomarker in a variety of cancers, including pituitary adenomas. The purpose of this study was to assess whether miR-106b~25 and MCM7 levels correlate with tumor invasiveness in a cohort of ACTH-immunopositive adenomas. METHODS: Tissue samples were obtained intraoperatively from 25 patients with pituitary adenoma...
April 21, 2017: Pituitary
https://www.readbyqxmd.com/read/28432458/is-the-evaluation-of-the-anterior-inferior-iliac-spine-aiis-in-the-ap-pelvis-possible-analysis-of-conventional-x-rays-and-3d-ct-reconstructions
#16
David R Krueger, Markus Windler, Markus Geßlein, Michael Schuetz, Carsten Perka, Joerg H Schroeder
INTRODUCTION: A hypertrophic AIIS has been identified as a cause for extraarticular hip impingement and is classified according to Hetsroni using 3D-CT reconstructions. The role of the conventional AP pelvis X-ray, which is the first standard imaging step for the evaluation of hip pain, has not been investigated yet. MATERIALS AND METHODS: AP pelvis X-rays and 3D-CT reconstructions of patients were evaluated regarding their morphology of the AIIS. The conventional X-rays were categorized into three groups according to the projection of the AIIS: above (A) or below (B) the acetabular sourcil or even exceeding the anterior acetabular rim (C)...
April 21, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28432452/fluorescent-angioscopic-imaging-of-calcium-phosphate-tribasic-precursor-of-hydroxyapatite-the-major-calcium-deposit-in-human-coronary-plaques
#17
Takanobu Kobayashi, Osamu Nakagawa, Seiichiro Shirai, Ei Shimoyama, Nobuyuki Hiruta, Yasumi Uchida
Coronary calcification is a risk factor for ischemic heart disease. Hydroxyapatite that is formed by polymerization from calcium phosphate tribasic (CPT) is the major constituent of coronary calcium deposits. If CPT could be visualized, coronary calcification could be predicted and prevented. We discovered that when CPT and collagen I, the main constituent of collagen fibers, are mixed with lac dye (LD) and then exposed to fluorescent light excited at 345 ± 15 nm and emitted at 420 nm, a purple fluorescence that is characteristic of CPT only is elicited...
April 21, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28432443/progastrin-a-potential-predictive-marker-of-liver-metastasis-in-colorectal-cancer
#18
David A Westwood, Oneel Patel, Christopher Christophi, Arthur Shulkes, Graham S Baldwin
BACKGROUND AND AIMS: Staging of colorectal cancer often fails to discriminate outcomes of patients with morphologically similar tumours that exhibit different clinical behaviours. Data from several studies suggest that the gastrin family of growth factors potentiates colorectal cancer tumourigenesis. The aim of this study was to investigate whether progastrin expression may predict clinical outcome in colorectal cancer. METHODS: Patients with colorectal adenocarcinoma of identical depth of invasion who had not received neoadjuvant therapy were included...
April 21, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28432437/an-italian-multicentre-study-on-adult-atopic-dermatitis-persistent-versus-adult-onset-disease
#19
Matteo Megna, Cataldo Patruno, Anna Balato, Franco Rongioletti, Luca Stingeni, Nicola Balato
Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease which predominantly affects children. However, AD may persist until adulthood (persistent AD), or directly start in adults (adult-onset AD). AD often shows a non-flexural rash distribution, and atypical morphologic variants in adults and specific diagnostic criteria are lacking. Moreover, adult AD prevalence as well as detailed data which can characterize persistent vs adult-onset subtype are scant. The aim of this study was to investigate on the main features of adult AD particularly highlighting differences between persistent vs adult-onset form...
April 21, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28432323/refractive-index-tomograms-and-dynamic-membrane-fluctuations-of-red-blood-cells-from-patients-with-diabetes-mellitus
#20
SangYun Lee, HyunJoo Park, Kyoohyun Kim, YongHak Sohn, Seongsoo Jang, YongKeun Park
In this paper, we present the optical characterisations of diabetic red blood cells (RBCs) in a non-invasive manner employing three-dimensional (3-D) quantitative phase imaging. By measuring 3-D refractive index tomograms and 2-D time-series phase images, the morphological (volume, surface area and sphericity), biochemical (haemoglobin concentration and content) and mechanical (membrane fluctuation) parameters were quantitatively retrieved at the individual cell level. With simultaneous measurements of individual cell properties, systematic correlative analyses on retrieved RBC parameters were also performed...
April 21, 2017: Scientific Reports
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