keyword
https://read.qxmd.com/read/38497274/development-of-a-novel-human-stratum-corneum-mimetic-phospholipid-vesicle-based-permeation-assay-models-for-in-vitro-permeation-studies
#21
JOURNAL ARTICLE
Yuerong Qian, Xuchao Wei, Yiwei Wang, Shaoping Yin, Jun Chen, Jie Dong
Objectives: Development and evaluation of a novel human stratum corneum (SC) mimetic phospholipid vesicle-based permeation assay (PVPASC ) model for in vitro permeation studies. Significance: Due Owing to the increasing restrictions ion the use of human and animal skins, artificial skin models have attracted lots of substantial interest in pharmaceuticals and cosmetic industrials. In this study, a modified PVPASC model containing both SC lipids and proteins was developed. Methods: The PVPASC model was optimized by altering changing the lipid composition and adding keratin in the formulation of large liposomes...
March 18, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38496993/understanding-the-modulation-of-%C3%AE-synuclein-fibrillation-by-n-acetyl-aspartate-a-brain-metabolite
#22
JOURNAL ARTICLE
Tanzeel Khan, Rashid Waseem, Mohammad Shahid, Jaoud Ansari, Md Imtaiyaz Hassan, Anas Shamsi, Asimul Islam
α-Synuclein (α-Syn) fibrillation is a prominent contributor to neuronal deterioration and plays a significant role in the advancement of Parkinson's Disease (PD). Considering this, the exploration of novel compounds that can inhibit or modulate the aggregation of α-Syn is a topic of significant research. This study, for the first time, elucidated the effect of N -acetyl aspartate (NAA), a brain osmolyte, on α-Syn aggregation using spectroscopic and microscopic approaches. Thioflavin T (ThT) assay revealed that a lower concentration of NAA inhibits α-Syn aggregation, whereas higher concentrations of NAA accelerate the aggregation...
March 12, 2024: ACS Omega
https://read.qxmd.com/read/38493799/resolution-of-painful-trichodysplasia-spinulosa-with-topical-cidofovir-case-report
#23
JOURNAL ARTICLE
Kevin M Burningham, Ritu N Swali, Peter L Rady, Anisha B Patel, Stephen K Tyring
Purpose: Trichodysplasia spinulosa (TS) is a rare, disfiguring skin condition which presents with widespread asymptomatic or pruritic, skin-colored papules with white protruding keratin spiculations in immunocompromised individuals. Due to its rarity, there is little data to guide treatment decisions. The purpose of this article is to report a case of TS that completely resolved after treatment with topical cidofovir. Materials and methods: A 19-year-old immunosuppressed female presented with widespread painful, itchy bumps on the nose and face...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38488848/selective-anticervical-cancer-injectable-and-self-healable-hydrogel-platforms-constructed-of-drug-loaded-cross-linkable-unimolecular-micelles-in-a-single-and-combination-therapy
#24
JOURNAL ARTICLE
Monika Gosecka, Mateusz Gosecki, Piotr Ziemczonek, Malgorzata Urbaniak, Ewelina Wielgus, Monika Marcinkowska, Anna Janaszewska, Barbara Klajnert-Maculewicz
In the face of severe side effects of systemic chemotherapy used in cervical cancer, topical selective drug carriers with long-lasting effects are being sought. Hydrogels are suitable platforms, but their use is problematic in the case of delivery of hydrophobic drugs with anticancer activity. Herein, hydrogels constructed of unimolecular micelles displaying enhanced solubilization of aromatic lipophilic bioactive compounds are presented. Star-shaped poly(benzyl glycidyl ether)- block -poly(glycidyl glycerol ether) with an aryl-enriched core show high encapsulation capacity of poor water-soluble nifuratel and clotrimazole...
March 15, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38488071/-homoleptic-tetracoordinate-boron-compounds
#25
REVIEW
Xin Li, Qiuling Song
"Homoleptic" tetracoordinate boron compounds, in which the central boron atom links to four identical atoms, are a special and important family of boron compounds. During the past decades, they have been extensively employed in inorganic, organic, macromolecular, and materials chemistry. Many of them exhibit a diverse range of outstanding properties, and therefore, the synthesis and application of those compounds have emerged as a hot research topic in modern boron chemistry. This review summarizes and discusses the "homoleptic" tetracoordinate boron compounds, which are organized according to the kinds of atoms coordinated to the central boron...
March 15, 2024: Inorganic Chemistry
https://read.qxmd.com/read/38487088/niosome-as-a-promising-tool-for-increasing-the-effectiveness-of-anti-inflammatory-compounds
#26
REVIEW
Mohammad Saleh Fadaei, Mohammad Reza Fadaei, Amir Emad Kheirieh, Pouria Rahmanian-Devin, Mohammad Mahdi Dabbaghi, Kiarash Nazari Tavallaei, Abouzar Shafaghi, Hooman Hatami, Vafa Baradaran Rahimi, Ali Nokhodchi, Vahid Reza Askari
Niosomes are drug delivery systems with widespread applications in pharmaceutical research and the cosmetic industry. Niosomes are vesicles of one or more bilayers made of non-ionic surfactants, cholesterol, and charge inducers. Because of their bilayer characteristics, similar to liposomes, niosomes can be loaded with lipophilic and hydrophilic cargos. Therefore, they are more stable and cheaper in preparation than liposomes. They can be classified into four categories according to their sizes and structures, namely small unilamellar vesicles (SUVs), large unilamellar vesicles (LUVs,), multilamellar vesicles (MLVs), and multivesicular vesicles (MVVs)...
2024: EXCLI Journal
https://read.qxmd.com/read/38485679/actinomycetes-the-repertoire-of-diverse-bioactive-chemical-molecules-from-structures-to-antibiotics
#27
JOURNAL ARTICLE
Ishfaq Ahmad Baba, Zubair Ahmad Wani, Shazia Ali, Zahoor Ahmad, Mohamad Mosa Mubarak
The urgent need for novel antibiotics in the face of escalating global antimicrobial resistance necessitates innovative approaches to identify bioactive compounds. Actinomycetes, renowned for their prolific production of antimicrobial agents, stand as a cornerstone in this pursuit. Their diverse metabolites exhibit multifaceted bioactivities, including potent antituberculosis, anticancer, immunomodulatory, immuno-protective, antidiabetic, etc. Though terrestrial sources have been exploited significantly, contemporary developments in the field of antimicrobial drug discovery have put marine actinomycetes in a prominent light as a promising and relatively unexplored source of novel bioactive molecules...
March 11, 2024: Current Topics in Medicinal Chemistry
https://read.qxmd.com/read/38485678/immunomodulatory-plant-natural-products-as-therapeutics-against-inflammatory-skin-diseases
#28
JOURNAL ARTICLE
Nikhila Sampath Kumar, Navaneetha Reddy, Halmuthur Kumar, Sravanthi Vemireddy
Frequently occurring inflammatory skin conditions such as psoriasis, dermatitis, acne, including skin cancer, wounds and other disorders arising out of premature skin aging, deteriorate skin health and adversely impact human life. Even though several synthetic compounds have evolved for treating these skin conditions, natural-product-based therapeutics are gaining popularity with growing evidence of their efficacy and safety for treating skin disorders. Many of these inflammatory skin diseases have underlying disturbances in our immune system and immunomodulatory natural products provide solutions for their effective treatment and aid in understanding the underlying mechanism of such inflammatory skin conditions...
March 11, 2024: Current Topics in Medicinal Chemistry
https://read.qxmd.com/read/38484828/reactive-skin-decontamination-lotion-rsdl-safety-with-clinical-antiseptics-and-hemostatic-agents
#29
JOURNAL ARTICLE
Jessica Franken, John Mikler
Reactive skin decontamination lotion (RSDL) is a Health Canada approved product used by the Canadian Armed Forces for removal and inactivation of toxic chemicals on skin. Although it is considered very safe when used as directed, questions have been raised regarding whether topical RSDL in the medical setting will react exothermically with antiseptic compounds on the casualty's epidermis that could result in thermal burns. Benchtop experiments were conducted to investigate reactivity of RSDL with various antiseptic compounds or hemostatic agents...
March 12, 2024: Toxicology Letters
https://read.qxmd.com/read/38482050/-in-vitro-characterization-of-novel-hyaluronan-antioxidant-conjugates-as-potential-topical-therapeutics-against-hearing-loss
#30
JOURNAL ARTICLE
Elizabeth M Arrigali, Joachim G S Veit, Bhaskar Birru, Jack Van Tine, Kolton C Sandau, Emma Barrett-Catton, Zachary Tonnerre, Monica A Serban
Noise-induced hearing loss affects roughly 430 million people worldwide. Current treatment options often require invasive medical procedures, and to date, there are no FDA-approved drug therapies. While the causes can be diverse, noise induced hearing loss is unequivocally associated with oxidative stress and inflammation, and subsequent damage to the inner ear structures. Several studies have shown that various antioxidants such as glutathione, cysteine, and methionine can be used to mitigate oxidative damage from reactive oxygen species; however, these studies relied on invasive or systemic drug delivery methods...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38481233/support-not-blame-safe-partner-disclosure-among-women-diagnosed-with-hiv-late-in-pregnancy-in-south-africa-and-uganda
#31
JOURNAL ARTICLE
Adelline Twimukye, Yussif Alhassan, Beate Ringwald, Thokozile Malaba, Landon Myer, Catriona Waitt, Mohammed Lamorde, Helen Reynolds, Saye Khoo, Miriam Taegtmeyer
BACKGROUND: HIV partner disclosure rates remain low among pregnant women living with HIV in many African countries despite potential benefits for women and their families. Partner disclosure can trigger negative responses like blame, violence, and separation. Women diagnosed with HIV late in pregnancy have limited time to prepare for partner disclosure. We sought to understand challenges around partner disclosure and non-disclosure faced by women diagnosed with HIV late in pregnancy in South Africa and Uganda and to explore pathways to safe partner disclosure...
March 13, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38481119/using-automated-patch-clamp-electrophysiology-platforms-in-ion-channel-drug-discovery-an-industry-perspective
#32
JOURNAL ARTICLE
Marc Rogers, Alison Obergrussberger, Artem Kondratskyi, Niels Fertig
INTRODUCTION: Automated patch clamp (APC) is now well established as a mature technology for ion channel drug discovery in academia, biotech and pharma companies, and in contract research organizations (CRO), for a variety of applications including channelopathy research, compound screening, target validation and cardiac safety testing. AREAS COVERED: Ion channels are an important class of drugged and approved drug targets. The authors present a review of the current state of ion channel drug discovery along with new and exciting developments in ion channel research involving APC...
March 13, 2024: Expert Opinion on Drug Discovery
https://read.qxmd.com/read/38480474/easy-amanida-an-r-shiny-application-for-the-meta-analysis-of-aggregate-results-in-clinical-metabolomics-using-amanida-and-webchem
#33
REVIEW
Maria Llambrich, Pau Satorra, Eudald Correig, Josep Gumà, Jesús Brezmes, Cristian Tebé, Raquel Cumeras
Meta-analysis is a useful tool in clinical research, as it combines the results of multiple clinical studies to improve precision when answering a particular scientific question. While there has been a substantial increase in publications using meta-analysis in various clinical research topics, the number of published meta-analyses in metabolomics is significantly lower compared to other omics disciplines. Metabolomics is the study of small chemical compounds in living organisms, which provides important insights into an organism's phenotype...
March 13, 2024: Research Synthesis Methods
https://read.qxmd.com/read/38477206/repurposing-of-plant-based-antiviral-molecules-for-the-treatment-of-covid-19
#34
JOURNAL ARTICLE
Jabeena Khazir, Sajad Ahmed, Rakesh Kr Thakur, Manzoor Hussain, Sumit G Gandhi, Sadhana Babbar, Shabir Ahmad Mir, Nusrat Shafi, Libert Brice Tonfack, Vijay Rani Rajpal, Tariq Maqbool, Bilal Ahmad Mir, Latif Ahmad Peer
COVID-19, stemming from SARS-CoV-2, poses a formidable threat to global healthcare, with a staggering 77 million confirmed cases and 690,067 deaths recorded till December 24, 2023. Given the absence of specific drugs for this viral infection, the exploration of novel antiviral compounds becomes imperative. High-throughput technologies are actively engaged in drug discovery, and there is a parallel effort to repurpose plant-based molecules with established antiviral properties. In this context, the review meticulously delves into the potential of plant-based folk remedies and existing molecules...
February 20, 2024: Current Topics in Medicinal Chemistry
https://read.qxmd.com/read/38475324/chitosan-virgin-coconut-oil-based-emulsions-doped-with-photosensitive-curcumin-loaded-capsules-a-functional-carrier-to-topical-treatment
#35
JOURNAL ARTICLE
Luísa C Rodrigues, Adriana P Ribeiro, Simone S Silva, Rui L Reis
In recent years, there has been a growing interest in developing smart drug delivery systems based on natural resources combined with stimulus-sensitive elements. This trend aims to formulate innovative and sustainable delivery platforms tailored for topical applications. This work proposed the use of layer-by-layer (LbL) methodology to fabricate biocompatible photo-responsive multilayer systems. These systems are composed of a polyoxometalate inorganic salt (POM) ([NaP5 W30 O110 ]14- ) and a natural origin polymer, chitosan (CHT)...
February 27, 2024: Polymers
https://read.qxmd.com/read/38474609/comparative-analysis-of-the-structure-and-pharmacological-properties-of-some-piperidines-and-host-guest-complexes-of-%C3%AE-cyclodextrin
#36
JOURNAL ARTICLE
Ulan Kemelbekov, Vitaly Volynkin, Symbat Zhumakova, Kulpan Orynbassarova, Marina Papezhuk, Valentina Yu
Pain and anesthesia are a problem for all physicians. Scientists from different countries are constantly searching for new anesthetic agents and methods of general anesthesia. In anesthesiology, the role and importance of local anesthesia always remain topical. In the present work, a comparative analysis of the results of pharmacological studies on models of the conduction and terminal anesthesia, as well as acute toxicity studies of the inclusion complex of 1-methyl-4-ethynyl-4-hydroxypiperidine (MEP) with β-cyclodextrin, was carried out...
February 29, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38474480/enhancing-the-efficacy-of-chiral-ligands-and-catalysts-siloxane-substituted-oxazoline-ferrocenes-as-next-generation-candidates
#37
REVIEW
Li Dai, Li Zhao, Di Xu, Chen Yang, Xin-Kuan Zhang
Since the discovery of classical chiral oxazoline ferrocene ligands in 1995, they have become pivotal in transition metal-catalyzed asymmetric transformations. Over the past decade, a notable evolution has been observed with the emergence of siloxane-substituted oxazoline ferrocenes, demonstrating significant potential as chiral ligands and catalysts. These compounds have consistently delivered exceptional results in diverse and mechanistically distinct transformations, surpassing the capabilities of classical oxazoline ferrocene ligands...
February 22, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38471795/analysis-of-preservatives-and-fragrances-in-topical-medical-devices-the-need-for-more-stringent-regulation
#38
JOURNAL ARTICLE
Ania Stras, Aleksandra Grassmann, Peter Van Campenhout, Eric Deconinck, Tamara Vanhaecke, Bart Desmedt
INTRODUCTION: Medical devices (MDs) have a long history of use, and come with regulatory frameworks to ensure user safety. Although topically applied MDs in the form of gels and creams might be used on damaged skin, their composition is often similar to that of cosmetic products applicable to intact skin, especially in terms of preservatives and fragrances. However, unlike cosmetics, these products are not subject to compound-specific restrictions when used in MDs. OBJECTIVE: This study aimed to identify and quantify preservatives and fragrances in topically applied MDs and assess their safety towards the Cosmetic Regulation (EC) 1223/2009...
March 12, 2024: Contact Dermatitis
https://read.qxmd.com/read/38465537/successes-and-challenges-in-the-development-of-bd1-selective-bet-inhibitors-a-patent-review
#39
JOURNAL ARTICLE
Monica Viviano, Alessandra Cipriano, Emanuele Fabbrizi, Alessandra Feoli, Sabrina Castellano, Gianluca Sbardella, Antonello Mai, Ciro Milite, Dante Rotili
INTRODUCTION: Bromodomain and ExtraTerminal (BET) domain proteins are transcriptional cofactors that, recognizing acetylated lysines of histone and non-histone proteins, can modulate gene expression. The BET family consists of four members, each of which contains two bromodomains (BD1 and BD2) able to recognize the acetylated mark. Pan-BET inhibitors (BETi) have shown a promising anticancer potential in many clinical trials; however, their further development has been in part hampered by the side effects due to their lack of selectivity...
March 11, 2024: Expert Opinion on Therapeutic Patents
https://read.qxmd.com/read/38463254/study-on-the-efficacy-and-potential-mechanism-of-topical-shen-bai-hair-growing-decoction-against-androgenetic-alopecia-based-on-ultrahigh-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-and-rna-seq
#40
JOURNAL ARTICLE
Mingxi Li, Xiujun Zhang, Yan Wang, Beibei Xiang, Zhaoyi Liu, Wenwen Zhang, Xuanming Liu, Ruoxi Guo
Androgenetic alopecia (AGA) is a major problem that can happen to people of all ages, leading to psychological problems, such as anxiety and depression. Topical Shen Bai hair growing decoction (TSBHGD) is based on the pathogenesis of AGA, combined with Traditional Chinese Medicine theory, improved by the Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital according to its clinical treatment experience. This study was designed to demonstrate the therapeutic efficacy of TSBHGD against AGA, analyze the chemical components of TSBHGD as well as the skin-retained and blood-retained components in mice after topical administration of TSBHGD, and clarify the mechanism of its therapeutic efficacy...
March 5, 2024: ACS Omega
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