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https://www.readbyqxmd.com/read/28225264/fatty-acid-comprising-lysine-conjugates-anti-mrsa-agents-that-display-in-vivo-efficacy-by-disrupting-biofilms-with-no-resistance-development
#1
Mohini Mohan Konai, Jayanta Haldar
Methicillin-resistant Staphylococcus aureus (MRSA) have developed resistance to antibiotics of last resort such as vancomycin, linezolid and daptomycin. Additionally, their biofilm forming capability has set an alarming situation in the treatment of bacterial infections. Herein we report the potency of fatty acid comprising lysine conjugates as novel anti-MRSA agents, which were not only capable of killing growing planktonic MRSA at low concentration (MIC = 3.1-6.3 µg/mL), but also displayed potent activity against non-dividing stationary phase cells...
February 22, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28224349/mapping-the-health-information-landscape-in-a-rural-culturally-diverse-region-implications-for-interventions-to-reduce-information-inequality
#2
A Susana Ramírez, Erendira Estrada, Ariana Ruiz
The media is an important source of health information, especially critical in rural communities with geographically-dispersed populations that are harder to reach through other channels. Yet health information is unequally distributed; these information disparities are compounded in rural areas, which may contribute to health disparities. We identify and describe health-related news in a culturally-diverse rural California county characterized by high levels of poverty, unemployment, low educational attainment, and over half of Mexican-origin...
February 21, 2017: Journal of Primary Prevention
https://www.readbyqxmd.com/read/28223753/five-cases-of-phytophotodermatitis-caused-by-fig-leaves-and-relevant-literature-review
#3
Jin-Hwa Son, Hyunju Jin, Hyang-Suk You, Woo-Haing Shim, Jeong-Min Kim, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Byung-Soo Kim
Phytophotodermatitis is a condition caused by sequential exposure to photosensitizing substances present in plants followed by ultraviolet light. Several plants (e.g., limes, celery, fig, and wild parsnip) contain furocoumarin compounds (psoralens). It is important for dermatologists to be aware of phytophotodermatitis because it may be misdiagnosed as cellulitis, tinea, or allergic contact dermatitis. We present five patients with a sharply defined erythematous swollen patch with bullae on both feet. They described soaking their feet in a fig leaves decoction to treat their underlying dermatologic diseases...
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28222400/antiprotozoal-antimycobacterial-and-anti-inflammatory-evaluation-of-cnidoscolus-chayamansa-mc-vaugh-extract-and-the-isolated-compounds
#4
Mariana Z Pérez-González, Gabriel A Gutiérrez-Rebolledo, Lilián Yépez-Mulia, Irma S Rojas-Tomé, Julieta Luna-Herrera, María A Jiménez-Arellanes
Cnidoscolus chayamansa is a medicinal and edible plant known as Chaya, is commonly used as an anti-inflammatory, antiprotozoal, antibacterial agent and as a remedy for respiratory illness, gastrointestinal disorders, and vaginal infections related with the inflammation process. In this paper, we describe the plant's phytochemical analysis and biological activities (antimycobacterial, antibacterial, antiprotozoal, and anti-inflammatory properties) of the CHCl3:MeOH (1:1) leaves extract and isolated compounds, as well as the acute and sub-acute toxic effects...
February 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28221001/synthesis-of-dual-stimuli-responsive-microcontainers-with-two-payloads-in-different-storage-spaces-for-preprogrammable-release
#5
Ying Cong, Qiuju Li, Min Chen, Limin Wu
Stimuli-responsive microcontainers have become a major topic of interest, from fundamental aspects to applications in materials science. However, microcontainers that enable the loading of multiple species and programmable release are mostly unexplored. Herein, we describe the design and synthesis of a dual-responsive organic/inorganic hybrid microcontainer with two payloads in separate storage spaces that is formed by the rapid UV-initiated polymerization of Pickering emulsions. The stellate mesopore silica nanoparticles with poly(N-isopropylacrylamide) grafted inside the mesopores were loaded with one compound (Nile red) and used as Pickering emulsifiers to stabilize oil-in-water droplets...
February 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28220834/stellera-chamaejasme-and-its-constituents-induce-cutaneous-wound-healing-and-anti-inflammatory-activities
#6
Myungsuk Kim, Hee Ju Lee, Ahmad Randy, Ji Ho Yun, Sang-Rok Oh, Chu Won Nho
Stellera chamaejasme L. (Thymelaeaceae) is a perennial herb that is widely used in traditional Chinese medicine to treat tumours, tuberculosis and psoriasis. S. chamaejasme extract (SCE) possesses anti-inflammatory, analgesic and wound healing activities; however, the effect of S. chamaejasme and its active compounds on cutaneous wound healing has not been investigated. We assessed full-thickness wounds of Sprague-Dawley (SD) rats and topically applied SCE for 2 weeks. In vitro studies were performed using HaCaT keratinocytes, Hs68 dermal fibroblasts and RAW 264...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28219661/protective-effects-of-topical-vitamin-c-compound-mixtures-against-ozone-induced-damage-in-human-skin
#7
Giuseppe Valacchi, Alessandra Pecorelli, Giuseppe Belmonte, Erika Pambianchi, Franco Cervellati, Stephen Lynch, Yevgeniy Krol, Christian Oresajo
No abstract text is available yet for this article.
February 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28215167/chemical-modifications-of-ketoprofen-nsaid-in-search-of-better-lead-compounds-a-review-of-literature-from-2004-2016
#8
Gita Chawla, Chanda Ranjan, Anees A Siddiqui, Jagdish Kumar, Ankita Pathak
BACKGROUND: Ketoprofen, a potent anti-inflammatory, analgesic and anti-pyretic drug belonging to the propionic acid class was synthesized in 1968. Rapid absorption, simple metabolism, faster blood brain barrier crossing and high antinociceptive activity are the features responsible for its high use. But, free acidic moiety present in its structure is the major factor that declines its popularity by causing various gastric side effects .Many researchers have chemically modified this drug with the aim to discover an improved and safe NSAID candidate or a new drug with altered activity...
February 16, 2017: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28210627/hyperforin-hp-%C3%AE-cyclodextrin-enhances-mechanosensitive-ca-2-signaling-in-hacat-keratinocytes-and-in-atopic-skin-ex-vivo-which-accelerates-wound-healing
#9
Hiroya Takada, Jun Yonekawa, Masami Matsumoto, Kishio Furuya, Masahiro Sokabe
Cutaneous wound healing is accelerated by mechanical stretching, and treatment with hyperforin, a major component of a traditional herbal medicine and a known TRPC6 activator, further enhances the acceleration. We recently revealed that this was due to the enhancement of ATP-Ca(2+) signaling in keratinocytes by hyperforin treatment. However, the low aqueous solubility and easy photodegradation impede the topical application of hyperforin for therapeutic purposes. We designed a compound hydroxypropyl-β-cyclodextrin- (HP-β-CD-) tetracapped hyperforin, which had increased aqueous solubility and improved photoprotection...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28209447/topical-aqueous-extract-of-ephedra-alata-can-improve-wound-healing-in-an-animal-model
#10
Naim Kittana, Hanood Abu-Rass, Ruba Sabra, Lama Manasra, Hadeel Hanany, Nidal Jaradat, Fatima Hussein, Abdel Naser Zaid
PURPOSE: Ephedra alata (E. alata) is perennial tough shrub plant that grows in Palestine and other regions. It is used often in folk's medicine for the treatment of various diseases. In this project, E. alata extract was tested for its ability to improve wound and burn healing. METHODS: An aqueous extract of E. alata was prepared and underwent several phytochemical analyses for the presence of the major classes of phytochemical compounds. After that, a polyethylene glycol-based ointment containing the extract of E...
January 20, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28208818/hydroxycinnamic-acids-and-their-derivatives-cosmeceutical-significance-challenges-and-future-perspectives-a-review
#11
Oludemi Taofiq, Ana M González-Paramás, Maria Filomena Barreiro, Isabel C F R Ferreira
Bioactive compounds from natural sources, due to their widely-recognized benefits, have been exploited as cosmeceutical ingredients. Among them, phenolic acids emerge with a very interesting potential. In this context, this review analyzes hydroxycinnamic acids and their derivatives as multifunctional ingredients for topical application, as well as the limitations associated with their use in cosmetic formulations. Hydroxycinnamic acids and their derivatives display antioxidant, anti-collagenase, anti-inflammatory, antimicrobial and anti-tyrosinase activities, as well as ultraviolet (UV) protective effects, suggesting that they can be exploited as anti-aging and anti-inflammatory agents, preservatives and hyperpigmentation-correcting ingredients...
February 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28202045/identification-of-micrornas-and-their-response-to-the-stress-of-plant-allelochemicals-in-aphis-gossypii-hemiptera-aphididae
#12
Kang-Sheng Ma, Fen Li, Ying Liu, Ping-Zhuo Liang, Xue-Wei Chen, Xi-Wu Gao
BACKGROUND: MicroRNAs (miRNAs) are a group of short non-coding RNAs involved in the inhibition of protein translation or in mRNA degradation. Although the regulatory roles of miRNAs in various biological processes have been investigated, there is as yet an absence of studies about the regulatory roles of miRNAs involved in the metabolism of plant allelochemicals in insects. RESULTS: We constructed five small RNA libraries from apterous Aphis gossypii adults that had fed on an artificial diet containing various allelochemicals...
February 16, 2017: BMC Molecular Biology
https://www.readbyqxmd.com/read/28196712/ipomoea-pes-caprae-l-r-br-convolvulaceae-as-a-topical-herbal-medicine-to-relieve-pain-and-inflammation-promising-tool-against-effects-due-to-toxin-skin-contact
#13
Cristiane da Silva Barth, Hugo Guilherme Tolentino de Souza, Lilian W Rocha, Gislaine Francieli da Silva, Mariana Ferreira Dos Anjos, Veronica D'Avila Pastor, Tania Mari Belle Bresolin, Angelica Garcia Couto, José Roberto Santin, Nara Lins Meira Quintão
ETHNOPHARMACOLOGICAL RELEVANCE: Ipomoea pes-caprae is known as bayhops, beach morning glory or goat's foot, and in Brazil as salsa-de-praia. Its leaves are used in worldwide folk medicine for the relief of jellyfish-stings symptoms. The literature only reports the anti-inflammatory and neutralizing effects of a nonpolar plant derived, without validating the popular use or exploring the mechanism of action. AIM OF THE STUDY: This study aimed to evaluate and validate the topical effects of a semisolid containing hydroethanolic extract obtained from the aerial parts of I...
February 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28195547/phenolic-compounds-from-citrus-leaves-antioxidant-activity-and-enzymatic-browning-inhibition
#14
Bachra Khettal, Nabil Kadri, Karim Tighilet, Ahmed Adjebli, Farid Dahmoune, Fadila Maiza-Benabdeslam
Background Phenolic compounds from Citrus are known to be a topic of many studies due to their biological properties including antioxidant activity. Methods Methanolic and aqueous extracts were isolated from Citrus leaves of different species (C. clementina, C. limon, C. hamlin, C. navel, C. aurantifolia, C. aurantium and C. grandis) harvested in Algeria. Results The results showed that aqueous extracts of all species are rich in total phenolic compounds and flavonoids (from 68.23 to 125.28 mg GAE/g DM) and (from 11...
February 14, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28191476/pharmacological-treatments-of-presbyopia-a-review-of-modern-perspectives
#15
REVIEW
Antonio Renna, Jorge Luciano Alió, Luis Felipe Vejarano
INTRODUCTION: Presbyopia affects people from the 4(th) decade of life and is characterized by accommodative loss that leads to negative effects on vision-targeted health-related quality of life. A non-invasive pharmacological treatment providing near-lenses independence would be a truly groundbreaking approach in the treatment of presbyopia. The purpose of this review is to analyze the emerging pharmacological solutions proposed to address presbyopia. RESULTS: Several ophthalmic eye drops compounds solutions have been described in peer-reviewed papers or presented in ophthalmological tabloids and congresses...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/28184214/modeling-pancreatic-endocrine-cell-adaptation-and-diabetes-in-the-zebrafish
#16
REVIEW
Lisette A Maddison, Wenbiao Chen
Glucose homeostasis is an important element of energy balance and is conserved in organisms from fruit fly to mammals. Central to the control of circulating glucose levels in vertebrates are the endocrine cells of the pancreas, particularly the insulin-producing β-cells and the glucagon producing α-cells. A feature of α- and β-cells is their plasticity, an ability to adapt, in function and number as a response to physiological and pathophysiological conditions of increased hormone demand. The molecular mechanisms underlying these adaptive responses that maintain glucose homeostasis are incompletely defined...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28181776/cardiovascular-adjustments-to-heat-stress-during-prolonged-exercise
#17
Luna Rizzo, Martin W Thompson
Prolonged effort in hot environments is increasing popular in extreme sports. The number of long distance athletes taking part in races in extremely warm condition, as in deserts, is larger than in the past and also the race distances are increased thus. The demanding for the heart function are higher than those challenged in the past only by few athletes and in easier conditions. This puts news challenges on the professional involved in these activities and there is a need to better understand how the cardiocirculatory system responses in these extreme environmental conditions...
February 8, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28181673/laser-induced-thermal-coagulation-enhances-skin-uptake-of-topically-applied-compounds
#18
C S Haak, J Hannibal, U Paasch, R R Anderson, M Haedersdal
BACKGROUND: Ablative fractional laser (AFL) generates microchannels in skin surrounded by a zone of thermally altered tissue, termed the coagulation zone (CZ). The thickness of CZ varies according to applied wavelength and laser settings. It is well-known that AFL channels facilitate uptake of topically applied compounds, but the importance of CZ is unknown. METHODS: Franz Cells were used to investigate skin uptake and permeation of fluorescent labeled polyethylene glycols (PEGs) with mean molecular weights (MW) of 350, 1,000, and 5,000 Da...
February 9, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28181580/penetration-enhancement-underlies-synergy-of-plant-essential-oil-terpenoids-as-insecticides-in-the-cabbage-looper-trichoplusia-ni
#19
Jun-Hyung Tak, Murray B Isman
Many plant essential oils and their terpenoid constituents possess bioactivities including insecticidal activity, and they sometimes act synergistically when mixed. Although several hypotheses for this have been proposed, the underlying mechanism has not been fully elucidated thus far. In the present study, we report that in larvae of the cabbage looper, Trichoplusia ni, most synergistic or antagonistic insecticidal activities among mixtures of plant essential oil constituents are pharmacokinetic effects, owing to changes in solubility as well as spreadability on a wax layer...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28180946/new-developments-and-directions-in-the-clinical-application-of-the-echinocandins
#20
REVIEW
C C Chang, M A Slavin, S C-A Chen
The echinocandins-caspofungin, anidulafungin and micafungin-are semi-synthetic cyclic hexapeptide antimicrobial agents with modified N-linked acyl lipid side chains which anchor the compounds to the phospholipid bilayer of the fungal cell membrane, thereby inhibiting synthesis of fungal cell wall glucan. Over the last 10 years, echinocandins have become the first-line antifungal treatment of candidaemia and other forms of invasive candidiasis (IC). Echinocandins are generally well tolerated, but their use is limited by their requirement for daily intravenous dosing, lack of oral formulation and limited spectrum...
February 8, 2017: Archives of Toxicology
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