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https://www.readbyqxmd.com/read/28081293/role-of-pyridoxal-5-phosphate-at-the-titanium-implant-interface-in-vivo-increased-hemophilicity-inactive-platelet-adhesion-and-osteointegration
#1
Jung Seung Lee, Kyuri Kim, Joseph P Park, Seung-Woo Cho, Haeshin Lee
Titanium is the most biocompatible inorganic biomaterial with a long history of use in orthopedic and dental implants. However, promoting rapid and effective bone formation and integration onto etched, rough TiO2 surfaces has been a challenging topic. Here, 21 commercially available molecules are examined that met the following criteria: (1) contain phosphonic acid for stable immobilization onto TiO2 surfaces and (2) have a molecular weight less than 500 Da for negligible coating thickness. Of these molecules, the surface immobilization of pyridoxal 5'-phosphate (PLP), an active form of vitamin B6 , dramatically increases the hemophilic property of the surface and accelerated osteointegration in vivo...
January 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28079417/the-experiences-of-black-and-minority-ethnic-nurses-working-in-the-uk
#2
John Pendleton
Evidence suggests that black and minority ethnic (BME) midwives are more likely to face fitness to practise hearings than white registrants and BME NHS staff are less likely to be in senior positions. This literature review critically evaluates the literature published since a systematic review on the topic was conducted in 2005. It found that BME nurses and midwives, especially those who registered abroad and subsequently came to live and work in the UK are 'underemployed' and consequently expressed feelings of loss of self-confidence...
January 12, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28078415/gc-ms-method-validation-and-levels-of-methyl-eugenol-in-a-diverse-range-of-tea-tree-melaleuca-alternifolia-oils
#3
Carolyn A Raymond, Noel W Davies, Tony Larkman
Tea tree oil distilled from Melaleuca alternifolia has widespread use in the cosmetic industry as an antimicrobial as well as for other functions in topical products. Concerns were first raised by the European Commission's Scientific Committee on Consumer Products in 2004 about the level of the potentially carcinogenic phenylpropanoid compound methyl eugenol in tea tree oil. Limits on oil content in different types of cosmetic products were set based on a reported upper level of 0.9% methyl eugenol in the oil...
January 11, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28070753/dodecyl-amino-glucoside-enhances-transdermal-and-topical-drug-delivery-via-reversible-interaction-with-skin-barrier-lipids
#4
Monika Kopečná, Miloslav Macháček, Eva Prchalová, Petr Štěpánek, Pavel Drašar, Martin Kotora, Kateřina Vávrová
PURPOSE: Skin permeation/penetration enhancers are substances that enable drug delivery through or into the skin. METHODS: To search for new enhancers with high but reversible activity and acceptable toxicity, we synthesized a series of D-glucose derivatives, both hydrophilic and amphiphilic. RESULTS: Initial evaluation of the ability of these sugar derivatives to increase permeation and penetration of theophylline through/into human skin compared with a control (no enhancer) or sorbitan monolaurate (Span 20; positive control) revealed dodecyl 6-amino-6-deoxy-α-D-glucopyranoside 5 as a promising enhancer...
January 9, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28061344/monitoring-of-persistent-organic-pollutants-in-the-polar-regions-knowledge-gaps-gluts-through-evidence-mapping
#5
Maria Cristina Mangano, Gianluca Sarà, Simonetta Corsolini
Persistent organic pollutants (POPs) are widespread compounds that accumulating in polar regions canalise through trophic webs. Although several dozens of studies have been carried out in the last decades, the information is generally scattered across a large number of literature sources. This does not allow an efficient synthesis and constraints our understanding on how address future monitoring plans and environmental conservation strategies on the Polar Regions with respect to POPs. Thus, here, we present the outcome of a systematic map (SM) to scope, screen and chart evidences from literature dealing with POPs in Polar regions...
December 28, 2016: Chemosphere
https://www.readbyqxmd.com/read/28060302/a-platform-of-anti-biofilm-assays-suited-to-the-exploration-of-natural-compound-libraries
#6
Malena E Skogman, Pia M Vuorela, Adyary Fallarero
Biofilms are regarded as one of the most challenging topics of modern biomedicine, and they are potentially responsible for over 80% of antibiotic-tolerant infections. Biofilms have displayed an exceptionally high tolerance for chemotherapy, which is thought to be multifactorial. For instance, the matrix provides a physical barrier that decreases the penetration of antibiotics into the biofilm. Also, cells within the biofilms are phenotypically diverse. Likely, biofilm resilience arises from a combination of these and other, yet unknown, mechanisms...
December 27, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28054052/structural-phase-transitions-of-bi1-xsbx-2-te1-ysey-3-compounds-under-high-pressure-and-the-influence-of-the-atomic-radius-on-the-compression-processes-of-tetradymites
#7
Jinggeng Zhao, Zhenhai Yu, Qingyang Hu, Yong Wang, John Schneeloch, Chunyu Li, Ruidan Zhong, Yi Wang, Zhiguo Liu, Genda Gu
Recently, A2B3-type tetradymites have developed into a hot topic in physical and material research fields, where the A and B atoms represent V and VI group elements, respectively. In this study, in situ angle-dispersive X-ray diffraction measurements were performed on Bi2Te2Se, BiSbTeSe2, and Sb2Te2Se tetradymites under high pressure. Bi2Te2Se transforms from a layered rhombohedral structure (phase I) into 7-fold monoclinic (phase II) and body-centered tetragonal (phase IV) structures at about 8.0 and 14.3 GPa, respectively, without an 8-fold monoclinic structure (phase III) similar to that in Bi2Te3...
January 5, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28043556/antimycobacterial-ingredients-from-plants-used-in-traditional-medicine-to-treat-buruli-ulcer
#8
Patrick Valere Tsouh Fokou, Abena Adomah Kissi-Twum, Dorothy Yeboah-Manu, Regina Appiah-Opong, Phyllis Addo, Lauve Rachel Tchokouaha Yamthe, Alvine Ngoutane Mfopa, Fabrice Fekam Boyom, Alexander Kwadwo Nyarko
AIM AND OBJECTIVES: Buruli ulcer (BU) is a neglected tropical disease caused by a mycobacteria, Mycobacterium ulcerans. The WHO recommended Rifampicin-Streptomycin combination side effects and poor compliance, leaves rural populations with no choice than to patronise indigenous remedies. This study is aimed at validating medicinal plants used in traditional medicine to treat BU by investigating the in vitro efficacy and safety as well as their composition in active molecules. METHODS: A short report-based survey was used to identify medicinal plants used traditionally for BU treatment...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28039787/topical-antiedematogenic-and-anti-inflammatory-effect-of-scutia-buxifolia-reissek-gel-and-stability-study
#9
Aline Augusti Boligon, Laís da Rosa Moreira, Mariana Piana, Marli Matiko Anraku de Campos, Sara Marchesan Oliveira
Scutia buxifolia Reissek (Rhamnaceae), popularly known in Brazil as "coronilha", is a plant species used in folk medicine for several disorders, including inflammation. However, no studies have been done with this species to confirm its topical anti-inflammatory action. In this study we evaluate the topical antiedematogenic and anti-inflammatory effects of the gel containing crude extract (CE) and the gel containing ethyl acetate (EtOAc) fraction of S. buxifolia on croton oil or UVB radiation-induced ear edema in mice, and perform gel stability study...
December 22, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28032142/overlooking-relevant-confounders-in-the-assessment-of-pesticides-and-human-health-a-reply-to-mostafalou-and-abdollahi
#10
EDITORIAL
Keith Fluegge
Mostafalou and Abdollahi (Arch Toxicol, 2016. doi: 10.1007/s00204-016-1849-x ) have recently conducted a review exploring human exposure to pesticides and systematically highlighting known toxic mechanisms from these exposures. Their review is extensive and appraises the literature on pesticide toxicity in a number of domains, including neurotoxicity and developmental toxicity. However, as important as it may be to understand the toxicological potential of these chemicals in humans and other species, the role of these chemicals as proxies for other environmental exposures should not be excluded...
December 28, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/28031725/skin-matters-the-role-of-keratinocytes-in-nociception-a-rational-argument-for-the-development-of-topical-analgesics
#11
REVIEW
Jan M Keppel Hesselink, David J Kopsky, Arun K Bhaskar
Treatment of neuropathic pain using topical formulations is still in its infancy. Only few topical analgesic formulations have become available for clinical use, and among these, analgesic creams are still rare. This is unfortunate because analgesic creams offer a number of advantages over patches, such as convenience, ease of adapting the frequency of application, and dose, and "rubbing cream where it hurts" involves the patient much more in the therapeutic process compared to patches and other localized treatment modalities...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28028794/effect-of-liquid-crystalline-systems-containing-antimicrobial-compounds-on-infectious-skin-bacteria
#12
Carla Souza, Evandro Watanabe, Carolina Patrícia Aires, Marilisa Guimarães Lara
This study aimed (i) to prepare liquid crystalline systems (LCS) of glyceryl monooleate (GMO) and water containing antibacterial compounds and (ii) to evaluate their potential as drug delivery systems for topical treatment of bacterial infections. Therefore, LCS containing CPC (cetylpyridinium chloride) (LCS/CPC) and PHMB (poly(hexamethylene biguanide) hydrochloride) (LCS/PHMB) were prepared and the liquid crystalline phases were identified by polarizing light microscopy 24 h and 7 days after preparation...
December 27, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28025943/phenolic-compounds-as-nutraceuticals-or-functional-food-ingredients
#13
Cristina Caleja, Andreia Ribeiro, Maria Filomena Barreiro, Isabel C F R Ferreira
BACKGROUND: Nowadays, the functional foods represent one the most promising, interesting and innovative areas in the food industry. Various components are being added to foods in order to render them functional. METHODS: One example of these components are plant naturally occurring phenolic compounds, which are associated with a high antioxidant capacity and thus with benefits in relation to human health. RESULTS: However, despite the huge number of scientific studies and patents on this topic and their natural presence in foods, namely in the ones from plant origin, there are still few marketable products enriched with these compounds...
December 27, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28025598/estimating-access-to-drinking-water-supply-sanitation-and-hygiene-facilities-in-wolaita-sodo-town-southern-ethiopia-in-reference-to-national-coverage
#14
Amha Admasie, Ashenafi Debebe
Introduction. The coverage of sanitation and access to safe drinking water in Ethiopia especially in Wolaita Sodo town are not well studied. Therefore, the main objective of this study was estimating access to drinking water supply, sanitation, and hygiene facilities in Wolaita Sodo town, southern Ethiopia, in reference to national coverage. Methods. A community based cross-sectional study design method was employed in the study in 588 households of Wolaita Sodo town inhabitants. Face-to-face interview to household owners, in-depth interview to key informants, reviewing secondary data, and observational check lists were used to collect data...
2016: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28025488/toxicity-and-physiological-actions-of-carbonic-anhydrase-inhibitors-to-aedes-aegypti-and-drosophila-melanogaster
#15
Sheena A M Francis, Jennina Taylor-Wells, Aaron D Gross, Jeffrey R Bloomquist
The physiological role of carbonic anhydrases in pH and ion regulation is crucial to insect survival. We examined the toxic and neurophysiological effects of five carbonic anhydrase inhibitors (CAIs) against Aedes aegypti. The 24 h larvicidal toxicities followed this rank order of potency: dichlorphenamide > methazolamide > acetazolamide = brinzolamide = dorzolamide. Larvicidal activity increased modestly in longer exposures, and affected larvae showed attenuated responses to probing without overt tremors, hyperexcitation, or convulsions...
December 22, 2016: Insects
https://www.readbyqxmd.com/read/28025109/deet-potentiates-the-development-and-persistence-of-anticholinesterase-dependent-chronic-pain-signs-in-a-rat-model-of-gulf-war-illness-pain
#16
L K Flunker, T J Nutter, R D Johnson, B Y Cooper
Exposure to DEET (N,N-diethyl-meta-toluamide) may have influenced the pattern of symptoms observed in soldiers with GWI (Gulf War Illness; Haley and Kurt, 1997). We examined how the addition of DEET (400mg/kg; 50% topical) to an exposure protocol of permethrin (2.6mg/kg; topical), chlorpyrifos (CP; 120mg/kg), and pyridostigmine bromide (PB;13mg/kg) altered the emergence and pattern of pain signs in an animal model of GWI pain (Nutter et al., 2015). Rats underwent behavioral testing before, during and after a 4week exposure: 1) hindlimb pressure withdrawal threshold; 2) ambulation (movement distance and rate); and 3) resting duration...
December 23, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28012990/assessment-of-skin-barrier-function-and-biochemical-changes-of-ex-vivo-human-skin-in-response-to-physical-and-chemical-barrier-disruption
#17
Nadine Döge, Araks Avetisyan, Sabrina Hadam, Eva Katharina Barbosa Pfannes, Fiorenza Rancan, Ulrike Blume-Peytavi, Annika Vogt
Topical dermatotherapy is intended to be used on diseased skin. Novel drug delivery systems even address differences between intact and diseased skin underlining the need for pre-clinical assessment of different states of barrier disruption. Herein, we studied how short-term incubation in culture media compared to incubation in humidified chambers affects human skin barrier function and viability. On both models we assessed different types and intensities of physical and chemical barrier disruption methods with regard to structural integrity, biophysical parameters and cytokine-levels...
December 21, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28008287/searching-for-sex-and-gender-sensitive-tuberculosis-research-in-public-health-finding-a-needle-in-a-haystack
#18
Bilkis Vissandjee, Assia Mourid, Christina A Greenaway, Wendy E Short, Jodi A Proctor
Despite broadening consideration of sex- and gender-based issues in health research, when seeking information on how sex and gender contribute to disease contexts for specific health or public health topics, a lack of consistent or systematic use of terminology in health literature means that it remains difficult to identify research with a sex or gender focus. These inconsistencies are driven, in part, by the complexity and terminological inflexibility of the indexing systems for gender- and sex-related terms in public health databases...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/28003630/in-vitro-evaluation-of-the-biocompatibility-of-newly-synthesized-bis-quaternary-ammonium-compounds-with-spacer-structures-derived-from-pentaerythritol-or-hydroquinone
#19
Masashi Yamamoto, Takashi Takami, Reiko Matsumura, Alexander Dorofeev, Yoshihiko Hirata, Hideaki Nagamune
 With the object of developing new biocides milder for human use than the current antiseptics, we synthesized a series of bis-quaternary ammonium compounds (bis-QACs). The antimicrobial activity of the newly synthesized bis-QACs and common biocides used as antiseptics was compared by examining minimum inhibitory concentrations and minimum bactericidal concentrations (MBCs). Moreover, the cytotoxicity of these compounds against human cells was determined to calculate the biocompatibility index (BI) of these compounds...
2016: Biocontrol Science
https://www.readbyqxmd.com/read/28003376/selective-irak4-inhibition-attenuates-disease-in-murine-lupus-models-and-demonstrates-steroid-sparing-activity
#20
Shailesh Dudhgaonkar, Sourabh Ranade, Jignesh Nagar, Siva Subramani, Durga Shiv Prasad, Preethi Karunanithi, Ratika Srivastava, Kamala Venkatesh, Sabariya Selvam, Prasad Krishnamurthy, T Thanga Mariappan, Ajay Saxena, Li Fan, Dawn K Stetsko, Deborah A Holloway, Xin Li, Jun Zhu, Wen-Pin Yang, Stefan Ruepp, Satheesh Nair, Joseph Santella, John Duncia, John Hynes, Kim W McIntyre, Julie A Carman
The serine/threonine kinase IL-1R-associated kinase (IRAK)4 is a critical regulator of innate immunity. We have identified BMS-986126, a potent, highly selective inhibitor of IRAK4 kinase activity that demonstrates equipotent activity against multiple MyD88-dependent responses both in vitro and in vivo. BMS-986126 failed to inhibit assays downstream of MyD88-independent receptors, including the TNF receptor and TLR3. Very little activity was seen downstream of TLR4, which can also activate an MyD88-independent pathway...
December 21, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
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