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https://www.readbyqxmd.com/read/29786643/controlled-deactivation-cb1-receptor-ligands-as-a-novel-strategy-to-lower-intraocular-pressure
#1
Sally Miller, Shashank Kulkarni, Alex Ciesielski, Spyros P Nikas, Ken Mackie, Alexandros Makriyannis, Alex Straiker
Nearly half a century has passed since the demonstration that cannabis and its chief psychoactive component Δ⁸-THC lowers intraocular pressure (IOP). Elevated IOP remains the chief hallmark and therapeutic target for glaucoma, a condition that places millions at risk of blindness. It is likely that Δ⁸-THC exerts much of its IOP-lowering effects via the activation of CB1 cannabinoid receptors. However, the initial promise of CB1 as a target for treating glaucoma has not thus far translated into a credible therapeutic strategy...
May 22, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29784074/effects-of-fenbendazole-impregnated-feed-and-topical-moxidectin-during-quarantine-on-the-gut-microbiota-of-c57bl-6-mice
#2
Scott W Korte, Craig L Franklin, Rebecca A Dorfmeyer, Aaron C Ericsson
To protect the biosecurity of research rodent colonies, research institutions frequently require a quarantine period for live animals transferred into their facilities. Quarantine practices often include antibiotic and antiparasitic treatment with drugs such as fenbendazole and macrolide lactones. The influence of these compounds on the resident gut microbiota of mice is unknown, and any effects might subsequently affect model reproducibility. To test the influence of standard quarantine procedures on the composition of the microbiota, C57BL/6 mice, purchased from 2 different commercial suppliers, were randomly assigned to treatment groups (n = 12) by vendor and treated with fenbendazole-supplemented feed, topical moxidectin, both treatments, or no treatment (control), according to our institution's standard treatment regimen and duration...
May 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29782305/tatami-mats-a-source-of-pitted-keratolysis-in-a-martial-arts-athlete
#3
Anamaria Balić, Zrinka Bukvić Mokos, Branka Marinović, Daniela Ledić Drvar
Dear Editor, Pitted keratolysis (PK), also known as keratosis plantaris sulcatum, is a non-inflammatory, bacterial, superficial cutaneous infection, characterized by many discrete superficial crateriform ''pits'' and erosions in the thickly keratinized skin of the weight-bearing regions of the soles of the feet (1). The disease often goes unnoticed by the patient, but when it is noticed it is because of the unbearable malodor and hyperhidrosis of the feet, which are socially unacceptable and cause great anxiety to many of the patients...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29775760/synthesis-of-axially-disubstituted-silicon-phthalocyanines-and-investigation-of-photodynamic-effects-on-hct-116-colorectal-cancer-cell-line
#4
Ceren Sarı, Figen Celep Eyüpoğlu, İsmail Değirmencioğlu, Rıza Bayrak
Photodynamic therapy is one of the hot topics in cancer studies recently. Basically, photosensitizing chemical substrates which are stimulated by light having a specific wavelength cause fatal effect on different kind of cells in photodynamic therapy. In this study, axially 4-{[(1E)-2-furylmethylene]amino}phenol, 4-{[(1E)-2-thienylmethylene]amino}phenol and 4-{[(1E)-(4-nitro-2-thienyl)methylene]amino}phenol disubstituted silicon phthalocyanines were synthesized as Photosensitizers for photodynamic therapy in cancer treatment for the first time...
May 15, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29768709/comprehensive-multi-modal-characterization-of-an-imiquimod-induced-human-skin-inflammation-model-for-drug-development
#5
Tessa van der Kolk, Salma Assil, Rianne Rijneveld, Erica S Klaassen, Gary Feiss, Edwin Florencia, Errol P Prens, Jacobus Burggraaf, Matthijs Moerland, Robert Rissmann, Martijn B A van Doorn
Imiquimod (IMQ) is often used as topical challenge agent to provoke local skin inflammation. The objective of this study was to develop and refine a rapid, temporary and reversible human skin inflammation model with IMQ for application in clinical drug development. A randomized, vehicle-controlled, open-label, dose-ranging study was conducted in 16 healthy male subjects. IMQ (5 mg) was applied once daily for 72h under occlusion to intact skin (n = 8) or tape stripped (TS) skin (n = 8). Although IMQ alone induced limited effects, TS+IMQ treatment showed larger responses in several domains including erythema and perfusion (p<0...
May 16, 2018: Clinical and Translational Science
https://www.readbyqxmd.com/read/29763605/inos-inhibits-hair-regeneration-in-obese-diabetic-ob-ob-mice
#6
Mari Sasaki, Shohei Shinozaki, Hironobu Morinaga, Masao Kaneki, Emi Nishimura, Kentaro Shimokado
Previous studies have shown that androgenic alopecia is associated with metabolic syndrome and diabetes. However, the detailed mechanism whereby diabetes causes alopecia still remains unclear. We focused on the inflammatory response that is caused by diabetes or obesity, given that inflammation is a risk factor for hair loss. Inducible nitric oxide synthase (iNOS) is known to be upregulated under conditions of acute or chronic inflammation. To clarify the potential role of iNOS in diabetes-related alopecia, we generated obese diabetic iNOS-deficient (ob/ob; iNOS-KO mice)...
May 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29760825/a-current-approach-to-halitosis-and-oral-malodor-a-mini-review
#7
REVIEW
Damla Aksit Bicak
Background: Halitosis, in other words, oral malodor is an important multifactorial health problem affecting the psychological and social life of individuals and is the most common reason for referral to dentists after dental caries and periodontal diseases. Objective: The objective of this review was to present and discuss conventional and recently introduced information about the types, causes, detection and treatment methods of halitosis. Methods: An expanded literature review was conducted which targeted all articles published in peer-reviewed journals relating to the topic of halitosis...
2018: Open Dentistry Journal
https://www.readbyqxmd.com/read/29760142/-in-vitro-and-in-vivo-activity-of-peptidomimetic-compounds-that-target-the-periodontal-pathogen-porphyromonas-gingivalis
#8
Jinlian Tan, Pravin C Patil, Frederick A Luzzio, Donald R Demuth
The interaction of the periodontal pathogen Porphyromonas gingivalis with oral streptococci is important for initial colonization of the oral cavity by P. gingivalis and is mediated by a discrete motif of the streptococcal antigen I/II protein. A synthetic peptide encompassing this motif functions as a potent inhibitor of P. gingivalis adherence but the use of peptides as topically applied therapeutic agents in the oral cavity has limitations arising from the relatively high cost of peptide synthesis and their susceptibility to degradation by proteases expressed by oral organisms...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29759553/the-role-of-heme-iron-molecules-derived-from-red-and-processed-meat-in-the-pathogenesis-of-colorectal-carcinoma
#9
REVIEW
S M K Gamage, Lakal Dissabandara, Alfred King-Yin Lam, Vinod Gopalan
Emerging evidence that heme iron in red meat is a risk factor for colorectal carcinogenesis is a topic that has received recent scrutiny. This review aims to summarise the mechanism of colorectal carcinogenesis by heme contained in red and processed meat. Heme iron can induce cytotoxicity by 'cytotoxic heme factor' and promote surface epithelial cell apoptosis and compensatory epithelial hyperplasia. Heme, induces peroxidation of lipids, leading to free radical formation and generation of DNA adducts in colorectal epithelial cells...
June 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29755971/impact-of-increasing-levels-of-oxygen-consumption-on-the-evolution-of-color-phenolic-and-volatile-compounds-of-nebbiolo-wines
#10
Maurizio Petrozziello, Fabrizio Torchio, Federico Piano, Simone Giacosa, Maurizio Ugliano, Antonella Bosso, Luca Rolle
Since the end of the last century, many works have been carried out to verify the effect of controlled oxygen intake on the chemical and organoleptic characteristics of red wines. In spite of the large number of studies on this subject, oxygen remains a cutting-edge research topic in oenology. Oxygen consumption leads to complex and not univocal changes in wine composition, sometimes positive such as color stabilization, softening of mouthfeel, increase of aroma complexity. However, the variability of these effects, which depend both on the oxygenation conditions and the composition of the wine, require more efforts in this research field to effectively manage wine oxygen exposure...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29750454/extemporaneous-formulations-in-germany-relevance-for-everyday-clinical-practice
#11
Petra Staubach, Stefan Salzmann, Adriane Peveling-Oberhag, Veronika Weyer, Sebastian Zimmer, Gabriele Gradl, Berenice M Lang
BACKGROUND: Extemporaneous formulations broaden the spectrum of therapeutic options for topical treatment in particular and thus improve patient care. The latest amendment to the Regulation on the Operation of Pharmacies issued in 2012 brought about changes in prescribing and manufacturing practices. The aim of the present study was to assess the relevance of extemporaneous formulations in everyday clinical practice. METHODS: We used data from the German Institute for Drug Use Evaluation (DAPI) to analyze the prescribing practice for compounded preparations in Germany between the fourth quarter of 2011 and the third quarter of 2014...
May 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29749562/medicinal-fungi-a-source-of-antiparasitic-secondary-metabolites
#12
REVIEW
Juliana Lenzi, Tania Maria Costa, Michele Debiasi Alberton, Juliane Araújo Greinert Goulart, Lorena Benathar Ballod Tavares
Regions with a tropical climate are frequently affected by endemic diseases caused by pathogenic parasites. More than one billion people worldwide are exposed directly to tropical parasites. The literature cites several antiparasitic metabolites obtained from medicinal plants or via synthetic pathways. However, fungi produce a diversity of metabolites that play important biological roles in human well-being. Thus, they are considered a potential source of novel natural agents for exploitation in the pharmaceutical industry...
May 10, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29748977/paeonol-extracted-from-paeonia-suffruticosa-andr-ameliorated-uvb-induced-skin-photoaging-via-dld-nrf2-are-and-mapk-ap-1-pathway
#13
ZhengWang Sun, Juan Du, Eunson Hwang, Tae-Hoo Yi
Paeonia suffruticosa Andr. (PS) has been used in traditional Chinese medicine for a long time. However, there are no studies that investigate the preventive effects of PS on ultraviolet B (UVB)-induced photoaging. In this study, paeonol (PA) was detected the main compound in PS root. In vitro, PS and PA significantly inhibited UVB-induced phosphorylation of mitogen-activated protein kinase and activator protein 1 in keratinocytes, which consequently led to degradation of procollagen type I. On the other hand, PS and PA increased NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 expression, confirmed by greater nuclear accumulation of nuclear factor E2-releated factor 2 (Nrf2)...
May 10, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29747006/bioinspired-bone-therapies-using-naringin-applications-and-advances
#14
REVIEW
Pedro Lavrador, Vitor M Gaspar, João F Mano
The use of natural compounds for treating chronic bone diseases holds remarkable potential. Among these therapeutics, naringin, a flavanone glycoside, represents one of the most promising candidates owing to its multifaceted effect on bone tissues. This review provides an up-to-date overview on naringin applications in the treatment of bone disorders, such as osteoporosis and osteoarthritis, and further highlights its potential for stem cell pro-osteogenic differentiation therapies. A critical perspective on naringin clinical translation is also provided...
May 7, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29745239/studies-on-articular-and-general-toxicity-of-orally-administered-ozenoxacin-in-juvenile-rats-and-dogs
#15
Jorge Ignacio González Borroto, Malaika Sharon Awori, Luc Chouinard, Susan Y Smith, Cristina Tarragó, Teresa Blazquez, Domingo Gargallo-Viola, Ilonka Zsolt
AIM: Ozenoxacin is a nonfluorinated quinolone antibacterial approved for topical treatment of impetigo. Because quinolones have known chondrotoxic effects in juvenile animals, the potential toxicity of ozenoxacin was assessed in preclinical studies. MATERIALS & METHODS: Ozenoxacin or ofloxacin (300 mg/kg/day for 5 days, for each compound) was orally administered to juvenile rats, and oral ozenoxacin (10-100 mg/kg/day for 14 days) was administered to juvenile dogs...
May 1, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29740318/natural-antioxidants-multiple-mechanisms-to-protect-skin-from-solar-radiation
#16
REVIEW
Spencer Dunaway, Rachel Odin, Linli Zhou, Liyuan Ji, Yuhang Zhang, Ana L Kadekaro
Human skin exposed to solar ultraviolet radiation (UVR) results in a dramatic increase in the production of reactive oxygen species (ROS). The sudden increase in ROS shifts the natural balance toward a pro-oxidative state, resulting in oxidative stress. The detrimental effects of oxidative stress occur through multiple mechanisms that involve alterations to proteins and lipids, induction of inflammation, immunosuppression, DNA damage, and activation of signaling pathways that affect gene transcription, cell cycle, proliferation, and apoptosis...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29737984/environmentally-responsive-plasmonic-nanoassemblies-for-biosensing
#17
Xiaoling Wu, Changlong Hao, Jatish Kumar, Hua Kuang, Nicholas A Kotov, Luis M Liz-Marzán, Chuanlai Xu
Assemblies of plasmonic nanoparticles enable new modalities for biosensing. Engineered superstructures from metal nanoparticles can enhance the plasmon resonances and chiroptical activity of nanoscale dispersions. Such phenomena are keys to the fabrication of highly sensitive, selective and fast-responding detection platforms, making them promising candidates for clinical applications. This tutorial review summarizes and discusses recent advances in this area. The topics covered in the review include the basic strategies adopted for assembly and engineering of plasmonic nanoparticles, optical properties of the assembled nanostructures and their applications to both in vitro and in vivo detection of biological compounds...
May 8, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29737298/a-preliminary-study-on-the-anticancer-efficacy-of-caulis-spatholobi-compound-1802
#18
Yingnan Cao, Qiling Tang, Lan Luo, Ziying Gao, Suzhong Zhang
In recent years, antitumor and antiviral effect of Caulis spatholobi becomes a hot topic of medical drug research. Experiment shows that the water extract of Caulis spatholobi compound 1802 showed the effect of inhibiting tumor growth, the difference was statistically significant (P<0.05); the rate of tumor inhibition was highest in the high dose group of compound 1802, which could reach 41.99%. Anti tumor drugs generally have high toxicity, therefore, low toxicity is the significant characteristic of Caulis spatholobi...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29735465/a-preliminary-study-on-the-anticancer-efficacy-of-caulis-spatholobi-compound-1802
#19
Yingnan Cao, Qiling Tang, Lan Luo, Ziying Gao, Suzhong Zhang
In recent years, antitumor and antiviral effect of Caulis spatholobi becomes a hot topic of medical drug research. Experiment shows that the water extract of Caulis spatholobi compound 1802 showed the effect of inhibiting tumor growth, the difference was statistically significant (P<0.05); the rate of tumor inhibition was highest in the high dose group of compound 1802, which could reach 41.99%. Anti tumor drugs generally have high toxicity, therefore, low toxicity is the significant characteristic of Caulis spatholobi...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29732990/ozenoxacin-a-novel-drug-discovery-for-the-treatment-of-impetigo
#20
Jagdish K Sahu, Arun K Mishra
OBJECTIVE: Ozenoxacin is one of the potent quinolone antibiotics, recently approved by the United States Food and Drug Administration (USFDA) with reported pharmacology to treat the impetigo. The demand for better acting topical formulation is increasing day by day. The present review is an attempt to summarize the facts behind the chemistry and biological applications of Ozenoxacin. Mechanism of action: This novel drug being a quinolone antibiotic compound, acts by inhibiting DNA gyrase A and topoisomerase IV and affects supercoiling, supercoil relaxation, chromosomal condensation, chromosomal decatenation and many others...
May 2, 2018: Current Drug Discovery Technologies
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