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https://www.readbyqxmd.com/read/29909600/patients-knowledge-about-the-outcomes-of-thyroid-biopsy-a-patient-survey
#1
Naykky Singh Ospina, Ana Castaneda-Guarderas, Russell Ward, Juan P Brito, Spyridoula Maraka, Claudia Zeballos Palacios, Kathleen J Yost, Diana S Dean, Victor M Montori
PURPOSE: Fine-needle aspiration biopsy of the thyroid is an increasingly common outpatient procedure. Patients are counseled about the indications and risks of this procedure and informed consent is obtained. We aimed to assess the extent to which patients acquired necessary knowledge during this process. METHODS: Survey study conducted in a thyroid nodule clinic at a referral center. Adult patients who had just undergone a thyroid biopsy were asked to complete a survey, including eight questions regarding the indications and potential outcomes of thyroid biopsy...
June 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29909565/topical-pimecrolimus-versus-betamethasone-for-oral-lichen-planus-a-randomized-clinical-trial
#2
Ola M Ezzatt, Iman M Helmy
OBJECTIVES: Oral lichen plans (OLP) is a potentially malignant inflammatory mucocutaneous disease. CD133 is an investigated surface marker for cancer stem-like cells (CSCs) that may be involved in tumor initiation in head and neck carcinomas. We compared short-term clinical effectiveness of topical pimecrolimus as selective inflammatory cytokine release inhibitor with betamethasone cream for erosive/atrophic OLP and investigated the influence of this therapy on CD133 expression. MATERIAL AND METHODS: Thirty patients were randomly assigned into two equal groups to receive topical pimecrolimus (group I) or betamethasone (group II) four times daily for 4 weeks...
June 16, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29909557/defining-normal-apical-vaginal-support-a-relook-at-the-posst-study
#3
Radhika Patnam, Autumn Edenfield, Steven Swift
INTRODUCTION AND HYPOTHESIS: The purpose of this study is to reanalyze data from the original 2005 Pelvic Organ Support Study (POSST) data set to define normal values for apical Pelvic Organ Prolapse Quantification (POP-Q) points C and D and total vaginal length (TVL) in an asymptomatic population of women. METHODS: In this retrospective observational data-set review, patient were >18 years presenting for annual gynecologic exams to six centers in the United States...
June 16, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29909555/effects-of-mesh-related-complications-in-vaginal-surgery-on-quality-of-life
#4
Claudia R Kowalik, Mariëlle M E Lakeman, Alyde T de Kraker, Jan Paul W R Roovers
INTRODUCTION AND HYPOTHESIS: Vaginal mesh surgery is subject of debate due to the impact of mesh-related complications on patient's lives. Not all of these complications are symptomatic. Restoration of the anatomy and improvement of pelvic floor function as a result may counter the experienced discomfort related to adverse events. We hypothesized that health-related quality of life (HR-QoL) is comparable in women after vaginal mesh surgery regardless of the presence or absence of a mesh-specific complication...
June 16, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29909483/understanding-patient-reported-outcome-measures-in-huntington-disease-at-what-point-is-cognitive-impairment-related-to-poor-measurement-reliability
#5
N E Carlozzi, S Schilling, A L Kratz, J S Paulsen, S Frank, J C Stout
PURPOSE: Symptom progression in Huntington disease (HD) is associated with cognitive decline which may interfere with the self-report of symptoms. Unfortunately, data to support or refute the psychometric reliability of patient-reported outcomes (PROs) as HD progresses are limited. This is problematic given that PROs are increasingly recognized as important measures of efficacy for new treatments. METHODS: We examined PRO data from the HDQLIFE Measurement System (Speech Difficulties; Swallowing Difficulties; Chorea) in 509 individuals with premanifest, early-stage, or late-stage HD...
June 16, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29909471/pet-ct-and-prediction-of-thyroid-cancer-in-patients-with-follicular-neoplasm-or-atypia
#6
Thao T Nguyen, Natascha G E Lange, Anne L Nielsen, Anders Thomassen, Helle Døssing, Christian Godballe, Max Rohde
PURPOSE: To examine whether addition of 18 F-fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) to fine needle aspiration biopsy (FNAB) would improve prediction of thyroid cancer in patients with FNAB-derived follicular neoplasm or atypia, classified according to focal, multifocal, diffuse, or no FDG uptake. MATERIALS AND METHODS: Consecutive patients with FNAB-derived follicular neoplasm or atypia planned for surgery from September 2013 to March 2016 were prospectively included and considered for analysis...
June 16, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29909419/outcomes-of-local-excision-plus-chemoradiotherapy-in-patients-with-t1-rectal-cancer
#7
Toshiyuki Suzuki, Sotaro Sadahiro, Akira Tanaka, Kazutake Okada, Gota Saito, Hiroshi Miyakita, Takeshi Akiba, Hiroshi Yamamuro
OBJECTIVE: The National Comprehensive Cancer Network (NCCN) guidelines recommend local excision and observation as standard treatment for selected patients with clinical T1N0M0 rectal cancer. In patients with pathological T1 (pT1) rectal cancer who received local excision, the local recurrence rate is at least 10%. We studied oncological outcomes in patients with pT1 rectal cancer who received chemoradiotherapy (CRT) after local excision. METHODS: Local excision was performed in 65 patients with clinical T1N0M0 rectal cancer (≤8 cm from the anal verge, tumor size < 30 mm, well or moderately differentiated adenocarcinoma)...
June 15, 2018: Oncology
https://www.readbyqxmd.com/read/29909418/cell-block-in-cytological-diagnostics-review-of-preparatory-techniques
#8
REVIEW
Leena Krogerus, Ivana Kholová
OBJECTIVE: The cell block (CB) technique refers to the processing of sediments, blood clots, or grossly visible tissue fragments from cytological specimens into paraffin blocks that can be cut and stained by the same methods used for histopathology. The technique brings additional tissue architectural information. CB can be used for ancillary techniques such as immunocytochemistry and molecular techniques. STUDY DESIGN: We reviewed the literature on the various preparatory techniques of CBs...
June 15, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29909416/non-invasive-detection-of-anastomotic-leakage-following-esophageal-and-pancreatic-surgery-by-urinary-analysis
#9
Victor D Plat, Nora van Gaal, James A Covington, Matthew Neal, Tim G J de Meij, Donald L van der Peet, Babs Zonderhuis, Geert Kazemier, Nanne K H de Boer, Freek Daams
BACKGROUND: Esophagectomy or pancreaticoduodenectomy is the standard surgical approach for patients with tumors of the esophagus or pancreatic head. Postoperative mortality is strongly correlated with the occurrence of anastomotic leakage (AL). Delay in diagnosis leads to delay in treatment, which ratifies the need for development of novel and accurate non-invasive diagnostic tests for detection of AL. Urinary volatile organic compounds (VOCs) reflect the metabolic status of an individual, which is associated with a systemic immunological response...
June 15, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29909401/prevalence-and-long-term-survival-after-coronary-artery-bypass-grafting-in-women-and-men-with-heart-failure-and-preserved-versus-reduced-ejection-fraction
#10
Louise Y Sun, Jack V Tu, Anan Bader Eddeen, Peter P Liu
BACKGROUND: Heart failure (HF) with reduced ejection fraction (rEF) is a widely regarded prognosticator after coronary artery bypass grafting. HF with preserved ejection fraction (pEF) accounts for up to half of all HF cases and is associated with considerable morbidity and mortality in hospitalized cohorts. However, HFpEF outcomes have not been elucidated in cardiac surgical patients. We investigated the prevalence and outcomes of HFpEF and HFrEF in women and men following coronary artery bypass grafting...
June 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29909364/semiquantitative-analysis-using-standardized-uptake-value-in-123-i-fp-cit-spect-ct
#11
Akira Toriihara, Hiromitsu Daisaki, Akihiro Yamaguchi, Makoto Kobayashi, Shogo Furukawa, Katsuya Yoshida, Jun Isogai, Ukihide Tateishi
PURPOSE: To evaluate potential of a semiquantitative method using standardized uptake value (SUV) in 123 I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (123 I-FP-CIT) single photon emission computed tomography/computed tomography (SPECT/CT) compared with specific binding ratio (SBR). MATERIALS AND METHODS: First, we performed a phantom study to validate the accuracy of measuring SUV. 52 patients (25 male, 27 female; mean age of 75.1-year-old; 40 and 12 patients with neurodegenerative diseases with or without presynaptic dopaminergic deficits, respectively) were enrolled in a retrospective study...
June 14, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29909319/simultaneous-determination-of-plasma-methotrexate-and-7-hydroxy-methotrexate-by-uhplc-ms-ms-in-patients-receiving-high-dose-methotrexate-therapy
#12
Shenghui Mei, Xiaoxu Shi, Yaming Du, Yong Cui, Chun Zeng, Xiaohui Ren, Kefu Yu, Zhigang Zhao, Song Lin
The plasma concentrations of methotrexate (MTX) and its major metabolite 7-hydroxy methotrexate (7-OH-MTX) are highly correlated with the toxicities in patients with high-dose MTX therapy. Routine monitoring of MTX and 7-OH-MTX plasma levels is useful for dose adjustment of rescue drugs and toxicity prevention. A UHPLC-MS/MS method for simultaneous determination of plasma MTX and 7-OH-MTX was developed, validated, and applied in 181 plasma samples. The ion transition was m/z 455.2 → 308.2 for MTX and m/z 471...
June 11, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29909264/tamoxifen-versus-clomiphene-citrate-for-ovulation-induction-in-infertile-women
#13
REVIEW
Li Jie, Deng Li, Chen Yang, Zhang Haiying
This systematic review aimed to compare the clinical efficacy of tamoxifen with that of clomiphene citrate (CC) in anovulatory patients. The PubMed, EMBASE, and CNKI databases were searched up to October 2016 for literature comparing tamoxifen with CC in anovulatory women. The pooled risk ratios (RR) or standardized mean differences (SMD) with 95% confidence intervals (CIs) were subjected to statistical analysis. Twelve studies involving 1302 patients with 2030 ovulation-induction cycles were summarized. There were no statistically significant differences for the ovulation and pregnancy rates in the tamoxifen comparing to the CC group in the pooled analysis...
June 12, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29909256/task-induced-gamma-band-effect-in-type-ii-focal-cortical-dysplasia-an-exploratory-study
#14
Sabrine Souci, Mathilde Petton, Julien Jung, Pierre Bourdillon, Romain Bouet, Aurélie Richard-Mornas, Nathalie Streichenberger, Hélène Catenoix, Alexandra Montavont, Jean Isnard, Marc Guenot, Philippe Kahane, Jean-Philippe Lachaux, Sylvain Rheims
OBJECTIVE: Few data are available about the functionality of type II focal cortical dysplasia (FCD). Identification of high-frequency activities (HFAs) induced by cognitive tasks has been proposed as an additional way to map cognitive functions in patients undergoing presurgical evaluation using stereoelectroencephalography (SEEG). However, the repetitive subcontinuous spiking pattern which characterizes type II FCD might limit the reliability of this approach, and its feasibility in these patients remains to be evaluated...
June 14, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29909213/pipeline-embolization-device-flow-diversion-for-a-dissecting-ruptured-posterior-cerebral-artery-aneurysm-in-a-pediatric-patient
#15
Murillo Cunegatto-Braga, Brian Hogan, Pedro Aguilar-Salinas, Alexandra D Beier, Ricardo A Hanel
BACKGROUND: Intracranial aneurysms(IAs) are rare in the pediatric population and are usually considered difficult to treat with traditional microsurgery due to their complex morphology. Endovascular techniques have become the standard option for treating IAs in adults. More recently, flow diverters such as the Pipeline Embolization Device(PED) are being widely adopted for unruptured IAs with safety and efficacy in adults, yet their use in the pediatric population is not well defined. In this paper we present a pediatric patient with a ruptured PCA aneurysm successfully treated with a PED and a review of the literature of the current status of PED use in this subset of patients...
June 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29909185/accuracy-of-smartphone-based-evaluation-of-emergent-large-vessel-occlusion-on-cta
#16
Douglas T Hidlay, Ryan A McTaggart, Grayson Baird, Shadi Yaghi, Morgan Hemendinger, Eric L Tung, Eleanor L Dibiasio, Richard A Haas, Mahesh V Jayaraman
OBJECTIVES: Mechanical thrombectomy is the standard of care for stroke caused by an emergent large vessel occlusion in the anterior circulation, and the ability to rapidly review CTA is one hurdle in minimizing the time from diagnosis to intervention. We evaluated the diagnostic accuracy and confidence in review of stroke CTA for ELVO via a smartphone-based application as compared to PACS workstation. PATIENTS AND METHODS: Seventy-six head and neck CTA studies performed for stroke from one comprehensive and seven primary stroke centers were independently reviewed remotely on smartphone by two blinded interventional neuroradiologists in actual-use circumstances...
June 11, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29909156/high-dose-influenza-vaccine-to-reduce-clinical-outcomes-in-high-risk-cardiovascular-patients-rationale-and-design-of-the-invested-trial
#17
Orly Vardeny, Jacob A Udell, Jacob Joseph, Michael E Farkouh, Adrian F Hernandez, Alison J McGeer, H Keipp Talbot, Deepak L Bhatt, Christopher P Cannon, Shaun G Goodman, Inder Anand, David L DeMets, Jon Temte, Janet Wittes, Kristin Nichol, Clyde W Yancy, J Michael Gaziano, Lawton S Cooper, KyungMann Kim, Scott D Solomon
BACKGROUND: Influenza leads to significant cardiopulmonary morbidity and mortality-particularly in patients with cardiovascular disease-that may be prevented with a standard influenza vaccine. However, patients with cardiovascular conditions have a reduced immune response to influenza vaccine, potentially resulting in reduced effectiveness for preventing clinical events. High-dose vaccine augments immune response in cardiac patients, suggesting that a high-dose influenza vaccination strategy may further reduce morbidity and mortality...
May 23, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29909084/clinical-outcomes-in-the-treatment-of-unilateral-condylar-fractures-a-cross-sectional-study
#18
A V J Rozeboom, L T Klumpert, M Koutris, L Dubois, C M Speksnijder, F Lobbezoo, J de Lange
The treatment of mandibular condyle fractures has been the subject of considerable discussion, especially whether open or closed treatment should be used. There is a need for practical,evidence-based guidelines, and both objective and subjective parameters should be measured. To date, fewstudies have considered clinically relevant subjective parameters. This study was performed to evaluate the outcomes of the treatment of condylar fractures using the Mandibular Function Impairment Questionnaire (MFIQ) and the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) and to compare the outcomes of open and the closed treatment...
June 13, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29909060/quantification-of-bone-microstructure-in-the-wrist-using-cone-beam-computed-tomography
#19
Karen Mys, Filip Stockmans, Evie Vereecke, G Harry van Lenthe
Due to the rising life expectancy, bone diseases (e.g. osteoporosis, osteoarthritis) and trauma (e.g. fracture) have become an important socio-economic burden. Accurate visualization and quantification of the bone microstructure in vivo is seen as an important step to enhance diagnosis and treatment. Micro-computed tomography (microCT) has become the gold standard in three-dimensional (3D) imaging of trabecular bone structure. Yet, usage is limited to ex vivo analyses, hence, it cannot be used to evaluate bone and bone adaptive responses in a patient...
June 14, 2018: Bone
https://www.readbyqxmd.com/read/29909013/impact-and-prevalence-of-physical-and-verbal-violence-toward-healthcare-workers
#20
Lisa J Rosenthal, Ashley Byerly, Adrienne D Taylor, Zoran Martinovich
BACKGROUND: Threatening and assaultive behaviors against healthcare workers is a growing national concern.1,2,3 To assess the incidence and impact of aggression against healthcare workers, a safety and quality improvement project was initiated in an academic, tertiary care, and urban hospital. METHODS: Through the Northwestern Academy of Quality and Safety Initiatives program, an invitation to complete an online survey was sent to healthcare workers. The survey inquired about prevalence, location, and type of experience of physical or verbal abuse by patients or families...
May 9, 2018: Psychosomatics
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