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Vanessa Verdin, Joseph Weerts, David Francart, Constant Jehaes, David Magis, Paul Magotteaux, Laurine Mattart, Benoit Monami, Christian Wahlen, Serge Markiewicz
BACKGROUND: Rectal adenocarcinomas surgery morbidity and mortality might be impaired by neoadjuvant therapy. We performed this retropsective study to be compared with the PROCARE study running afterwards. METHODS: We performed a retrospective study of 95 patients operated on for rectal adenocarcinoma in a single institution during the period of 2007-2009. We used logistic regression to estimate the relationship between possible predictive parameters of anastomotic leakage (AL)...
October 17, 2016: Acta Chirurgica Belgica
Kénora Chau, Bernard Kabuth, Odile Causin-Brice, Yves Delacour, Catherine Richoux-Picard, Monique Verdin, Isabelle Armand, Nearkasen Chau
Health-related problems and risky behaviours (substance use) are frequent in adolescents, may alter their physical and mental capabilities, and may thus generate school absenteeism, low academic performance, and school dropout ideation. This study assessed their associations and the contribution of socioeconomic factors among 1559 middle-school adolescents (mean age 13.5+1.3) from north-eastern France. They completed a questionnaire including socioeconomic characteristics, health-related problems (poor physical health, psychological health, social relationships, and living environment) assessed with the World Health Organization's quality of life measure (score<25th percentile), risky behaviours, school absences during the present school year, last-trimester academic performance, and school dropout ideation...
October 30, 2016: Psychiatry Research
Cécile Desbiez, Eric Verdin, Mark Tepfer, Catherine Wipf-Scheibel, Pauline Millot, Gasim Dafalla, Hervé Lecoq
Two members of the genus Ipomovirus (family Potyviridae) are known to infect cucurbits: cucumber vein yellowing virus (CVYV), which is emerging throughout the Mediterranean Basin, and squash vein yellowing virus (SqVYV), which has been described in America and the Caribbean Basin, and more recently in Israel. In this work, an ipomovirus different from CVYV and SqVYV, tentatively named coccinia mottle virus (CocMoV), was detected in a sample of the cucurbit Coccinia grandis collected in central Sudan in 2012...
October 2016: Archives of Virology
Lenard S Vranckx, Jonas Demeulemeester, Suha Saleh, Annegret Boll, Gerlinde Vansant, Rik Schrijvers, Caroline Weydert, Emilie Battivelli, Eric Verdin, Anna Cereseto, Frauke Christ, Rik Gijsbers, Zeger Debyser
Persistence of latent, replication-competent Human Immunodeficiency Virus type 1 (HIV-1) provirus is the main impediment towards a cure for HIV/AIDS (Acquired Immune Deficiency Syndrome). Therefore, different therapeutic strategies to eliminate the viral reservoirs are currently being explored. We here propose a novel strategy to reduce the replicating HIV reservoir during primary HIV infection by means of drug-induced retargeting of HIV integration. A novel class of integration inhibitors, referred to as LEDGINs, inhibit the interaction between HIV integrase and the LEDGF/p75 host cofactor, the main determinant of lentiviral integration site selection...
June 2016: EBioMedicine
Shaina A Kelly, Carlos Torres-Verdín, Matthew T Balhoff
Micro/nanofluidic experiments in synthetic representations of tight porous media, often referred to as "reservoir-on-a-chip" devices, are an emerging approach to researching anomalous fluid transport trends in energy-bearing and fluid-sequestering geologic porous media. We detail, for the first time, the construction of dual-scale micro/nanofluidic devices that are relatively large-scale, two-dimensional network representations of granular and fractured nanoporous media. The fabrication scheme used in the development of the networks on quartz substrates (master patterns) is facile and replicable: transmission electron microscopy (TEM) grids with lacey carbon support film were used as shadow masks in thermal evaporation/deposition and reactive ion etch (RIE) was used for hardmask pattern transfer...
August 7, 2016: Lab on a Chip
Rahul Palchaudhuri, Borja Saez, Jonathan Hoggatt, Amir Schajnovitz, David B Sykes, Tiffany A Tate, Agnieszka Czechowicz, Youmna Kfoury, Fnu Ruchika, Derrick J Rossi, Gregory L Verdine, Michael K Mansour, David T Scadden
Hematopoietic stem cell transplantation (HSCT) offers curative therapy for patients with hemoglobinopathies, congenital immunodeficiencies, and other conditions, possibly including AIDS. Autologous HSCT using genetically corrected cells would avoid the risk of graft-versus-host disease (GVHD), but the genotoxicity of conditioning remains a substantial barrier to the development of this approach. Here we report an internalizing immunotoxin targeting the hematopoietic-cell-restricted CD45 receptor that effectively conditions immunocompetent mice...
July 2016: Nature Biotechnology
Fabrice Cazier, Paul Genevray, Dorothée Dewaele, Habiba Nouali, Anthony Verdin, Frédéric Ledoux, Adam Hachimi, Lucie Courcot, Sylvain Billet, Saâd Bouhsina, Pirouz Shirali, Guillaume Garçon, Dominique Courcot
Atmospheric aerosol samples (PM2.5-0.3, i.e., atmospheric particles ranging from 0.3 to 2.5μm) were collected during two periods: spring-summer 2008 and autumn-winter 2008-2009, using high volume samplers equipped with cascade impactors. Two sites located in the Northern France were compared in this study: a highly industrialised city (Dunkirk) and a rural site (Rubrouck). Physicochemical analysis of particulate matter (PM) was undertaken to propose parameters that could be used to distinguish the various sources and to exhibit seasonal variations but also to provide knowledge of chemical element composition for the interpretation of future toxicological studies...
June 2016: Journal of Environmental Sciences (China)
Kotaro Shirakawa, Lan Wang, Na Man, Jasna Maksimoska, Alexander W Sorum, Hyung W Lim, Intelly S Lee, Tadahiro Shimazu, John C Newman, Sebastian Schröder, Melanie Ott, Ronen Marmorstein, Jordan Meier, Stephen Nimer, Eric Verdin
Salicylate and acetylsalicylic acid are potent and widely used anti-inflammatory drugs. They are thought to exert their therapeutic effects through multiple mechanisms, including the inhibition of cyclo-oxygenases, modulation of NF-κB activity, and direct activation of AMPK. However, the full spectrum of their activities is incompletely understood. Here we show that salicylate specifically inhibits CBP and p300 lysine acetyltransferase activity in vitro by direct competition with acetyl-Coenzyme A at the catalytic site...
2016: ELife
David Medellín, Vivek R Ravi, Carlos Torres-Verdín
Multidimensional NMR inversion using Kronecker products poses several challenges. First, kernel compression is only possible when the kernel matrices are separable, and in recent years, there has been an increasing interest in NMR sequences with non-separable kernels. Second, in three or more dimensions, the singular value decomposition is not unique; therefore kernel compression is not well-defined for higher dimensions. Without kernel compression, the Kronecker product yields matrices that require large amounts of memory, making the inversion intractable for personal computers...
August 2016: Journal of Magnetic Resonance
Serge Nicolas
The importance of instrument firms in the development of psychology, and science in general, should not be underestimated since it would not have been possible for various leading psychologists at the turn of the twentieth century to conduct certain experiments without the assistance of instrument makers, as is often the case today. To illustrate the historical perspective introduced here, the example of Alfred Binet is taken, as he is an interesting case of a psychologist working in close collaboration with various French instrument designers of the time...
July 2016: Journal of the History of the Behavioral Sciences
Mark Tepfer, Gregory Girardot, Lucie Fénéant, Hana Ben Tamarzizt, Eric Verdin, Benoît Moury, Mireille Jacquemond
An isolate of cucumber mosaic virus (CMV), designated CMV-Rom, was isolated from rosemary (Rosmarinus officinalis) plants in several locations near Avignon, France. Laboratory studies showed that, unlike typical CMV isolates, CMV-Rom has a particularly narrow host range. It could be transmitted by aphids Aphis gossypii and Myzus persicae, but with low efficacy compared to a typical CMV isolate. Phylogenetic analysis of the nucleotide sequences of the CMV-Rom genomic RNAs shows that this isolate does not belong to any of the previously described CMV subgroups, IA, IB, II or III...
July 2016: Archives of Virology
Meriel McEntagart, Kathleen A Williamson, Jacqueline K Rainger, Ann Wheeler, Anne Seawright, Elfride De Baere, Hannah Verdin, L Therese Bergendahl, Alan Quigley, Joe Rainger, Abhijit Dixit, Ajoy Sarkar, Eduardo López Laso, Rocio Sanchez-Carpintero, Jesus Barrio, Pierre Bitoun, Trine Prescott, Ruth Riise, Shane McKee, Jackie Cook, Lisa McKie, Berten Ceulemans, Françoise Meire, I Karen Temple, Fabienne Prieur, Jonathan Williams, Penny Clouston, Andrea H Németh, Siddharth Banka, Hemant Bengani, Mark Handley, Elisabeth Freyer, Allyson Ross, Veronica van Heyningen, Joseph A Marsh, Frances Elmslie, David R FitzPatrick
Gillespie syndrome (GS) is characterized by bilateral iris hypoplasia, congenital hypotonia, non-progressive ataxia, and progressive cerebellar atrophy. Trio-based exome sequencing identified de novo mutations in ITPR1 in three unrelated individuals with GS recruited to the Deciphering Developmental Disorders study. Whole-exome or targeted sequence analysis identified plausible disease-causing ITPR1 mutations in 10/10 additional GS-affected individuals. These ultra-rare protein-altering variants affected only three residues in ITPR1: Glu2094 missense (one de novo, one co-segregating), Gly2539 missense (five de novo, one inheritance uncertain), and Lys2596 in-frame deletion (four de novo)...
May 5, 2016: American Journal of Human Genetics
Ma Guadalupe Aguilera-Arreola, Marcos Daniel Martínez-Peña, Fabiola Hernández-Martínez, Sara R Juárez Enriques, Beatriz Rico Verdín, Cristina Majalca-Martínez, Graciela Castro-Escarpulli, Enrique Albarrán-Fernández, S Cecilia Serrano-López
Administration of empirical antibiotic therapy prior to microbiological diagnosis is thought to be associated the failure of subsequent bacterial growth in culture. The aim of this study was to detect bacterial pathogens via direct amplification and sequencing of the 16S rDNA gene in samples showing negative culture results as alternative diagnostic tools to troubleshoot difficult samples. Twenty-three (7.66 %) positive samples were detected, most of which were monomicrobial infections; 15 of the cases were identified as HAIs, 6 had catheter colonisation, and 2 had sample colonisation...
2016: SpringerPlus
Brian N Verdine, Kelsey R Lucca, Roberta Michnick Golinkoff, Kathy Hirsh-Pasek, Nora S Newcombe
How do toddlers learn the names of geometric forms? Past work suggests that preschoolers have fragmentary knowledge and that defining properties are not understood until well into elementary school. The current study investigates when children first begin to understand shape names and how they apply those labels to unusual instances. We tested 25- and 30-month-old children's (N = 30 each) understanding of names for canonical shapes (commonly-encountered instances, e.g., equilateral triangles), non-canonical shapes (more irregular instances, e...
January 1, 2016: Journal of Cognition and Development: Official Journal of the Cognitive Development Society
Ido Amit, David Baker, Roger Barker, Bonnie Berger, Carolyn Bertozzi, Sangeeta Bhatia, Alessandra Biffi, Francesca Demichelis, Jennifer Doudna, Steven F Dowdy, Drew Endy, Moritz Helmstaedter, Howard Junca, Carl June, Sasha Kamb, Anastasia Khvorova, Dae-Hyeong Kim, Jin-Soo Kim, Yamuna Krishnan, Melike Lakadamyali, Tuuli Lappalainen, Sharon Lewin, James Liao, Nick Loman, Emma Lundberg, Lee Lynd, Cathie Martin, Ira Mellman, Atsushi Miyawaki, Christine Mummery, Karen Nelson, Jeanne Paz, Pamela Peralta-Yahya, Paola Picotti, Kornelia Polyak, Kristala Prather, Jun Qin, Stephen Quake, Aviv Regev, John A Rogers, Reshma Shetty, Morten Sommer, Molly Stevens, Gustavo Stolovitzky, Masayo Takahashi, Fuchou Tang, Sarah Teichmann, Maria-Elena Torres-Padilla, Leena Tripathi, Praveen Vemula, Greg Verdine, Frank Vollmer, Jun Wang, Jackie Y Ying, Feng Zhang, Tian Zhang
No abstract text is available yet for this article.
March 2016: Nature Biotechnology
H Lecoq, E Verdin, M Tepfer, C Wipf-Scheibel, P Millot, G Dafalla, C Desbiez
During a survey conducted in Sudan in 2012, a virus with spherical particles was isolated from a squash plant showing chlorotic leaf spots. The virus was transmitted mechanically and by two whitefly species, but not by aphids. RT-PCR with generic torradovirus primers yielded a band of expected size from total RNA of a symptomatic plant. Next-generation sequencing confirmed that this is tentatively a new torradovirus, for which we propose the name 'squash chlorotic leaf spot virus'. Using specific RT-PCR primers, the virus was detected in cucurbit samples collected since 1992 at different locations in Sudan...
June 2016: Archives of Virology
Géraldine Bidar, Christophe Waterlot, Anthony Verdin, Nicolas Proix, Dominique Courcot, Sébastien Détriché, Hervé Fourrier, Antoine Richard, Francis Douay
Aided phytostabilisation using trees and fly ashes is a promising technique which has shown its effectiveness in the management of highly metal-contaminated soils. However, this success is generally established based on topsoil physicochemical analysis and short-term experiments. This paper focuses on the long-term effects of the afforestation and two fly ashes (silico-aluminous and sulfo-calcic called FA1 and FA2, respectively) by assessing the integrity of fly ashes 10 years after their incorporation into the soil as well as the vertical distribution of the physicochemical parameters and trace elements (TEs) in the amended soils (F1 and F2) in comparison with a non-amended soil (R)...
April 15, 2016: Journal of Environmental Management
Imane Abbas, Anthony Verdin, Fabienne Escande, Françoise Saint-Georges, Fabrice Cazier, Philippe Mulliez, Dominique Courcot, Pirouz Shirali, Pierre Gosset, Guillaume Garçon
Although its adverse health effects of air pollution particulate matter (PM2.5) are well-documented and often related to oxidative stress and pro-inflammatory response, recent evidence support the role of the remodeling of the airway epithelium involving the regulation of cell death processes. Hence, the overarching goals of the present study were to use an in vitro coculture model, based on human AM and L132 cells to study the possible alteration of TP53-RB gene signaling pathways (i.e. cell cycle phases, gene expression of TP53, BCL2, BAX, P21, CCND1, and RB, and protein concentrations of their active forms), and genetic instability (i...
May 2016: Environmental Research
Yao Fu, Michael Kinter, Joanna Hudson, Kenneth M Humphries, Rachel S Lane, Jeremy R White, Michael Hakim, Yong Pan, Eric Verdin, Timothy M Griffin
OBJECTIVE: To quantify functional age-related changes in the cartilage antioxidant network in order to discover novel mediators of cartilage oxidative stress and osteoarthritis (OA) pathophysiology. METHODS: We evaluated histopathologic changes of knee OA in 10-, 20-, and 30-month-old male F344BN rats and analyzed cartilage oxidation according to the ratio of reduced to oxidized glutathione. Antioxidant gene expression and protein abundance were analyzed by quantitative reverse transcription-polymerase chain reaction and selected reaction-monitoring mass spectrometry, respectively...
August 2016: Arthritis & Rheumatology
Tracy Fasolino, Terry Verdin
A retrospective chart review was conducted to determine the impact of nursing surveillance on rapid deterioration. Data were collected on vital signs, recognition of mentation changes, and assessment of urinary output. Specific components of nursing surveillance that permit recognition of deteriorating patients remain unclear.
November 2015: Medsurg Nursing: Official Journal of the Academy of Medical-Surgical Nurses
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