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pigment dispersion syndrome

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https://www.readbyqxmd.com/read/28410728/corneal-collagen-crosslinking-and-pigment-dispersion-syndrome
#1
Benjamin R LaHood, Sacha Moore
We describe the case of a keratoconus patient with pigment dispersion syndrome (PDS) who was treated for progressive corneal ectasia with corneal collagen crosslinking (CXL). Pigment dispersion syndrome has been shown to have associated morphologic changes of the corneal endothelium. Corneal CXL has the potential to cause toxicity to the corneal endothelium, and adjacent pigment might increase the likelihood of damage. In this case, the presence of PDS had no detrimental effect on the outcome of treatment, and no complications were observed at 12 months follow-up, indicating that it may be safe to perform corneal CXL in the setting of PDS...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28298869/pigment-dispersion-syndrome-associated-with-spontaneous-subluxation-of-crystalline-lens
#2
Vikas Veerwal, Jawahar Lal Goyal, Parul Jain, Ritu Arora
Pigment dispersion syndrome (PDS) is an ocular condition characterized by a dispersion of iris pigment throughout the eye. This pigment is deposited in a characteristic manner on the corneal endothelium as Krukenberg's spindle, anterior surface of the iris, in the trabecular meshwork, on the lens and zonule and occasionally on the anterior hyaloid face. Even with deposition of pigment on zonular fibers, no zonular weakness, or zonular dehiscence has been reported in these cases. We report a unique case of PDS with bilateral spontaneous subluxation of crystalline lens...
January 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28182171/early-clinical-features-of-pseudoexfoliation-syndrome-in-anterior-segment-and-gonioscopy-examination
#3
Sirel Gür Güngör, Atilla Bayer, Ahmet Akman, Leyla Asena
OBJECTIVES: To determine the early signs of pseudoexfoliation (PEX) in fellow eyes of cases with unilateral PEX. MATERIALS AND METHODS: Fellow eyes of 34 cases with unilateral PEX were evaluated by slit-lamp and gonioscopy. Findings associated with PEX were recorded. RESULTS: Mean age was 67.8±8.1 years (range 55-86 years). Twenty-five patients (73.5%) had pigmentation in the inferior angle and 23 patients (67.6%) had Sampaolesi's line located on the inferior angle in fellow eyes...
January 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28112127/retropupillary-iris-claw-intraocular-lens-for-the-surgical-correction-of-aphakia-in-cases-with-microspherophakia
#4
Sameh Mosaad Fouda, Mahmoud A Al Aswad, Basem M Ibrahim, Ashraf Bori, Hala K Mattout
PURPOSE: This study aimed to evaluate the safety and efficacy of retropupillary fixation of an iris-claw intraocular lens (IOL; Verisyse polymethyl methacrylate IOL, Abbott Medical Optics [AMO], Netherlands) for the surgical correction of aphakia in microspherophakic eyes without sufficient capsular support. DESIGN: This was a prospective, interventional, noncomparative case series. METHODS: This interventional case series comprised 17 eyes of 9 microspherophakic patients...
December 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27898469/update-on-pigment-dispersion-syndrome-and-pigmentary-glaucoma
#5
REVIEW
Kingsley Okafor, Kateki Vinod, Steven J Gedde
PURPOSE OF REVIEW: The present article reviews the clinical features and pathogenesis of pigment dispersion syndrome and pigmentary glaucoma and provides an update regarding their diagnosis and management. RECENT FINDINGS: Newer imaging modalities including ultrasound biomicroscopy and anterior segment optical coherence tomography facilitate visualization of the iris concavity characteristic of eyes with pigment dispersion syndrome and pigmentary glaucoma. Patients with pigmentary glaucoma may be distinguished from those with other glaucoma types by the presence of typical symptoms, personality type, and patterns of diurnal intraocular pressure fluctuation...
March 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27259167/molecular-and-clinical-findings-in-patients-with-knobloch-syndrome
#6
Sarah Hull, Gavin Arno, Cristy A Ku, Zhongqi Ge, Naushin Waseem, Aman Chandra, Andrew R Webster, Anthony G Robson, Michel Michaelides, Richard G Weleber, Indran Davagnanam, Rui Chen, Graham E Holder, Mark E Pennesi, Anthony T Moore
IMPORTANCE: Knobloch syndrome is a rare, recessively inherited disorder classically characterized by high myopia, retinal detachment, and occipital encephalocele, but it is now known to have an increasingly variable phenotype. There is a lack of reported electrophysiologic data, and some key clinical features have yet to be described. OBJECTIVE: To expand on current clinical, electrophysiologic, and molecular genetic findings in Knobloch syndrome. DESIGN, SETTING, AND PARTICIPANTS: Twelve patients from 7 families underwent full ophthalmic examination and retinal imaging...
July 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27175994/a-severe-case-of-pigmentary-glaucoma-in-a-child-with-a-family-history-of-pigment-dispersion-syndrome
#7
Vittoria Aragno, Pierre Zeboulon, Christophe Baudouin, Antoine Labbé
PURPOSE: To report a case of severe pigmentary glaucoma (PG) in a 13-year-old boy of a family affected by pigment dispersion syndrome (PDS). PATIENTS AND METHODS: A 13-year-old child was referred to our hospital for severe bilateral glaucoma. A complete ophthalmologic evaluation including refraction, intraocular pressure, central corneal thickness, slit-lamp biomicroscopy, gonioscopy, fundus examination, and ultrasound biomicroscopy was performed. Family members were also examined and a family pedigree was obtained...
August 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27095816/the-retina-and-other-light-sensitive-ocular-clocks
#8
REVIEW
Joseph C Besharse, Douglas G McMahon
Ocular clocks, first identified in the retina, are also found in the retinal pigment epithelium (RPE), cornea, and ciliary body. The retina is a complex tissue of many cell types and considerable effort has gone into determining which cell types exhibit clock properties. Current data suggest that photoreceptors as well as inner retinal neurons exhibit clock properties with photoreceptors dominating in nonmammalian vertebrates and inner retinal neurons dominating in mice. However, these differences may in part reflect the choice of circadian output, and it is likely that clock properties are widely dispersed among many retinal cell types...
June 2016: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/26997839/pigment-dispersion-syndrome-progression-to-pigmentary-glaucoma-in-a-latin-american-population
#9
REVIEW
Hector Fernando Gomez Goyeneche, Diana Patricia Hernandez-Mendieta, Diego Andres Rodriguez, Ana Irene Sepulveda, Jose Daniel Toledo
OBJECTIVE: To determine the progression of pigment dispersion syndrome (PDS) into pigmentary glaucoma (PG) in a population at the Central Military Hospital in Bogotá, Colombia. MATERIALS AND METHODS: A retrospective study was conducted, based on a review of medical records of patients with PDS evaluated in the Glaucoma Clinic. Data were collected in a database in excel and subsequently analyzed with the software Statistical Package for the Social Sciences (SPSS), performing Chi-square test analysis and Spearman's rho test...
September 2015: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/26933430/what-s-in-a-gene-pseudoexfoliation-syndrome-and-pigment-dispersion-syndrome-in-the-same-patient
#10
Olya Pokrovskaya, Colm O'Brien
Pseudoexfoliation syndrome (PXS) and pigment dispersion syndrome (PDS) are two of the commonest disorders to produce secondary open-angle glaucoma through trabecular meshwork blockage. Each is a defined clinical entity, and while genetics likely play a significant role in the pathogenesis of both, the specific genes involved appear to be distinct. There is surprisingly little published in the literature regarding the coexistence of PDS and PXS in the same patient. We present the intriguing case of a patient who developed PDS in one eye and PXS in the other...
January 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/26871761/peripheral-iridotomy-for-pigmentary-glaucoma
#11
REVIEW
Manuele Michelessi, Kristina Lindsley
BACKGROUND: Glaucoma is a chronic optic neuropathy characterized by retinal ganglion cell death resulting in damage to the optic nerve head and the retinal nerve fiber layer. Pigment dispersion syndrome is characterized by a structural disturbance in the iris pigment epithelium (the densely pigmented posterior surface of the iris) that leads to dispersion of the pigment and its deposition on various structures within the eye. Pigmentary glaucoma is a specific form of open-angle glaucoma found in patients with pigment dispersion syndrome...
February 12, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26291741/comparison-of-ganglion-cell-and-retinal-nerve-fiber-layer-thickness-in-pigment-dispersion-syndrome-pigmentary-glaucoma-and-healthy-subjects-with-spectral-domain-oct
#12
COMPARATIVE STUDY
Hasan Basri Arifoglu, Huseyin Simavli, Inci Midillioglu, Sule Berk Ergun, Saban Simsek
PURPOSE: To evaluate the ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL) thickness in pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) with RTVue spectral domain optical coherence tomography (SD-OCT). METHODS: A total of 102 subjects were enrolled: 29 with PDS, 18 with PG, and 55 normal subjects. Full ophthalmic examination including visual field analysis was performed. SD-OCT was used to analyze GCC superior, GCC inferior, and average RNFL thickness...
2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/26139047/stability-and-safety-of-ma50-intraocular-lens-placed-in-the-sulcus
#13
P S Kemp, T A Oetting
PURPOSE: To describe the safety and stability of sulcus placement of the MA50 intraocular lens (IOL). PATIENTS AND METHODS: Consecutive patients with MA50 IOLs placed in the sulcus at the University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA, from 1997 to 2012 were identified. Inclusion criteria included patients with over 4 weeks of follow-up data. AEL was compared with incidence of IOL decentration using at two-tailed Student's t-test. RESULTS: Fifty eyes of 49 patients meeting the inclusion criteria were identified...
November 2015: Eye
https://www.readbyqxmd.com/read/26115040/it-s-not-easy-being-blue-are-there-olfactory-and-visual-trade-offs-in-plant-signalling
#14
Kim Valenta, Kevin A Brown, Amanda D Melin, Spencer K Monckton, Sarah A Styler, Derek A Jackson, Colin A Chapman
Understanding the signals used by plants to attract seed disperses is a pervasive quest in evolutionary and sensory biology. Fruit size, colour, and odour variation have long been discussed in the controversial context of dispersal syndromes targeting olfactory-oriented versus visually-oriented foragers. Trade-offs in signal investment could impose important physiological constraints on plants, yet have been largely ignored. Here, we measure the reflectance and volatile organic compounds of a community of Malagasy plants and our results indicate that extant plant signals may represent a trade-off between olfactory and chromatic signals...
2015: PloS One
https://www.readbyqxmd.com/read/26008928/pigment-dispersion-syndrome-associated-with-optic-nerve-melanocytoma
#15
A Asorey-García, C D Méndez-Hernández, E Santos-Bueso, J García-Feijoo
CASE REPORT: A 60-year old patient was referred for cataract surgery. The examination showed retrokeratic pigment in the left eye, which had an intraocular pressure of 24 mm Hg. The funduscopy showed a brown lesion on the left optic disk, with adjacent vitreous seeding of pigment. The patient was thus diagnosed with secondary pigment dispersion syndrome due to optic disk melanocytoma. DISCUSSION: Although melanocytoma is most commonly a benign, stationary tumor, it may present with major complications leading to significant visual loss...
October 2015: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/25945534/bilateral-acute-iris-transillumination-bait-initially-misdiagnosed-as-acute-iridocyclitis
#16
Saban Gonul, Banu Bozkurt
Bilateral acute iris transillumination (BAIT) is a relatively new clinical entity characterized by bilateral acute loss of iris pigment epithelium, iris transillumination, pigment dispersion in the anterior chamber, and sphincter paralysis. We report the case of a 30-year-old male who was initially diagnosed with acute iridocyclitis in a different clinic and treated with topical and systemic corticosteroids. He was referred to our clinic to seek another opinion because his symptoms did not improve. An ocular examination revealed bilateral pigment dispersion into the anterior chamber, diffuse iris transillumination, pigment dusting on the anterior lens capsule, atonic and distorted pupils, and increased intraocular pressure, suggesting a diagnosis of BAIT rather than iridocyclitis...
March 2015: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/25316067/longitudinal-stability-of-the-diurnal-rhythm-of-intraocular-pressure-in-subjects-with-healthy-eyes-ocular-hypertension-and-pigment-dispersion-syndrome
#17
Cord Huchzermeyer, Udo Reulbach, Folkert Horn, Robert Lämmer, Christian Y Mardin, Anselm G M Jünemann
BACKGROUND: The diurnal fluctuation of intraocular pressure may be relevant in glaucoma. The aim of this study was to find out whether the timing of diurnal fluctuation is stable over the years. METHODS: Long-term IOP data from the Erlangen Glaucoma Registry, consisting of several annual extended diurnal IOP profiles for each patient, was retrospectively analyzed. Normal subjects, patients with ocular hypertension and with pigment dispersion syndrome were included because these subjects had not been treated with antiglaucomatous medications at the time of data acquisition...
October 15, 2014: BMC Ophthalmology
https://www.readbyqxmd.com/read/25312464/-long-term-efficacy-of-laser-peripheral-iridotomy-in-preventing-progression-in-eyes-with-pigment-dispersion-syndrome
#18
Guoping Qing, Shaodan Zhang, Huaizhou Wang, Tao Wang, Shuhua Wang, Hong Chen, Hua Wang, Ningli Wang
OBJECTIVE: To evaluate the long-term efficacy of laser peripheral iridotomy (LPI) in preventing deterioration in eyes with pigment dispersion syndrome (PDS). METHODS: A cohort study. Nineteen patients with PDS were treated with LPI and followed up periodically in Beijing Tongren Eye Center from May 2006 to April 2007. One eye of each patient was chosen randomly for the study. Main investigating items included iris configuration, intraocular pressure (IOP), anterior chamber pigmentation, and visual field analysis...
July 2014: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/25275896/ocular-and-systemic-manifestations-of-exfoliation-syndrome
#19
Robert Ritch
Exfoliation syndrome is an age-related disease characterized by the production and progressive accumulation of a fibrillar extracellular material in many ocular tissues. It leads to the most common identifiable cause of open-angle glaucoma worldwide, comprising the majority of glaucoma in some countries. The material in the eye appears as white deposits on the anterior lens surface and/or pupillary border. During pupillary movement, the iris scrapes exfoliation material from the lens surface, while the material on the lens causes rupture of iris pigment epithelial cells, with concomitant pigment dispersion into the anterior chamber and its deposition on anterior chamber structures...
October 2014: Journal of Glaucoma
https://www.readbyqxmd.com/read/25188224/a-10-year-follow-up-to-determine-the-effect-of-yag-laser-iridotomy-on-the-natural-history-of-pigment-dispersion-syndrome-a-randomized-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
Stefano A Gandolfi, Nicola Ungaro, Maria Grazia Tardini, Stella Ghirardini, Arturo Carta, Paolo Mora
IMPORTANCE: Prospective long-term analyses of the role of drug-induced mydriasis and laser peripheral iridotomy (LPI) are needed to identify and manage the eyes of patients with pigment dispersion syndrome (PDS) at risk for progressing to ocular hypertension. OBJECTIVE: To assess the 10-year incidence of increased intraocular pressure (IOP) in the 2 eyes of patients with PDS, with 1 eye that underwent LPI and the other that did not. DESIGN, SETTING, AND PARTICIPANTS: In a randomized clinical trial in the glaucoma research unit at the University Hospital of Parma, Italy, 72 patients with PDS underwent phenylephrine testing...
December 2014: JAMA Ophthalmology
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