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https://www.readbyqxmd.com/read/29739459/sheng-jiang-san-a-traditional-multi-herb-formulation-exerts-anti-influenza-effects-in-vitro-and-in-vivo-via-neuraminidase-inhibition-and-immune-regulation
#1
Tianbo Zhang, Mengjie Xiao, Chun-Kwok Wong, Ka-Pun Chris Mok, Xin Zhao, Huihui Ti, Pang-Chui Shaw
BACKGROUND: Sheng Jiang San (SJS), a multi-herb formulation, is used in treating high fever, thirsty and anxiety in ancient China and it is sometimes used to treat seasonal influenza nowadays. However, there is no evidence-based investigation and mechanism research to support the anti-influenza efficacy of SJS. This study aims at evaluating the anti-influenza effect of SJS and investigating its possible mechanism. METHODS: The inhibitory effect of SJS against different influenza virus strains on MDCK cells was examined...
May 8, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29720836/identification-of-potential-anticancer-protein-targets-in-cytotoxicity-mediated-by-tropical-medicinal-fern-extracts
#2
Siok-Thing Tan, Hean-Chooi Ong, Tsun-Thai Chai, Fai-Chu Wong
Background: Medicinal fern species represent a potentially important source for both food and medicinal applications. Previously, two underutilized tropical fern species (Blechnum orientale and Phymatopteris triloba) were reported with cytotoxic activities against selected cancer cell lines. However, the exact mechanism remains elusive. Objective: In this paper, we reported the identification of six differentially expressed proteins isolated from cancer cells, following exposure to the cytotoxic fern extracts...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29697027/dna-related-enzymes-as-molecular-targets-for-antiviral-and-antitumoral-chemotherapy-a-natural-overview-of-the-current-perspectives
#3
Hugo A Garro, Carlos R Pungitore
BACKGROUND: The discovery of new chemotherapeutic agents still remains a continuous goal to achieve. DNA polymerases and topoisomerases act in nucleic acids metabolism modulating different processes like replication, mitosis, damage repair, DNA topology and transcription. It has been widely documented that Polymerases serve as molecular targets for antiviral and antitumoral chemotherapy. Furthermore, telomerase is a ribonucleoprotein with exacerbated activity in most of tumor cell lines, becoming as an emergent target in Cancer treatment...
April 25, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29667101/clinical-features-risk-factors-and-outcomes-of-patients-with-interstitial-pneumonia-with-autoimmune-features-a-population-based-study
#4
Jinghong Dai, Lei Wang, Xin Yan, Hui Li, Kefeng Zhou, Jian He, Fanqing Meng, Siyi Xu, Geyu Liang, Hourong Cai
To investigate the clinical features, risk factors and outcomes of patients with interstitial pneumonia with autoimmune features (IPAF). A total of 1429 patients with idiopathic interstitial pneumonia (IIP) and undifferentiated connective tissue disease-associated interstitial lung disease (UCTD-ILD) were screened to identify patients who met IPAF criteria. Clinical, serological, and morphological features of patients with IPAF were characterized. Outcomes between patients with IPAF, UCTD-ILD, and IIP who were divided into idiopathic pulmonary fibrosis (IPF) and non-IPF groups were compared using survival as an endpoint...
April 18, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29664983/longitudinal-quantification-of-retinal-nonperfusion-in-the-macula-of-eyes-with-retinal-vein-occlusion-receiving-anti-vegf-therapy-secondary-analysis-of-the-wave-randomized-trial
#5
William C Ou, Shaun I R Lampen, Charles C Wykoff
BACKGROUND AND OBJECTIVE: Longitudinal quantification of retinal nonperfusion (RNP) in eyes with retinal vein occlusion (RVO) undergoing anti-vascular endothelial growth factor therapy. PATIENTS AND METHODS: Thirty eyes with ischemic RVO were randomized to ranibizumab (Lucentis; Genentech, South San Francisco, CA) (monotherapy) or ranibizumab plus peripheral laser (combination therapy) in a 12-month, prospective trial. RNP on fluorescein angiography was quantified within the macula through 12 months of follow-up...
April 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29662624/arsenic-trioxide-mediated-suppression-of-mir-182-5p-is-associated-with-potent-anti-oxidant-effects-through-up-regulation-of-sesn2
#6
Liang-Ting Lin, Shin-Yi Liu, Jyh-Der Leu, Chun-Yuan Chang, Shih-Hwa Chiou, Te-Chang Lee, Yi-Jang Lee
Arsenic trioxide (ATO) is a traditional Chinese medicine that can induce oxidative stress for treatment of cancer cells. However, ATO may generate anti-oxidative responses to compromise the cytotoxic effect, but the underlying mechanisms remain unclear. Here we found that ATO could inhibit miR-182-5p expression in patient-derived primary S1 glioblastoma (GBM) cells accompanied by up-regulation of Sestrin-2 ( SESN2 ) mRNA, a known anti-oxidant molecule. This phenomenon was also detected in a U87MG glioma cell line, human lung adenocarcinoma H1299 cell line and A549 cell line...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29652643/expression-of-a-recombinant-nucleocapsid-protein-of-rift-valley-fever-virus-in-vero-cells-as-an-immunofluorescence-antigen-and-its-use-for-serosurveillance-in-traditional-cattle-herds-in-zambia
#7
Ngonda Saasa, Masahiro Kajihara, George Dautu, Akina Mori-Kajihara, Shuetsu Fukushi, Yona Sinkala, Shigeru Morikawa, Aaron Mweene, Ayato Takada, Kumiko Yoshimatsu, Jiro Arikawa
The open reading frame of the nucleocapsid protein (NP) of Rift Valley fever virus (RVFV) strain MP12 was cloned and expressed in Vero E6 cells. The recombinant NP (rNP)-expressing cells were used as antigens for an indirect immunofluorescent antibody assay (IFA). The rNP-based IFA and RVFV-infected Vero E6 cell (authentic antigen)-based IFA showed similar IFA profiles with immune rabbit serum, which was prepared by immunization with rNP expressed using a baculovirus vector. A total of 942 traditional cattle sera obtained in five districts in Central, Southern, and Western provinces of Zambia were screened for anti-RVFV antibodies by the authentic antigen-based and rNP-based IFAs...
March 13, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29645079/antinuclear-antibodies-in-patients-with-breast-cancer
#8
Renato Nisihara, Mariana C C Machoski, Aline Neppel, Carlos A Maestri, Iara Messias-Reason, Thelma L Skare
PURPOSE: To study the prevalence of ANA in breast cancer patients and its association with tumor characteristics. METHODS: Ninety one patients with breast mass detected by image studies and assigned to do diagnostic biopsy and eventual surgical treatment were studied for demographical, tumor data and presence of ANA. Serum of positive ANA patients was screened for ENA (extractable nuclear antigens) profile. As comparison, 91 healthy individuals matched for age and from same geographical area were included...
April 12, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29629666/clinical-significance-of-anti-ribosomal-p-protein-antibodies-in-patients-with-lupus-nephritis
#9
Sabahat Sarfaraz, Sabiha Anis, Ejaz Ahmed, Rana Muzaffar
BACKGROUND: Systemic lupus erythematosus (SLE) is achronic inflammatory disorder affecting multiplesystems of the body. Clinical features show wide variations in patients with different ethnic background. Renal involvement is a predictor of poor prognosis. Immunological workup is an integral part of SLE diagnostic criteria. Anti-ribosomal P Protein (anti-P) antibodies are highly specific for SLE. They may be present inantinuclear antibodies (ANA) negative SLE patients. Their role in lupus nephritis (LN) is under debate, some researchers found them associated with poor prognosiswhereasothers found favorable effect of these antibodies on renal disease...
April 9, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29617862/generation-of-tumor-antigen-specific-murine-cd8-t-cells-with-enhanced-anti-tumor-activity-via-highly-efficient-crispr-cas9-genome-editing
#10
Yasuo Ouchi, Ashwini Patil, Yusuke Tamura, Hiroshi Nishimasu, Aina Negishi, Sudip Kumar Paul, Naoki Takemura, Takeshi Satoh, Yasumasa Kimura, Makoto Kurachi, Osamu Nureki, Kenta Nakai, Hiroshi Kiyono, Satoshi Uematsu
Immunotherapies have led to the successful development of novel therapies for cancer. However, there is increasing concern regarding the adverse effects caused by non-tumor-specific immune responses. Here, we report an effective strategy to generate high-avidity tumor-antigen-specific CTLs, using Cas9/single-guide RNA (sgRNA) ribonucleoprotein (RNP) delivery. As a proof-of-principle demonstration, we selected the gp100 melanoma-associated tumor antigen, and cloned the gp100-specific high-avidity TCR from gp100-immunized mice...
April 3, 2018: International Immunology
https://www.readbyqxmd.com/read/29593104/commensal-orthologs-of-the-human-autoantigen-ro60-as-triggers-of-autoimmunity-in-lupus
#11
Teri M Greiling, Carina Dehner, Xinguo Chen, Kevin Hughes, Alonso J Iñiguez, Marco Boccitto, Daniel Zegarra Ruiz, Stephen C Renfroe, Silvio M Vieira, William E Ruff, Soyeong Sim, Christina Kriegel, Julia Glanternik, Xindi Chen, Michael Girardi, Patrick Degnan, Karen H Costenbader, Andrew L Goodman, Sandra L Wolin, Martin A Kriegel
The earliest autoantibodies in lupus are directed against the RNA binding autoantigen Ro60, but the triggers against this evolutionarily conserved antigen remain elusive. We identified Ro60 orthologs in a subset of human skin, oral, and gut commensal bacterial species and confirmed the presence of these orthologs in patients with lupus and healthy controls. Thus, we hypothesized that commensal Ro60 orthologs may trigger autoimmunity via cross-reactivity in genetically susceptible individuals. Sera from human anti-Ro60-positive lupus patients immunoprecipitated commensal Ro60 ribonucleoproteins...
March 28, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29579358/a-22-year-old-woman-with-systemic-lupus-erythematosus-presents-with-two-damaged-kidneys-one-seizure-no-platelets-and-many-possible-diagnoses
#12
Lisa Zickuhr, Leal C Herlitz, Soumya Chatterjee
A 22-year-old woman with a history of systemic lupus erythematosus (SLE) was admitted with progressive edema. Two years before hospitalization, a local rheumatologist diagnosed her with SLE based on a syndrome of oral ulcers, inflammatory arthritis, discoid lupus lesions, and Raynaud phenomenon. Serum analysis revealed high-titer anti-nuclear antibodies, the presence of anti-SSA, anti-SSB, anti-Smith, anti-RNP, anti-histone, and anti-double-stranded DNA antibodies, and low complement (C3 and C4) levels. Hydroxychloroquine and topical clobetasol ointment were started...
March 26, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29569858/an-autoimmune-basis-for-raynaud-s-phenomenon-murine-model-and-human-disease
#13
D P Ascherman, Y Zang, I Fernandez, E S Clark, W N Khan, L Martinez, E L Greidinger
OBJECTIVE: Raynaud's Phenomenon is common in rheumatic diseases with anti-ribonucleoprotein antibodies (RNP+), but is not itself known to be caused by autoimmunity. This study assessed for autoantibodies that could mediate this process. METHODS: Antibodies from patient sera and from murine models of anti-RNP autoimmunity were screened for the ability to induce Raynaud's-like tissue ischemia and endothelial apoptosis in murine models and in vitro systems. RESULTS: RNP+ human sera from Raynaud's patients and murine sera from RNP+ B cell adoptive transfer recipients induced Raynaud's-like tissue ischemia and endothelial apoptosis...
March 23, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29566965/predicting-eventual-development-of-lupus-nephritis-at-the-time-of-diagnosis-of-systemic-lupus-erythematosus
#14
Oh Chan Kwon, Jung Sun Lee, Byeongzu Ghang, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Seokchan Hong
OBJECTIVES: To investigate factors predictive of future lupus nephritis development when systemic lupus erythematosus (SLE) is diagnosed. METHODS: Patients with newly diagnosed SLE without renal manifestations were followed for development of lupus nephritis, comparing findings at baseline between those who did or did not develop nephritis. Albumin-to-globulin ratio (AGR) was calculated as albumin/(total protein-albumin). Cox proportional hazard model was used to identify predictors of lupus nephritis...
February 23, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29515069/-mixed-connective-tissue-disease-with-pulmonary-hypertension-developing-in-a-chronic-myeloid-leukemia-patient-on-dasatinib-treatment
#15
Shintaro Watanuki, Taku Kikuchi, Takaaki Toyama, Ryohei Abe, Hitomi Nakayama, Daiki Karigane, Takayuki Shimizu, Jun Kikuchi, Kotaro Matsumoto, Hidetaka Yasuoka, Masaharu Kataoka, Shinichiro Okamoto, Takehiko Mori
A 37-year-old woman was diagnosed with chronic phase chronic myeloid leukemia. Nilotinib treatment was initiated; however, it had to be discontinued due to an allergic reaction one month later, and dasatinib treatment was provided. Although favorable response was obtained, she started complaining of shortness of breath 7 months after initiating dasatinib treatment. Chest X-ray and echocardiography indicated pulmonary congestion and hypertension. Further, she was diagnosed with mixed connective tissue disease (MCTD) based on Raynaud phenomenon, swollen fingers, sclerodactyly, pancytopenia, hypocomplementemia, and positive anti-U1-RNP antibody...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29507032/following-leads-connecting-dysphagia-to-mixed-connective-tissue-disease
#16
Rita de Sousa Gameiro, Ana Isabel Alves Reis, Ana Cristina Grilo, Carla Noronha
Mixed connective tissue disease (MCDT) is a rare condition characterised by the presence of high titres of anti-U1 ribonucleoprotein antibodies and selected clinical features of systemic lupus erythematosus, systemic sclerosis and polymyositis/dermatomyositis. Early symptoms are non-specific, including easy fatigability, myalgia, arthralgia and Raynaud's phenomenon. Some reports emphasised the favourable outcome and excellent response to glucocorticoids, but there are contradictory studies reporting worse prognosis...
March 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29479391/massive-hemorrhagic-pericardial-effusion-with-cardiac-tamponade-as-initial-manifestation-of-mixed-connective-tissue-disease
#17
Ashraf Abugroun, Osama Hallak, Fatima Ahmed, Safwan Gaznabi
Mixed connective tissue disease (MCTD) is a distinct entity of connective tissue disorders characterized by overlapping clinical features of various autoimmune diseases along with the presence of antibodies to ribonucleoprotein (anti-RNP). The prevalence of cardiac involvement in MCTD varies from 13% to 65% and accounts for approximately 20% of MCTD related mortality. In this case, we describe an elderly female patient with multiple complaints without a clear etiology on presentation. Echocardiogram revealed severe rapidly accumulating pericardial effusion causing tamponade necessitating pericardial window...
February 2018: Cardiology Research
https://www.readbyqxmd.com/read/29469721/lupus-and-scleroderma-overlap-features-in-a-28-year-old-man-with-anti-pl-12-anti-synthetase-syndrome
#18
Jasmine Rana, Andrea Primiani Moy, Adriano Piris, Gideon P Smith
A 28-year-old man with clinically and laboratory diagnosed anti-PL-12 anti-synthetase syndrome (AS) in 2009 developed cutaneous lupus lesions, discoid lupus lesions, and sclerodacytly with finger-tip ulcerations four years following his AS diagnosis. Laboratory tests including +ANA, +anti-dsDNA antibody, +anti-Smith antibody, and +anti-RNP antibody in 2014 confirmed the diagnosis of progression to an overlap syndrome including systemic lupus erythematosus. The patient now also has clinical findings (sclerodacytly, Raynaud phenomenon, finger-tip ulcerations) consistent with scleroderma overlap...
September 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29460700/the-lupus-patient-with-positive-rheumatoid-factor
#19
A Fedrigo, T A F G Dos Santos, R Nisihara, T Skare
Background Patients with systemic lupus erythematosus (SLE) may form clusters with clinical manifestations and autoantibodies. Objective The objective of this report is to study whether SLE patients with positive rheumatoid factor (RF) have a special clinical and/or serological profile. Methods A retrospective study of 467 SLE patients seen at a single rheumatology unit was conducted. Epidemiological data (age, gender, age at disease onset, ethnic background and tobacco use), clinical data (malar rash, photosensitivity, oral ulcers, discoid lesions, serositis, glomerulonephritis, convulsions, psychosis, hemolytic anemia, leukopenia, lymphocytopenia, arthritis and hypothyroidism) and serological profile (anti-dsDNA, anti-Ro/SS-A, anti-La/SS-B, anti-RNP, anti-Sm, IgG aCL, IgM aCL, lupus anticoagulant, direct Coombs and RF) were collected...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29423919/ten-year-retrospective-clinicohistological-study-of-cutaneous-lupus-erythematosus-in-korea
#20
Eui Hyun Oh, Eun Jin Kim, Young Suck Ro, Joo Yeon Ko
An understanding of the differences in clinical manifestations and laboratory abnormalities between subtypes of cutaneous lupus erythematosus (CLE) is still lacking. The purpose of this study was to analyze demographic, clinical and histological features of CLE according to three main presentation subsets: acute (ACLE), subacute (SCLE) and chronic (CCLE). A 10-year retrospective analysis was performed on data from patients who were diagnosed with CLE between March 2005 and September 2015 in a Korean tertiary referral dermatology clinic...
April 2018: Journal of Dermatology
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