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https://www.readbyqxmd.com/read/27909917/strength-training-prior-to-muscle-injury-potentiates-low-level-laser-therapy-lllt-induced-muscle-regeneration
#1
Samuel Rodrigues Lourenço Morais, Alexandre Ginei Goya, Úrsula Urias, Paulo Roberto Jannig, Aline Villa Nova Bacurau, Wagner Garcez Mello, Paula Lazilha Faleiros, Sandra Helena Penha Oliveira, Valdir Gouveia Garcia, Edilson Ervolino, Patricia Chakur Brum, Rita Cássia Menegati Dornelles
We evaluated whether strength training (ST) performed prior to skeletal muscle cryolesion would act as a preconditioning, improving skeletal muscle regeneration and responsiveness to low-level laser therapy (LLLT). Wistar rats were randomly assigned into non-exercised (NE), NE plus muscle lesion (NE + LE), NE + LE plus LLLT (NE + LE + LLLT), strength training (ST), ST + LE, and ST + LE + LLLT. The animals performed 10 weeks of ST (climbing ladder; 3× week; 80% overload). Forty-eight hours after the last ST session, tibialis anterior (TA) cryolesion was induced and LLLT (InGaAlP, 660 nm, 0...
December 1, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27909671/endoscopic-resection-of-the-tibialis-anterior-tendon-bursa
#2
Tun Hing Lui
The tibialis anterior tendon bursa is located between the tibialis anterior tendon and the medial cuneiform bone and close to the tendon insertion. Bursitis can occur as a result of excessive local friction, infection, arthritides, or direct trauma. Endoscopic resection of the bursa is indicated in case of symptomatic bursitis that is not responding to conservative treatment or infection is suspected. It is contraindicated if there is skin infection at the portal sites. The purpose of this technical note is to describe a minimally invasive approach of endoscopic resection of the tibialis anterior tendon bursa through anterior tibial tendoscopy...
October 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27909227/castration-alters-protein-balance-following-high-frequency-muscle-contraction
#3
Jennifer L Steiner, David H Fukuda, Michael L Rossetti, Jay R Hoffman, Bradley S Gordon
Resistance exercise increases muscle mass by shifting protein balance in favor of protein accretion. Androgens independently alter protein balance, but it is unknown whether androgens alter this measure following resistance exercise. To answer this, male mice were subjected to sham or castration surgery 7-8 weeks prior to undergoing a bout of unilateral, high frequency, electrically induced muscle contractions in the fasted or refed state. Puromycin was injected 30 min prior to sacrifice to measure protein synthesis...
December 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27908630/non-linear-dose-response-of-aluminium-hydroxide-adjuvant-particles-selective-low-dose-neurotoxicity
#4
Guillemette Crépeaux, Housam Eidi, Marie-Odile David, Yasmine Baba-Amer, Eleni Tzavara, Bruno Giros, François-Jérôme Authier, Christopher Exley, Christopher A Shaw, Josette Cadusseau, Romain K Gherardi
Aluminium (Al) oxyhydroxide (Alhydrogel(®)), the main adjuvant licensed for human and animal vaccines, consists of primary nanoparticles that spontaneously agglomerate. Concerns about its safety emerged following recognition of its unexpectedly long-lasting biopersistence within immune cells in some individuals, and reports of chronic fatigue syndrome, cognitive dysfunction, myalgia, dysautonomia and autoimmune/inflammatory features temporally linked to multiple Al-containing vaccine administrations. Mouse experiments have documented its capture and slow transportation by monocyte-lineage cells from the injected muscle to lymphoid organs and eventually the brain...
November 28, 2016: Toxicology
https://www.readbyqxmd.com/read/27906090/muscle-specific-deletion-of-socs3-increases-the-early-inflammatory-response-but-does-not-affect-regeneration-after-myotoxic-injury
#5
Kristy Swiderski, Savant S Thakur, Timur Naim, Jennifer Trieu, Annabel Chee, David I Stapleton, René Koopman, Gordon S Lynch
BACKGROUND: Muscles of old animals are injured more easily and regenerate poorly, attributed in part to increased levels of circulating pro-inflammatory cytokines. The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling cascade is a key mediator of inflammatory cytokine action, and signaling via this pathway is increased in muscles with aging. As a negative regulator of JAK/STAT signaling, a key mediator of myogenic proliferation and differentiation, altered expression of suppressor of cytokine signaling (SOCS3) is likely to have important consequences for muscle regeneration...
October 24, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27905294/glucocorticoids-increase-skeletal-muscle-nf-%C3%AE%C2%BAb-inducing-kinase-nik-links-to-muscle-atrophy
#6
Christopher S Fry, Syed Z Nayeem, Edgar L Dillon, Partha S Sarkar, Batbayar Tumurbaatar, Randall J Urban, Traver J Wright, Melinda Sheffield-Moore, Ronald G Tilton, Sanjeev Choudhary
Glucocorticoids (GC) are a frontline therapy for numerous acute and chronic diseases because of their demonstrated efficacy at reducing systemic inflammation. An unintended side effect of GC therapy is the stimulation of skeletal muscle atrophy. Pathophysiological mechanisms responsible for GC-induced skeletal muscle atrophy have been extensively investigated, and the ability to treat patients with GC without unintended muscle atrophy has yet to be realized. We have reported that a single, standard-of-care dose of Methylprednisolone increases in vivo expression of NF-κB-inducing kinase (NIK), an important upstream regulatory kinase controlling NF-κB activation, along with other key muscle catabolic regulators such as Atrogin-1 and MuRF1 that induce skeletal muscle proteolysis...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27900541/tendon-transfer-to-unossified-bone-in-a-porcine-model-potential-implications-for-early-tibialis-anterior-tendon-transfers-in-children-with-clubfeet
#7
Matthew A Halanski, Sam Abrams, Rachel Lenhart, Ellen Leiferman, Teresa Kaiser, Emily Pierce, Rachel Rebekah Franklin, Dayton Opel, Kenneth J Noonan, Thomas D Crenshaw
PURPOSE: Tibialis anterior tendon transfers (TATT) are commonly performed in young children following Ponseti casting for clubfeet. The classic TATT involves advancing the tendon through a hole drilled in the ossified cuneiform. The aim of this study was to determine if tendons transferred through unossified bones have untoward effects on subsequent bone development. METHOD: Twenty-five piglets underwent one of five surgical procedures. An 18-gauge needle was then used to place a tunnel through the bony or cartilaginous portion of the calcaneus (through direct visualization) and isolated slips of the flexor digitorum superficialis (FDS) were placed through the tunnels, as determined by surgical procedure...
November 30, 2016: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/27893479/complex-training-the-effect-of-exercise-selection-and-training-status-on-post-activation-potentiation-in-rugby-league-players
#8
David J Scott, Massimiliano Ditroilo, Phil Marshall
This study compared the post-activation potentiation (PAP) response of the hex bar deadlift (HBD) and back squat (BS) exercises. The PAP response between different levels of athletes was also compared. Ten professional and ten amateur rugby league players performed two experimental sessions. Participants performed a countermovement jump (CMJ) before and 2, 4, 6, 8, 10, 12, 14 and 16 minutes after a conditioning activity (CA) that contained 1 set of 3 repetitions at 93% 1RM of either HBD or BS. A force platform determined peak power output (PPO), force at PPO, velocity at PPO and jump height of each CMJ...
November 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27884690/conditioned-pain-modulation-and-pressure-pain-sensitivity-in-the-adult-danish-general-population-the-danfund-study
#9
S Skovbjerg, T Jørgensen, L Arendt-Nielsen, J F Ebstrup, T Carstensen, T Graven-Nielsen
: Increased pressure pain sensitivity and impaired descending pain control have been associated with chronic pain, but knowledge on the variability in the adult general population is lacking. Pressure pain thresholds (PPTs) and descending pain control as assessed by conditioning pain modulation (CPM) were recorded in a randomly selected sample (n=2199, 53% females) of the Danish adult general population aged 18-70 years. PPTs were recorded over the tibialis anterior muscle and the upper trapezius muscle...
November 21, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27882331/ectopic-fat-deposition-on-insulin-sensitivity-correlation-of-hepatocellular-lipid-content-and-m-value
#10
Beverly S Hong, Ying Li, Shuiqing Lai, Juan Liu, Hongyu Guan, Weijian Ke, Xiaoying He, Yanbing Li
Purpose. This study aimed to explore the relationship among insulin sensitivity and ectopic fat depots in participants with different glucose status. Methods. Fifty-nine men and women were enrolled in this study: 29 with normal glucose tolerance (NGT), 17 with impaired glucose tolerance (IGT), and 13 with type 2 diabetes mellitus (T2DM). All participants underwent a hyperinsulinemic-euglycemic clamp to assess the insulin sensitivity index (M value) and magnetic resonance imaging to measure the hepatocellular lipid content (HCL), skeletal muscle fat content including intramyocellular lipid (IMCL) and extramyocellular lipid (EMCL) of tibialis anterior (ta), and soleus muscle (sol)...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27881584/tuberculosis-presenting-as-a-swollen-calf
#11
Deevia Kotecha, Mini Sardar, Mark David Latimer
We report the case of an 83-year-old man who presented with swelling of his left lower leg. Subsequent investigations revealed that the swelling was due to a Mycobacterium tuberculosis abscess in the tibialis anterior muscle.
November 23, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27876265/a-prospective-randomized-comparison-of-two-distinct-allogenic-tissue-constructs-for-anterior-cruciate-ligament-reconstruction
#12
Michael B Rose, Christopher Domes, Mehwish Farooqi, Dennis C Crawford
BACKGROUND: Conduct a prospective randomized study to compare clinical outcomes of anterior cruciate ligament (ACL) reconstruction using quadrupled hamstring tendon (HT) allograft or doubled tibialis anterior (TA) allograft. Limited level 1 data exist comparing outcomes of different soft tissue allograft constructs for ACL reconstruction. We hypothesized no difference would exist in the patient reported outcomes (PRO), arthrometric testing, or rate of re-rupture between the two constructs...
November 18, 2016: Knee
https://www.readbyqxmd.com/read/27874066/cl316-243-a-%C3%AE-3-adrenergic-receptor-agonist-induces-muscle-hypertrophy-and-increased-strength
#13
Daniela Puzzo, Roberto Raiteri, Clotilde Castaldo, Raffaele Capasso, Ester Pagano, Mariateresa Tedesco, Walter Gulisano, Lisaveta Drozd, Pellegrino Lippiello, Agostino Palmeri, Pietro Scotto, Maria Concetta Miniaci
Studies in vitro have demonstrated that β3-adrenergic receptors (β3-ARs) regulate protein metabolism in skeletal muscle by promoting protein synthesis and inhibiting protein degradation. In this study, we evaluated whether activation of β3-ARs by the selective agonist CL316,243 modifies the functional and structural properties of skeletal muscles of healthy mice. Daily injections of CL316,243 for 15 days resulted in a significant improvement in muscle force production, assessed by grip strength and weight tests, and an increased myofiber cross-sectional area, indicative of muscle hypertrophy...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27870893/activin-receptor-type-iib-inhibition-improves-muscle-phenotype-and-function-in-a-mouse-model-of-spinal-muscular-atrophy
#14
Min Liu, David W Hammers, Elisabeth R Barton, H Lee Sweeney
Spinal muscular atrophy (SMA) is a devastating neurodegenerative disorder that causes progressive muscle atrophy and weakness. Using adeno-associated virus-mediated gene transfer, we evaluated the potential to improve skeletal muscle weakness via systemic, postnatal inhibition of either myostatin or all signaling via the activin receptor type IIB (ActRIIB). After demonstrating elevated p-SMAD3 content and differential content of ActRIIB ligands, 4-week-old male C/C SMA model mice were treated intraperitoneally with 1x1012 genome copies of pseudotype 2/8 virus encoding a soluble form of the ActRIIB extracellular domain (sActRIIB) or protease-resistant myostatin propeptide (dnMstn) driven by a liver specific promoter...
2016: PloS One
https://www.readbyqxmd.com/read/27869621/ponseti-treatment-of-rigid-residual-deformity-in-congenital-clubfoot-after-walking-age
#15
Massimiliano Dragoni, Pasquale Farsetti, Giuseppe Vena, Diego Bellini, Pierluigi Maglione, Ernesto Ippolito
BACKGROUND: There is no established treatment for rigid residual deformity of congenital clubfoot (CCF) after walking age. Soft-tissue procedures, osseous procedures, and external fixation have been performed with unpredictable results. We applied the Ponseti method to patients with this condition in order to improve the outcomes of treatment. METHODS: We retrospectively reviewed the cases of 44 patients (68 feet) with congenital clubfoot whose mean age (and standard deviation) at treatment was 4...
October 19, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27868426/effects-of-regular-tai-chi-practice-and-jogging-on-neuromuscular-reaction-during-lateral-postural-control-in-older-people
#16
Shao-Jun Wang, Dong-Qing Xu, Jing-Xian Li
This study examined the effects of regular Tai Chi practice and jogging on the neuromuscular activity of the trunk, hip, and ankle joint muscles of older people during lateral postural perturbation. A total of 42 older people participated in the study and formed the Tai Chi, jogging, and sedentary control groups. Electromyography signals were collected from the peroneus longus, anterior tibialis, gluteus medius, and erector spinae during unpredictable mediolateral perturbation. The Tai Chi group exhibited significantly faster latencies of the tibialis anterior and erector spinae than the control group...
November 19, 2016: Research in Sports Medicine
https://www.readbyqxmd.com/read/27868064/shrimp-protein-hydrolysate-modulates-the-timing-of-proinflammatory-macrophages-in-bupivacaine-injured-skeletal-muscles-in-rats
#17
Junio Dort, Nadine Leblanc, Piotr Bryl, Marie-Gil Fortin, Marie-Elise Carbonneau, Charles Lavigne, Hélène Jacques
This study was designed to determine whether marine-derived proteins other than cod could have beneficial effects on inflammation following muscle injury. Macrophage and neutrophil densities were measured from bupivacaine-injured tibialis anterior muscle of rats fed isoenergetic diets containing either shrimp hydrolysate (Shr), casein hydrolysate (CaH), or whole casein (Ca). In this study, Shr reduced ED(1+)-macrophages at day 2 (p = 0.013), day 5 (p = 0.006), and day 14 after injury (p = 0.038) compared with Ca, indicating faster resolution of inflammation in Shr...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27867698/mapping-3d-fiber-orientation-in-tissue-using-dual-angle-optical-polarization-tractography
#18
Y Wang, M Ravanfar, K Zhang, D Duan, G Yao
Optical polarization tractography (OPT) has recently been applied to map fiber organization in the heart, skeletal muscle, and arterial vessel wall with high resolution. The fiber orientation measured in OPT represents the 2D projected fiber angle in a plane that is perpendicular to the incident light. We report here a dual-angle extension of the OPT technology to measure the actual 3D fiber orientation in tissue. This method was first verified by imaging the murine extensor digitorum muscle placed at various known orientations in space...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27863792/presence-of-latent-myofascial-trigger-points-and-determination-of-pressure-pain-thresholds-of-the-shoulder-girdle-in-healthy-children-and-young-adults-a-cross-sectional-study
#19
Luciane S Sacramento, Paula R Camargo, Aristides L Siqueira-Júnior, Jean P Ferreira, Tania F Salvini, Francisco Alburquerque-Sendín
OBJECTIVE: The primary objective of this study was to compare the number of myofascial trigger points (MTPs) and the pressure pain thresholds (PPTs) in the shoulder girdle, on the dominant and nondominant sides, between healthy children and adults. The secondary aim was to assess the correlations between the number of MTPs and the PPTs in these populations. METHODS: A cross-sectional study was performed. Thirty-five children (aged 9.1 ± 1.7 years) and 35 adults (aged 23...
November 15, 2016: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/27863284/landing-from-different-heights-biomechanical-and-neuromuscular-strategies-in-trained-gymnasts-and-untrained-prepubescent-girls
#20
Α Christoforidou, D A Patikas, E Bassa, I Paraschos, S Lazaridis, C Christoforidis, C Kotzamanidis
The purpose of this study was to examine the biomechanics of the lower limb, during landing in female prepubertal gymnasts and prepubertal untrained girls, aged 9-12years. Ten healthy participants were included in each group and performed five landings from 20, 40, and 60cm. Kinematics, ground reaction forces (GRF) and electromyogram (EMG) from the lateral gastrocnemius, tibialis anterior, and vastus lateralis are presented. Gymnasts had higher vertical GRF and shorter braking phase during landing. Compared to untrained girls, gymnasts exhibited for all examined drop heights more knee flexion before and at ground contact, but less knee flexion at maximum knee flexion position...
November 9, 2016: Journal of Electromyography and Kinesiology
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