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https://www.readbyqxmd.com/read/29164148/relative-and-absolute-interrater-reliabilities-of-a-hand-held-myotonometer-to-quantify-mechanical-muscle-properties-in-patients-with-acute-stroke-in-an-inpatient-ward
#1
Wai Leung Ambrose Lo, Jiang Li Zhao, Le Li, Yu Rong Mao, Dong Feng Huang
Introduction: The reliability of using MyotonPRO to quantify muscles mechanical properties in a ward setting for the acute stroke population remains unknown. Aims: To investigate the within-session relative and absolute interrater reliability of MyotonPRO. Methods: Mechanical properties of biceps brachii, brachioradialis, rectus femoris, and tibialis anterior were recorded at bedside. Participants were within 1 month of the first occurrence of stroke...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29157305/evaluation-of-the-effect-of-a-floxed-neo-cassette-within-the-dystroglycan-dag1-gene
#2
Francesca Sciandra, Bianca Maria Scicchitano, Giulia Signorino, Maria Giulia Bigotti, Barbara Tavazzi, Francesca Lombardi, Manuela Bozzi, Gigliola Sica, Bruno Giardina, Sandra Blaess, Andrea Brancaccio
OBJECTIVE: Dystroglycan (DG) is an adhesion complex formed by two subunits, α-DG and β-DG. In skeletal muscle, DG is part of the dystrophin-glycoprotein complex that is crucial for sarcolemma stability and it is involved in a plethora of muscular dystrophy phenotypes. Due to the important role played by DG in skeletal muscle stability as well as in a wide variety of other tissues including brain and the peripheral nervous system, it is essential to investigate its genetic assembly and transcriptional regulation...
November 21, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29156739/electroacupuncture-alleviates-neuromuscular-dysfunction-in-an-experimental-rat-model-of-immobilization
#3
Jun Yang, Su Min, Fei Xie, Jingyuan Chen, Xuechao Hao, Li Ren
Immobilization-related skeletal muscle atrophy is a major concern to patients in Intensive Care Units and it has a profound effect on the quality of life. However, the underlying molecular events for the therapeutic effect of electroacupuncture to treat muscle atrophy have not been fully elucidated. Here we developed an immobilization mouse model and tested the hypothesis that skeletal muscle weakness may be caused by the increased expression of γ and α7 nicotinic acetylcholine receptors (nAChRs) on muscle cell membranes, while electroacupuncture could decrease the expression of γ and α7 nicotinic acetylcholine receptors...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156320/localised-sampling-of-myoelectric-activity-may-provide-biased-estimates-of-cocontraction-for-gastrocnemius-though-not-for-soleus-and-tibialis-anterior-muscles
#4
Maria Vinti, Jean-Michel Gracies, Marco Gazzoni, Taian Vieira
Proper muscle activity quantification is highly relevant to monitor and treat spastic cocontraction. As activity may distribute unevenly within muscle volumes, particularly for pennate calf muscles, surface electromyograms (EMGs) detected by traditional bipolar montage may provide biased estimations of muscle activity. We compared cocontraction estimates obtained using bipolar vs grids of electrodes (high-density EMG, HD-EMG). EMGs were collected from medial gastrocnemius, soleus and tibialis anterior during isometric plantar and dorsi-flexion efforts at three levels (30%, 70% and 100% MVC), knee flexed and extended...
November 14, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29150952/ck-2127107-amplifies-skeletal-muscle-response-to-nerve-activation-in-humans
#5
Jinsy A Andrews, Timothy M Miller, Vipin Vijayakumar, Randall Stoltz, Joyce K James, Lisa Meng, Andrew A Wolff, Fady I Malik
INTRODUCTION: Three studies evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of CK-2127107 (CK-107), a next-generation fast skeletal muscle troponin activator (FSTA), in healthy subjects. We tested the hypothesis that CK-107 would amplify the force-frequency response of muscle in humans. METHODS: To assess the force-frequency response, subjects received single doses of CK-107 and placebo in a randomized, double-blind, 4-period, crossover study...
November 18, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29145773/forced-use-of-the-paretic-leg-induced-by-a-constraint-force-applied-to-the-nonparetic-leg-in-individuals-poststroke-during-walking
#6
Chao-Jung Hsu, Janis Kim, Elliot J Roth, William Z Rymer, Ming Wu
BACKGROUND: Individuals with stroke usually show reduced muscle activities of the paretic leg and asymmetrical gait pattern during walking. OBJECTIVE: To determine whether applying a resistance force to the nonparetic leg would enhance the muscle activities of the paretic leg and improve the symmetry of spatiotemporal gait parameters in individuals with poststroke hemiparesis. METHODS: Fifteen individuals with chronic poststroke hemiparesis participated in this study...
November 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29145167/contraction-response-to-muscle-percussion-a-reappraisal-of-the-mechanism-of-this-bedside-test
#7
Christoph Czarnetzki, André Truffert, Abdelhafid Mekideche, Antoine Poncet, Christopher Lysakowski, Martin R Tramèr, Michel R Magistris
OBJECTIVE: To study whether the contraction evoked by muscle percussion stems from the excitation of the muscle or of the nerve and to discuss the changes of this response in neuromuscular disorders. METHODS: In 30 neurologically healthy patients undergoing surgery (for ear, nose, or throat problems unrelated to the study) under general anesthesia with propofol and sufentanil we measured with an electrogoniometer the maximal dorsiflexion of the ankle evoked by reflex hammer percussion of the tibialis anterior muscle before and under neuromuscular junction blockade with rocuronium bromide...
October 28, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29144551/the-impact-of-volumetric-muscle-loss-injury-on-persistent-motoneuron-axotomy
#8
Benjamin T Corona, Kate E Flanagan, Christian M Brininger, Stephen M Goldman, Jarrod A Call, Sarah M Greising
INTRODUCTION: Volumetric muscle loss (VML) occurs following significant traumatic injury or surgical removal of skeletal muscle, resulting in non-recoverable loss of tissue and long-term dysfunction. Perhaps less recognized is that VML injuries inherently disrupt the neuromuscular unit, resulting in fiber denervation and presumptive motor unit rearrangement, expansion, and/or loss. To characterize neural dysfunction we quantified motoneuron axotomy, in efforts to understand how this relates to the temporal coordination of neuromuscular and morphological alterations due to injury...
November 16, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29134575/impact-of-intramuscular-administration-of-lipid-soluble-and-water-soluble-vehicles-into-regenerating-muscle-at-the-distinct-phases-of-skeletal-muscle-regeneration
#9
Ratchakrit Srikuea, Kanokwan Suhatcho
Interpretation on the effectiveness of potential substances to enhance skeletal muscle regeneration is difficult if an inappropriate vehicle is administered, since vehicle administration can directly enhance or suppress regenerative capacity. In the current study, intramuscular administration of lipid-soluble and water-soluble vehicles into regenerating muscle at the distinct phases of skeletal muscle regeneration (regenerative vs. remodeling) were investigated. Tested vehicles included lipid-soluble [olive oil, (0...
November 13, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29132482/effectiveness-of-functional-electrical-stimulation-fes-versus-conventional-electrical-stimulation-in-gait-rehabilitation-of-patients-with-stroke
#10
Freeha Sharif, Samina Ghulam, Arshad Nawaz Malik, Quratulain Saeed
OBJECTIVE: To compare the effectiveness of functional electrical stimulation (FES) versus conventional electrical stimulation in gait rehabilitation of patients with stroke for finding the most appropriate problem-oriented treatment for foot drop patients in a shorter time period. STUDY DESIGN: Randomized controlled trial. PLACE AND DURATION OF STUDY: Armed Forces Institute of Rehabilitation Medicine, Rawalpindi, from July to December 2016...
November 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29130633/the-mitochondrial-metabolic-reprogramming-agent-trimetazidine-as-an-exercise-mimetic-in-cachectic-c26-bearing-mice
#11
Francesca Molinari, Fabrizio Pin, Stefania Gorini, Sergio Chiandotto, Laura Pontecorvo, Fabio Penna, Emanuele Rizzuto, Simona Pisu, Antonio Musarò, Paola Costelli, Giuseppe Rosano, Elisabetta Ferraro
BACKGROUND: Cancer cachexia is characterized by muscle depletion and exercise intolerance caused by an imbalance between protein synthesis and degradation and by impaired myogenesis. Myofibre metabolic efficiency is crucial so as to assure optimal muscle function. Some drugs are able to reprogram cell metabolism and, in some cases, to enhance metabolic efficiency. Based on these premises, we chose to investigate the ability of the metabolic modulator trimetazidine (TMZ) to counteract skeletal muscle dysfunctions and wasting occurring in cancer cachexia...
November 11, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29128629/influence-of-emotional-stimuli-on-lower-limb-cutaneous-reflexes-during-human-gait
#12
Martin Zaback, Brian C Horslen, Taylor W Cleworth, Laurel Collings, Cécile Langlet, J Timothy Inglis, Mark G Carpenter
Previous research has shown that cutaneous reflexes are modulated when walking with a threat to stability. It is unclear if this reflex modulation is purely related to the context of the imposed threat or if emotional changes associated with the threat exert an independent influence on reflex excitability. This study investigated the influence of emotional stimuli on lower limb cutaneous reflexes during treadmill walking. Twenty-eight healthy young adults walked at a self-selected pace while viewing pictures that manipulated emotional arousal and valence (confirmed with electrodermal and self-report measures)...
November 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29122966/skeletal-muscle-function-during-the-progression-of-cancer-cachexia-in-the-male-apc-min-mouse
#13
Brandon N VanderVeen, Justin P Hardee, Dennis K Fix, James A Carson
While cancer-induced skeletal muscle wasting has been widely investigated, the drivers of cancer-induced muscle functional decrements are only beginning to be understood. Decreased muscle function impacts cancer patient quality of life and health status, and several potential therapeutics have failed in clinical trials due to a lack of functional improvement. Furthermore, systemic inflammation and intrinsic inflammatory signaling's role in the cachectic disruption of muscle function requires further investigation...
November 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29122192/physiological-consequences-of-using-an-upper-limb-exoskeleton-during-manual-handling-tasks
#14
Jean Theurel, Kevin Desbrosses, Terence Roux, Adriana Savescu
This study aimed to assess the physiological consequences of using an upper limb exoskeleton during manual handling task, as muscle activity, upper limb kinematics, postural balance and cardiac cost. Participants performed three tasks (load lifting (LIFT), carrying (WALK) and stacking-unstacking (STACK)) with (EXOS) and without (FREE) an exoskeleton. During LIFT and STACK, the activity of the deltoid anterior muscle was significantly lower for EXOS than for FREE. During LIFT, the activity of the triceps brachii (TB) and tibialis anterior muscles significantly increased for EXO...
February 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29121992/a-mouse-anti-myostatin-antibody-increases-muscle-mass-and-improves-muscle-strength-and-contractility-in-the-mdx-mouse-model-of-duchenne-muscular-dystrophy-and-its-humanized-equivalent-domagrozumab-pf-06252616-increases-muscle-volume-in-cynomolgus-monkeys
#15
Michael St Andre, Mark Johnson, Prashant N Bansal, Jeremy Wellen, Andrew Robertson, Alan Opsahl, Peter M Burch, Peter Bialek, Carl Morris, Jane Owens
BACKGROUND: The treatments currently approved for Duchenne muscular dystrophy (DMD), a progressive skeletal muscle wasting disease, address the needs of only a small proportion of patients resulting in an urgent need for therapies that benefit all patients regardless of the underlying mutation. Myostatin is a member of the transforming growth factor-β (TGF-β) family of ligands and is a negative regulator of skeletal muscle mass. Loss of myostatin has been shown to increase muscle mass and improve muscle function in both normal and dystrophic mice...
November 9, 2017: Skeletal Muscle
https://www.readbyqxmd.com/read/29121510/emg-normalization-method-based-on-grade-3-of-manual-muscle-testing-within-and-between-day-reliability-of-normalization-tasks-and-application-to-gait-analysis
#16
Anne Tabard-Fougère, Kevin Rose-Dulcina, Vincent Pittet, Romain Dayer, Nicolas Vuillerme, Stéphane Armand
Electromyography (EMG) is an important parameter in Clinical Gait Analysis (CGA), and is generally interpreted with timing of activation. EMG amplitude comparisons between individuals, muscles or days need normalization. There is no consensus on existing methods. The gold standard, maximum voluntary isometric contraction (MVIC), is not adapted to pathological populations because patients are often unable to perform an MVIC. The normalization method inspired by the isometric grade 3 of manual muscle testing (isoMMT3), which is the ability of a muscle to maintain a position against gravity, could be an interesting alternative...
November 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29121509/modifications-in-lower-leg-muscle-activation-when-walking-barefoot-or-in-minimalist-shoes-across-different-age-groups
#17
Simon Franklin, François-Xavier Li, Michael J Grey
Ageing is associated with a decline in muscle strength and impaired sensory mechanisms which contribute to an increased risk of falls. Walking barefooted has been suggested to promote increased muscle strength and improved proprioceptive sensibility through better activation of foot and ankle musculature. Minimalist footwear has been marketed as a method of reaping the suggested benefits of barefoot walking whilst still providing a protective surface. The aim of this study was to investigate if walking barefoot or in minimalist footwear provokes increased muscle activation compared to walking in conventional footwear...
October 28, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29119953/-the-influence-of-non-invasive-electrical-stimulation-of-the-spinal-cord-on-the-locomotor-function-of-patients-presenting-with-movement-disorders-of-central-genesis
#18
M V Balykin, R N Yakupov, V V Mashin, E Yu Kotova, Yu M Balykin, Yu P Gerasimenko
AIM: The objective of the present study was to evaluate the influence of non-invasive (transcutaneous) electrical spinal cord stimulation on the locomotor function of the patients suffering from movement disorders. PATIENTS AND METHODS: The study involved 10 patients of both sexes at the age from 32 to 70 years (including 40% of men and 60% of women) presenting with the compromised locomotor function of varying severity associated with the disturbances of cerebral blood circulation caused either by an injury to the brain and spinal cord or by stroke...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29110475/preslaughter-transport-effect-on-broiler-meat-quality-and-post-mortem-glycolysis-metabolism-of-muscles-with-different-fiber-types
#19
Xiaofei Wang, Jiaolong Li, Jiahui Cong, Xiangxing Chen, Xudong Zhu, Lin Zhang, Feng Gao, Guanghong Zhou
Preslaughter transport has been reported to decrease the quality of breast meat but not thigh meat of broilers. However, tissue-specific difference in glycogen metabolism between breast and thigh muscles of transported broilers has not been well studied. We thus investigated the differences in meat quality, adenosine phosphates, glycolysis, and bound key enzymes associated with glycolysis metabolism in skeletal muscles with different fiber types of preslaughter transported broilers during summer. Compared to a 0...
November 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29100184/does-a-not-so-recent-ankle-sprain-influence-interjoint-coordination-during-walking
#20
Philippe Dedieu, Rima Chamoun, Guilhaume Lacaud, Thibault Moulinat, Maxime Queron, Pier-Giorgio Zanone
BACKGROUND: Ankle sprains are common joint injuries in daily and sports activities, whose underlying mechanisms have been amply studied. If joint structures are directly damaged, neuromuscular activity can be affected, particularly in the time domain. This study aims to establish whether previous ankle injury correlates with changes in the inter-joint synergy of the entire lower limb and in the muscle activity pattern during walking. METHODS: Three-dimensional walking-gait analysis was conducted on twenty-four adults...
October 18, 2017: Clinical Biomechanics
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