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Silibinin

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https://www.readbyqxmd.com/read/28926892/-effect-and-mechanism-of-silibinin-on-the-inhibition-of-alk-positive-nsclc-cells-by-sensitizing-crizotinib
#1
C C Lin, C H Lu, Y H Pan, L Jiao, H Y Chen, L Li, Y He
Objective: To explore the synergistic effect of silibinin combined with crizotinib on anaplastic lymphoma kinase positive (ALK+ ) non-small cell lung cancer (NSCLC) cells and its mechanism. Methods: H2228 and H3122 cells were treated with silibinin, crizotinib alone or in combination. Cell proliferation was measured by 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay and colony formation assay. Migration or invasion ability was tested by wound healing assay or transwell assay, respectively...
September 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28925892/natural-active-compounds-from-plant-food-and-chinese-herbal-medicine-for-nonalcoholic-fatty-liver-disease
#2
Qian Liu, Lixin Zhu, Chen Cheng, Yiyang Hu, Qin Feng
Nonalcoholic fatty liver disease (NAFLD) has become more prevalent worldwide. It is often associated with some metabolic diseases, such as obesity, type 2 diabetes, and metabolic syndrome. With increasing focus on the treatment of fatty liver, much attention has been paid to numerous medicinal herbs and dietary substances to provide a new strategy for NAFLD treatment. The natural active compounds from the herbs or diet have been studied as promising treatments for NAFLD. This study aimed to summarize the use and mechanism of action of natural active compounds in the treatment of NAFLD in the recent 10 years...
September 18, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28885916/calcitriol-reverses-induced-expression-of-efflux-proteins-and-potentiates-cytotoxic-activity-of-gemcitabine-in-capan-2-pancreatic-cancer-cells
#3
Hamed Gilzad-Kohan, Shabnam Sani, Mehdi Boroujerdi
PURPOSE: Efflux and influx proteins play a major role in chemo-resistance by affecting the net cellular uptake of anti-cancer drugs. Hence, alteration of the efflux and influx protein expression may result in variations of chemotherapeutics uptake and consequently cell death rate. The present study investigated the effects of pre-treatment of capan-2 pancreatic cancer cells with calcitriol, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA) or silibinin on the induction of three major efflux proteins and the main gemcitabine influx protein...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28884602/enhancement-of-anticancer-activity-by-silibinin-and-paclitaxel-combination-on-the-ovarian-cancer
#4
Fatima Pashaei-Asl, Roghiyeh Pashaei-Asl, Khodadad Khodadadi, Abolfazl Akbarzadeh, Esmaeil Ebrahimie, Maryam Pashaiasl
BACKGROUND: Ovarian carcinoma is the most lethal cancer among all gynaecological malignancies. One of the most chemotherapy drugs used for ovarian cancer is paclitaxel which induces apoptosis. Paclitaxel has been used for many years. Similar to the most cancers this responds to chemotherapy initially but in a long run, drug resistance happens which fails the treatment procedure. Combination of chemotherapy drugs has been suggested to deal with this issue. Silibinin, a plant extraction, has been used from ancient time in traditional medicine and identified to have powerful antioxidant activity...
September 8, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28852940/antioxidative-and-anti-apoptotic-roles-of-silibinin-in-reversing-learning-and-memory-deficits-in-app-ps1-mice
#5
Dafeng Bai, Ge Jin, Shiliang Yin, Dan Zou, Qiwen Zhu, Zhihang Yang, Xuan Liu, Lizheng Ren, Yifeng Sun, Shiming Gan
Silibinin has been widely used to treat liver diseases due to its antioxidant activity. However, the effects of silibinin on the central nervous system have not been thoroughly investigated. The pathological hallmarks of Alzheimer's disease are the accumulation of amyloid β protein, development of neurofibrillary tangles and increased oxidative stress, which ultimately lead to irreversible neuronal loss and cognitive impairment. Our findings show that silibinin ameliorated memory impairments in APP/PS1 mice in the Morris water maze via suppression of oxidative stress and inhibition of apoptosis...
August 29, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28843263/adjuvant-therapy-with-silibinin-improves-the-efficacy-of-paclitaxel-and-cisplatin-in-mcf-7-breast-cancer-cells
#6
Hadi Chavoshi, Vahid Vahedian, Somaiyeh Saghaei, Mohammad Bagher Pirouzpanah, Mortaza Raeisi, Nasser Samadi
Herbal-derived medicines have introduced as sources of novel drugs due to minimum systemic side effects. Silibinin as a flavonoid compound has showed with effective chemotherapeutic effects on different cancers. Here, we investigated the impact of combination therapy of silibinin, with paclitaxel and cisplatin in inhibition of proliferation and induction of apoptosis in MCF-7 cells. Cell proliferation was assessed by MTT assay and the percentage of apoptotic cells was measured using flowcytometric assay. Understand of molecular mechanism of this combination related to apoptotic pathway were evaluated by Real Time RT-PCR assays...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28801864/isolation-and-characterization-of-iron-chelators-from-turmeric-curcuma-longa-selective-metal-binding-by-curcuminoids
#7
Donald J Messner, Christine Surrago, Celia Fiordalisi, Wing Yin Chung, Kris V Kowdley
Iron overload disorders may be treated by chelation therapy. This study describes a novel method for isolating iron chelators from complex mixtures including plant extracts. We demonstrate the one-step isolation of curcuminoids from turmeric, the medicinal food spice derived from Curcuma longa. The method uses iron-nitrilotriacetic acid (NTA)-agarose, to which curcumin binds rapidly, specifically, and reversibly. Curcumin, demethoxycurcumin, and bisdemethoxycurcumin each bound iron-NTA-agarose with comparable affinities and a stoichiometry near 1...
August 11, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28800072/phosphate-linked-silibinin-dimers-plsd-new-promising-modified-metabolites
#8
Valeria Romanucci, Raffaele Gravante, Martina Cimafonte, Cinzia Di Marino, Gilles Mailhot, Marcello Brigante, Armando Zarrelli, Giovanni Di Fabio
By exploiting the regioselective protection of the hydroxyl groups of silibinin along with the well-known phosphoramidite chemistry, we have developed an efficient strategy for the synthesis of new silibinin-modified species, which we have named Phosphate-Linked Silibinin Dimers (PLSd), in which the monomer units are linked by phosphodiester bonds. The antioxidant abilities of the new PLSd were estimated on HepG2 cells using DPPH free radical scavenging and xanthine/xanthine oxidase assays. The new phosphate-metabolites showed a higher anti-oxidant activity than the silibinin, as well as very low toxicity...
August 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28791405/silibinin-suppresses-bladder-cancer-cell-malignancy-and-chemoresistance-in-an-nf-%C3%AE%C2%BAb-signal-dependent-and-signal-independent-manner
#9
Yi Sun, Zhenfeng Guan, Wencai Zhao, Yazhuo Jiang, Qing Li, Yongyi Cheng, Yonggang Xu
Because bladder cancer (BCa) is the 9th most common malignant tumor and 13th leading cause of death due to cancer, therapeutic approaches have attracted a great deal of attention from both clinicians and BCa patients. Although the development of surgery and targeted drugs has brought new challenges for the traditional concept of BCa therapy, various types of chemotherapy remain the final treatment method for many BCa patients. However, chemoresistance inevitably appears, leading to the failure of chemotherapy...
August 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28735062/silibinin-ameliorates-anxiety-depression-like-behaviors-in-amyloid-%C3%AE-treated-rats-by-upregulating-bdnf-trkb-pathway-and-attenuating-autophagy-in-hippocampus
#10
Xiaoyu Song, Bo Liu, Lingyu Cui, Biao Zhou, Weiwei Liu, Fanxing Xu, Toshihiko Hayashi, Shunji Hattori, Yuko Ushiki-Kaku, Shin-Ichi Tashiro, Takashi Ikejima
Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Depression and anxiety are associated with increased risk of developing AD. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. In this study, the effect of silibinin on Aβ-induced anxiety/depression-like behaviors in rats was investigated. Silibinin significantly attenuated anxiety/depression-like behaviors caused by Aβ1-42-treatment as shown in tail suspension test (TST), elevated plus maze (EPM) and forced swimming tests (FST)...
July 19, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28732370/silibinin-an-old-drug-for-hematological-disorders
#11
REVIEW
Hai Zou, Xing-Xing Zhu, Guo-Bing Zhang, Yuan Ma, Yi Wu, Dong-Sheng Huang
Silibinin (silybin), a non-toxic natural polyphenolic flavonoid, is the principal and the most biologically active component of silymarin. It is efficient in the treatment of acute and chronic liver disorders caused by toxins, drug, alcohol, hepatitis, and gall bladder disorders. Further, in our previous studies, we explored the anti-cancer efficacy in common cancers, such as lung, prostatic, colon, breast, bladder, as well as, hepatocellular carcinoma. Interestingly, silibinin is still not solely limited to the treatment of these diseases...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28713159/co-delivery-of-docetaxel-and-silibinin-using-ph-sensitive-micelles-improves-therapy-of-metastatic-breast-cancer
#12
Xin-Yue Dong, Tian-Qun Lang, Qi Yin, Peng-Cheng Zhang, Ya-Ping Li
Breast cancer is the most vicious killer for women, and tumor metastasis is one of the leading causes of breast cancer therapy failure. In this study, a new pH-sensitive polymer (polyethylene glycol-block-poly[(1,4-butanediol)-diacrylate-β-N,N-diisopropylethylenediamine], BDP) was synthesized. Based on BDP, docetaxel/silibinin co-delivery micelles (DSMs) was constructed. DSM had a well-defined spherical shape under the transmission electron microscope with average hydrodynamic diameter of 85.3±0.4 nm, and were stable in the bloodstream but could dissociate to release the chemotherapeutic agents in the low pH environment of the endo/lysosomes in the tumor cells...
July 17, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28711017/alginate-gelatin-scaffolds-incorporated-with-silibinin-loaded-chitosan-nanoparticles-for-bone-formation-in-vitro
#13
R S Leena, M Vairamani, N Selvamurugan
Silibinin is a plant derived flavonolignan known for its multiple biological properties, but its role in the promotion of bone formation has not yet been well studied. Moreover, the delivery of Silibinin is hindered by its complex hydrophobic nature, which limits its bioavailability. Hence, in this study, we fabricated a drug delivery system using chitosan nanoparticles loaded with Silibinin at different concentrations (20μM, 50μM, and 100μM). They were then incorporated into scaffolds containing Alginate and Gelatin (Alg/Gel) for the sustained and prolonged release of Silibinin...
July 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28686955/targeting-stat3-with-silibinin-to-improve-cancer-therapeutics
#14
REVIEW
Joaquim Bosch-Barrera, Bernardo Queralt, Javier A Menendez
Signal transducer and activator of transcription 3 (STAT3) has a prominent role in mediating resistance to conventional chemo-/radio-therapies and modern targeted drugs. While a number of STAT3 inhibitors have been shown to enhance the efficacy of therapeutic agents in vitro, the majority of them have yet to enter clinical evaluation mostly because of lack of efficacy issues. Silibinin is the main component of the silymarin complex, a standardized extract obtained from the seeds of the milk thistle herb Silybum marianum...
July 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28657208/silibinin-stimluates-apoptosis-by-inducing-generation-of-ros-and-er-stress-in-human-choriocarcinoma-cells
#15
Jiyeon Ham, Whasun Lim, Fuller W Bazer, Gwonhwa Song
Silibinin is a flavonolignan extracted from seeds of milk thistles. Traditionally, it has been used as a therapeutic agent for liver disorders, and now it is well-known for its anti-cancer effects. However, studies on anti-cancer effects of silibinin on choriocarcinoma are very limited. Therefore, we performed proliferation and apoptosis assays to determine effects of silibinin on the viability of human choriocarcinoma (JAR and JEG3) cells. Our results showed that silibinin significantly inhibited proliferation and induced apoptosis in both JAR and JEG3 cells, and significantly increased reactive oxygen species (ROS) and lipid peroxidation...
June 28, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28648927/silibinin-capsules-improves-high-fat-diet-induced-nonalcoholic-fatty-liver-disease-in-hamsters-through-modifying-hepatic-de-novo-lipogenesis-and-fatty-acid-oxidation
#16
Chun-Xue Cui, Jing-Na Deng, Li Yan, Yu-Ying Liu, Jing-Yu Fan, Hong-Na Mu, Hao-Yu Sun, Ying-Hong Wang, Jing-Yan Han
ETHNOPHARMACOLOGICAL RELEVANCE: Silibinin Capsules (SC) is a silybin-phospholipid complex with silybin as the bioactive component. Silybin accounts for 50-70% of the seed extract of Silybum marianum (L.) Gaertn.. As a traditional medicine, silybin has been used for treatment of liver diseases and is known to provide a wide range of hepatoprotective effects. AIM OF THE STUDY: High fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) is a worldwide health problem...
June 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28643437/silibinin-affects-the-pharmacokinetics-of-methadone-in-rats
#17
Pei-Pei Pan, Jun Wang, Jun Luo, Shuang-Hu Wang, Yun-Fang Zhou, Sai-Zhen Chen, Zhou Du
The aim of the present study was to investigate the pharmacokinetic effect of silibinin on methadone in rats. 24 male Sprague-Dawley rats were randomly divided into 4 groups: control group, single dose of 100 mg/kg group, multiple doses of 100 mg/kg group and multiple doses of 30 mg/kg group. A single dose of 6 mg/kg methadone was administrated to rats orally without or with silibinin. Plasma samples were collected via tail vein at different time points and concentrations of methadone and its metabolite, EDDP, were determined by UPLC-MS/MS...
June 22, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28636236/assessment-of-silibinin-as-a-potential-antifungal-agent-and-investigation-of-its-mechanism-of-action
#18
Dae Gyu Yun, Dong Gun Lee
Silibinin, which is derived from Silybum marianum (milk thistle), has used as a traditional remedy for liver or biliary disorders and known to have superior antioxidant activity. In addition, silibinin was recently reported to have antifungal effect related to fungal apoptosis against Candida albicans and the interest in the therapeutic effect is increasing. In this study, we found another mode of antifungal action of silibinin and its antibiofilm activity on C. albicans. To investigate influence on fungal plasma membrane, propidium iodide and bis-(1, 3-dibutylbarbituric acid) trimethineoxonol [DiBAC4 (3)] assay were primarily carried out...
June 21, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28619387/evaluation-of-ameliorative-ability-of-silibinin-against-zidovudine-and-isoniazid-induced-hepatotoxicity-and-hyperlipidaemia-in-rats-role-of-silibinin-in-phase-i-and-ii-drug-metabolism
#19
Raghu Ramanathan, Karthikeyan Sivanesan
HIV/AIDS patients have suppressed immune system, making them vulnerable to many opportunistic infections including tuberculosis (TB). The patients who are co-infected with TB undergo combined regimens with anti-retroviral drugs such as zidovudine (AZT) and anti-tubercular drug such as isoniazid (INH) for therapy leading to hepatotoxicty. Silibinin (SBN), extracted from Silybum marianum commonly called as "Milk thistle" is used against several drugs-induced hepatotoxicity. The present study evaluates the ameliorative effect of SBN against AZT alone, INH alone, and INH + AZT-induced toxic insults to liver of rats...
June 13, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28610415/synergistic-anticancer-effects-of-silibinin-and-chrysin-in-t47d-breast-cancer-cells
#20
Zahra Javan Maasomi, Younes Pilehvar Soltanahmadi, Mehdi Dadashpour, Shahriar Alipour, Somayeh Abolhasani, Nosratollah Zarghami
Objective: Breast cancer is one of the most significant causes of female cancer death worldwide. Although several chemotherapeutics have been developed to treat this type of cancer, issues remain such as low survival rates and high reoccurrence after chemotherapy and radiotherapy. To explore a chemopreventive approach to enhancing breast cancer treatment efficacy, the antiproliferative effects of a combination of chrysin and silibinin, two herbal substances, in T47D breast cancer cells were assessed. Materials and Methods: Cytotoxicity of the agents singly and in combination was evaluated by MTT assay...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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