keyword
https://read.qxmd.com/read/38444031/toxicities-intensive-care-management-and-outcome-of-chimeric-antigen-receptor-t-cells-in-adults-an-update
#21
REVIEW
Mathieu Bellal, Jolan Malherbe, Gandhi Damaj, Damien Du Cheyron
BACKGROUND: Chimeric antigen receptor T cells are a promising new immunotherapy for haematological malignancies. Six CAR-T cells products are currently available for adult patients with refractory or relapsed high-grade B cell malignancies, but they are associated with severe life-threatening toxicities and side effects that may require admission to ICU. OBJECTIVE: The aim of this short pragmatic review is to synthesize for intensivists the knowledge on CAR-T cell therapy with emphasis on CAR-T cell-induced toxicities and ICU management of complications according to international recommendations, outcomes and future issues...
March 5, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38443969/application-status-and-optimization-suggestions-of-tumor-organoids-and-car-t-cell-co-culture-models
#22
REVIEW
Rong-Xuan Ning, Cun-Yu Liu, Shi-Qi Wang, Wen-Kai Li, Xia Kong, Zhi-Wei He
Tumor organoids, especially patient-derived organoids (PDOs) exhibit marked similarities in histopathological morphology, genomic alterations, and specific marker expression profiles to those of primary tumour tissues. They are applied in various fields including drug screening, gene editing, and identification of oncogenes. However, CAR-T therapy in the treatment of solid tumours is still at an exploratory stage. Tumour organoids offer unique advantages over other preclinical models commonly used for CAR-T therapy research, which the preservation of the biological characteristics of primary tumour tissue is critical for the study of early-stage solid tumour CAR-T therapies...
March 5, 2024: Cancer Cell International
https://read.qxmd.com/read/38442561/green-infant-formula-analysis-optimizing-headspace-solid-phase-microextraction-of-carbonyl-compounds-associated-with-lipid-peroxidation-using-gc-ms-and-pentafluorophenylhydrazine-derivatization
#23
JOURNAL ARTICLE
Jorge A Custodio-Mendoza, Ana Lopez Blanco, Ana M Ares-Fuentes, Antonia M Carro Díaz
The refinement and optimization of a method combining headspace solid-phase microextraction (HS-SPME) with gas chromatography-mass spectrometry (GC-MS) was successfully performed for the first time to determine seven carbonyl and dicarbonyl compounds, including glyoxal, methylglyoxal, dimethylglyoxal, and malondialdehyde in infant formulae, related to lipid peroxidation. HS-SPME was utilized for simultaneous extraction and derivatization with pentafluorophenylhydrazine (PFPH). Critical parameters such as temperature, pH, extractive phase, and salting-out were meticulously investigated and fine-tuned by an asymmetrical 22 32 //9 screening design to ensure the method's efficacy and reliability...
March 1, 2024: Talanta
https://read.qxmd.com/read/38439865/the-parking-dilemma-for-solar-powered-vehicles
#24
JOURNAL ARTICLE
Guilherme Gaspar, Ivo Costa, Miguel Centeno Brito
Parking a solar electric car in the sunshine will help charge its battery, increasing its driving range. On the other hand, it will also raise its indoor temperature, leading to the need to switch on the air conditioning to make it comfortable when driving, increasing the driving load and reducing the vehicle range. Thus, one may wonder if the solar-extended range is somehow reduced or even eliminated by the increasing demand due to air conditioning. To address this "parking dilemma", we have characterized the thermal properties of a passenger car for typical summer conditions in a moderate latitude temperate location (Lisbon, Portugal) to be able to explore the vehicle's thermal performance when parked in the sun...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38437908/immune-therapies-of-b-cell-acute-lymphoblastic-leukaemia-in-children-and-adults
#25
REVIEW
David Kegyes, Gabriel Ghiaur, Anamaria Bancos, Ciprian Tomuleasa, Robert Peter Gale
B-cell acute lymphoblastic leukaemia (B-cell ALL) is a common haematologic cancer in children and adults. About 10 percent of children and 50 percent of adults fail to achieve a histological complete remission or subsequently relapse despite current anti-leukaemia drug therapies and/or haematopoietic cell transplants. Several new immune therapies including monoclonal antibodies and chimeric antigen receptor (CAR)-T-cells are proved safe and effective in this setting. We review data on US Food and Drug Administration (FDA)-approved immune therapies for B-cell ALL in children and adults including blinatumomab, inotuzumab ozogamicin, tisagenlecleucel, and brexucabtagene autoleucel...
March 2, 2024: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/38434676/mechanical-forces-amplify-tcr-mechanotransduction-in-t-cell-activation-and-function
#26
REVIEW
Nicholas Jeffreys, Joshua M Brockman, Yunhao Zhai, Donald E Ingber, David J Mooney
Adoptive T cell immunotherapies, including engineered T cell receptor (eTCR) and chimeric antigen receptor (CAR) T cell immunotherapies, have shown efficacy in treating a subset of hematologic malignancies, exhibit promise in solid tumors, and have many other potential applications, such as in fibrosis, autoimmunity, and regenerative medicine. While immunoengineering has focused on designing biomaterials to present biochemical cues to manipulate T cells ex vivo and in vivo , mechanical cues that regulate their biology have been largely underappreciated...
March 2024: Applied Physics Reviews
https://read.qxmd.com/read/38433827/artificial-targets-a-versatile-cell-free-platform-to-characterize-car-t-cell-function%C3%A2-in-vitro
#27
JOURNAL ARTICLE
Xueting Wang, Nicholas J A Tokarew, Nadine Borgelt, Ramona Siemer, Cristiane Casonato Melo, Christian Langer, Ioannis Kasampalidis, Isabella E Y Ogusuku, Toni Cathomen, Isabel Gessner, Christian Dose, Jonathan A Fauerbach, Anne Richter, César Evaristo
Cancer immunotherapies using chimeric antigen receptor (CAR) T cells have tremendous potential and proven clinical efficacy against a number of malignancies. Research and development are emerging to deepen the knowledge of CAR T cell efficacy and extend the therapeutic potential of this novel therapy. To this end, functional characterization of CAR T cells plays a central role in consecutive phases across fundamental research and therapeutic development, with increasing needs for standardization. The functional characterization of CAR T cells is typically achieved by assessing critical effector functions, following co-culture with cell lines expressing the target antigen...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38430779/microbial-profile-of-broiler-carcasses-processed-at-a-university-scale-mobile-poultry-processing-unit
#28
JOURNAL ARTICLE
Rebecca Stearns, Kristina Bowen, Robert L Taylor, Joe Moritz, Kristen Matak, Janet Tou, Annette Freshour, Jacek Jaczynski, Timothy Boltz, Xiang Li, Carly Long, Cangliang Shen
Chicken and chicken products have been associated with foodborne pathogens such as Salmonella, Campylobacter, and Escherichia coli (E. coli). Poultry comprises an important segment of the agricultural economy (75 million birds processed as of 2019) in West Virginia (WV). The risk of pathogens on processed chickens has risen with the increased popularity of mobile poultry processing units (MPPUs). This study evaluated the microbial safety of broilers processed in a MPPU in WV. This study assessed aerobic plate counts (APCs), E...
February 20, 2024: Poultry Science
https://read.qxmd.com/read/38428702/targeted-immunotherapy-to-cancer-stem-cells-a-novel-strategy-of-anticancer-immunotherapy
#29
REVIEW
Shan-Yong Yi, Mei-Zhuo Wei, Ling Zhao
Cancer is a major disease that endangers human health. Cancer drug resistance and relapse are the two main causes contributing to cancer treatment failure. Cancer stem cells (CSCs) are a small fraction of tumor cells that are responsible for tumorigenesis, metastasis, relapse, and resistance to conventional anticancer therapies. Therefore, CSCs are considered to be the root of cancer recurrence, metastasis, and drug resistance. Novel anticancer strategies need to face this new challenge and explore their efficacy against CSCs...
February 28, 2024: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/38421714/role-of-natural-killer-t-nkt-cells-in-myeloma-biology-and-therapy
#30
JOURNAL ARTICLE
Madhav V Dhodapkar
Natural Killer T (NKT) cells are distinct innate lymphocytes that recognize lipid antigens in the context of nonpolymorphic molecule CD1d. Multiple myeloma (MM) is a hematologic malignancy wherein malignant plasma cells express CD1d and are sensitive to lysis by NKT cells. Progressive malignancy in MM is characterized by NKT cell dysfunction. Several studies have tried to harness the anti-tumor properties of NKT cells in MM to mediate tumor regression. NKT cells are also attractive targets for approaches at immune redirection in MM with chimeric-antigen receptor NKT (CAR-NKT) and bispecific antibodies...
2024: Critical Reviews in Oncogenesis
https://read.qxmd.com/read/38417916/car-mediated-targeting-of-nk-cells-overcomes-tumor-immune-escape-caused-by-icam-1-downregulation
#31
JOURNAL ARTICLE
Jiri Eitler, Wiebke Rackwitz, Natalie Wotschel, Venugopal Gudipati, Nivedha Murali Shankar, Anastasia Sidorenkova, Johannes B Huppa, Paola Ortiz-Montero, Corinna Opitz, Stephan R Künzel, Susanne Michen, Achim Temme, Liliana Rodrigues Loureiro, Anja Feldmann, Michael Bachmann, Laurent Boissel, Hans Klingemann, Winfried S Wels, Torsten Tonn
BACKGROUND: The antitumor activity of natural killer (NK) cells can be enhanced by specific targeting with therapeutic antibodies that trigger antibody-dependent cell-mediated cytotoxicity (ADCC) or by genetic engineering to express chimeric antigen receptors (CARs). Despite antibody or CAR targeting, some tumors remain resistant towards NK cell attack. While the importance of ICAM-1/LFA-1 interaction for natural cytotoxicity of NK cells is known, its impact on ADCC induced by the ErbB2 (HER2)-specific antibody trastuzumab and ErbB2-CAR-mediated NK cell cytotoxicity against breast cancer cells has not been investigated...
February 27, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38414659/kibble-diet-is-associated-with-higher-faecal-glucocorticoid-metabolite-concentrations-in-zoo-managed-red-wolves-canis-rufus
#32
JOURNAL ARTICLE
Morgan Bragg, Carly R Muletz-Wolz, Nucharin Songsasen, Elizabeth W Freeman
The red wolf ( Canis rufus ) is a critically endangered canid that exists solely because of the establishment of the ex situ population in the late 1980s. Yet, the population under human care suffers from gastrointestinal (GI) disease in captivity. While the cause of GI disease is unknown, it is speculated that environmental factors can influence GI health of zoo-managed red wolves. The goal of the present study was to investigate the relationship between faecal glucocorticoid metabolite (FGM) concentrations, a biomarker for stress, and environmental factors for zoo-managed red wolves...
2024: Conservation Physiology
https://read.qxmd.com/read/38414005/decoding-of-the-surfaceome-and-endocytome-in-primary-glioblastoma-cells-identifies-potential-target-antigens-in-the-hypoxic-tumor-niche
#33
JOURNAL ARTICLE
Kelin Gonçalves de Oliveira, Anna Bång-Rudenstam, Sarah Beyer, Axel Boukredine, Hugo Talbot, Valeria Governa, Maria C Johansson, Ann-Sofie Månsson, Karin Forsberg-Nilsson, Johan Bengzon, Johan Malmström, Charlotte Welinder, Mattias Belting
Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. Here, we decode the surfaceome and endocytome and its remodeling by hypoxic stress in glioblastoma (GBM), the most common and aggressive brain tumor in adults. We employed a comprehensive approach for global and dynamic profiling of the surfaceome and endocytosed (endocytome) proteins and their regulation by hypoxia in patient-derived GBM cultures...
February 27, 2024: Acta Neuropathologica Communications
https://read.qxmd.com/read/38412023/attrition-in-conversational-agent-delivered-mental-health-interventions-systematic-review-and-meta-analysis
#34
REVIEW
Ahmad Ishqi Jabir, Xiaowen Lin, Laura Martinengo, Gemma Sharp, Yin-Leng Theng, Lorainne Tudor Car
BACKGROUND: Conversational agents (CAs) or chatbots are computer programs that mimic human conversation. They have the potential to improve access to mental health interventions through automated, scalable, and personalized delivery of psychotherapeutic content. However, digital health interventions, including those delivered by CAs, often have high attrition rates. Identifying the factors associated with attrition is critical to improving future clinical trials. OBJECTIVE: This review aims to estimate the overall and differential rates of attrition in CA-delivered mental health interventions (CA interventions), evaluate the impact of study design and intervention-related aspects on attrition, and describe study design features aimed at reducing or mitigating study attrition...
February 27, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38408246/enhancing-chimeric-antigen-receptor-t-cell-therapy-by-modulating-the-p53-signaling-network-with-%C3%AE-133p53%C3%AE
#35
JOURNAL ARTICLE
Christopher Roselle, Izumi Horikawa, Linhui Chen, Andre R Kelly, Donna Gonzales, Tong Da, Nils Wellhausen, Philipp C Rommel, Daniel Baker, Megan Suhoski, John Scholler, Roddy S O'Connor, Regina M Young, Curtis C Harris, Carl H June
Chimeric antigen receptor (CAR) T cell dysfunction is a major barrier to achieving lasting remission in hematologic cancers, especially in chronic lymphocytic leukemia (CLL). We have shown previously that Δ133p53α, an endogenous isoform of the human TP53 gene, decreases in expression with age in human T cells, and that reconstitution of Δ133p53α in poorly functional T cells can rescue proliferation [A. M. Mondal et al. , J. Clin. Invest. 123 , 5247-5257 (2013)]. Although Δ133p53α lacks a transactivation domain, it can form heterooligomers with full-length p53 and modulate the p53-mediated stress response [I...
March 5, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38405774/increased-pediatric-rsv-case-counts-following-the-emergence-of-sars-cov-2-are-attributable-to-increased-testing
#36
Brittany A Petros, Carly E Milliren, Pardis C Sabeti, Al Ozonoff
BACKGROUND: The incidence of respiratory syncytial virus (RSV) dropped markedly early in the COVID-19 pandemic, followed by a resurgence with heightened case counts. The "immunity debt" hypothesis proposes that the RSV-naive pediatric population increased during the period of low transmission, resulting in a subsequent increased risk of infection. However, the evidence supporting this hypothesis is limited, and no studies have comprehensively evaluated the role of changing respiratory viral testing practices in the perceived surge...
February 12, 2024: medRxiv
https://read.qxmd.com/read/38405292/cultural-responsiveness-in-behavior-analysis-provider-and-recipient-perceptions-in-ontario
#37
JOURNAL ARTICLE
Paige O'Neill, Carly Magnacca, Karl F Gunnarsson, Nazurah Khokhar, Julie Koudys, Albert Malkin
UNLABELLED: Cultural responsiveness is critical to providing high-quality behavior analytic services, particularly when providers and recipients have different cultural backgrounds. The purpose of this study was to systematically replicate and extend (Beaulieu et al. (2019) Behavior Analysis in Practice, 12(3), 557-575) by investigating the diversity among applied behavior analysis (ABA) service providers and service recipients in Ontario, service providers' training and experiences in working with diverse families, and service providers' and recipients' perceptions of behavior analysts' cultural responsiveness in practice...
March 2024: Behavior Analysis in Practice
https://read.qxmd.com/read/38404574/car-nk-cells-for-cancer-immunotherapy-recent-advances-and-future-directions
#38
REVIEW
Tianye Li, Mengke Niu, Weijiang Zhang, Shuang Qin, Jianwei Zhou, Ming Yi
Natural Killer (NK) cells, intrinsic to the innate immune system, are pivotal in combating cancer due to their independent cytotoxic capabilities in antitumor immune response. Unlike predominant treatments that target T cell immunity, the limited success of T cell immunotherapy emphasizes the urgency for innovative approaches, with a spotlight on harnessing the potential of NK cells. Despite tumors adapting mechanisms to evade NK cell-induced cytotoxicity, there is optimism surrounding Chimeric Antigen Receptor (CAR) NK cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38403501/the-crossroads-of-cancer-therapies-and-clonal-hematopoiesis
#39
JOURNAL ARTICLE
Abhay Singh, Suresh Balasubramanian
The intricate interplay between Clonal Hematopoiesis (CH) and the repercussions of cancer therapies has garnered significant research focus in recent years. Previously perceived as an age-related phenomenon, CH is now closely linked to inflammation ("Inflammaging") and cancer, impacting leukemogenesis, cancer progression, and treatment responses. This review explores the complex interplay between CH and diverse cancer therapies, including chemotherapy, targeted treatments, radiation, stem cell transplants, CAR-T cell therapy, and immunotherapy, like immune checkpoint inhibitors...
January 18, 2024: Seminars in Hematology
https://read.qxmd.com/read/38400240/a-novel-framework-for-image-matching-and-stitching-for-moving-car-inspection-under-illumination-challenges
#40
JOURNAL ARTICLE
Andreas El Saer, Lazaros Grammatikopoulos, Giorgos Sfikas, George Karras, Elli Petsa
Vehicle exterior inspection is a critical operation for identifying defects and ensuring the overall safety and integrity of vehicles. Visual-based inspection of moving objects, such as vehicles within dynamic environments abounding with reflections, presents significant challenges, especially when time and accuracy are of paramount importance. Conventional exterior inspections of vehicles require substantial labor, which is both costly and prone to errors. Recent advancements in deep learning have reduced labor work by enabling the use of segmentation algorithms for defect detection and description based on simple RGB camera acquisitions...
February 7, 2024: Sensors
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