Christopher Roselle, Izumi Horikawa, Linhui Chen, Andre R Kelly, Donna Gonzales, Tong Da, Nils Wellhausen, Philipp C Rommel, Daniel Baker, Megan Suhoski, John Scholler, Roddy S O'Connor, Regina M Young, Curtis C Harris, Carl H June
Chimeric antigen receptor (CAR) T cell dysfunction is a major barrier to achieving lasting remission in hematologic cancers, especially in chronic lymphocytic leukemia (CLL). We have shown previously that Δ133p53α, an endogenous isoform of the human TP53 gene, decreases in expression with age in human T cells, and that reconstitution of Δ133p53α in poorly functional T cells can rescue proliferation [A. M. Mondal et al. , J. Clin. Invest. 123 , 5247-5257 (2013)]. Although Δ133p53α lacks a transactivation domain, it can form heterooligomers with full-length p53 and modulate the p53-mediated stress response [I...
March 5, 2024: Proceedings of the National Academy of Sciences of the United States of America