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https://www.readbyqxmd.com/read/28327843/-geographic-information-systems
#1
Akram Hernández-Vásquez, Diego Azañedo, Guido Bendezú-Quispe, Josmel Pacheco-Mendoza, R Martín Chaparro
The aim of this study was to geospatially explore the occurrence rates of car accidents involving pedestrians in Cercado de Lima (Lima District), Peru. Car accidents involving pedestrians recorded in the 2015 National Police Station Census of the National Statistics and Information Institute were described and georeferenced. Subsequently, a Kernel Density analysis was carried out to locate areas with high, medium, and low density events. Records of 171 car accidents involving pedestrians were studied: the types of vehicles involved were automobiles (56...
October 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28297966/traffic-model-with-an-absorbing-state-phase-transition
#2
M L L Iannini, Ronald Dickman
We consider a modified Nagel-Schreckenberg (NS) model in which drivers do not decelerate if their speed is smaller than the headway (number of empty sites to the car ahead). (In the original NS model, such a reduction in speed occurs with probability p, independent of the headway, as long as the current speed is greater than zero.) In the modified model the free-flow state (with all vehicles traveling at the maximum speed, v_{max}) is absorbing for densities ρ smaller than a critical value ρ_{c}=1/(v_{max}+2)...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28285708/acquisition-and-analysis-of-road-incidents-based-on-vehicle-dynamics
#3
Claire Naude, Thierry Serre, Maxime Dubois-Lounis, Jean-Yves Fournier, Daniel Lechner, Michèle Guilbot, Vincent Ledoux
Because motor vehicle crashes have decreased during the last decade in many countries in the world and are more diffuse, local authorities have difficulties to define road safety policies. An experiment with 51 cars of public fleets equipped with a specific Event Data Recorder was carried out in France during one year. The purposes of this research were to evaluate if incident data (critical driving situations) help to understand crashes, and to explore a new way for road infrastructure safety diagnosis. The analysis of 339 genuine incidents and 1237 simple events recorded illustrates the potentiality of such an experiment and provides: some insights about conditions in which incidents occur, a general overview of their distribution according to different road layouts, as well as information on the different levels of accelerations reached...
March 9, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28265001/phosphorylated-nuclear-receptor-car-forms-a-homodimer-to-repress-its-constitutive-activity-for-ligand-activation
#4
Ryota Shizu, Makoto Osabe, Lalith Perera, Rick Moore, Tatsuya Sueyoshi, Masahiko Negishi
Nuclear receptor CAR (NR1I3) regulates hepatic drug and energy metabolism as well as cell fate. Its activation can be a critical factor in drug-induced toxicity and disease development such as diabetes and tumors. CAR inactivates its constitutive activity by phosphorylation at threonine 38. Utilizing receptor for protein kinase 1 (RACK1) as the regulatory subunit, protein phosphatase PP2A dephosphorylates threonine 38 to activate CAR. Here we have demonstrated that CAR undergoes its homodimer-monomer conversion to regulate this dephosphorylation...
March 6, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28236480/effect-of-biodiesel-fuel-on-real-world-nonroad-heavy-duty-diesel-engine-particulate-matter-emissions-composition-and-cytotoxicity
#5
Nathan Martin, Melissa Lombard, Kirk R Jensen, Patrick Kelley, Tara Pratt, Nora Traviss
Biodiesel is regarded by many as a "greener" alternative fuel to petroleum diesel with potentially lower health risk. However, recent studies examining biodiesel particulate matter (PM) characteristics and health effects are contradictive, and typically utilize PM generated by passenger car engines in laboratory settings. There is a critical need to analyze diesel and biodiesel PM generated in a "real-world" setting where heavy duty-diesel (HDD) engines and commercially purchased fuel are utilized. This study compares the mass concentrations, chemical composition and cytotoxicity of real-world PM from combustion of both petroleum diesel and a waste grease 20% biodiesel blend (B20) at a community recycling center operating HDD nonroad equipment...
May 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28224758/physical-and-social-determinants-of-dietary-variety-among-older-adults-living-alone-in-japan
#6
Yoshiharu Fukuda, Midori Ishikawa, Tetsuji Yokoyama, Tatsumi Hayashi, Tomoki Nakaya, Yukari Takemi, Kaoru Kusama, Nobuo Yoshiike, Miho Nozue, Kaori Yoshiba, Nobuko Murayama
AIM: Food security and sufficient nutrient intake are critical to longevity and active aging. The present study aimed to elucidate physical and social factors related to dietary variety among single-living older adults in Japanese communities. METHODS: The cross-sectional survey with a self-administrated questionnaire was carried out for all older adults living alone aged 65 years and older in three cities of Japan during 2014. Dietary variety score (DVS) was determined by counting the number of 10 food groups consumed at least once in 2 days using a food frequency questionnaire...
February 22, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28216434/human-nlrp3-inflammasome-activity-is-regulated-by-and-potentially-targetable-via-btk
#7
Xiao Liu, Tica Pichulik, Olaf-Oliver Wolz, Truong-Minh Dang, Andrea Stutz, Carly Dillen, Magno Delmiro Garcia, Helene Kraus, Sabine Dickhöfer, Ellen Daiber, Lisa Münzenmayer, Silke Wahl, Nikolaus Rieber, Jasmin Kümmerle-Deschner, Amir Yazdi, Mirita Franz-Wachtel, Boris Macek, Markus Radsak, Sebastian Vogel, Berit Schulte, Juliane Sarah Walz, Dominik Hartl, Eicke Latz, Stephan Stilgenbauer, Bodo Grimbacher, Lloyd Miller, Cornelia Brunner, Christiane Wolz, Alexander N R Weber
BACKGROUND: The Nod-like receptor, NACHT, LRR and PYD domains-containing protein 3 (NLRP3), and Bruton's tyrosine kinase (BTK) are protagonists in innate and adaptive immunity, respectively: NLRP3 senses exogenous and endogenous insults leading to inflammasome activation, which occurs spontaneously in Muckle-Wells Syndrome (MWS); BTK mutations cause the genetic immunodeficiency X-linked agammaglobulinemia (XLA). However, to date few proteins that regulate NLRP3 inflammasome activity in human primary immune cells have been identified and clinically promising pharmacological targeting strategies remain elusive...
February 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28208435/mechanisms-of-jamming-in-the-nagel-schreckenberg-model-for-traffic-flow
#8
Henrik M Bette, Lars Habel, Thorsten Emig, Michael Schreckenberg
We study the Nagel-Schreckenberg cellular automata model for traffic flow by both simulations and analytical techniques. To better understand the nature of the jamming transition, we analyze the fraction of stopped cars P(v=0) as a function of the mean car density. We present a simple argument that yields an estimate for the free density where jamming occurs, and show satisfying agreement with simulation results. We demonstrate that the fraction of jammed cars P(v∈{0,1}) can be decomposed into the three factors (jamming rate, jam lifetime, and jam size) for which we derive, from random walk arguments, exponents that control their scaling close to the critical density...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28186345/quantifying-the-extent-of-protected-area-downgrading-downsizing-and-degazettement-in-australia
#9
Carly N Cook, Rebecca S Valkan, Michael B Mascia, Melodie McGeoch
The use of total area protected as the predominant indicator of progress in building protected areas (PAs) is receiving growing criticism. Documenting the full dynamics of a PA network, both in terms of the gains and losses in protection, provides a much more informative approach to tracking progress. To this end, there has been growing emphasis on documenting examples of PADDD: Protected Area Downgrading, Downsizing and Degazettement. Studies of PADDD events generally fail to place these losses in the context of gains in protection, omitting important elements of PA network dynamics...
February 10, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28176670/cerebrospinal-fluid-pleocytosis-in-critical-care-patients-with-seizures
#10
Carly Scramstad, Alan C Jackson
OBJECTIVES: To assess the etiology of cerebrospinal fluid (CSF) pleocytosis in critical care patients with seizure(s) or status epilepticus (SE). Many previous studies, some performed decades ago, concluded that CSF pleocytosis may be entirely attributable to seizure activity. METHODS: We undertook a retrospective chart review of adult patients with an admitting or acquired diagnosis of seizure(s) or SE in critical care units at the Winnipeg Health Sciences Centre between 2009 and 2012...
February 8, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28160714/estimation-of-the-critical-quality-attributes-for-hydroxypropyl-methylcellulose-with-near-infrared-spectroscopy-and-chemometrics
#11
Qingli Guo, Lei Nie, Lian Li, Hengchang Zang
With the implementation of quality by design (QbD), critical attributes of raw material (drug substance and excipients) are of significantly importance in pharmaceutical manufacturing process. It is desirable for the quality control of critical material attributes (CMAs) of excipients to ensure the quality of end product. This paper explored the feasibility of an at-line method for the quantitative analysis of hydroxypropoxy group in hydroxypropyl methylcellulose (HPMC) with near infrared spectroscopy (NIRS)...
April 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28152767/understanding-the-comorbidome-and-its-effect-on-survival-in-colorectal-cancer
#12
Ernest Shen, Janet S Lee, Corrine E Munoz-Plaza, Carly Parry, Michael K Gould
210 Background: Effectively managing comorbidities is an essential component of high-quality cancer care. Evidence suggests colorectal cancer (CRC) patients with multiple comorbid conditions are less likely to complete standard treatments and can have lower rates of survival. In order to provide personalized care, it is critical to understand how comorbid conditions cluster within CRC patients. METHODS: We identified Kaiser Permanente Southern California CRC patients diagnosed with first malignancy between 01/01/2008 - 12/31/2013...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28151783/organizational-learning-in-a-cardiac-intensive-care-unit-a-learning-history
#13
Bret Lyman, Kalene M Ethington, Carly King, Jonathan D Jacobs, Hayley Lundeen
INTRODUCTION: Providing high-quality care to every patient is challenging, particularly in critical care units (CCUs). However, this standard can be achieved through organizational learning. Unfortunately, the process of organizational learning in CCUs is not well understood. OBJECTIVE: The objective of this study is to describe the developmental progression of a cardiac intensive care unit (CICU) to reach its current state of reliably excellent clinical performance...
March 2017: Dimensions of Critical Care Nursing: DCCN
https://www.readbyqxmd.com/read/28128229/prognostic-role-of-the-pretreatment-c-reactive-protein-albumin-ratio-in-solid-cancers-a-meta-analysis
#14
Nan Li, Guang-Wei Tian, Ying Wang, Hui Zhang, Zi-Hui Wang, Guang Li
The C-reactive protein/albumin ratio (CAR) has been shown to play a significant prognostic role in several cancers. We aimed to comprehensively explore the potential role of the CAR as a prognostic indicator in solid cancers. In this meta-analysis, we collected data from 10 studies that examined the association between serum CAR and overall survival in patients with cancer. This meta-analysis included 4592 tumor patients. The eligible studies were found through the PubMed and Web of Science databases updated on 6 Oct 2016...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28123943/systemic-insulin-sensitivity-is-regulated-by-gps2-inhibition-of-akt-ubiquitination-and-activation-in-adipose-tissue
#15
Carly T Cederquist, Claudia Lentucci, Camila Martinez-Calejman, Vanessa Hayashi, Joseph Orofino, David Guertin, Susan K Fried, Mi-Jeong Lee, M Dafne Cardamone, Valentina Perissi
OBJECTIVE: Insulin signaling plays a unique role in the regulation of energy homeostasis and the impairment of insulin action is associated with altered lipid metabolism, obesity, and Type 2 Diabetes. The main aim of this study was to provide further insight into the regulatory mechanisms governing the insulin signaling pathway by investigating the role of non-proteolytic ubiquitination in insulin-mediated activation of AKT. METHODS: The molecular mechanism of AKT regulation through ubiquitination is first dissected in vitro in 3T3-L1 preadipocytes and then validated in vivo using mice with adipo-specific deletion of GPS2, an endogenous inhibitor of Ubc13 activity (GPS2-AKO mice)...
January 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28051972/characteristics-classification-and-prevention-of-child-maltreatment-fatalities
#16
James E McCarroll, Joscelyn E Fisher, Stephen J Cozza, Renè J Robichaux, Carol S Fullerton
BACKGROUND: Preventing child maltreatment fatalities is a critical goal of the U.S. society and the military services. Fatality review boards further this goal through the analysis of circumstances of child deaths, making recommendations for improvements in practices and policies, and promoting increased cooperation among the many systems that serve families. The purpose of this article is to review types of child maltreatment death, proposed classification models, risk and protective factors, and prevention strategies...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28049062/adenovirus-transduction-more-complicated-than-receptor-expression
#17
Priyanka Sharma, Prithy C Martis, Katherine J D A Excoffon
The abundance and accessibility of a primary virus receptor are critical factors that impact the susceptibility of a host cell to virus infection. The Coxsackievirus and adenovirus receptor (CAR) has two transmembrane isoforms that occur due to alternative splicing and differ in localization and function in polarized epithelia. To determine the relevance of isoform-specific expression across cell types, the abundance and localization of both isoforms were determined in ten common cell lines, and correlated with susceptibility to adenovirus transduction relative to polarized primary human airway epithelia...
February 2017: Virology
https://www.readbyqxmd.com/read/28039360/inhibition-of-ubc13-mediated-ubiquitination-by-gps2-regulates-multiple-stages-of-b-cell-development
#18
Claudia Lentucci, Anna C Belkina, Carly T Cederquist, Michelle Chan, Holly E Johnson, Sherry Prasad, Amanda Lopacinski, Barbara S Nikolajczyk, Stefano Monti, Jennifer Snyder-Cappione, Bogdan Tanasa, M Dafne Cardamone, Valentina Perissi
Non-proteolytic ubiquitin signaling mediated by Lys(63) ubiquitin chains plays a critical role in multiple pathways that are key to the development and activation of immune cells. Our previous work indicates that GPS2 (G-protein Pathway Suppressor 2) is a multifunctional protein regulating TNFα signaling and lipid metabolism in the adipose tissue through modulation of Lys(63) ubiquitination events. However, the full extent of GPS2-mediated regulation of ubiquitination and the underlying molecular mechanisms are unknown...
February 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28026051/the-effects-of-electromagnetic-fields-on-b16-bl6-cells-are-dependent-on-their-spatial-and-temporal-character
#19
Carly A Buckner, Alison L Buckner, Stan A Koren, Michael A Persinger, Robert M Lafrenie
Exposure to low intensity, low frequency electromagnetic fields (EMF) has effects on several biological systems. Spatiotemporal characteristics of these EMFs are critical. The effect of several complex EMF patterns on the proliferation of B16-BL6 mouse melanoma cells was tested. Exposure to one of these patterns, the Thomas-EMF, inhibited cell proliferation and promoted calcium uptake. The Thomas-EMF is coded from a digital-to-analog file comprised of 849 points, which provides power to solenoids and can be set to alter timing, intensity, and duration of variable EMF...
April 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28025333/modulation-of-bilirubin-neurotoxicity-by-the-abcb1-transporter-in-the-ugt1-lethal-mouse-model-of-neonatal-hyperbilirubinemia
#20
Luka Bočkor, Giulia Bortolussi, Simone Vodret, Alessandra Iaconcig, Jana Jašprová, Jaroslav Zelenka, Libor Vitek, Claudio Tiribelli, Andrés F Muro
Moderate neonatal jaundice is the most common clinical condition during newborn life. However, a combination of factors may result in acute hyperbilirubinemia, placing infants at risk of developing bilirubin encephalopathy and death by kernicterus. While most risk factors are known, the mechanisms acting to reduce susceptibility to bilirubin neurotoxicity remain unclear. The presence of modifier genes modulating the risk of developing bilirubin-induced brain damage is increasingly being recognised. The Abcb1 and Abcc1 members of the ABC family of transporters have been suggested to have an active role in exporting unconjugated bilirubin from the central nervous system into plasma...
December 25, 2016: Human Molecular Genetics
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