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https://www.readbyqxmd.com/read/29148219/breaking-free-from-vascular-confinement-status-and-prospects-for-submicron-ultrasound-contrast-agents
#1
REVIEW
Carly Pellow, David E Goertz, Gang Zheng
The development of encapsulated microbubbles (~1-6 μm) has expanded the utility of ultrasound from soft tissue anatomical imaging to not only functional intravascular imaging, but therapeutic interventions, with compelling studies of elicited biological effects. The large diameter of these bubbles has confined their utility to the vasculature, but converging interdisciplinary research pathways are giving rise to new submicron ultrasound contrast agents capable of extending their effects beyond the vascular compartment...
November 17, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29123889/a-case-of-non-cardiogenic-pulmonary-edema-provoked-by-intravenous-acetazolamide
#2
Yuichiro Ono, Makiko Morifusa, Satoru Ikeda, Chika Kunishige, Yoshiki Tohma
Case: A 61-year-old man was diagnosed with severe chest trauma after a car accident and had had difficulty in weaning from a ventilator because of flail chest and dilated cardiomyopathy. On the 17th day in the intensive care unit, he received i.v. acetazolamide to increase urine output. One hour after the injection, he suddenly developed severe hypoxia. Chest radiography revealed a butterfly shadow. He received other diuretics and a vasodilator, which seemed slowly to resolve the respiratory failure...
July 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29105032/bonding-structural-and-thermodynamic-analysis-of-dissociative-adsorption-of-h3o-ion-onto-calcite-formula-see-text-surface-cpmd-and-dft-calculations
#3
Mohammad Hadi Ghatee, Mohammad Mehdi Koleini
We used density functional theory (DFT) and Car-Parrinello molecular dynamics (CPMD) simulation to investigate the adsorption and bond formation of hydronium ion (H3O(+)) onto a [Formula: see text] calcite surface. For surface coverage of 25% to 100%, the nature of H3O(+) interaction was explored through electron density and energetics in the context of bond critical points. The adsorbate-adsorbent structure was studied by simulation of pair correlation function. The results revealed that dissociation into water molecule(s) and proton(s) complements H3O(+) ion(s) adsorbtion...
November 6, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29095863/conservation-genetics-of-the-eastern-yellow-bellied-racer-coluber-constrictor-flaviventris-and-bullsnake-pituophis-catenifer-sayi-river-valleys-are-critical-features-for-snakes-at-northern-range-limits
#4
Christopher M Somers, Carly F Graham, Jessica A Martino, Timothy R Frasier, Stacey L Lance, Laura E Gardiner, Ray G Poulin
On the North American Great Plains, several snake species reach their northern range limit where they rely on sparsely distributed hibernacula located in major river valleys. Independent colonization histories for the river valleys and barriers to gene flow caused by the lack of suitable habitat between them may have produced genetically differentiated snake populations. To test this hypothesis, we used 10 microsatellite loci to examine the population structure of two species of conservation concern in Canada: the eastern yellow-bellied racer (Coluber constrictor flaviventris) and bullsnake (Pituophis catenifer sayi) in 3 major river valleys in southern Saskatchewan...
2017: PloS One
https://www.readbyqxmd.com/read/29091206/dynamics-and-phylogenetic-relationships-of-hiv-1-transmitted-drug-resistance-according-to-subtype-in-italy-over-the-years-2000-14
#5
L Fabeni, C Alteri, D Di Carlo, N Orchi, L Carioti, A Bertoli, C Gori, F Forbici, F Continenza, G Maffongelli, C Pinnetti, A Vergori, A Mondi, A Ammassari, V Borghi, M Giuliani, G De Carli, S Pittalis, S Grisetti, A Pennica, C M Mastroianni, F Montella, A Cristaudo, C Mussini, E Girardi, M Andreoni, A Antinori, F Ceccherini-Silberstein, C F Perno, M M Santoro
Background: Transmitted drug-resistance (TDR) remains a critical aspect for the management of HIV-1-infected individuals. Thus, studying the dynamics of TDR is crucial to optimize HIV care. Methods: In total, 4323 HIV-1 protease/reverse-transcriptase sequences from drug-naive individuals diagnosed in north and central Italy between 2000 and 2014 were analysed. TDR was evaluated over time. Maximum-likelihood and Bayesian phylogenetic trees with bootstrap and Bayesian-probability supports defined transmission clusters...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29080743/temperature-sensitive-point-mutations-in-fission-yeast-tropomyosin-have-long-range-effects-on-the-stability-and-function-of-the-actin-tropomyosin-copolymer
#6
Chloe A Johnson, Holly R Brooker, Irene Gyamfi, Jennifer O'Brien, Brogan Ashley, Jodie E Brazier, Annette Dean, James Embling, Elisabeth Grimsey, Alice C Tomlinson, Elliot G Wilson, Michael A Geeves, Daniel P Mulvihill
The actin cytoskeleton is modulated by regulatory actin-binding proteins which fine-tune the dynamic properties of the actin polymer to regulate function. One such actin-binding protein is tropomyosin (Tpm), a highly-conserved alpha-helical dimer which stabilises actin and regulates interactions with other proteins. Temperature sensitive mutants of Tpm are invaluable tools in the study of actin filament dependent processes, critical to the viability of a cell. Here we investigated the molecular basis of the temperature sensitivity of fission yeast Tpm mutants which fail to undergo cytokinesis at the restrictive temperatures...
November 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29051723/autopilot-mind-wandering-and-the-out-of-the-loop-performance-problem
#7
REVIEW
Jonas Gouraud, Arnaud Delorme, Bruno Berberian
To satisfy the increasing demand for safer critical systems, engineers have integrated higher levels of automation, such as glass cockpits in aircraft, power plants, and driverless cars. These guiding principles relegate the operator to a monitoring role, increasing risks for humans to lack system understanding. The out of the loop performance problem arises when operators suffer from complacency and vigilance decrement; consequently, when automation does not behave as expected, understanding the system or taking back manual control may be difficult...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29038795/immune-engineering-from-systems-immunology-to-engineering-immunity
#8
Ning Jiang
The smallpox vaccine represents the earliest attempt in engineering immunity. The recent success of chimeric antigen receptor T cells (CAR-T cells) in cancer once again demonstrates the clinical potential of immune engineering. Inspired by this success, diverse approaches have been used to boost various aspects of immunity: engineering dendritic cells (DCs), natural killer (NK) cells, T cells, antibodies, cytokines, small peptides, and others. With recent development of various high-throughput technologies (of which engineers, especially biomedical engineers/bioengineers contributed significantly), such as immune repertoire sequencing, and analytical methods, a systems level of understanding immunity (or the lack of it) beyond model animals has provided critical insights into the human immune system...
March 2017: Curr Opin Biomed Eng
https://www.readbyqxmd.com/read/29029813/innovative-therapy-monoclonal-antibodies-and-beyond
#9
M Di Nicola, L Apetoh, M Bellone, M P Colombo, G Dotti, S Ferrone, M Muscolini, J Hiscott, A Anichini, S M Pupa, F de Braud, M Del Vecchio
The seventh Edition of "Innovative Therapy, Monoclonal Antibodies and Beyond" Meeting took place in Milan, Italy, on January 27, 2017. The two sessions of the meeting were focused on: 1) Preclinical assays and novel biotargets; and 2) monoclonal antibodies, cell therapies and targeted molecules. Between these two sessions, a lecture entitled "HLA-antigens modulation and response to immune checkpoint inhibitor immunotherapy" was also presented. Despite the impressive successes in cancer immunotherapy in recent years, the response to immune based interventions occurs only in a minority of patients (∼20%)...
October 5, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28992492/tracing-platinum-accumulation-kinetics-in-oyster-crassostrea-gigas-a-sentinel-species-in-coastal-marine-environments
#10
Melina Abdou, Lionel Dutruch, Jörg Schäfer, Beñat Zaldibar, Rebeca Medrano, Urtzi Izagirre, Teba Gil-Díaz, Cécile Bossy, Charlotte Catrouillet, Ruoyu Hu, Alexandra Coynel, Antoine Lerat, Antonio Cobelo-García, Gérard Blanc, Manu Soto
Platinum Group Elements (PGEs) are extremely scarce in the Earth's Crust and of strong interest for high-end technologies due to their specific properties. They belong to the Technology Critical Elements (TCEs) for which use is forecast to increase, implying growing emissions into the environment in the following years. In particular, with the intensive use of platinum (Pt) in car catalytic converters, the anthropogenic geochemical cycle of this element has surpassed the natural cycle. Yet, environmental Pt levels are still in the sub picomolar range, making its analytical detection a challenge...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28978241/treating-hematological-malignancies-with-cell-therapy-where-are-we-now
#11
Elisa Landoni, Barbara Savoldo
Adoptive cell therapy (ACT) is becoming an increasingly successful and widespread form of treatment for different types of cancer. Compared to chemotherapy or monoclonal antibodies, ACT is an active biological strategy, with infused immune cells featuring dynamic migration, expansion and long-term persistence properties. ACT in hematological malignancies offered the initial proof of principle of the feasibility for this innovative 'live-drug'. Areas covered: In this review, the authors summarize the clinical results achieved with two specific strategies in hematological malignancies: chimeric antigen receptor (CAR) and T cell receptor (transgenic TCR) redirected T cells...
October 5, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28973544/loss-of-the-imprinted-non-coding-snord116-gene-cluster-in-the-interval-deleted-in-the-prader-willi-syndrome-results-in-murine-neuronal-and-endocrine-pancreatic-developmental-phenotypes
#12
Lisa Cole Burnett, Gabriela Hubner, Charles LeDuc, Michael V Morabito, Jayne F Martin Carli, Rudolph L Leibel
Global neurodevelopmental delay is a prominent characteristic of individuals with Prader-Willi syndrome (PWS). The neuromolecular bases for these delays are unknown. We identified neuroanatomical changes in the brains of mice deficient for a gene in the minimal critical deletion region for PWS (Snord116p-/m+). In Snord116p-/m+ mice, reduced primary forebrain neuron cell body size is apparent in embryonic day 15.5 fetuses, and persists until postnatal day 30 in cerebellar purkinje neurons. Snord116 is a snoRNA gene cluster of unknown function that can localize to the nucleolus...
September 6, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28954429/are-mhealth-interventions-to-improve-child-restraint-system-installation-of-value-a-mixed-methods-study-of-parents
#13
Linda Fleisher, Danielle Erkoboni, Katherine Halkyard, Emily Sykes, Marisol S Norris, Lorrie Walker, Flaura Winston
Childhood death from vehicle crashes and the delivery of information about proper child restraint systems (CRS) use continues to be a critical public health issue. Safe Seat, a sequential, mixed-methods study identified gaps in parental knowledge about and perceived challenges in the use of appropriate CRS and insights into the preferences of various technological approaches to deliver CRS education. Focus groups (eight groups with 21 participants) and a quantitative national survey (N = 1251) using MTurk were conducted...
September 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28952660/medical-emergencies-on-large-passenger-ships-without-doctors-the-oslo-kiel-oslo-ferry-experience
#14
Thor-Erik Holt, Agnar Tveten, Eilif Dahl
BACKGROUND: The Oslo-Kiel-Oslo route is currently the only direct ferry crossing between Norway and Germany, covered by 2 cruise-and-cars ferries carrying about 2,600 passengers each and sailing every day (20 h at sea, 4 h in port). Unlike most ocean going cruise vessels, they are not required to carry a physician but an on-board paramedic handles medical emergencies. The aim of the study was to provide data on medical emergencies leading to helicopter evacuations (helivacs) or other urgent transfers to facilities ashore from the two ferries during a 3-year period...
2017: International Maritime Health
https://www.readbyqxmd.com/read/28951562/a-compound-chimeric-antigen-receptor-strategy-for-targeting-multiple-myeloma
#15
K H Chen, M Wada, K G Pinz, H Liu, X Shuai, X Chen, L E Yan, J C Petrov, H Salman, L Senzel, E L H Leung, X Jiang, Y Ma
Current clinical outcomes using CARs against multiple myeloma show promise in the eradication of bulk disease. However, these anti-BCMA (CD269) CARs observe relapse as a common phenomenon after treatment due to the reemergence of either antigen positive or negative cells. Hence, the development of improvements in CAR design to target antigen loss and increase effector cell persistency represents a critical need. Here, we report on the anti-tumor activity of a CAR T-cell possessing 2 complete and independent CAR receptors against the multiple myeloma antigens BCMA and CS1...
September 27, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28942894/wavelet-based-information-filtering-for-fault-diagnosis-of-electric-drive-systems-in-electric-ships
#16
Andre A Silva, Shalabh Gupta, Ali M Bazzi, Arthur Ulatowski
Electric machines and drives have enjoyed extensive applications in the field of electric vehicles (e.g., electric ships, boats, cars, and underwater vessels) due to their ease of scalability and wide range of operating conditions. This stems from their ability to generate the desired torque and power levels for propulsion under various external load conditions. However, as with the most electrical systems, the electric drives are prone to component failures that can degrade their performance, reduce the efficiency, and require expensive maintenance...
September 21, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28934184/rural-and-urban-differences-in-passenger-vehicle-occupant-deaths-and-seat-belt-use-among-adults-united-states-2014
#17
Laurie F Beck, Jonathan Downs, Mark R Stevens, Erin K Sauber-Schatz
PROBLEM/CONDITION: Motor-vehicle crashes are a leading cause of death in the United States. Compared with urban residents, rural residents are at an increased risk for death from crashes and are less likely to wear seat belts. These differences have not been well described by levels of rurality. REPORTING PERIOD: 2014. DESCRIPTION OF SYSTEMS: Data from the Fatality Analysis Reporting System (FARS) and the Behavioral Risk Factor Surveillance System (BRFSS) were used to identify passenger-vehicle-occupant deaths from motor-vehicle crashes and estimate the prevalence of seat belt use...
September 22, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28932243/sensitive-wavelengths-selection-in-identification-of-ophiopogon-japonicus-based-on-near-infrared-hyperspectral-imaging-technology
#18
Zhengyan Xia, Chu Zhang, Haiyong Weng, Pengcheng Nie, Yong He
Hyperspectral imaging (HSI) technology has increasingly been applied as an analytical tool in fields of agricultural, food, and Traditional Chinese Medicine over the past few years. The HSI spectrum of a sample is typically achieved by a spectroradiometer at hundreds of wavelengths. In recent years, considerable effort has been made towards identifying wavelengths (variables) that contribute useful information. Wavelengths selection is a critical step in data analysis for Raman, NIRS, or HSI spectroscopy. In this study, the performances of 10 different wavelength selection methods for the discrimination of Ophiopogon japonicus of different origin were compared...
2017: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/28927721/agonistic-effects-of-diverse-xenobiotics-on-the-constitutive-androstane-receptor-as-detected-in-a-recombinant-yeast-cell-assay
#19
Ryo Kamata, Daisuke Nakajima, Fujio Shiraishi
The constitutive androstane receptor (CAR) is a nuclear receptor and transcription factor regulating proteins involved in xenobiotic metabolism. Agonist activation of the CAR can trigger metabolic activation and toxification as well as detoxification and clearance; accordingly, xenobiotic substances acting as CAR ligands may pose a threat to human and animal health. We used yeast cells transduced with the human CAR and the response pathway to measure the CAR-agonistic activities of 549 synthetic or natural compounds: 216 of the tested compounds exhibited CAR-agonistic effects...
September 18, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28888074/early-recovery-of-circulating-immature-b-cells-in-b-lymphoblastic-leukemia-patients-after-cd19-targeted-car-t-cell-therapy-a-pitfall-for-minimal-residual-disease-detection
#20
Wenbin Xiao, Dalia Salem, Catherine McCoy, Daniel Lee, Nirali N Shah, Maryalice Stetler-Stevenson, Constance M Yuan
BACKGROUND: CD19-targeted chimeric-antigen receptor-modified T-cells (CAR-T) are promising in the treatment of refractory B-lymphoblastic leukemia (B-ALL). Minimal residual disease (MRD) detection by multicolor flow cytometry (FCM) is critical to distinguish B-ALL MRD from regenerating, non-neoplastic B-cell populations. METHODS: FCM was performed on samples from 9 patients with B-ALL treated with CAR-T. RESULTS: All 9 patients showed response to CAR-T...
September 9, 2017: Cytometry. Part B, Clinical Cytometry
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