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https://www.readbyqxmd.com/read/28224758/physical-and-social-determinants-of-dietary-variety-among-older-adults-living-alone-in-japan
#1
Yoshiharu Fukuda, Midori Ishikawa, Tetsuji Yokoyama, Tatsumi Hayashi, Tomoki Nakaya, Yukari Takemi, Kaoru Kusama, Nobuo Yoshiike, Miho Nozue, Kaori Yoshiba, Nobuko Murayama
AIM: Food security and sufficient nutrient intake are critical to longevity and active aging. The present study aimed to elucidate physical and social factors related to dietary variety among single-living older adults in Japanese communities. METHODS: The cross-sectional survey with a self-administrated questionnaire was carried out for all older adults living alone aged 65 years and older in three cities of Japan during 2014. Dietary variety score (DVS) was determined by counting the number of 10 food groups consumed at least once in 2 days using a food frequency questionnaire...
February 22, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28216434/human-nlrp3-inflammasome-activity-is-regulated-by-and-potentially-targetable-via-btk
#2
Xiao Liu, Tica Pichulik, Olaf-Oliver Wolz, Truong-Minh Dang, Andrea Stutz, Carly Dillen, Magno Delmiro Garcia, Helene Kraus, Sabine Dickhöfer, Ellen Daiber, Lisa Münzenmayer, Silke Wahl, Nikolaus Rieber, Jasmin Kümmerle-Deschner, Amir Yazdi, Mirita Franz-Wachtel, Boris Macek, Markus Radsak, Sebastian Vogel, Berit Schulte, Juliane Sarah Walz, Dominik Hartl, Eicke Latz, Stephan Stilgenbauer, Bodo Grimbacher, Lloyd Miller, Cornelia Brunner, Christiane Wolz, Alexander N R Weber
BACKGROUND: The Nod-like receptor, NACHT, LRR and PYD domains-containing protein 3 (NLRP3), and Bruton's tyrosine kinase (BTK) are protagonists in innate and adaptive immunity, respectively: NLRP3 senses exogenous and endogenous insults leading to inflammasome activation, which occurs spontaneously in Muckle-Wells Syndrome (MWS); BTK mutations cause the genetic immunodeficiency X-linked agammaglobulinemia (XLA). However, to date few proteins that regulate NLRP3 inflammasome activity in human primary immune cells have been identified and clinically promising pharmacological targeting strategies remain elusive...
February 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28208435/mechanisms-of-jamming-in-the-nagel-schreckenberg-model-for-traffic-flow
#3
Henrik M Bette, Lars Habel, Thorsten Emig, Michael Schreckenberg
We study the Nagel-Schreckenberg cellular automata model for traffic flow by both simulations and analytical techniques. To better understand the nature of the jamming transition, we analyze the fraction of stopped cars P(v=0) as a function of the mean car density. We present a simple argument that yields an estimate for the free density where jamming occurs, and show satisfying agreement with simulation results. We demonstrate that the fraction of jammed cars P(v∈{0,1}) can be decomposed into the three factors (jamming rate, jam lifetime, and jam size) for which we derive, from random walk arguments, exponents that control their scaling close to the critical density...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28186345/quantifying-the-extent-of-protected-area-downgrading-downsizing-and-degazettement-in-australia
#4
Carly N Cook, Rebecca S Valkan, Michael B Mascia, Melodie McGeoch
The use of total area protected as the predominant indicator of progress in building protected areas (PAs) is receiving growing criticism. Documenting the full dynamics of a PA network, both in terms of the gains and losses in protection, provides a much more informative approach to tracking progress. To this end, there has been growing emphasis on documenting examples of PADDD: Protected Area Downgrading, Downsizing and Degazettement. Studies of PADDD events generally fail to place these losses in the context of gains in protection, omitting important elements of PA network dynamics...
February 10, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28176670/cerebrospinal-fluid-pleocytosis-in-critical-care-patients-with-seizures
#5
Carly Scramstad, Alan C Jackson
OBJECTIVES: To assess the etiology of cerebrospinal fluid (CSF) pleocytosis in critical care patients with seizure(s) or status epilepticus (SE). Many previous studies, some performed decades ago, concluded that CSF pleocytosis may be entirely attributable to seizure activity. METHODS: We undertook a retrospective chart review of adult patients with an admitting or acquired diagnosis of seizure(s) or SE in critical care units at the Winnipeg Health Sciences Centre between 2009 and 2012...
February 8, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28160714/estimation-of-the-critical-quality-attributes-for-hydroxypropyl-methylcellulose-with-near-infrared-spectroscopy-and-chemometrics
#6
Qingli Guo, Lei Nie, Lian Li, Hengchang Zang
With the implementation of quality by design (QbD), critical attributes of raw material (drug substance and excipients) are of significantly importance in pharmaceutical manufacturing process. It is desirable for the quality control of critical material attributes (CMAs) of excipients to ensure the quality of end product. This paper explored the feasibility of an at-line method for the quantitative analysis of hydroxypropoxy group in hydroxypropyl methylcellulose (HPMC) with near infrared spectroscopy (NIRS)...
January 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28152767/understanding-the-comorbidome-and-its-effect-on-survival-in-colorectal-cancer
#7
Ernest Shen, Janet S Lee, Corrine E Munoz-Plaza, Carly Parry, Michael K Gould
: 210 Background: Effectively managing comorbidities is an essential component of high-quality cancer care. Evidence suggests colorectal cancer (CRC) patients with multiple comorbid conditions are less likely to complete standard treatments and can have lower rates of survival. In order to provide personalized care, it is critical to understand how comorbid conditions cluster within CRC patients. METHODS: We identified Kaiser Permanente Southern California CRC patients diagnosed with first malignancy between 01/01/2008 - 12/31/2013...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28151783/organizational-learning-in-a-cardiac-intensive-care-unit-a-learning-history
#8
Bret Lyman, Kalene M Ethington, Carly King, Jonathan D Jacobs, Hayley Lundeen
INTRODUCTION: Providing high-quality care to every patient is challenging, particularly in critical care units (CCUs). However, this standard can be achieved through organizational learning. Unfortunately, the process of organizational learning in CCUs is not well understood. OBJECTIVE: The objective of this study is to describe the developmental progression of a cardiac intensive care unit (CICU) to reach its current state of reliably excellent clinical performance...
March 2017: Dimensions of Critical Care Nursing: DCCN
https://www.readbyqxmd.com/read/28128229/prognostic-role-of-the-pretreatment-c-reactive-protein-albumin-ratio-in-solid-cancers-a-meta-analysis
#9
Nan Li, Guang-Wei Tian, Ying Wang, Hui Zhang, Zi-Hui Wang, Guang Li
The C-reactive protein/albumin ratio (CAR) has been shown to play a significant prognostic role in several cancers. We aimed to comprehensively explore the potential role of the CAR as a prognostic indicator in solid cancers. In this meta-analysis, we collected data from 10 studies that examined the association between serum CAR and overall survival in patients with cancer. This meta-analysis included 4592 tumor patients. The eligible studies were found through the PubMed and Web of Science databases updated on 6 Oct 2016...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28123943/systemic-insulin-sensitivity-is-regulated-by-gps2-inhibition-of-akt-ubiquitination-and-activation-in-adipose-tissue
#10
Carly T Cederquist, Claudia Lentucci, Camila Martinez-Calejman, Vanessa Hayashi, Joseph Orofino, David Guertin, Susan K Fried, Mi-Jeong Lee, M Dafne Cardamone, Valentina Perissi
OBJECTIVE: Insulin signaling plays a unique role in the regulation of energy homeostasis and the impairment of insulin action is associated with altered lipid metabolism, obesity, and Type 2 Diabetes. The main aim of this study was to provide further insight into the regulatory mechanisms governing the insulin signaling pathway by investigating the role of non-proteolytic ubiquitination in insulin-mediated activation of AKT. METHODS: The molecular mechanism of AKT regulation through ubiquitination is first dissected in vitro in 3T3-L1 preadipocytes and then validated in vivo using mice with adipo-specific deletion of GPS2, an endogenous inhibitor of Ubc13 activity (GPS2-AKO mice)...
January 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28051972/characteristics-classification-and-prevention-of-child-maltreatment-fatalities
#11
James E McCarroll, Joscelyn E Fisher, Stephen J Cozza, Renè J Robichaux, Carol S Fullerton
BACKGROUND: Preventing child maltreatment fatalities is a critical goal of the U.S. society and the military services. Fatality review boards further this goal through the analysis of circumstances of child deaths, making recommendations for improvements in practices and policies, and promoting increased cooperation among the many systems that serve families. The purpose of this article is to review types of child maltreatment death, proposed classification models, risk and protective factors, and prevention strategies...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28049062/adenovirus-transduction-more-complicated-than-receptor-expression
#12
Priyanka Sharma, Prithy C Martis, Katherine J D A Excoffon
The abundance and accessibility of a primary virus receptor are critical factors that impact the susceptibility of a host cell to virus infection. The Coxsackievirus and adenovirus receptor (CAR) has two transmembrane isoforms that occur due to alternative splicing and differ in localization and function in polarized epithelia. To determine the relevance of isoform-specific expression across cell types, the abundance and localization of both isoforms were determined in ten common cell lines, and correlated with susceptibility to adenovirus transduction relative to polarized primary human airway epithelia...
February 2017: Virology
https://www.readbyqxmd.com/read/28039360/inhibition-of-ubc13-mediated-ubiquitination-by-gps2-regulates-multiple-stages-of-b-cell-development
#13
Claudia Lentucci, Anna C Belkina, Carly T Cederquist, Michelle Chan, Holly E Johnson, Sherry Prasad, Amanda Lopacinski, Barbara S Nikolajczyk, Stefano Monti, Jennifer Snyder-Cappione, Bogdan Tanasa, M Dafne Cardamone, Valentina Perissi
Non-proteolytic ubiquitin signaling mediated by Lys(63) ubiquitin chains plays a critical role in multiple pathways that are key to the development and activation of immune cells. Our previous work indicates that GPS2 (G-protein Pathway Suppressor 2) is a multifunctional protein regulating TNFα signaling and lipid metabolism in the adipose tissue through modulation of Lys(63) ubiquitination events. However, the full extent of GPS2-mediated regulation of ubiquitination and the underlying molecular mechanisms are unknown...
February 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28026051/the-effects-of-electromagnetic-fields-on-b16-bl6-cells-are-dependent-on-their-spatial-and-temporal-character
#14
Carly A Buckner, Alison L Buckner, Stan A Koren, Michael A Persinger, Robert M Lafrenie
Exposure to low intensity, low frequency electromagnetic fields (EMF) has effects on several biological systems. Spatiotemporal characteristics of these EMFs are critical. The effect of several complex EMF patterns on the proliferation of B16-BL6 mouse melanoma cells was tested. Exposure to one of these patterns, the Thomas-EMF, inhibited cell proliferation and promoted calcium uptake. The Thomas-EMF is coded from a digital-to-analog file comprised of 849 points, which provides power to solenoids and can be set to alter timing, intensity, and duration of variable EMF...
December 27, 2016: Bioelectromagnetics
https://www.readbyqxmd.com/read/28025333/modulation-of-bilirubin-neurotoxicity-by-the-abcb1-transporter-in-the-ugt1-lethal-mouse-model-of-neonatal-hyperbilirubinemia
#15
Luka Bočkor, Giulia Bortolussi, Simone Vodret, Alessandra Iaconcig, Jana Jašprová, Jaroslav Zelenka, Libor Vitek, Claudio Tiribelli, Andrés F Muro
Moderate neonatal jaundice is the most common clinical condition during newborn life. However, a combination of factors may result in acute hyperbilirubinemia, placing infants at risk of developing bilirubin encephalopathy and death by kernicterus. While most risk factors are known, the mechanisms acting to reduce susceptibility to bilirubin neurotoxicity remain unclear. The presence of modifier genes modulating the risk of developing bilirubin-induced brain damage is increasingly being recognised. The Abcb1 and Abcc1 members of the ABC family of transporters have been suggested to have an active role in exporting unconjugated bilirubin from the central nervous system into plasma...
December 25, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28009208/structural-phase-transition-and-material-properties-of-few-layer-monochalcogenides
#16
Mehrshad Mehboudi, Benjamin M Fregoso, Yurong Yang, Wenjuan Zhu, Arend van der Zande, Jaime Ferrer, L Bellaiche, Pradeep Kumar, Salvador Barraza-Lopez
GeSe and SnSe monochalcogenide monolayers and bilayers undergo a two-dimensional phase transition from a rectangular unit cell to a square unit cell at a critical temperature T_{c} well below the melting point. Its consequences on material properties are studied within the framework of Car-Parrinello molecular dynamics and density-functional theory. No in-gap states develop as the structural transition takes place, so that these phase-change materials remain semiconducting below and above T_{c}. As the in-plane lattice transforms from a rectangle into a square at T_{c}, the electronic, spin, optical, and piezoelectric properties dramatically depart from earlier predictions...
December 9, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27997558/beyond-synchrony-joint-action-in-a-complex-production-task-reveals-beneficial-effects-of-decreased-interpersonal-synchrony
#17
Sebastian Wallot, Panagiotis Mitkidis, John J McGraw, Andreas Roepstorff
A variety of joint action studies show that people tend to fall into synchronous behavior with others participating in the same task, and that such synchronization is beneficial, leading to greater rapport, satisfaction, and performance. It has been noted that many of these task environments require simple interactions that involve little planning of action coordination toward a shared goal. The present study utilized a complex joint construction task in which dyads were instructed to build model cars while their hand movements and heart rates were measured...
2016: PloS One
https://www.readbyqxmd.com/read/27974860/a-novel-microfluidic-assay-for-rapid-phenotypic-antibiotic-susceptibility-testing-of-bacteria-detected-in-clinical-blood-cultures
#18
Christer Malmberg, Pikkei Yuen, Johanna Spaak, Otto Cars, Thomas Tängdén, Pernilla Lagerbäck
BACKGROUND: Appropriate antibiotic therapy is critical in the management of severe sepsis and septic shock to reduce mortality, morbidity and health costs. New methods for rapid antibiotic susceptibility testing are needed because of increasing resistance rates to standard treatment. AIMS: The purpose of this study was to evaluate the performance of a novel microfluidic method and the potential to directly apply this method on positive blood cultures. METHODS: Minimum inhibitory concentrations (MICs) of ciprofloxacin, ceftazidime, tigecycline and/or vancomycin for Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus were determined using a linear antibiotic concentration gradient in a microfluidic assay...
2016: PloS One
https://www.readbyqxmd.com/read/27941249/deficiency-in-prohormone-convertase-pc1-impairs-prohormone-processing-in-prader-willi-syndrome
#19
Lisa C Burnett, Charles A LeDuc, Carlos R Sulsona, Daniel Paull, Richard Rausch, Sanaa Eddiry, Jayne F Martin Carli, Michael V Morabito, Alicja A Skowronski, Gabriela Hubner, Matthew Zimmer, Liheng Wang, Robert Day, Brynn Levy, Ilene Fennoy, Beatrice Dubern, Christine Poitou, Karine Clement, Merlin G Butler, Michael Rosenbaum, Jean Pierre Salles, Maithe Tauber, Daniel J Driscoll, Dieter Egli, Rudolph L Leibel
Prader-Willi syndrome (PWS) is caused by a loss of paternally expressed genes in an imprinted region of chromosome 15q. Among the canonical PWS phenotypes are hyperphagic obesity, central hypogonadism, and low growth hormone (GH). Rare microdeletions in PWS patients define a 91-kb minimum critical deletion region encompassing 3 genes, including the noncoding RNA gene SNORD116. Here, we found that protein and transcript levels of nescient helix loop helix 2 (NHLH2) and the prohormone convertase PC1 (encoded by PCSK1) were reduced in PWS patient induced pluripotent stem cell-derived (iPSC-derived) neurons...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27939095/a-multiscale-bayesian-data-integration-approach-for-mapping-air-dose-rates-around-the-fukushima-daiichi-nuclear-power-plant
#20
Haruko M Wainwright, Akiyuki Seki, Jinsong Chen, Kimiaki Saito
This paper presents a multiscale data integration method to estimate the spatial distribution of air dose rates in the regional scale around the Fukushima Daiichi Nuclear Power Plant. We integrate various types of datasets, such as ground-based walk and car surveys, and airborne surveys, all of which have different scales, resolutions, spatial coverage, and accuracy. This method is based on geostatistics to represent spatial heterogeneous structures, and also on Bayesian hierarchical models to integrate multiscale, multi-type datasets in a consistent manner...
February 2017: Journal of Environmental Radioactivity
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