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https://www.readbyqxmd.com/read/28522030/ensuring-universal-access-to-old-antibiotics-a-critical-but-neglected-priority
#1
C Pulcini, B Beovic, G Béraud, J Carlet, O Cars, P Howard, G Levy-Hara, G Li, D Nathwani, F Roblot, M Sharland
No abstract text is available yet for this article.
May 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28505886/modeling-carbon-emissions-from-urban-traffic-system-using-mobile-monitoring
#2
Daniel Jian Sun, Ying Zhang, Rui Xue, Yi Zhang
Comprehensive analyses of urban traffic carbon emissions are critical in achieving low-carbon transportation. This paper started from the architecture design of a carbon emission mobile monitoring system using multiple sets of equipment and collected the corresponding data about traffic flow, meteorological conditions, vehicular carbon emissions and driving characteristics on typical roads in Shanghai and Wuxi, Jiangsu province. Based on these data, the emission model MOVES was calibrated and used with various sensitivity and correlation evaluation indices to analyze the traffic carbon emissions at microscopic, mesoscopic and macroscopic levels, respectively...
May 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28500990/evaluating-the-safety-impact-of-adaptive-cruise-control-in-traffic-oscillations-on-freeways
#3
Ye Li, Zhibin Li, Hao Wang, Wei Wang, Lu Xing
Adaptive cruise control (ACC) has been considered one of the critical components of automated driving. ACC adjusts vehicle speeds automatically by measuring the status of the ego-vehicle and leading vehicle. Current commercial ACCs are designed to be comfortable and convenient driving systems. Little attention is paid to the safety impacts of ACC, especially in traffic oscillations when crash risks are the highest. The primary objective of this study was to evaluate the impacts of ACC parameter settings on rear-end collisions on freeways...
May 10, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28494259/mechanisms-underlying-cognitive-conspicuity-in-the-detection-of-cyclists-by-car-drivers
#4
Joceline Rogé, Daniel Ndiaye, Isabelle Aillerie, Stéphane Aillerie, Jordan Navarro, Fabrice Vienne
OBJECTIVE: The aim of this study was to evaluate the visibility of cyclists for motorists in a simulated car driving task. BACKGROUND: In several cases involving collisions between cars and cyclists, car drivers failed to detect the latter in time to avoid collision because of their low conspicuity. METHOD: 2 groups of motorists (29.2 years old), including 12 cyclist-motorists and 13 non-cyclist-motorists, performed a vulnerable road user detection task in a car-driving simulator...
May 7, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28484827/-hot-rods-in-the-icu-what-is-the-antibiotic-mileage-of-your-renal-replacement-therapy
#5
REVIEW
J T Kielstein, A K Kruse, N Anderson, H Vaitiekunas, S Scherneck
We would neither be disappointed nor upset if the gas mileage on the sticker of a car didn't match our personal, real-life fuel consumption. Depending on our daily route to work, our style of accelerating and the number of passengers in our carpool, the gas mileage will vary. As soon as the falcon wing door of our car is closed and entrance to the ICU is granted, we tend to forget all of this, even though another hot rod is waiting there for us. Renal replacement therapy is like a car; it fulfills goals, such as the removal of uremic toxins and accumulated fluids, but it also "consumes" (removes) antibiotics...
May 8, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28481176/do-overgeneral-memories-make-us-feel-better-an-experimental-examination
#6
Sarah L Bunnell, Andrea Follmer Greenhoot
A critical assumption of the CaR-FA-X model, that overgeneral memory is partly attributable to the "functional avoidance" of specific details about one's past experiences, has not been experimentally tested. Further, while it is assumed that the reinforcing properties of said avoidance leads to the emergence of an overgeneral recall style over time, this question has not been addressed developmentally. To explore these issues, two studies were conducted. In Study 1, 41 children and adolescents (Mage = 12 years) were randomly assigned to recall overgeneral or specific negative memories on the Autobiographical Memory Test; participants later listened to their memories and provided pre- and post-tests of their emotional states at four time points: before and after memory generation and before and after memory exposure...
May 8, 2017: Memory
https://www.readbyqxmd.com/read/28480271/epidemiological-surveillance-of-poliomyelitis-during-the-military-and-political-conflict-in-the-central-african-republic-2013-and-2014
#7
Alain Farra, Ella C Gonofio, Alexandre Manirakiza, Arthur Mazitchi, Raphaël Mbaïlao, Casimir Manengu, Ionela Gouandjika-Vasilache
BACKGROUND: Since December 2012, the Central African Republic (CAR) has been undergoing a severe military and political conflict. This situation has resulted in general insecurity and total disorganization of surveillance activities, including those for acute flaccid paralysis (AFP). In this study, we used laboratory data to evaluate surveillance of AFP in 2013 and 2014, the most critical period of the conflict. METHODS: The laboratory data on AFP were analyzed retrospectively for the age, sex, vaccination status (oral poliovirus vaccines), and geographical origin of the samples...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28441153/discharge-criteria-for-the-late-preterm-infant-a-review-of-the-literature
#8
Jenny M Quinn, Marteen Sparks, Sheila M Gephart
BACKGROUND: Standardized late preterm infant (LPI) discharge criteria ensure best practice and help guide the neonatal provider to determine the appropriate level of care following birth. However, the location can vary from the well newborn setting to the neonatal intensive care unit (NICU). PURPOSE: The purpose of this review is to examine differences in LPI discharge criteria between the well newborn setting and the NICU by answering the clinical questions, "What are the recommended discharge criteria for the LPI and do they differ if admitted to the well newborn setting versus the NICU?" SEARCH STRATEGY: Databases searched include CINAHL, TRIP, PubMed, and the Cochrane Library...
April 24, 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/28437778/strengthening-governance-for-intertidal-ecosystems-requires-a-consistent-definition-of-boundaries-between-land-and-sea
#9
Stefanie M Rog, Carly N Cook
The protection of intertidal ecosystems is complex because they straddle both marine and terrestrial realms. This leads to inconsistent characterisation as marine and/or terrestrial systems, or neither. Vegetated intertidal ecosystems are especially complex to classify because they can have an unclear border with terrestrial vegetation, causing confusion around taxonomy (e.g., mangrove-like plants). This confusion and inconsistency in classification can impact these systems through poor governance and incomplete protection...
April 21, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28421069/engineering-chimeric-antigen-receptor-t-cells-for-racing-in-solid-tumors-don-t-forget-the-fuel
#10
REVIEW
Melita Irving, Romain Vuillefroy de Silly, Kirsten Scholten, Nahzli Dilek, George Coukos
T-cells play a critical role in tumor immunity. Indeed, the presence of tumor-infiltrating lymphocytes is a predictor of favorable patient prognosis for many indications and is a requirement for responsiveness to immune checkpoint blockade therapy targeting programmed cell death 1. For tumors lacking immune infiltrate, or for which antigen processing and/or presentation has been downregulated, a promising immunotherapeutic approach is chimeric antigen receptor (CAR) T-cell therapy. CARs are hybrid receptors that link the tumor antigen specificity and affinity of an antibody-derived single-chain variable fragment with signaling endodomains associated with T-cell activation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28419659/making-visible-the-politics-and-ethics-of-alcohol-policy-research
#11
David Moore
Although research on alcohol policy has produced a huge international literature, alcohol research and policy itself-its cultural assumptions, methods, politics and ethics-has rarely been subject to critical analysis. In this article, I provide an appreciative review of an exception to this trend: Joseph Gusfield's 1981 classic, The Culture of Public Problems: Drinking-Driving and the Symbolic Order. I first outline Gusfield's argument that the 'problem of drinking-driving' is constructed as a 'drama of individualism' centring on the 'killer drunk'...
April 16, 2017: Addiction
https://www.readbyqxmd.com/read/28417971/greater-cerebellar-gray-matter-volume-in-car-drivers-an-exploratory-voxel-based-morphometry-study
#12
Hiroyuki Sakai, Takafumi Ando, Norihiro Sadato, Yuji Uchiyama
Previous functional neuroimaging studies have identified multiple brain areas associated with distinct aspects of car driving in simulated traffic environments. Few studies, however, have examined brain morphology associated with everyday car-driving experience in real traffic. Thus, the aim of the current study was to identify gray matter volume differences between drivers and non-drivers. We collected T1-weighted structural brain images from 73 healthy young adults (36 drivers and 37 non-drivers). We performed a whole-brain voxel-based morphometry analysis to examine between-group differences in regional gray matter volume...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28412023/precise-prediction-of-activators-for-the-human-constitutive-androstane-receptor-using-structure-based-three-dimensional-quantitative-structure-activity-relationship-methods
#13
Harutoshi Kato, Noriyuki Yamaotsu, Norihiko Iwazaki, Shigeaki Okamura, Toshiyuki Kume, Shuichi Hirono
The constitutive androstane receptor (CAR, NR1I3) regulates the expression of numerous drug-metabolizing enzymes and transporters. The upregulation of various enzymes, including CYP2B6, by CAR activators is a critical problem leading to clinically severe drug-drug interactions (DDIs). To date, however, few effective computational approaches for identifying CAR activators exist. In this study, we aimed to develop three-dimensional quantitative structure-activity relationship (3D-QSAR) models to predict the CAR activating potency of compounds emerging in the drug-discovery process...
February 9, 2017: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28405539/quantifying-biomass-consumption-and-carbon-release-from-the-california-rim-fire-by-integrating-airborne-lidar-and-landsat-oli-data
#14
Mariano Garcia, Sassan Saatchi, Angeles Casas, Alexander Koltunov, Susan Ustin, Carlos Ramirez, Jorge Garcia-Gutierrez, Heiko Balzter
Quantifying biomass consumption and carbon release is critical to understanding the role of fires in the carbon cycle and air quality. We present a methodology to estimate the biomass consumed and the carbon released by the California Rim fire by integrating postfire airborne LiDAR and multitemporal Landsat Operational Land Imager (OLI) imagery. First, a support vector regression (SVR) model was trained to estimate the aboveground biomass (AGB) from LiDAR-derived metrics over the unburned area. The selected model estimated AGB with an R(2) of 0...
February 2017: Journal of Geophysical Research. Biogeosciences
https://www.readbyqxmd.com/read/28377517/nanoparticle-amount-and-not-size-determines-chain-alignment-and-nonlinear-hardening-in-polymer-nanocomposites
#15
H Samet Varol, Fanlong Meng, Babak Hosseinkhani, Christian Malm, Daniel Bonn, Mischa Bonn, Alessio Zaccone, Sapun H Parekh
Polymer nanocomposites-materials in which a polymer matrix is blended with nanoparticles (or fillers)-strengthen under sufficiently large strains. Such strain hardening is critical to their function, especially for materials that bear large cyclic loads such as car tires or bearing sealants. Although the reinforcement (i.e., the increase in the linear elasticity) by the addition of filler particles is phenomenologically understood, considerably less is known about strain hardening (the nonlinear elasticity)...
April 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28366563/solid-phase-microextraction-set-up-for-the-analysis-of-liver-volatolome-to-detect-livestock-exposure-to-micropollutants
#16
Jihéne Bouhlel, Jérémy Ratel, Said Abouelkaram, Frédéric Mercier, Angelique Travel, Elisabeth Baéza, Catherine Jondreville, Gaud Dervilly-Pinel, Philippe Marchand, Bruno Le Bizec, Estelle Dubreil, Sophie Mompelat, Eric Verdon, Chanthadary Inthavong, Thierry Guérin, Douglas N Rutledge, Erwan Engel
Starting from a critical analysis of a first "proof of concept" study on the utility of the liver volatolome for detecting livestock exposure to environmental micropollutants (Berge et al., 2011), the primary aim of this paper is to improve extraction conditions so as to obtain more representative extracts by using an extraction temperature closer to livestock physiological conditions while minimizing analytical variability and maximizing Volatile Organic Compound (VOC) abundancies. Levers related to extraction conditions and sample preparation were assessed in the light of both abundance and coefficient of variation of 22 candidate VOC markers identified in earlier volatolomic studies...
May 12, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28346400/t-lymphocyte-homing-an-underappreciated-yet-critical-hurdle-for-successful-cancer-immunotherapy
#17
Robert Sackstein, Tobias Schatton, Steven R Barthel
Advances in cancer immunotherapy have offered new hope for patients with metastatic disease. This unfolding success story has been exemplified by a growing arsenal of novel immunotherapeutics, including blocking antibodies targeting immune checkpoint pathways, cancer vaccines, and adoptive cell therapy (ACT). Nonetheless, clinical benefit remains highly variable and patient-specific, in part, because all immunotherapeutic regimens vitally hinge on the capacity of endogenous and/or adoptively transferred T-effector (Teff) cells, including chimeric antigen receptor (CAR) T cells, to home efficiently into tumor target tissue...
June 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28334801/a-systematic-review-of-the-physical-activity-assessment-tools-used-in-primary-care
#18
Toby O Smith, Máire C McKenna, Charlotte Salter, Wendy Hardeman, Kathryn Richardson, Melvyn Hillsdon, Carly A Hughes, Nicholas Steel, Andy P Jones
Background.: Primary care is an ideal setting for physical activity interventions to prevent and manage common long-term conditions. To identify those who can benefit from such interventions and to deliver tailored support, primary care professionals (e.g. GPs, practice nurses, physiotherapists, health care assistants) need reliable and valid tools to assess physical activity. However, there is uncertainty about the best-performing tool. Objective.: To identify the tools used in the literature to assess the physical activity in primary care and describe their psychometric properties...
February 21, 2017: Family Practice
https://www.readbyqxmd.com/read/28332869/perceived-enjoyment-concentration-intention-and-speed-violation-behavior-using-flow-theory-and-theory-of-planned-behavior
#19
Charles Atombo, Chaozhong Wu, Hui Zhang, Tina D Wemegah
OBJECTIVE: Road accidents are an important public health concern and speeding is a major contributor. Although, flow theory (FLT) is a valid model for understanding behavior, currently the nature of the roles and interplay, of FLT constructs within the theory of planned behavior (TPB) framework when attempting to explain the determinants of motivations for intention to speed and speeding behavior of car drivers is not yet known. The study aims to synthesize TPB and FLT in explaining drivers of advanced vehicles intention to speed and speed violation behavior and evaluate factors which are critical for explaining intention and behavior...
March 23, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28327843/-geographic-information-systems
#20
Akram Hernández-Vásquez, Diego Azañedo, Guido Bendezú-Quispe, Josmel Pacheco-Mendoza, R Martín Chaparro
The aim of this study was to geospatially explore the occurrence rates of car accidents involving pedestrians in Cercado de Lima (Lima District), Peru. Car accidents involving pedestrians recorded in the 2015 National Police Station Census of the National Statistics and Information Institute were described and georeferenced. Subsequently, a Kernel Density analysis was carried out to locate areas with high, medium, and low density events. Records of 171 car accidents involving pedestrians were studied: the types of vehicles involved were automobiles (56...
October 2016: Revista Peruana de Medicina Experimental y Salud Pública
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