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allograft augmentation

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https://www.readbyqxmd.com/read/29349022/arthroscopic-delivery-of-injectable-bone-graft-for-staged-revision-anterior-cruciate-ligament-reconstruction
#1
Kent T Yamaguchi, Gina M Mosich, Kristofer J Jones
Bone defects caused by femoral and tibial tunnel enlargement can pose a significant technical challenge when planning to perform revision anterior cruciate ligament reconstruction. A number of options have been described for managing osseous deficiencies, including the use of large autograft or allograft bone dowels to provide sufficient tunnel fill and subsequent structural support for revision surgery. These techniques can be time-consuming and technically demanding to ensure proper tunnel fill and press-fit stability of the bone graft...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29348999/open-repair-of-quadriceps-tendon-with-suture-anchors-and-semitendinosus-tendon-allograft-augmentation
#2
Jorge Chahla, Nicholas N DePhillipo, Mark E Cinque, Nicholas I Kennedy, George F Lebus, Filippo Familiari, Gilbert Moatshe, Robert F LaPrade
Quadriceps tendinopathy in an increasingly recognized diagnosis can lead to quadriceps tendon rupture, especially in the older population. It can be caused by repeated micro trauma or also predisposed by systemic diseases such as diabetes mellitus and connective tissue disorders that can in turn lead to extensor mechanism deficits. Although a trial of conservative treatment is advocated, operative treatment should be performed in cases of persistent pain, extension deficit, or complete rupture of the tendon...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29338084/importance-of-b-cells-to-development-of-tregs-and-prolongation-of-tissue-allograft-survival-in-recipients-receiving-autologous-bone-marrow-transplantation
#3
Reginald M Gorczynski, Kaveh Farrokhi, Christopher Gorczynski, Hassan Sadozai, Fang Zhu, Ismat Khatri
We previously showed that congenic bone marrow transplantation (BMTx) post myeloablation augmented tissue allograft survival in association with increased Tregs of both host and bone marrow donor origin. Regulatory B cells (Bregs) can also modulate T cell immunity and B cells may be implicated in the development of Tregs. Accordingly, we explored the effect of B cell depletion in vivo on augmented graft survival post BMTx. C57BL/6 mice received BALB/c skin allografts followed 7d later by myeloablation using cyclophosphamide and busulphan...
January 16, 2018: Immunology
https://www.readbyqxmd.com/read/29318178/outcomes-after-dermal-allograft-reconstruction-of-chronic-or-subacute-pectoralis-major-tendon-ruptures
#4
Julie A Neumann, Christopher M Klein, Carola F van Eck, Hithem Rahmi, John M Itamura
Background: Avoiding delay in the surgical management of pectoralis major (PM) ruptures optimizes outcomes. However, this is not always possible, and when a tear becomes chronic or when a subacute tear has poor tissue quality, a graft can facilitate reconstruction. Purpose: The primary aim was to evaluate the clinical outcomes of PM reconstruction with dermal allograft augmentation for chronic tears or for subacute tears with poor tissue quality. A second aim was to determine patient and surgical factors affecting outcome...
January 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29317260/growth-factor-delivery-strategies-for-rotator-cuff-repair-and-regeneration
#5
Anupama Prabhath, Varadraj N Vernekar, Enid Sanchez, Cato T Laurencin
The high incidence of degenerative tears and prevalence of retears (20-95%) after surgical repair makes rotator cuff injuries a significant health problem. This high retear rate is attributed to the failure of the repaired tissue to regenerate the native tendon-to-bone insertion (enthesis). Biological augmentation of surgical repair such as autografts, allografts, and xenografts are confounded by donor site morbidity, immunogenicity, and disease transmission, respectively. In contrast, these risks may be alleviated via growth factor therapy, which can actively influence the healing environment to promote functional repair...
January 6, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29316182/lateral-bone-augmentation-in-narrow-posterior-mandibles-description-of-a-novel-approach-and-analysis-of-results
#6
Ilan Beitlitum, Alon Sebaoun, Carlos E Nemcovsky, Shimshon Slutzkey
BACKGROUND: Combination of particulate grafts and collagen membranes is widely used for augmentation of bony defects for implant placement. Fixation of the barrier membrane may avoid complications due to unfavorable mechanical properties and poor stability leading to collapse of the augmented area. PURPOSE: To evaluate a new simplified method for resorbable collagen membrane fixation in lateral bone augmentation procedures in narrow posterior mandibles. MATERIALS AND METHODS: This retrospective study analyzed 16 procedures performed in 15 patients who followed lateral ridge augmentation procedures before implant placement in the posterior mandible...
January 8, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29310917/mid-term-results-of-graft-augmentation-prosthesis-ii-cage-and-impacted-allograft-bone-in-revision-hip-arthroplasty
#7
Hazem A H Hosny, Ahmed El-Bakoury, Helmy Fekry, Jonathan Keenan
BACKGROUND: Several techniques have been described for management of severe acetabular bone defects during revision hip surgery including reconstructive cages. The purpose of this study is to analyze the survival and the mid-term clinical and radiological outcome using the Graft Augmentation Prosthesis (GAP II cage) (Stryker Orthopaedics, Mahwah, NJ) in addition to impaction grafting for acetabular defects in revision hip surgery. METHODS: This is a retrospective review of all patients who underwent acetabular revision hip replacement using GAP II cage and impaction bone grafting between 2009 and 2013 at our institution...
December 8, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29248483/dose-dependent-resorption-of-allograft-by-rhbmp-2-uncompensated-by-new-bone-formation-a-canine-study-with-implants-and-zoledronate
#8
Rasmus Cleemann, Joan E Bechtold, Mette Sorensen, Kjeld Soballe, Jorgen Baas
BACKGROUND: Impacted bone allograft is used to restore lost bone in total joint arthroplasties. Bone morphogenetic proteins (BMPs) can induce new bone formation to improve allograft incorporation, but they simultaneously invoke a seemingly dose-dependent allograft resorption mediated by osteoclasts. Bisphosphonates effectively inhibit osteoclast activity. Predicting allograft resorption when augmented with bone morphogenetic protein 2 (BMP-2), we intended to investigate whether a balanced bone metabolism was achievable within a range of BMP-2 doses with systemic zoledronate treatment...
November 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29240210/three-dimensional-bone-augmentation-and-immediate-implant-placement-via-transcrestal-sinus-lift-five-year-clinical-outcomes
#9
Rosario Rizzo, Alessandro Quaranta, Massimo De Paoli, Giorgio Rappelli, Matteo Piemontese
This study proposed a surgical technique that solves three-dimensional conditions of extreme bone atrophy. A total of 278 surgeries with transcrestal sinus lift and fresh frozen allogenous bone blocks were performed. A total of 1,024 implants were placed. After 60 months of observation, 969 implants were considered grade I (successful), 24 grade II (satisfactory survival), and 8 grade III (compromised survival). The cumulative success and survival rates, respectively, were 94.6% and 97.7%. This innovative procedure is very effective in selected cases...
January 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29216869/horizontal-ridge-reconstruction-of-the-anterior-maxilla-using-customized-allogeneic-bone-blocks-with-a-minimally-invasive-technique-a-case-series
#10
Laurent Venet, Michel Perriat, Francesco Guido Mangano, Thomas Fortin
BACKGROUND: Different surgical procedures have been proposed to achieve horizontal ridge reconstruction of the anterior maxilla; all these procedures, however, require bone replacement materials to be adapted to the bone defect at the time of implantation, resulting in complex and time-consuming procedures. The purpose of this study was to describe how to use a 3D printed hardcopy model of the maxilla to prepare customized milled bone blocks, to be adapted on the bone defect areas using a minimally invasive subperiosteal tunneling technique...
December 8, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29202263/does-graft-particle-type-and-size-affect-ridge-dimensional-changes-after-alveolar-ridge-split-procedure
#11
Mohit G Kheur, Supriya Kheur, Tabrez Lakha, Shantanu Jambhekar, Bach Le, Vinay Jain
PURPOSE: The absence of an adequate volume of bone at implant sites requires augmentation procedures before the placement of implants. The aim of the present study was to assess the ridge width gain with the use of allografts and biphasic β-tricalcium phosphate with hydroxyapatite (alloplast) in ridge split procedures, when each were used in small (0.25 to 1 mm) and large (1 to 2 mm) particle sizes. PATIENTS AND METHODS: A randomized controlled trial of 23 subjects with severe atrophy of the mandible in the horizontal dimension was conducted in a private institute...
December 1, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29198938/outcomes-of-arthroscopic-revision-rotator-cuff-repair-with-acellular-human-dermal-matrix-allograft-augmentation
#12
Eric A Hohn, Blake P Gillette, Joseph P Burns
BACKGROUND: The purpose was to assess the minimum 2-year patient-reported outcomes and failure rate of patients who underwent revision arthroscopic rotator cuff repair augmented with acellular human dermal matrix (AHDM) allograft for repairable retears. METHODS: From 2008-2014, patients who underwent revision rotator cuff repair augmented with AHDM with greater than 2 years' follow-up by a single surgeon were retrospectively reviewed. Data regarding surgical history, demographic characteristics, and medical comorbidities were collected...
November 30, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29194937/age-related-new-bone-formation-following-the-use-of-cancellous-bone-block-allografts-for-reconstruction-of-atrophic-alveolar-ridges
#13
Joseph Nissan, Roni Kolerman, Liat Chaushu, Marilena Vered, Sarit Naishlos, Gavriel Chaushu
BACKGROUND: An age-related decrease in the number of osteogenic progenitor cells may compromise bone augmentation. PURPOSE: Histomorphometrical assessment of age-related new bone formation, following atrophic alveolar ridge reconstruction, using cancellous bone-block allografts. MATERIAL AND METHODS: Ninety-three consecutive patients (58 females and 35 males) were referred for implant-supported restoration of 122 severe atrophic alveolar ridges...
December 1, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29184753/tissue-augmentation-with-allograft-adipose-matrix-for-the-diabetic-foot-in-remission
#14
Tala B Shahin, Kairavi V Vaishnav, Marcy Watchman, Vignesh Subbian, Ethan Larson, Evangelia Chnari, David G Armstrong
Background: Repetitive stress on the neuropathic plantar foot is the primary cause of diabetic foot ulcers. After healing, recurrence is common. Modulating plantar pressure has been associated with extension of ulcer free days. Therefore, the goal of this study was to determine the effects of an injectable allograft adipose matrix in providing a protective padding and reducing the pressure in the plantar foot. Methods: After healing his recurrent ulcer using total contact casting, a 71-year-old man with a 9-year history of recurrent diabetic foot ulcers was treated with injection of allograft adipose matrix, procured from donated human tissue...
October 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29178588/early-barriers-to-neonatal-porcine-islet-engraftment-in-a-dual-transplant-model
#15
K P Samy, R P Davis, Q Gao, B M Martin, M Song, J Cano, A B Farris, A McDonald, E K Gall, C R Dove, F V Leopardi, T How, K D Williams, G R Devi, B H Collins, A D Kirk
Porcine islet xenografts have the potential to provide an inexhaustible source of islets for β cell replacement. Proof-of-concept has been established in nonhuman primates. However, significant barriers to xenoislet transplantation remain, including, the poorly understood instant blood mediated inflammatory reaction (IBMIR), and a thorough understanding of early xeno-specific immune responses. A paucity of data exist comparing xeno-specific immune responses to allo-islet responses in primates. We recently developed a dual islet transplant model, which enables direct histological comparison of early engraftment immunobiology...
November 25, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29167416/second-look-arthroscopic-evaluation-and-clinical-outcomes-of-anatomic-anterior-cruciate-ligament-reconstruction-with-autograft-and-hybrid-graft-a-retrospective-study
#16
Hongtao Xu, Jiangtao Dong, Dongmei Xin, Jian Zhang, Kai Kang, Shijun Gao
BACKGROUND Graft choice is very controversial. This study compared the second-look evaluation and clinical outcomes of anatomic ACL-R using a thin autograft versus a thick hybrid graft. MATERIAL AND METHODS Sixty-eight patients who had received ACL-R with hamstring autograft or autograft-allograft hybrid graft accepted second-look arthroscopy were grouped (autograft: n=31, age: 32.8±8.9, Male/Female: 16/15, and hybrid graft: n=37, age: 33.9±8.4, Male/Female: 27/10). Patients were evaluated with the functional score and KT-1000 test before reconstruction...
November 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29166217/the-radiologist-s-primer-to-imaging-the-noncuff-nonlabral-postoperative-shoulder
#17
Christopher R Smith, Jason T Yoon, Jeremiah R Long, Michael V Friedman, Travis J Hillen, James D Stensby
Many radiologists are familiar with the preoperative imaging assessment of patients with labral tears, rotator cuff abnormalities, and end-stage arthritis, as well as the subsequent primary reconstructions and repairs commonly encountered in routine clinical management. However, the second-line surgical procedures and augmentation procedures performed for refractory or recurrent shoulder instability and the extra-articular surgical procedures of the shoulder girdle may challenge even the most experienced musculoskeletal radiologist...
November 22, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29135351/human-studies-of-vertical-and-horizontal-alveolar-ridge-augmentation-comparing-different-types-of-bone-graft-materials-a-systematic-review
#18
Suraj Chavda, Liran Levin
Alveolar ridge augmentation can be completed with various types of bone augmentation materials (autogenous, allograft, xenograft & alloplast). Currently autogenous bone is labelled as the "gold standard" due to faster healing times and integration between native and foreign bone. No systematic review has currently determined whether there is a difference of implant success between various bone augmentation materials. The purpose of this paper was to systematically review comparative human studies of vertical and horizontal alveolar ridge augmentation comparing different types of bone graft materials (autogenous, allograft, xenograft & alloplast)...
November 14, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29120889/bone-resorption-during-submerged-healing-after-guided-bone-regeneration-a-prospective-case-series
#19
Yong Hur, Yumi Ogata, Douglas W Kim, Charles M Pham, Tae-Ho Yoon, Hirokazu Ogata
OBJECTIVE: The aim of this study was to evaluate bone resorption quantitatively during the healing period subsequent to ridge augmentation. MATERIALS AND METHODS: Sixteen patients requiring vertical ridge augmentation before implant placement were recruited in the study. The study used an allograft and nonresorbable membrane. A custom acrylic stent was used to measure changes in bone volume. Augmented bone was compared with remaining bone 6 months after guided bone regeneration (α = 0...
December 2017: Implant Dentistry
https://www.readbyqxmd.com/read/29095664/graphene-based-scaffolds-on-bone-tissue-engineering
#20
Nasrin Shadjou, Mohammad Hasanzadeh, Balal Khalilzadeh
Tissue engineering has been emerging as a valid approach to the current therapies for bone regeneration/substitution. Tissue-engineered bone constructs have the potential to alleviate the demand arising from the shortage of suitable autograft and allograft materials for augmenting bone healing. Scaffolds play a central role in tissue engineering research, they not only provide as structural support for specific cells but also provide as the templates to guide new tissue growth and construction. In this survey we describe application of graphene based nano-biomaterials for bone tissue engineering...
November 2, 2017: Bioengineered
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