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allograft augmentation

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https://www.readbyqxmd.com/read/28894277/host-expression-of-the-cd8-treg-nk-cell-restriction-element-qa-1-is-dispensable-for-transplant-tolerance
#1
Blair T Stocks, Christopher S Wilson, Andrew F Marshall, Lauren A Brewer, Daniel J Moore
Disruption of the non-classical Major Histocompatibility Complex (MHC) Ib molecule Qa-1 impairs CD8 Treg and natural killer (NK) cell function and promotes a lupus-like autoimmune disease. This immune perturbation would be expected to enhance anti-transplant responses and impair tolerance induction, but the effect of Qa-1 deficiency on the transplant response has not been previously reported. Qa-1 deficiency enhanced CD4 TFH and germinal center (GC) B cell numbers in naïve mice and hastened islet allograft rejection...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28886100/biomechanical-evaluation-of-tibial-bone-adaptation-after-revision-total-knee-arthroplasty-a-comparison-of-different-implant-systems
#2
María Paz Quilez, Belen Seral, María Angeles Pérez
The best methods to manage tibial bone defects following total knee arthroplasty remain under debate. Different fixation systems exist to help surgeons reconstruct knee osseous bone loss (such as tantalum cones, cement, modular metal augments, autografts, allografts and porous metaphyseal sleeves) However, the effects of the various solutions on the long-term outcome remain unknown. In the present work, a bone remodeling mathematical model was used to predict bone remodeling after total knee arthroplasty (TKA) revision...
2017: PloS One
https://www.readbyqxmd.com/read/28865557/multimodality-noninvasive-imaging-in-the-monitoring-of-pediatric-heart-transplantation
#3
REVIEW
Steven J Kindel, Hao H Hsu, Tarique Hussain, Jonathan N Johnson, Colin J McMahon, Shelby Kutty
Orthotopic heart transplantation is a well-established and effective therapeutic option for children with end-stage heart failure. Multiple modalities, including noninvasive cardiac imaging, cardiac catheterization, angiography, and endomyocardial biopsy, are helpful to monitor these patients for graft dysfunction, rejection, and vasculopathy. Because of morbidities associated with invasive monitoring, noninvasive imaging plays a key role in the surveillance and evaluation of symptoms in pediatric transplant recipients...
September 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28860398/revision-anatomical-reconstruction-of-the-lateral-ligaments-of-the-ankle-augmented-with-suture-tape-for-patients-with-a-failed-brostr%C3%A3-m-procedure
#4
B K Cho, Y M Kim, S M Choi, H W Park, N F SooHoo
AIMS: The aim of this prospective study was to evaluate the intermediate-term outcomes after revision anatomical ankle ligament reconstruction augmented with suture tape for a failed modified Broström procedure. PATIENTS AND METHODS: A total of 30 patients with persistent instability of the ankle after a Broström procedure underwent revision augmented with suture tape. Of these, 24 patients who were followed up for more than two years were included in the study...
September 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28836446/modified-brostr%C3%A3-m-procedure-using-distal-fibular-periosteal-flap-augmentation-vs-anatomic-reconstruction-using-a-free-tendon-allograft-in-patients-who-are-not-candidates-for-standard-repair
#5
Hong Joon Choi, Dae Wook Kim, Jea Seok Park
BACKGROUND: The modified Broström procedure (MBP) is widely accepted as the primary operative treatment for chronic lateral ankle instability (CLAI). However, the MBP does not produce good clinical results in all patients, and anatomic reconstruction using a free tendon graft may be considered in those patients. The purpose of this study was to evaluate the efficacy of the MBP using distal fibular periosteal flap augmentation for CLAI in patients who were not candidates for standard repair...
August 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28817160/extensor-mechanism-reconstruction-for-chronic-patellar-fracture
#6
Antonio Cusano, Emily J Curry, Lee N Marinko, Xinning Li
Patients with displaced patellar fractures typically present with disruption to the extensor mechanism requiring acute surgical intervention. Chronic patellar fractures with disruption of the extensor mechanism are uncommon, and few surgical options are available. The authors present a patient who sustained a fracture to the inferior pole of the patella in Africa 5 years prior that was managed conservatively with bands and a brace. He decided to pursue surgical intervention because of difficulties with leg extension, weakness, and ambulation...
August 17, 2017: Orthopedics
https://www.readbyqxmd.com/read/28806294/the-tissue-engineered-tendon-bone-interface-in-vitro-and-in-vivo-synergistic-effects-of-adipo-derived-stem-cells-platelet-rich-plasma-and-extracellular-matrix-hydrogel
#7
Rory McGoldrick, Arhana Chattopadhyay, Christopher Crowe, Grace Chiou, Kenneth Hui, Simon Farnebo, Christopher Davis, Anais Le Grand, Molly Jacobs, Hung Pham, James Chang
INTRODUCTION: Suboptimal healing of the tendon bone interface (TBI) remains an unsolved problem. One solution is a biocompatible tissue engineered construct that promotes augmented healing. We hypothesisze that 1.) the presence of Platelet Rich Plasma (PRP) and prolonged in vitro incubation produces tissue engineered tendon bone interface scaffolds with greater reseeding of viable Adipo-derived Stem Cells (ADSC) and 2.) when implanted with extracellular matrix hydrogel, constructs will display superior in vivo strength repair and biocompatibility...
August 3, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28802414/management-of-resistant-distal-femur-non-unions-with-allograft-strut-and-autografts-combined-with-osteosynthesis-in-a-series-of-22-patients
#8
Raja Bhaskara Kanakeshwar, Dheenadhayalan Jayaramaraju, Devendra Agraharam, Shanmuganathan Rajasekaran
INTRODUCTION AND PURPOSE: Challenges to the surgeon in managing cases of resistant non-union of the distal femur include poor bone stock, disuse osteopenia and joint contractures. Procedures varying from simple bone grafting to megaprosthesis revision have been described. We successfully managed such cases using our technique of combining cortical allograft struts to augment the defect in the femoral condyle coupled with autogenous iliac crest bone grafting and locking plate osteosynthesis...
August 2017: Injury
https://www.readbyqxmd.com/read/28777920/complications-associated-with-the-use-of-recombinant-human-bone-morphogenic-protein-2-in-ridge-augmentation-a-case-report
#9
Panagiotis Dragonas, Charles Palin, Saba Khan, Praveen Gajendrareddy, Whitney Weiner
This case report aims to describe in detail a complication associated with resorption of regenerated bone following implant placement and ridge augmentation using rhBMP-2 in combination with allograft and xenograft. Bilateral maxillary sinus and ridge augmentation procedures were completed using rhBMP-2 combined with allograft and xenograft. Five months later, significant bone augmentation was achieved which allowed for the placement of 4 implants. Upon stage 2 surgery, significant dehiscence was noted in all implants...
August 4, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28772243/daphnoretin-modulates-differentiation-and-maturation-of-human-dendritic-cells-through-down-regulation-of-c-jun-n-terminal-kinase
#10
Chien-An Chen, Chien-Kuo Liu, Ming-Ling Hsu, Chih-Wen Chi, Chun-Chuan Ko, Jian-Syun Chen, Cheng-Ta Lai, Hen-Hong Chang, Tzung-Yan Lee, Yuen-Liang Lai, Yu-Jen Chen
Daphnoretin, an active constituent of Wikstroemia indica C.A. Meys, has been shown possessing anti-cancer activity. In this study, we examined the effect of daphnoretin on differentiation and maturation of human myeloid dendritic cells (DCs). After treatment with daphnoretin (0, 1.1, 3.3, 10 and 30μM) to initiate monocytes, the recovery rate of DCs was reduced in a dose-dependent manner. The mature DCs differentiated in the presence of daphnoretin had fewer and shorter dendrites. Daphnoretin modulated DCs differentiation and maturation in terms of lower expression of CD1a, CD40, CD83, DC-SIGN, and HLA-DR...
July 31, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28752693/comparison-between-mineralized-cancellous-bone-allograft-and-an-alloplast-material-for-sinus-augmentation-a-split-mouth-histomorphometric-study
#11
Roni Kolerman, Joseph Nissan, Marina Rahmanov, Hana Vered, Omer Cohen, Haim Tal
BACKGROUND: Several grafting materials have been used in sinus augmentation procedures including autogenous bone, demineralized freeze-dried bone, hydroxyapatite, β-tricalcium phosphate, anorganic deproteinized bovine bone, and combination of these and others. Yet, the issue of the optimal graft material for sinus floor augmentation is controversial. PURPOSE: This prospective, randomized split-mouth study was undertaken to histomorphometrically compare a biphasic calcium phosphate (BCP) alloplastic bone substitute and a human bone mineral allograft (freeze-dried bone allograft, FDBA) in patients undergoing bilateral maxillary lateral sinus floor augmentation...
July 27, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28706848/bipolar-bone-loss-of-the-shoulder-joint-due-to-recurrent-instability-use-of-fresh-osteochondral-distal-tibia-and-humeral-head-allografts
#12
Daniel B Haber, Anthony Sanchez, George Sanchez, Marcio B Ferrari, Sami Ferdousian, Matthew T Provencher
With increasing shoulder instability events, the likelihood of a bony lesion of the glenoid and/or humeral head rises. Although bone loss of either the glenoid or humeral head may result in recurrent instability, bipolar lesions have been shown, in particular, to result in a negative and additive effect on glenohumeral stability. In the case of a bipolar lesion comprising severe glenoid bone loss and an engaging, "off-track" Hill-Sachs lesion, the bony foundation of the glenohumeral joint is compromised and bony augmentation is necessary...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28706796/arthroscopic-removal-of-a-loose-polyethylene-glenoid-component-with-bone-grafting-and-patch-augmentation-for-glenoid-osseous-defect
#13
Jeffrey T Abildgaard, Jared C Bentley, Richard J Hawkins, John M Tokish
Glenoid component loosening is a common cause of failed total shoulder arthroplasty. Many different treatment options exist for the management of a symptomatic loose polyethylene glenoid component, ranging from component removal to revision arthroplasty. Arthroscopic removal and conversion to hemiarthroplasty provides a minimally invasive management option that avoids takedown of the subscapularis and allows for humeral prosthesis retention. Frequently, however, osteolysis is encountered concomitantly leading to cavitary glenoid bone deficits at the time of glenoid implant removal, limiting both immediate and future treatment options...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28706180/serum-uric-acid-and-arterial-function-after-renal-transplantation
#14
Frederic Bauer, Nikolaos Pagonas, Felix S Seibert, Walter Zidek, Richard Viebahn, Nina Babel, Timm H Westhoff
BACKGROUND Hyperuricemia is associated with an increased risk of cardiovascular disease and chronic allograft nephropathy after renal transplantation. It has recently been demonstrated that treatment of asymptomatic hyperuricemia is associated with improved patient and graft survival; although, the underlying mechanisms remain elusive. The present study investigated the association of serum uric acid (SUA) and systemic arterial function after renal transplantation. MATERIAL AND METHODS In a cross-sectional study, arterial function was analyzed in 54 renal transplant recipients by means of pulse wave analysis...
July 14, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28686641/the-prognostic-importance-of-cxcr3-chemokine-during-organizing-pneumonia-on-the-risk-of-chronic-lung-allograft-dysfunction-after-lung-transplantation
#15
Michael Y Shino, S Samuel Weigt, Ning Li, Vyacheslav Palchevskiy, Ariss Derhovanessian, Rajan Saggar, David M Sayah, Richard H Huynh, Aric L Gregson, Michael C Fishbein, Abbas Ardehali, David J Ross, Joseph P Lynch, Robert M Elashoff, John A Belperio
RATIONALE: Since the pathogenesis of chronic lung allograft dysfunction (CLAD) remains poorly defined with no known effective therapies, the identification and study of key events which increase CLAD risk is a critical step towards improving outcomes. We hypothesized that bronchoalveolar lavage fluid (BALF) CXCR3 ligand concentrations would be augmented during organizing pneumonia (OP) and that episodes of OP with marked chemokine elevations would be associated with significantly higher CLAD risk...
2017: PloS One
https://www.readbyqxmd.com/read/28672142/how-effective-is-the-tent-screw-pole-technique-compared-to-other-forms-of-horizontal-ridge-augmentation
#16
George R Deeb, Dan Tran, Caroline K Carrico, Erin Block, Daniel M Laskin, Janina Golob Deeb
PURPOSE: The tent screw pole technique is one of the methods available for practitioners to perform horizontal ridge augmentation to facilitate dental implant placement. The purpose of this study was to evaluate the efficacy of the tent screw pole technique for horizontal ridge augmentation and to compare the results with those of the tunnel technique and open ridge augmentation. PATIENTS AND METHODS: In this retrospective cohort study, 35 patients underwent horizontal ridge augmentation with the tent screw pole technique, a 1:1 ratio of mineralized freeze-dried bone allograft and particulate bovine hydroxyapatite, and a resorbable collagen membrane...
June 13, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28663406/intercalary-allograft-augmented-with-intramedullary-cement-and-plate-fixation-is-a-reliable-solution-after-resection-of-a-diaphyseal-tumour
#17
S Gupta, L A Kafchinski, K R Gundle, K Saidi, A M Griffin, J S Wunder, P C Ferguson
AIMS: Intercalary allografts following resection of a primary diaphyseal tumour have high rates of complications and failures. At our institution intercalary allografts are augmented with intramedullary cement and fixed using compression plating. Our aim was to evaluate their long-term outcomes. PATIENTS AND METHODS: A total of 46 patients underwent reconstruction with an intercalary allograft between 1989 and 2014. The patients had a mean age of 32.8 years (14 to 77)...
July 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28662954/structural-allograft-supporting-a-trabecular-metal-cup-provides-durable-results-in-complex-revision-arthroplasty
#18
Hernan A Prieto, Michael E Kralovec, Daniel J Berry, Robert T Trousdale, Rafael J Sierra, Miguel E Cabanela
BACKGROUND: Revision total hip arthroplasty (THA) is challenging specially in the presence of severe acetabular bone deficiency. We report the use of a highly porous revision shell augmented by structural allograft to provide structural support and coverage to the acetabular component. METHODS: We identified 56 patients (58 hips) undergoing revision THA, where a trabecular metal revision cup was supported by structural allograft. Mean follow-up was 5.4 years (range 2-12 years)...
June 8, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28660143/distal-triceps-injuries-including-snapping-triceps-a-systematic-review-of-the-literature
#19
Kimberley Shuttlewood, James Beazley, Christopher D Smith
AIM: To review current literature on types of distal triceps injury and determine diagnosis and appropriate management. METHODS: We performed a systematic review in PubMed, Cochrane and EMBASE using the terms distal triceps tears and snapping triceps on the 10(th) January 2017. We excluded all animal, review, foreign language and repeat papers. We reviewed all papers for relevance and of the papers left we were able to establish the types of distal triceps injury, how these injuries are diagnosed and investigated and the types of management of these injuries including surgical...
June 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28657571/management-of-metaphyseal-bone-loss-in-revision-knee-arthroplasty
#20
Francesco Mancuso, Arianna Beltrame, Elia Colombo, Enrick Miani, Fabrizio Bassini
BACKGROUND AND AIM OF THE WORK: Revision total knee arthroplasty (TKA) is usually made more complex by the presence of bone defects, which may be caused by periprosthethic infection, polyethylene wear, implant loosening or fractures. The main aim of the present work is to review the available literature to understand the current options to manage with the bone loss during knee revisions. METHODS: Available English literature for bone defects in revision TKAs has been evaluated looking at treatment options and their results in terms of clinical and radiological outcomes and failure rates...
June 7, 2017: Acta Bio-medica: Atenei Parmensis
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