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https://www.readbyqxmd.com/read/28892184/systematic-review-with-meta-analysis-the-global-recurrence-rate-of-helicobacter-pylori
#1
REVIEW
Y Hu, J-H Wan, X-Y Li, Y Zhu, D Y Graham, N-H Lu
BACKGROUND: Up-to-date information regarding the recurrence rate of Helicobacter pylori (H. pylori) after eradication therapy is not available. AIM: To evaluate the global recurrence rate following H. pylori eradication therapy and confirm its association with socioeconomic and sanitary conditions. METHODS: A systematic search of PubMed, EMBASE and the Cochrane library was performed to identify potentially relevant publications using the following keywords: "Helicobacter pylori" or "H...
November 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28662503/the-effects-of-switching-to-vonoprazan-a-novel-potassium-competitive-acid-blocker-on-gastric-acidity-and-reflux-patterns-in-patients-with-erosive-esophagitis-refractory-to-proton-pump-inhibitors
#2
Hiroshi Yamashita, Atsushi Kanamori, Chise Kano, Hiroki Hashimura, Kei Matsumoto, Masahiro Tsujimae, Tetsuya Yoshizaki, Kenji Momose, Daisuke Obata, Takaaki Eguchi, Mikio Fujita, Akihiko Okada
BACKGROUND/AIM: The effects of vonoprazan and proton pump inhibitors (PPIs) in patients with reflux esophagitis (RE) have not yet been compared using multichannel intraluminal impedance-pH (MII-pH). METHODS: A total of 8 patients with persistent gastric mucosal injury, despite completing an 8-week standard PPI therapy, were enrolled in the study. While they were on standard PPI therapy, the baseline values of reflux parameters, holding time ratio (HTR) of gastric pH >4, and esophageal pH <4 were obtained by using 24 h MII-pH monitoring...
2017: Digestion
https://www.readbyqxmd.com/read/28507835/endoscopic-view-of-gastroduodenal-artery-coils-at-the-base-of-duodenal-ulcer-in-case-of-recurrent-massive-upper-gastrointestinal-bleed
#3
Rawaa Ebrahem, Salam Kadhem, John W Frey, William Salyers
Helicobacter pylori (H. pylori) infection is one of the major causes of bleeding peptic ulcer disease, which is associated with serious complications; therefore, the eradication of H. pylori is essential to prevent these devastating complications. Post-treatment follow-up is crucial to guarantee the eradication of the organism and may be conducted via the urea breath test, the stool antigen test, or a gastric biopsy. Acute massive upper gastrointestinal (UGI) bleeding is one of the most common complications of peptic ulcer disease...
April 13, 2017: Curēus
https://www.readbyqxmd.com/read/28440977/low-re-infection-rate-of-helicobacter-pylori-after-successful-eradication-in-thailand-a-2-years-study
#4
Ratha Korn Vilaichone, Arti Wongcha Um, Peranart Chotivitayatarakorn
Background: H. pylori is an important cause of chronic gastritis, peptic ulcers and gastric cancer. Re-infection rates after successful eradication vary in different regions of the world but only limited studies have been performed in ASEAN Countries to clarify this important issue. The present study was designed to evaluate the H. pylori re-infection rate and predictors of re-infection in Thailand. Methods: We recruited patients with chronic gastritis after 1 and 2 years successful H. pylori eradication from Thammasat University Hospital, Pathumthani (Central urban area) and Maesod district, Tak (Northern rural area), Thailand...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28440099/antibiotic-susceptibility-of-helicobacter-pylori-in-iceland
#5
Anna Ingibjorg Gunnarsdottir, Hallgrimur Gudjonsson, Hjordis Hardardottir, Karen Drofn Jonsdottir, Einar Stefan Bjornsson
BACKGROUND: Increasing resistance of Helicobacter pylori (H. pylori) to antibiotics calls for constant re-evaluation of multidrug regimens that have been used to eradicate the infection. The aim of this study was to evaluate the current antibiotic susceptibility of H. pylori in an Icelandic cohort. METHODS: Patients referred for gastroscopy were recruited prospectively. Those found to have a positive rapid urease test were included in the study. Susceptibility testing was conducted by the Epsilometer test (E-test) method for ampicillin, clarithromycin, levofloxacin, metronidazole and tetracycline...
April 25, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/27785038/association-of-medications-for-lifestyle-related-diseases-with-reflux-esophagitis
#6
Daisuke Asaoka, Akihito Nagahara, Mariko Hojo, Kenshi Matsumoto, Hiroya Ueyama, Kohei Matsumoto, Kentaro Izumi, Tsutomu Takeda, Hiroyuki Komori, Yoichi Akazawa, Yuji Shimada, Taro Osada, Sumio Watanabe
BACKGROUND: Because of a change in lifestyle, especially adoption of westernized eating habits, lifestyle-related diseases have become increasingly prevalent. The aim of this study was to investigate the association of medications for lifestyle-related diseases with reflux esophagitis (RE). METHODS: We conducted a hospital-based, cross-sectional retrospective study of consecutive outpatients who received an upper gastrointestinal endoscopy in our department from February 2008 to November 2014, which was performed by one specialist who was a member of the Japan Gastroenterological Endoscopy Society...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27766298/epithelial-regeneration-after-gastric-ulceration-causes-prolonged-cell-type-alterations
#7
Eitaro Aihara, Andrea L Matthis, Rebekah A Karns, Kristen A Engevik, Peihua Jiang, Jiang Wang, Bruce R Yacyshyn, Marshall H Montrose
BACKGROUND & AIMS: The peptic ulcer heals through a complex process, although the ulcer relapse often occurs several years later after healing. Our hypothesis is that even after visual evidence of healing of gastric ulceration, the regenerated epithelium is aberrant for an extended interval, increasing susceptibility of the regenerated epithelium to damage and further diseases. METHODS: Gastric ulcers were induced in mice by serosal topical application of acetic acid...
September 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27707777/management-of-helicobacter-pylori-infection-the-maastricht-v-florence-consensus-report
#8
P Malfertheiner, F Megraud, C A O'Morain, J P Gisbert, E J Kuipers, A T Axon, F Bazzoli, A Gasbarrini, J Atherton, D Y Graham, R Hunt, P Moayyedi, T Rokkas, M Rugge, M Selgrad, S Suerbaum, K Sugano, E M El-Omar
Important progress has been made in the management of Helicobacter pylori infection and in this fifth edition of the Maastricht Consensus Report, key aspects related to the clinical role of H. pylori were re-evaluated in 2015. In the Maastricht V/Florence Consensus Conference, 43 experts from 24 countries examined new data related to H. pylori in five subdivided workshops: (1) Indications/Associations, (2) Diagnosis, (3) Treatment, (4) Prevention/Public Health, (5) H. pylori and the Gastric Microbiota. The results of the individual workshops were presented to a final consensus voting that included all participants...
January 2017: Gut
https://www.readbyqxmd.com/read/27441820/pepsinogens-to-distinguish-patients-with-gastric-intestinal-metaplasia-and-helicobacter-pylori-infection-among-populations-at-risk-for-gastric-cancer
#9
Valli De Re, Enrico Orzes, Vincenzo Canzonieri, Stefania Maiero, Mara Fornasarig, Lara Alessandrini, Silvia Cervo, Agostino Steffan, Giorgio Zanette, Cinzia Mazzon, Paolo De Paoli, Renato Cannizzaro
OBJECTIVES: The objectives of this study were to investigate the serum pepsinogen test for the prediction of OLGIM (Operative Link on Gastric Intestinal Metaplasia Assessment) stages in first-degree relatives (FDR-GC) of patients with gastric cancer (GC) and autoimmune chronic atrophic gastritis (ACAG). METHODS: In 67 consecutive patients with ACAG, 82 FDR-GC, and 53 controls (CTRL) without gastric disease (confirmed by biopsy), serum levels of pepsinogen 1 (PG1), pepsinogen 2 (PG2), G17, and the PG1/2 ratio were assessed by enzyme-linked immunosorbent assay kit...
July 21, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27355861/clarithromycin-resistance-and-prevalence-of-helicobacter-pylori-virulent-genotypes-in-patients-from-southern-m%C3%A3-xico-with-chronic-gastritis
#10
Judit Alarcón-Millán, Gloria Fernández-Tilapa, Enoc Mariano Cortés-Malagón, Carlos Alberto Castañón-Sánchez, José De Sampedro-Reyes, Iván Cruz-Del Carmen, Reyes Betancourt-Linares, Adolfo Román-Román
In developing countries, clarithromycin resistance and frequency of re-infection are factors that contribute to high prevalence of Helicobacter pylori infection. The aim of this research was determine the prevalence of clarithromycin resistance and its relation with A2142G, A2142C and A2143G mutations in the domain V of the 23S rRNA gene of H. pylori isolates in patients from Southern Mexico with chronic gastritis. Another purpose of this work was to study the prevalence of virulent genotypes and distribution of resistant strains according to the vacA/cagA/babA2 H...
October 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27312831/-non-helicobacter-pylori-non-nonsteroidal-anti-inflammatory-drug-peptic-ulcer-disease
#11
REVIEW
Young Woon Chang
Non-Helicobacter pylori, non-NSAID peptic ulcer disease (PUD), termed idiopathic PUD, is increasing in Korea. Diagnosis is based on exclusion of common causes such as H. pylori infection, infection with other pathogens, surreptitious ulcerogenic drugs, malignancy, and uncommon systemic diseases with upper gastrointestinal manifestations. The clinical course of idiopathic PUD is delayed ulcer healing, higher recurrence, higher re-bleeding after initial ulcer healing, and higher mortality than the other types of PUD...
June 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/27211882/dual-priming-oligonucleotide-based-multiplex-pcr-using-tissue-samples-from-the-rapid-urease-test-kit-for-the-detection-of-helicobacter-pylori-in-bleeding-peptic-ulcers
#12
Woo Chul Chung, Eun Jung Jeon, Jung Hwan Oh, Jae Myung Park, Tae Ho Kim, Dae Young Cheung, Byung Wook Kim, Sung Soo Kim, Jin Il Kim
BACKGROUND: In patients with peptic ulcer bleeding (PUB), diagnostic tests for Helicobacter pylori (H. pylori) infection have low sensitivity. The aim of our study was to investigate the diagnostic yield of dual-priming oligonucleotide-based multiplex (DPO)-PCR using tissue samples from the rapid urease test (RUT, CLO(®)test) kit in patients with PUB. METHODS: We prospectively enrolled patients with PUB. During second-look endoscopy, gastric biopsy specimens for histology and RUT were obtained from a total of 170 patients...
August 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27041578/epigenetic-silencing-of-mir-124-prevents-spermine-oxidase-regulation-implications-for-helicobacter-pylori-induced-gastric-cancer
#13
T Murray-Stewart, J C Sierra, M B Piazuelo, R M Mera, R Chaturvedi, L E Bravo, P Correa, B G Schneider, K T Wilson, R A Casero
Chronic inflammation contributes to the development of various forms of cancer. The polyamine catabolic enzyme spermine oxidase (SMOX) is induced in chronic inflammatory conditions, including Helicobacter pylori-associated gastritis, where its production of hydrogen peroxide contributes to DNA damage and subsequent tumorigenesis. MicroRNA expression levels are also altered in inflammatory conditions; specifically, the tumor suppressor miR-124 becomes silenced by DNA methylation. We sought to determine if this repression of miR-124 is associated with elevated SMOX activity and concluded that miR-124 is indeed a negative regulator of SMOX...
October 20, 2016: Oncogene
https://www.readbyqxmd.com/read/27003991/vaccine-against-helicobacter-pylori-inevitable-approach
#14
REVIEW
Amin Talebi Bezmin Abadi
Over three decades have passed since the discovery of Helicobacter pylori (H. pylori), and yet many questions about its treatment remain unanswered. For example, there is no certainty regarding continued use of current antibiotic therapy against H. pylori. The bad news is that even combined regimens are also unable to eradicate bacterial colonization. The worst problem with H. pylori chemotherapy is that even if we identify the most successful regimen, it cannot eliminate the risk of re-infection. This problem is further complicated by the fact that clinicians have no information as to whether probiotics are useful or not...
March 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26890160/helicobacter-negative-gastritis-polymerase-chain-reaction-for-helicobacter-dna-is-a-valuable-tool-to-elucidate-the-diagnosis
#15
S Kiss, V Zsikla, A Frank, N Willi, G Cathomas
BACKGROUND: Helicobacter-negative gastritis has been increasingly reported. Molecular techniques as the polymerase chain reaction (PCR) may detect bacterial DNA in histologically negative gastritis. AIM: To evaluate of Helicobacter PCR in gastric biopsies for the daily diagnostics of Helicobacter-negative gastritis. METHODS: Over a 5-year period, routine biopsies with chronic gastritis reminiscent of Helicobacter infection, but negative by histology, were tested by using a H...
April 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/26789391/gastroesophageal-reflux-disease-in-time-covering-eradication-for-all-patients-infected-with-helicobacter-pylori-in-japan
#16
REVIEW
Mitsushige Sugimoto, Takahiro Uotani, Hitomi Ichikawa, Akira Andoh, Takahisa Furuta
BACKGROUND: The prevalence of gastroesophageal reflux disease (GERD) has increased in Japan since the end of the 20th century due to changes in environmental factors, such as a decreased infection rate of Helicobacter pylori and increased ability of acid secretion in the Japanese population. In 2013, the Japanese health insurance system started to cover eradication treatment for all patients infected with H. pylori to prevent gastric cancer, suggesting we may soon be able to completely eradicate this infection in Japan...
2016: Digestion
https://www.readbyqxmd.com/read/26784882/diagnosis-of-helicobacter-pylori-recurrence-relapse-or-reinfection-usefulness-of-molecular-tools
#17
Josette Raymond, Jean Michel Thiberge, Catherine Dauga
BACKGROUND AND AIMS: Infection due to Helicobacter pylori causes many gastrointestinal diseases including peptic ulcers and gastric carcinoma. Their treatment and prevention depends on the successful eradication of H. pylori. However, even after a well-conducted treatment, H. pylori persists in about 10-30% of patients. Recurrent infections can correspond to relapse or to re-infection and require appropriate medical care. In this study, we explore retrospectively three clinical cases using molecular methods, and propose new guidelines for the diagnosis of recurrence...
2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/26430475/epidemiology-of-helicobacter-pylori-infection-in-dyspeptic-ghanaian-patients
#18
Timothy Nii Akushe Archampong, Richard Harry Asmah, Edwin Kwame Wiredu, Richard Kwasi Gyasi, Kofi Nyaako Nkrumah, Kumar Rajakumar
INTRODUCTION: Helicobacter pylori is a gram-negative urease-producing bacterium causally linked with gastritis, peptic ulcer disease and gastric adenocarcinoma. Infection is more frequent and acquired at an earlier age in developing countries compared to European populations. The incidence of Helicobacter pylori infection in dyspeptic Ghanaian patients was 75.4%. However, epidemiological factors associated with infection vary across populations. METHODS: This study used a cross-sectional design to consecutively sample dyspeptic patients at the Endoscopy Unit of the Korle-Bu Teaching Hospital, Accra between 2010 and 2012...
2015: Pan African Medical Journal
https://www.readbyqxmd.com/read/26229405/clinical-characteristics-of-helicobacter-pylori-negative-drug-negative-peptic-ulcer-bleeding
#19
COMPARATIVE STUDY
Woo Chul Chung, Eun Jung Jeon, Dae Bum Kim, Hea Jung Sung, Yeon-Ji Kim, Eun Sun Lim, Min-Ah Kim, Jung Hwan Oh
AIM: To investigate the clinical characteristics and outcomes of idiopathic Helicobacter pylori (H. pylori)-negative and drug-negative] peptic ulcer bleeding (PUB). METHODS: A consecutive series of patients who experienced PUB between 2006 and 2012 was retrospectively analyzed. A total of 232 patients were enrolled in this study. The patients were divided into four groups according to the etiologies of PUB: idiopathic, H. pylori-associated, drug-induced and combined (H...
July 28, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26106466/efficacy-of-clarithromycin-containing-bismuth-based-regimen-as-a-second-line-therapy-in-helicobacter-pylori-eradication
#20
Marjan Mokhtare, Shahram Agah, Hafez Fakheri, Vahid Hosseini, Mohsen Rezaei Hemami, Seyed Mohammad Sadegh Ghafoori
BACKGROUND The eradication of Helicobacter pylori infection, commonly prevailing in the stomach, has been important since its introduction. Adequate preparations should be made in finding alternatives when faced with first-line treatment failures. Currently, ideal second-line treatments are indistinct and varied among countries as result of different antibiotic resistance patterns. We aimed to evaluate the safety and efficacy of a clarithromycin-containing bismuth-based quadruple regimen as a second-line treatment...
April 2015: Middle East Journal of Digestive Diseases
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