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liver pediatric trasplant

Abha A Gupta, J Ted Gerstle, Vicky Ng, Ansely Wong, Annie Fecteau, Marcio H Malogolowkin, Rebecka L Meyers, David Grant, Ronald M Grant
Hepatocellular carcinoma (HCC) and hepatoblastoma (HB) are the most common primary tumors of liver in children. The management of patients with locally advanced, unresectable disease or those with extra-hepatic distant metastases provides substantial challenges to pediatric oncologists, hepatologists, and surgeons. Herein, we critically debate the two sides of three specific controversies: (1) the role of chemotherapy in the treatment of advanced pediatric HCC; (2) the indications for liver transplantation in children with HCC, specifically, the appropriateness of using adult Milan criteria; and (3) the role of liver trasplantation in children with unresectable HB that present with metastatic disease...
July 1, 2011: Pediatric Blood & Cancer
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