Pengfei Han, Xiaoyuan Jing, Shulei Han, Xinsheng Wang, Qiannan Li, Yuan Zhang, Pengpeng Yu, Xin-An Liu, Ping Wu, Huan Chen, Hongwei Hou, Qingyuan Hu
Since their introduction in the United States and Europe in 2007, electronic cigarettes (E-Cigs) have become increasingly popular among smokers. Nicotine, a key component in both tobacco and e-cigarettes, can exist in two forms: nicotine-freebase (FBN) and nicotine salts (NS). While nicotine salt is becoming more popular in e-cigarettes, the effect of nicotine salts on reinforcement-related behaviors remains poorly understood. This study aimed to compare the reinforcing effects of nicotine and nicotine salts in animal models of drug self-administration and explore potential mechanisms that may contribute to these differences...
2023: Frontiers in Neuroscience