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Paul T Harrell, Syeda Mahrukh H Naqvi, Andrew D Plunk, Ming Ji, Silvia S Martins
BACKGROUND: Despite significant declines in youth cigarette smoking, overall tobacco usage remains over 20% as non-cigarette tobacco product usage is increasingly common and polytobacco use (using 1+ tobacco product) remains steady. OBJECTIVES: The present study was designed to identify patterns of youth tobacco use and examine associations with sociodemographic characteristics and tobacco dependence. METHODS: The current analysis uses Latent Class Analysis (LCA) to examine the 6,958 tobacco users (n = 2,738 female) in the National Youth Tobacco Survey (2012 and 2013)...
September 26, 2016: American Journal of Drug and Alcohol Abuse
Alexandra R Hershberger, Kenny A Karyadi, Melissa A Cyders
Recently, research has suggested negative consequences related to electronic cigarette (e-cig) use, including the increased risk for alcohol use and abuse. Previous work found that cigarette smoking ban legislation lowered overall smoking and alcohol use rates; however, researchers have not yet examined the potential effects of prohibiting e-cig use. The present study surveyed 617 individuals from a community-based online sample in the US (mean age = 33.33, SD = 10.50, 54.7 per cent female) who reported their smoking/e-cig use status, alcohol consumption, and the presence of e-cig prohibitions where they consume alcohol...
September 12, 2016: Journal of Public Health Policy
Jessica M Yingst, Susan Veldheer, Erin Hammett, Shari Hrabovsky, Jonathan Foulds
BACKGROUND: Some jurisdictions have passed legislation that bans electronic cigarette (e-cig) use (vaping) in public places similarly to smoking. Many other jurisdictions have not yet determined how to regulate vaping in public places. This study examined the proportion of current e-cig users who find their vaping restricted in public places and further evaluated factors associated with the differences between restricted and unrestricted vapers. METHODS: 3960 experienced exclusive e-cig users completed an online survey from December 2012 to May 2014 about their e-cig use...
September 5, 2016: Tobacco Control
Esther Papaseit, Magí Farré, Silvia Graziano, Roberta Pacifici, Clara Pérez-Mañá, Oscar García-Algar, Simona Pichini
BACKGROUND: Electronic cigarettes (e-cig) known as electronic nicotine devices recently gained popularity among smokers. Despite many studies investigating their safety and toxicity, few examined the delivery of e-cig-derived nicotine and its metabolites in alternative biological fluids. METHODS: We performed a randomized, crossover, and controlled clinical trial in nine healthy smokers. Nicotine (NIC), cotinine (COT), and trans-3'-hydroxycotinine (3-HCOT) were measured in plasma and oral fluid by liquid chromatography-tandem mass spectrometry after consumption of two consecutive e-cig administrations or two consecutive tobacco cigarettes...
August 25, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Elizabeth G Klein, Micah Berman, Natalie Hemmerich, Cristen Carlson, SuSandi Htut, Michael Slater
OBJECTIVES: Electronic nicotine delivery systems (ENDS), or e-cigarettes, are heavily marketed online. The purpose of our study was to perform a systematic identification and evaluation of claims made within ENDS retailer and manufacturer websites, and the legal status of such claims. METHODS: We employed a systematic search protocol with popular search engines using 6 terms: (1) e-cigarettes; (2) e-cigs; (3) e-juice; (4) e-liquid; (5) e-hookah; and (6) vape pen...
July 2016: Tobacco Regulatory Science
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Community Practitioner: the Journal of the Community Practitioners' & Health Visitors' Association
Chad A Lerner, Pierrot Rutagarama, Tanveer Ahmad, Isaac K Sundar, Alison Elder, Irfan Rahman
Oxidants or nanoparticles have recently been identified as constituents of aerosols released from various styles of electronic cigarettes (E-cigs). Cells in the lung may be directly exposed to these constituents and harbor reactive properties capable of incurring acute cell injury. Our results show mitochondria are sensitive to both E-cig aerosols and aerosol containing copper nanoparticles when exposed to human lung fibroblasts (HFL-1) using an Air-Liquid Interface culture system, evident by elevated levels of mitochondrial ROS (mtROS)...
September 2, 2016: Biochemical and Biophysical Research Communications
Dinska Van Gucht, Frank Baeyens
BACKGROUND: Many misperceptions of both risks and opportunities of e-cigarettes (e-cigs) exist among the general population and among physicians, although e-cigs could be a valuable harm reduction tool for current smokers. METHODS: Two groups in Flanders, namely general practitioners (GPs; family doctors) and tobacco counselors filled out an online questionnaire with regard to their attitudes and risk perceptions concerning e-cigs. Statements included were on the safety and the addictive properties of e-cigs in absolute terms, whereas other items compared e-cigs with regular tobacco cigarettes...
2016: Harm Reduction Journal
Andrew Higham, Nicholas J W Rattray, Jennifer A Dewhurst, Drupad K Trivedi, Stephen J Fowler, Royston Goodacre, Dave Singh
BACKGROUND: The use of electronic cigarettes (e-cigs) is increasing and there is widespread perception that e-cigs are safe. E-cigs contain harmful chemicals; more research is needed to evaluate the safety of e-cig use. Our aim was to investigate the effects of e-cigs on the inflammatory response of human neutrophils. METHODS: Neutrophils were exposed to e-cig vapour extract (ECVE) and the expression of CD11b and CD66b was measured by flow cytometry and MMP-9 and CXCL8 by ELISA...
2016: Respiratory Research
Li Ping Wong, Sharina Mahavera Mohamad Shakir, Haridah Alias, Nasrin Aghamohammadi, Victor Cw Hoe
The rapidly increasing uptake of e-cigarettes in Malaysia as of late demands a study to identify factors leading to its increased popularity and user intentions to quit smoking e-cigarettes. A convenience sample of e-cigarette smokers visiting e-cigarette retail shops in Selangor and Kuala Lumpur was recruited. The majority of e-cigarette smokers were youth in colleges or universities (39 %), and young professionals and managers (36 %). The main reasons for using e-cigarettes were to help the user quit tobacco cigarettes (88 %), the perception that e-cigarettes are not as intrusive as tobacco cigarettes (85 %) and can be used in public areas (70 %), the perception that e-cigarettes are healthier than tobacco cigarettes (85 %), and its relatively lower cost compared to tobacco cigarettes (65 %)...
May 4, 2016: Journal of Community Health
Terry F Pechacek, Pratibha Nayak, Kyle R Gregory, Scott R Weaver, Michael P Eriksen
INTRODUCTION: This study evaluates the reasons for use and acceptance of Electronic Nicotine Delivery Systems (ENDS) among current and former cigarette smokers to assess if ENDS may become a satisfying alternative to cigarettes. METHODS: Data are from a national probability sample of 5717 US adults, surveyed June-November 2014. The survey contained questions on awareness, usage, and reasons for use of traditional and novel tobacco products. The analytic sample was current and former smokers who ever used ENDS (n = 729) and was divided into four mutually exclusive categories...
October 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Anita R Iskandar, Ignacio Gonzalez-Suarez, Shoaib Majeed, Diego Marescotti, Alain Sewer, Yang Xiang, Patrice Leroy, Emmanuel Guedj, Carole Mathis, Jean-Pierre Schaller, Patrick Vanscheeuwijck, Stefan Frentzel, Florian Martin, Nikolai V Ivanov, Manuel C Peitsch, Julia Hoeng
Various electronic nicotine delivery systems (ENDS), of which electronic cigarettes (e-cigs) are the most recognized prototype, have been quickly gaining ground on conventional cigarettes because they are perceived as less harmful. Research assessing the potential effects of ENDS exposure in humans is currently limited and inconclusive. New products are emerging with numerous variations in designs and performance parameters within and across brands. Acknowledging these challenges, we present here a proposed framework for an in vitro systems toxicology assessment of e-liquids and their aerosols, intended to complement the battery of assays for standard toxicity assessments...
July 2016: Toxicology Mechanisms and Methods
C Protano, M Manigrasso, P Avino, S Sernia, M Vitali
Passive exposure profiles to submicronic particles (SMPs, 5.6-560 nm) of traditional cigarettes and new electronic commercial devices (e-cig and IQOS®, a new heat-not-burn smoking device) were compared. During smoking, SMPs released by traditional cigarettes resulted four-times higher than those released by electronic and heat-not-burn devices and remained high for at least one hour, while SMPs values returned immediately similar to background for electronic and heat-not-burn devices. In all experiments, approximately half of SMPs resulted so small to reach the alveolar region...
March 2016: Annali di Igiene: Medicina Preventiva e di Comunità
Richard Holliday, Ralf Kist, Linda Bauld
MATERIALS AND METHODS: In vitro experiments were performed on normal epithelial cells as well as head and neck squamous cell carcinoma (HNSCC) cell lines. The widely available cell line HaCat, a spontaneously transformed immortal keratinocyte and the HNSCC cell lines HN30 and UMSCC10B were used. Cells were exposed to nicotine-containing and nicotine-free vapour extract from two popular e-cigarette brands for periods ranging from 48 hours to eight weeks. Cytotoxicity was assessed using Annexin V flow cytometric analysis, trypan blue exclusion and clonogenic assays...
March 2016: Evidence-based Dentistry
Ramakanth Kavuluru, A K M Sabbir
BACKGROUND: Electronic cigarettes (e-cigarettes or e-cigs) are a popular emerging tobacco product. Because e-cigs do not generate toxic tobacco combustion products that result from smoking regular cigarettes, they are sometimes perceived and promoted as a less harmful alternative to smoking and also as means to quit smoking. However, the safety of e-cigs and their efficacy in supporting smoking cessation is yet to be determined. Importantly, the federal drug administration (FDA) currently does not regulate e-cigs and as such their manufacturing, marketing, and sale is not subject to the rules that apply to traditional cigarettes...
June 2016: Journal of Biomedical Informatics
John W Ayers, Benjamin M Althouse, Jon-Patrick Allem, Eric C Leas, Mark Dredze, Rebecca S Williams
INTRODUCTION: Public perceptions of electronic nicotine delivery systems (ENDS) remain poorly understood because surveys are too costly to regularly implement and, when implemented, there are long delays between data collection and dissemination. Search query surveillance has bridged some of these gaps. Herein, ENDS' popularity in the U.S. is reassessed using Google searches. METHODS: ENDS searches originating in the U.S. from January 2009 through January 2015 were disaggregated by terms focused on e-cigarette (e...
June 2016: American Journal of Preventive Medicine
Peter V Dicpinigaitis, Alfredo Lee Chang, Alis J Dicpinigaitis, Abdissa Negassa
INTRODUCTION: Electronic cigarettes (e-cigs) have attained common usage worldwide, yet knowledge of their physiological effects remains minimal. The aim of this study was to evaluate the effect of a single exposure to e-cig vapor on the urge-to-cough (UTC) threshold and C5. METHODS: Seventeen healthy nonsmokers underwent C5 measurement employing capsaicin cough challenge at baseline, 15 minutes, and 24 hours after e-cig exposure (30 puffs 30 seconds apart). The endpoint of cough challenge is C5, the concentration of capsaicin inducing five or more coughs...
August 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Bertrand Dautzenberg, Ivan Berlin, Marie-Laure Tanguy, Nicole Rieu, Pierre Birkui
BACKGROUND: Electronic cigarettes (e-cig.) became widely used among adults. Data are insufficient about e-cig. experimentation among youth. METHODS: To assess prevalence of e-cig. experimentation and associated factors among the 12 to 19 years old we analyse a cross sectional school based survey in the city of Paris, France in 2013 on a randomly selected sample of 2 % of schoolchildren (n = 3 279). Self-report questionnaire include demographic, individual and family smoking characteristics and questions about e-cig: "Have you ever used an e-cigarette?"- "Did you use e-cigarette in the last 30 days?"-"Did you try e-cigarette as a first tobacco product?"...
2015: Tobacco Induced Diseases
Daniel Panitz, Harsha Swamy, Keith Nehrke
BACKGROUND: Electronic cigarettes (e-cigs) have recently become very popular particularly among the younger generation. These nicotine delivery devices are viewed as a preferable alternative to more conventional forms of tobacco use and are thought to reduce the risk of chronic obstructive pulmonary disease, the third leading cause of death worldwide. However, there is very little data available on the consequences of e-cig use, though recently nicotine-independent inflammatory responses have been reported...
2015: BMC Pharmacology & Toxicology
Nicholas McQueen, Erin J Partington, Kathleen F Harrington, Eben L Rosenthal, William R Carroll, Cecelia E Schmalbach
OBJECTIVES: (1) Investigate electronic cigarette (e-cig) use among head and neck (HN) cancer patients; (2) define quit methods, success, motivations, and barriers to smoking cessation; and (3) determine the impact of e-cig use in smoking cessation. STUDY DESIGN: Cross-sectional study. SETTING: Tertiary care center. METHODS: An in-office survey was administered to HN cancer patients ≥ 19 years of age with past/present tobacco use...
January 2016: Otolaryngology—Head and Neck Surgery
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