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https://www.readbyqxmd.com/read/28212519/early-calibration-of-the-hpa-axis-by-maternal-psychopathology
#1
Heidemarie Laurent
Given the central role of stress-responsive neurophysiology in mental and physical health, it is important to understand how particular patterns of stress responsivity may become entrained by the early caregiving environment. In this study we investigated links between maternal depression and anxiety symptom profiles and within-infant development of hypothalamic-pituitary-adrenal (HPA) axis responses from 6 to 18 months of life. Associations with infant cognitive and social-emotional development were also tested to gauge the adjustment implications of HPA response trajectories...
February 1, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28212015/discovery-and-preclinical-characterization-of-3-4-4-chlorophenyl-7-fluoroquinoline-3-yl-sulfonyl-benzonitrile-a-novel-non-acetylenic-metabotropic-glutamate-receptor-5-mglur5-negative-allosteric-modulator-for-psychiatric-indications
#2
János Galambos, Attila Bielik, Mikhail Krasavin, Zoltán Orgován, György Domány, Katalin Nógrádi, Gábor Wágner, György T Balogh, Zoltán Béni, János Koti, Zoltán Szakács, Amrita Bobok, Sándor Kolok, Mónika L Miko-Bakk, Mónika Vastag, Katalin Sághy, Judit Laszy, Attila Sándor Halász, Ottilia Balázs, Krisztina Gál, István Greiner, Zsolt Szombathelyi, György M Keserű
Negative allosteric modulators (NAM) of metabotropic glutamate receptor 5 (mGluR5) have been implicated as potential pharmacotherapy for a number of psychiatric diseases including anxiety and depression. Most of the mGluR5 NAM clinical candidates can be characterized by the central acetylenic moiety that connects the terminal pharmacophores. Identification of a sulfoquinoline hit via high throughput screening (HTS) followed by optimization provided a 4-phenyl-3-aryl-sulfoquinoline lead compound with the minimal pharmacophore...
February 17, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28210554/preoperative-psychosocial-characteristics-may-predict-body-image-and-sexuality-two-years-after-risk-reducing-mastectomy-a-prospective-study
#3
Dmytro Unukovych, Hemming Johansson, Yvonne Brandberg
BACKGROUND: Risk-reducing mastectomy (RRM) in patients at high risk has become more available and the rates of both bilateral (BRRM) and contralateral (CRRM) procedures are increasing. For women opting for RRM, psychosocial well-being, body image and sexuality are known to be important patient-reported outcomes. The aim of the present study was to investigate baseline health-related quality of life (HRQoL) and emotional distress (anxiety and depression) as predictors of body image and sexuality two years after RRM in women undergoing CRRM and BRRM...
February 2017: Gland Surgery
https://www.readbyqxmd.com/read/28210232/confirmatory-factor-analysis-of-the-combined-social-phobia-scale-and-social-interaction-anxiety-scale-support-for-a-bifactor-model
#4
Rapson Gomez, Shaun D Watson
For the Social Phobia Scale (SPS) and the Social Interaction Anxiety Scale (SIAS) together, this study examined support for a bifactor model, and also the internal consistency reliability and external validity of the factors in this model. Participants (N = 526) were adults from the general community who completed the SPS and SIAS. Confirmatory factor analysis (CFA) of their ratings indicated good support for the bifactor model. For this model, the loadings for all but six items were higher on the general factor than the specific factors...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28208013/sex-differences-in-autism-like-behavioral-phenotypes-and-postsynaptic-receptors-expression-in-the-prefrontal-cortex-of-tert-transgenic-mice
#5
Ki Chan Kim, Kyu Suk Cho, Sung Min Yang, Edson Luck Gonzales, Schley Valencia, Pyeong Hwa Eun, Chang Soon Choi, Darine Froy Mabunga, Ji-Woon Kim, Judy Kyoungju Noh, Hee Jin Kim, Se Jin Jeon, Seol-Heui Han, Geon Ho Bahn, Chan Young Shin
Autism spectrum disorder (ASD) remains unexplained and untreated despite the high attention of research in recent years. Aside from its various characteristics is the baffling male preponderance over the female population. Using a validated animal model of ASD which is the telomerase reverse transcriptase overexpressing mice (TERT-tg), we conducted ASD-related behavioral assessments and protein expression experiments to mark the difference between male and females of this animal model. After statistically analyzing the results, we found significant effects of TERT overexpression in sociability, social novelty preference, anxiety, nest building, and electroseizure threshold in the males but not their female littermates...
February 17, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28207863/identification-of-age-dependent-motor-and-neuropsychological-behavioural-abnormalities-in-a-mouse-model-of-mucopolysaccharidosis-type-ii
#6
Hélène F E Gleitz, Claire O'Leary, Rebecca J Holley, Brian W Bigger
Severe mucopolysaccharidosis type II (MPS II) is a progressive lysosomal storage disease caused by mutations in the IDS gene, leading to a deficiency in the iduronate-2-sulfatase enzyme that is involved in heparan sulphate and dermatan sulphate catabolism. In constitutive form, MPS II is a multi-system disease characterised by progressive neurocognitive decline, severe skeletal abnormalities and hepatosplenomegaly. Although enzyme replacement therapy has been approved for treatment of peripheral organs, no therapy effectively treats the cognitive symptoms of the disease and novel therapies are in development to remediate this...
2017: PloS One
https://www.readbyqxmd.com/read/28205604/selectively-bred-rats-provide-a-unique-model-of-vulnerability-to-ptsd-like-behavior-and-respond-differentially-to-fgf2-augmentation-early-in-life
#7
Katherine E Prater, Elyse L Aurbach, Hanna K Larcinese, Taylor N Smith, Cortney A Turner, Peter Blandino, Stanley J Watson, Stephen Maren, Huda Akil
Individuals respond differently to traumatic experiences including their propensity to develop post-traumatic stress disorder (PTSD). Understanding individual differences in PTSD vulnerability will allow the development of improved prevention and treatment options. Here, we characterized fear conditioning and extinction in rats selectively bred for differences in their locomotor response to a novel environment. Selectively bred high responder (bHR) and low responder (bLR) male rats are known to differ in their emotional reactivity on a range of measures of spontaneous anxiety- and depressive-like behaviors...
February 16, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28205232/preliminary-study-of-testosterone-and-empathy-in-determining-recidivism-and-antisocial-behavior
#8
Samuel J House, Jacob M Laan, Raymond K Molden, James C Ritchie, Zachary N Stowe
Recidivism, repeated criminal behavior after conviction and correction of prior offenses, is a costly problem across the nation. However, the contribution of empathy in determining the risk of recidivism has received limited attention, although lack of empathy has been related to antisocial personality disorder in various studies. Studies linked testosterone to aggression, antisocial behavior, and criminality, and evidence support hormonal connections between empathy and aggression. Adult male prison inmates convicted of violent or nonviolent offenses were included in a cross-sectional study of empathy, antisocial behavior, salivary testosterone, and recidivism...
February 15, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28203140/tamoxifen-activation-of-cre-recombinase-has-no-persisting-effects-on-adult-neurogenesis-or-learning-and-anxiety
#9
Peter Rotheneichner, Pasquale Romanelli, Lara Bieler, Sebastian Pagitsch, Pia Zaunmair, Christina Kreutzer, Richard König, Julia Marschallinger, Ludwig Aigner, Sébastien Couillard-Després
Adult neurogenesis is a tightly regulated process continuously taking place in the central nervous system of most mammalian species. In neuroscience research, transgenic animals bearing the tamoxifen-inducible CreER(T2)-Lox system are widely used. In this study, we made use of a Nestin-CreER(T2)/R26R-YFP transgenic mouse model in which the CreER(T2) activates the expression of YFP in multipotent neural stem cells upon tamoxifen application. Humoral factors, such as the levels of estrogens, have been reported to affect the hippocampal neurogenesis...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28203104/proton-magnetic-resonance-spectroscopy-assessment-of-metabolite-status-of-the-anterior-cingulate-cortex-in-chronic-pain-patients-and-healthy-controls
#10
Takahiro Ito, Sachiko Tanaka-Mizuno, Narihito Iwashita, Ikuo Tooyama, Akihiko Shiino, Katsuyuki Miura, Sei Fukui
BACKGROUND: Chronic pain is a common cause of reduced quality of life. Recent studies suggest that chronic pain patients have a different brain neurometabolic status to healthy people. Proton magnetic resonance spectroscopy ((1)H-MRS) can determine the concentrations of metabolites in a specific region of the brain without being invasive. PATIENTS AND METHODS: We recruited 56 chronic pain patients and 60 healthy controls to compare brain metabolic characteristics...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28202350/chronic-social-instability-increases-anxiety-like-behavior-and-ethanol-preference-in-male-long-evans-rats
#11
Alyssa R Roeckner, Alexandra Bowling, Tracy R Butler
Chronic stress during adolescence is related to increased prevalence of anxiety disorders and alcohol use disorders in humans. This phenotype has been consistently recapitulated in animal models with male subjects, but models using female subjects are fewer. The aim of these studies was to test the hypothesis that chronic social instability (CSI) during adolescence engenders increased anxiety-like behavior, increased corticosterone, and greater ethanol intake and/or preference than control groups in male and female rats...
February 13, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28202303/association-between-substance-use-diagnoses-and-psychiatric-disorders-in%C3%A2-an-adolescent-and-young-adult-clinic-based-population
#12
Justine Wittenauer Welsh, John R Knight, Sherry Shu-Yeu Hou, Monica Malowney, Patricia Schram, Lon Sherritt, J Wesley Boyd
PURPOSE: Adolescents with substance use disorders are more likely to have a current psychiatric disorder. However, when compared with the adult literature, there is relatively limited information regarding the specific co-occurrence of certain mental health diagnoses and substance use disorders in adolescents. The objectives of this study were to build on the previous literature regarding mental health diagnoses and different types of substance use disorders in adolescents, as well as explore the differences, if any, between groupings of mental health diagnosis and type of substance used...
February 12, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28199950/the-structure-of-vulnerabilities-for-social-anxiety-disorder
#13
Thomas L Rodebaugh, Cheri A Levinson, Julia K Langer, Justin W Weeks, Richard G Heimberg, Patrick J Brown, Andrew R Menatti, Franklin R Schneier, Carlos Blanco, Michael R Liebowitz
Social anxiety disorder symptoms are generally proposed to be related to broad temperamental vulnerabilities (e.g., a low level of approach and high level of avoidance temperament), specific psychological vulnerabilities (e.g., fears of negative and positive evaluation), and additional disorders (e.g., major depressive disorder). However, existing tests of such a model have either not considered depressive symptoms or relied on samples of undergraduates. We examined these and related questions via a latent variable model in a large dataset (N=2253) that combined participants across a variety of studies...
January 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28199414/direct-and-transgenerational-effects-of-low-doses-of-perinatal-di-2-ethylhexyl-phthalate-dehp-on-social-behaviors-in-mice
#14
Kayla M Quinnies, Erin P Harris, Rodney W Snyder, Susan S Sumner, Emilie F Rissman
Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine disrupting chemical commonly used as a plasticizer in medical equipment, food packaging, flooring, and children's toys. DEHP exposure during early development has been associated with adverse neurobehavioral outcomes in children. In animal models, early exposure to DEHP results in abnormal development of the reproductive system as well as altered behavior and neurodevelopment. Based on these data, we hypothesized that developmental exposure to DEHP would decrease social interactions and increase anxiety-like behaviors in mice in a dose-dependent manner, and that the effects would persist over generations...
2017: PloS One
https://www.readbyqxmd.com/read/28198953/predictors-of-hope-among-women-with-breast-cancer-during-chemotherapy
#15
Alessandra Cristina Sartore Balsanelli, Sonia Aurora Alves Grossi
OBJECTIVE: Identifying the predictors of hope in patients with breast cancer during chemotherapy treatment. METHOD: A prospective longitudinal study. The sample was composed of 122 women who responded to the instruments of hope, anxiety and depression, coping, fatigue, religiosity and self-esteem in the first and last cycle of chemotherapy. These variables were used in adjusting the logistic regression model that characterized multivariate statistics, allowing identification of predictor variables...
November 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28197862/influences-of-economic-social-and-cultural-marginalization-on-the-association-between-alcohol-use-and-sexual-risk-among-formerly-incarcerated-latino-men
#16
Miguel Muñoz-Laboy, Omar Martínez, Vincent Guilamo-Ramos, Jeffrey Draine, Karin Eyrich Garg, Ethan Levine, Alexandra Ripkin
Formerly incarcerated Latino men (FILM) have been significantly impacted by the HIV/AIDS and alcohol abuse epidemics in the United States. In this analysis, we examine the role of social, economic and cultural marginalization in the likelihood of alcohol-related sexual risk taking behavior among FILM. We recruited a non-random sample of FILM, ages 18-49 (n = 259). We performed logistic regression modeling to test four hypotheses examining the direct and moderating effects of socio-cultural factors. Drinking before sex was strongly associated with high likelihood of condomless intercourse (adjusted odds ratio, AOR = 2...
February 15, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28197749/the-effect-of-life-style-based-education-on-the-fathers-anxiety-and-depression-during-pregnancy-and-postpartum-periods-a-randomized-controlled-trial
#17
Sakineh Mohammad-Alizadeh Charandabi, Mojgan Mirghafourvand, Fovzieh Sanaati
Due to the harmful effects of prenatal and postnatal anxiety and depression on fathers, the aim of this study was to determine the impact of lifestyle-based training on paternal depression and anxiety (primary outcomes) during the prenatal and postnatal periods. This single-blind randomized controlled clinical trial was conducted on 126 spouses of pregnant women with gestational ages of 24-28 weeks. They were followed up until 6 weeks after childbirth. Using the block randomization method and stratified based on the number of children, the eligible samples were divided into two groups (one receiving two weekly group lifestyle-based training session (lasting 60-90 min) and a control group)...
February 14, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28197114/the-facebook-paradox-effects-of-facebooking-on-individuals-social-relationships-and-psychological-well-being
#18
Xiaomeng Hu, Andrew Kim, Nicholas Siwek, David Wilder
Research suggests that Facebooking can be both beneficial and detrimental for users' psychological well-being. The current study attempts to reconcile these seemingly mixed and inconsistent findings by unpacking the specific effects of Facebooking on users' online-offline social relationship satisfaction and psychological well-being. Using structural equation modeling, pathways were examined between Facebook intensity, online-offline social relationship satisfaction, perceived social support, social interaction anxiety, and psychological well-being...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28196772/intervening-variables-in-group-based-acceptance-commitment-therapy-for-severe-health-anxiety
#19
Trine Eilenberg, Ditte Hoffmann, Jens S Jensen, Lisbeth Frostholm
OBJECTIVE: The present study is based on a previously reported successful randomized controlled trial (RCT) on Acceptance and Commitment Group therapy (ACT-G) for severe health anxiety (HA) and investigates intervening variables of ACT for HA. The process primarily targeted by ACT is psychological flexibility (PF). No randomized study has yet examined the possible intervening variables of ACT for HA. METHODS: 126 patients diagnosed with severe HA were enrolled in the RCT of which 107 were included in the analyses...
January 19, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28195956/group-based-trajectory-analysis-of-emotional-symptoms-among-survivors-after-severe-traumatic-brain-injury
#20
Dianxu Ren, Jun Fan, Ava M Puccio, David O Okonkwo, Sue R Beers, Yvette Conley
OBJECTIVES: Depressive symptoms and anxiety are fairly common emotional outcomes after severe traumatic brain injury (TBI). Life satisfaction is a main factor in the general construct of subjective well-being. However, there is limited literature available on the interrelationship between emotional outcomes and life satisfaction post-severe TBI over time. The purpose of this study was to characterize distinct patterns of change in depressive symptoms, anxiety, and life satisfaction over 24 months after severe TBI and evaluate the interrelationship of different trajectory groups among them as well as associated subject characteristics...
February 10, 2017: Journal of Head Trauma Rehabilitation
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