Read by QxMD icon Read

anxiety models

Andrés Palacios Picos, Ruth Pinedo González, Myriam de la Iglesia Gutierrez
The aim of the researchers is to explore the causes and consequences of the psychological health of sex workers as well as provide an intervention model for the prevention of mental disorders in accordance with WHO levels. The study sample consisted of 146 sex workers from Spain. Loneliness and maltreatment have a negative influence on psychological health, while self-esteem has a protector role over psychological health. Psychological health has a positive impact on perceived quality of life and other health domains...
March 22, 2018: Health Care for Women International
Brad Bolman
Cold War curiosities about the dangers of radiation generated significant funding for an array of biomedical projects as enticing as they were unpredictable, introducing newly standardized experimental animals into laboratories and a novel merging of scientific disciplines. The desire to understand radiation's effects on human longevity spurred a multi-sited, multi-decade project that subjected beagle dogs to varying degrees of irradiation. One of those laboratories, located at the southern tip of the campus of the University of California, Davis, eventually hosted an elaborate experimental breeding kennel and a population of 'control' dogs that set new milestones for canine longevity...
March 1, 2018: Social Studies of Science
Abdullah Alhuzaimi, Alwaleed Aljohar, Ahmad N Alhadi, Abdulqudous Aljenedil, Ahmad S Hersi
Purpose: Syncope is a common condition affecting almost one-third of the general population. The present study measures the prevalence of psychiatric traits in patients presenting with syncope (unexplained and vasovagal) and whether recurrent attacks have an impact on psychiatric profiles. Patients and methods: This is a case-control study in a tertiary hospital enrolling all patients aged ≥12 years with single or recurrent syncopal attacks. A self-reporting psychometric questionnaire (The Symptoms Checklist-90-Revised) was used to screen for depression, anxiety, somatization disorder, and phobia...
2018: International Journal of General Medicine
Scott J Denstaedt, Joanna L Spencer-Segal, Michael W Newstead, Klaudia Laborc, Anne P Zhao, Alexander Hjelmaas, Xianying Zeng, Huda Akil, Theodore J Standiford, Benjamin H Singer
Sepsis commonly results in acute and chronic brain dysfunction, which dramatically increases the morbidity associated with this common disease. Chronic brain dysfunction in animal models of sepsis survival is linked to persistent neuroinflammation and expression of multiple cytokines. However, we have found previously that microglia predominantly upregulate the damage associated molecule S100A8/A9 after sepsis. In this article, we show that S100A8/A9 is increased in the brains of patients who died of sepsis and that S100A8 is expressed in astrocytes and myeloid cells...
March 21, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Hugh Cameron McCall, Chris G Richardson, Fjola Dogg Helgadottir, Frances S Chen
BACKGROUND: Treatment rates for social anxiety, a prevalent and potentially debilitating condition, remain among the lowest of all major mental disorders today. Although computer-delivered interventions are well poised to surmount key barriers to the treatment of social anxiety, most are only marginally effective when delivered as stand-alone treatments. A new, Web-based cognitive behavioral therapy (CBT) intervention called Overcome Social Anxiety was recently created to address the limitations of prior computer-delivered interventions...
March 21, 2018: Journal of Medical Internet Research
Claudio Vitari, Roxana Ologeanu-Taddei
BACKGROUND: Like other sectors, the healthcare sector has to deal with the issue of users' acceptance of IT. In healthcare, different factors affecting healthcare professionals' acceptance of software applications have been investigated. Unfortunately, inconsistent results have been found, maybe because the different studies focused on different IT and occupational groups. Consequently, more studies are needed to investigate these implications for recent technology, such as Electronic Health Records (EHR)...
March 21, 2018: BMC Health Services Research
Jinming Li, Yuan Yang, Yuankai Zhu, Liqiang Zhou, Yunfeng Han, Tao Yin, Zhaoting Cheng, Guopeng Zhang, Yanxia Shen, Jing Chen
BACKGROUND: Major depressive disorder (MDD) is a common mental disorder worldwide, but now there is a lack of clinically effective assessment and management of MDD. In this study, we used technetium-99 m ethylcysteinate dimer ([99m Tc]ECD) SPECT/CT to characterize the regional cerebral blood flow (rCBF) status of MDD patients, and to explore an objective image assessment model of MDD which is non- or minimally-invasive, convenient and accurate in a clinical setting. METHODS: The severity of MDD was assessed by three trained psychiatrists, based on scores obtained from HAMD and HAMA...
March 21, 2018: BMC Psychiatry
Qais Alemi, Carl Stempel, Patrick Marius Koga, Susanne Montgomery, Valerie Smith, Gagandeep Sandhu, Bianca Villegas, Jessica Requejo
BACKGROUND: We examined the mental health status and severity of psychological distress symptoms among young adults residing in Kabul, Afghanistan and determined how such outcomes might be influenced by an array of risk and protective factors. METHODS: A cross-sectional study design was adopted using convenience, snowball, and street-intercept recruitment techniques. Surveys were completed by 232 young adults between 18 and 35 years of age in September 2015. We used both etic (mental health component of the SF-8) and emic (Afghan Symptom Checklist) measures of mental health and psychological distress, respectively, and regressed these outcome measures against socio-demographic, physical health, and psychological variables (resilience, hope-optimism) using ordinary least squares (OLS) regression methods...
March 21, 2018: BMC Psychiatry
Leslie Pertz, Missy Plegue, Kathleen Diehl, Philip Zazove, Michael McKee
Deaf individuals struggle with accessing mental health services because of language and cultural discordance. Our project's purpose was to design and pilot an accessible, integrated mental health program for the Deaf population, scalable for other health centers interested in serving these individuals. Our team addressed several identified barriers to care. The addition of a language-concordant mental health clinician and telemental health appointments helped us better manage Deaf patients' mental health needs...
March 17, 2018: Journal of Deaf Studies and Deaf Education
M Saffari, A H Pakpour, F Al Zaben, H G Koenig
BACKGROUND: Chronic hepatitis B (CHB) is a serious and prevalent disease which may negatively influence health related quality of life (HRQOL) and fatigue. The aim of the present study was to examine the relationship between demographic variables, HRQOL, and fatigue. METHODS: A cross-sectional study was conducted involving 418 Iranian patients with CHB (average age 44.1 years, majority males). Participants completed a multidimensional fatigue inventory, chronic liver disease questionnaire, Euro quality of life-five dimensions questionnaire, and demographic information...
April 2017: Acta Gastro-enterologica Belgica
Elena K Schneider, Rachel M McQuade, Vincenzo C Carbone, Felisa Reyes-Ortega, John W Wilson, Brenda Button, Ayame Saito, Daniel P Poole, Daniel Hoyer, Jian Li, Tony Velkov
Ivacaftor-lumacaftor and ivacaftor are two new breakthrough cystic fibrosis transmembrane conductance modulators. The interactions of ivacaftor and its two metabolites hydroxymethylivacaftor (iva-M1) and ivacaftorcarboxylate (iva-M6) with neurotransmitter receptors were investigated in radioligand binding assays. Ivacaftor displayed significant affinity to the 5-hydroxytryptamine (5-HT; serotonin) 5-HT2C receptor (p K i =6.06±0.03), β3 -adrenergic receptor (p K i =5.71±0.07), δ-opioid receptor (p K i =5...
January 2018: ERJ Open Research
Felix Müller, Patrick C Dolder, André Schmidt, Matthias E Liechti, Stefan Borgwardt
LSD is an ambiguous substance, said to mimic psychosis and to improve mental health in people suffering from anxiety and depression. Little is known about the neuronal correlates of altered states of consciousness induced by this substance. Limited previous studies indicated profound changes in functional connectivity of resting state networks after the administration of LSD. The current investigation attempts to replicate and extend those findings in an independent sample. In a double-blind, randomized, cross-over study, 100 μg LSD and placebo were orally administered to 20 healthy participants...
2018: NeuroImage: Clinical
Juan C Olaya, Carrie L Heusner, Mitsuyuki Matsumoto, Cynthia Shannon Weickert, Tim Karl
Elevated levels of the type III (III) isoforms of neuregulin 1 (NRG1) have been observed in the brains of schizophrenia patients that carry NRG1 HapICE risk alleles, which is thought to contribute to the aetiology of the disease. We generated transgenic mice with forebrain driven Nrg1 III overexpression (Nrg1 III tg) and previously found that male heterozygous Nrg1 type III tg mice exhibit several schizophrenia-relevant behaviours including social and cognitive deficits as well as impaired sensorimotor gating...
March 17, 2018: Behavioural Brain Research
Nora E Fritz, Nicholas R Boileau, Julie C Stout, Rebecca Ready, Joel S Perlmutter, Jane S Paulsen, Kimberly Quaid, Stacey Barton, Michael K McCormack, Susan L Perlman, Noelle E Carlozzi
Up to 90% of individuals with Huntington's disease (HD)-a progressive, inherited neurodegenerative disorder-experience apathy. Apathy is particularly debilitating because it is marked by a reduction in goal-directed behaviors, including self-care, social interactions, and mobility. The objective of this study was to examine relationships between variables of apathy, functional status, physical function, cognitive function, behavioral status/emotional function, and health-related quality of life. Clinician-rated measures of physical, cognitive, and behavioral function, including one clinician-rated item on apathy, and self-reported measures of physical function, health-related quality of life, and emotional, cognitive, and social function were collected in a single session from 487 persons with the HD mutation (prodromal, N=193; early-stage manifest, N=186; late-stage manifest, N=108)...
March 21, 2018: Journal of Neuropsychiatry and Clinical Neurosciences
Barnabas Ohst, Brunna Tuschen-Caffier
The catastrophic misinterpretation model of panic disorder (PD) predicts that the catastrophic misinterpretation of bodily sensations is a distinctive characteristic of PD. Existing research on this prediction has produced mixed findings. This paper presents a systematic review and meta-analysis of studies comparing the strength of catastrophic misinterpretation of bodily sensations and external events in patients with PD, patients with other anxiety disorders, and healthy controls. Following a systematic screening, seven studies were included in the meta-analysis...
2018: PloS One
Lorra Garey, Lorraine R Reitzel, Julie Neisler, Darla E Kendzor, Michael J Zvolensky, Clayton Neighbors, Daphne C Hernandez, Michael S Businelle
PURPOSE: Health-related quality of life (HRQoL) is a multidimensional assessment of well-being and health status. Most previous work in this area assumes that HRQoL is a homogenous construct; however, it is possible HRQoL subgroups may exist. The purpose of the study was to characterize common classes of HRQoL among adult, homeless smokers, a particularly vulnerable group of the larger population, and to evaluate risk and protective factors of HRQoL class membership. METHODS: Homeless smokers (N = 456; 65...
March 20, 2018: Behavioral Medicine
Selene Valero-Moreno, Marián Pérez-Marín, Inmaculada Montoya-Castilla, Silvia Castillo-Corullón, Alvar Ramírez-Aguilar, Amparo Escribano-Montaner
INTRODUCTION: Adolescents with asthma face problems inherent to this stage in their development, to which the challenges of taking over control of their disease, complying with a daily treatment and regular medical followup are added. Any rejection generated by this may lead to treatment non-adherence and poor asthma control, which brings about problems in family dynamics, made worse by the stress or the emotional distress that this situation causes in caregivers. OBJECTIVE: Identify adjustment profiles and predictors of risk for the well-being of caregivers of pediatric patients with bronchial asthma...
April 1, 2018: Archivos Argentinos de Pediatría
Mohammad Shehata, Kareem Abdou, Kiriko Choko, Mina Matsuo, Hirofumi Nishizono, Kaoru Inokuchi
There is substantial interest in memory reconsolidation as a target for the treatment of anxiety disorders such as post-traumatic stress disorder (PTSD). However, its applicability is restricted by reconsolidation-resistant boundary conditions that constrain the initial memory destabilization. In this study, we investigated whether the induction of synaptic protein degradation through autophagy modulation, a major protein degradation pathway, can enhance memory destabilization upon retrieval and whether it can be utilized to overcome these conditions...
March 19, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Stephen P Becker, Matthew A Jarrett, Aaron M Luebbe, Annie A Garner, G Leonard Burns, Michael J Kofler
OBJECTIVES: To (1) describe sleep problems in a large, multi-university sample of college students; (2) evaluate sex differences; and (3) examine the unique associations of mental health symptoms (i.e., anxiety, depression, attention-deficit/hyperactivity disorder inattention [ADHD-IN], ADHD hyperactivity-impulsivity [ADHD-HI]) in relation to sleep problems. METHODS: 7,626 students (70% female; 81% White) ages 18-29 years (M=19.14, SD=1.42) from six universities completed measures assessing mental health symptoms and the Pittsburgh Sleep Quality Index (PSQI)...
April 2018: Sleep Health
Luciana Pereira de Sousa, Roberto Farina de Almeida, Flávia Lima Ribeiro-Gomes, Leonardo José de Moura Carvalho, Tadeu Mello E Souza, Diogo Onofre Gomes de Souza, Cláudio Tadeu Daniel-Ribeiro
BACKGROUND: Cerebral malaria, the main complication of Plasmodium falciparum infection in humans, is associated with persistent neurocognitive sequels both in human disease and the murine experimental model. In recent years, cognitive deficits related to uncomplicated (non-cerebral) malaria have also been reported in chronically exposed residents of endemic areas, but not in some murine experimental models of non-cerebral malaria. This study aimed at evaluating the influence of uncomplicated malaria on different behavioural paradigms associated with memory and anxiety-like parameters in a murine model that has the ability to develop cerebral malaria...
March 20, 2018: Parasites & Vectors
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"