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Svjetlana Karabuva, Ivica Brizić, Zorica Latinović, Adrijana Leonardi, Igor Križaj, Boris Lukšić
The nose-horned viper (Vipera ammodytes ammodytes) is the most venomous European snake. Its venom is known as haematotoxic, myotoxic and neurotoxic but it exerts also cardiotoxic effects. To further explore the cardiotoxicity of the venom we separated it into four fractions by gel filtration chromatography. Three fractions that contain polypeptides (A, B, and C) were tested for their effects on isolated rat heart. Heart rate (HR), incidence of arrhythmias (atrioventricular (AV) blocks, ventricular tachycardia, ventricular fibrillation, and asystolia), coronary flow (CF), systolic, developed and diastolic left ventricular pressure (LVP) were measured before, during, and after the application of venom fractions in three different concentrations...
October 2016: Toxicon: Official Journal of the International Society on Toxinology
B Safaee Fakhr, D Dondossola, M Cavenago, M Zanetti, S Gatti, L Gattinoni, F Valenza
INTRODUCTION: Uncontrolled donors after circulatory determination of death (uDCDD) represent a yet unexplored pool of organs potentially available for transplantation. The aims of this study were to validate a protocol of cardiac death in the pig and to investigate lung function during the process. MATERIALS AND METHODS: Cardiac death was induced in preanesthetized animals with an injection of 600 mg propofol; once systolic blood pressure was <50 mm Hg (Agonal Phase), a 20 mEq bolus of KCl was given and, after asystolia was documented, cardiopulmonary resuscitation (CPR) started, followed by 5 minutes no touch (end-CPR)...
March 2016: Transplantation Proceedings
Lisa Zimmer, Simone M Goldinger, Lars Hofmann, Carmen Loquai, Selma Ugurel, Ioannis Thomas, Maria I Schmidgen, Ralf Gutzmer, Jochen S Utikal, Daniela Göppner, Jessica C Hassel, Friedegund Meier, Julia K Tietze, Andrea Forschner, Carsten Weishaupt, Martin Leverkus, Renate Wahl, Ursula Dietrich, Claus Garbe, Michael C Kirchberger, Thomas Eigentler, Carola Berking, Anja Gesierich, Angela M Krackhardt, Dirk Schadendorf, Gerold Schuler, Reinhard Dummer, Lucie M Heinzerling
BACKGROUND: Anti-programmed cell death 1 (PD-1) antibodies represent an effective treatment option for metastatic melanoma and other cancer entities. They act via blockade of the PD-1 receptor, an inhibitor of the T-cell effector mechanisms that limit immune responses against tumours. As reported for ipilimumab, the anti-PD-1 antibodies pembrolizumab and nivolumab can induce immune-related adverse events (irAEs). These side-effects can involve skin, gastrointestinal tract, liver, the endocrine system and other organ systems...
June 2016: European Journal of Cancer
Cecilia Gómez Ravetti, Tatiana Oliveira Silva, Anselmo Dornas Moura, Frederico Bruzzi de Carvalho
OBJECTIVE: To determine the characteristics of patients undergoing standard institutional protocol for management of resuscitated patients after a cardiac arrest episode, including therapeutic hypothermia. METHODS: This was a retrospective analysis of 26 consecutive patients admitted following cardiac arrest, between January 2007 and November 2008. RESULTS: All cases underwent therapeutic hypothermia. Average age was 63 years, and the patients were predominantly male...
December 2009: Revista Brasileira de Terapia Intensiva
A Fudickar, K Smigaj, R Ensenauer, G Fischer, P Dütschke, M Steinfath, B Bein
BACKGROUND: Propofol is routinely used for anesthesia during pediatric heart catheterization. Propofol infusion syndrome (PRIS) is a rare, but often fatal complication mainly defined as bradycardia with progress to asystolia during propofol infusion. Metabolic acidosis is regarded as an early warning sign of PRIS. In this study the effect of propofol and sevoflurane on serum base excess, pH and lactate have been examined during pediatric heart catheterization. METHODS: In this prospective randomised study 42 children have been anesthetised for pediatric heart catheterization with propofol (N...
June 2013: Minerva Anestesiologica
Piotr Pietkiewicz, Waldemar Machała, Krzysztof Kuśmierczyk, Jarosław Miłoński, Tomasz Wiśniewski, Joanna Urbaniak, Jurek Olszewski
INTRODUCTION: The aim of the work was to assess early complications of Griggs percutaneous tracheotomy in the own material. MATERIAL AND METHODS: The study covered 155 patients aged 17-88, including 36 women and 119 men. The patients were treated at the Department of Anaesthesiology and Intensive Therapy between 2006-2010. They underwent Griggs percutaneous tracheostomy by a laryngologist or a trained anaesthesiologist. Each surgical procedure was conducted with the use of Portex Blue Line Ultra Percutaneous Tracheotomy Kit (Smiths Medical Co...
May 2012: Otolaryngologia Polska. the Polish Otolaryngology
Håvard Trønnes, Ansgar Berg
A 10-month-old boy with a previous upper spinal cord injury was admitted to hospital with acute respiratory and circulatory distress. Shortly after admission the boy had severe bradycardia leading to asystolia and pulseless electrical activity. He was successfully resuscitated, and the investigation that followed excluded infection, congenital heart defect, arrhythmia and cerebral haemorrhage. Over the following days the patient had several episodes of isolated bradycardia and combined bradycardia and hypotension...
May 15, 2012: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Pozza R Dalla, A Kleinmann, S Zysk, S Bechtold, N Netz
The head-up-tilt-test in pediatric patients for the evaluation of syncope shows a sensitivity of 35-85% and often requires pharmacological stimulation in order to improve its diagnostic value. We used a new device for beat-to-beat blood pressure monitoring combined with impedance cardiography in a 12-year-old girl during tilt testing. A seven seconds asystolia was provoked. The haemodynamic parameters showed clearly the drop in heart rate as well as in cardiac output, and returned to normal values after tilting back the patient...
January 2005: Images in Paediatric Cardiology
M L Avellanas, A Ricart, J Botella, F Mengelle, I Soteras, T Veres, M Vidal
Accidental hypothermia is an environmental condition with basic principles of classification and resuscitation that apply to mountain, sea or urban scenarios. Along with coagulopathy and acidosis, hypothermia belongs to the lethal triad of trauma victims requiring critical care. A customized healthcare chain is involved in its management, extending from on site assistance to intensive care, cardiac surgery and/or the extracorporeal circulation protocols. A good classification of the degree of hypothermia preceding admission contributes to improve management and avoids inappropriate referrals between hospitals...
April 2012: Medicina Intensiva
Nemanja Radojevic, Slobodan Savic, Vuk Aleksic, Dragana Cukic
It is well known that atrial infarctions are rare comparing to the ventricular. They cannot easily be verified on ECG and the standard autopsy technique does not include a detailed review of the atrial wall, so the atrial infarction often remains undiagnosed. A 63-year-old male was treated and died in an intensive care unit due to decompensated liver insufficiency and cardiac disease following long-lasting alcohol abuse. At autopsy, the extreme cardiomegaly was found, severe atherosclerosis of the anterior descending branch of left coronary artery...
February 2012: Journal of Forensic and Legal Medicine
E Doberentz, C Schyma, B Madea
The carotid body and carotid sinus are localized in the area of the carotid bifurcation and respond to pressure fluctuations in the arterial blood vessel system. In case of irritation or stimulation, nervous impulses can reflexively increase the ventilation or slow down the heart rate and blood pressure, respectively. The external stimulation of the carotid sinus by neck compression with subsequent bradycardia or asystolia, especially in pre-existing heart-disease, is discussed controversially in the literature...
March 10, 2012: Forensic Science International
Philipp von Heinemann, Oliver Grauer, Gerhard Schuierer, Markus Ritzka, Ulrich Bogdahn, Bernhard Kaiser, Felix Schlachetzki
Cardiac arrest is a rare complication in Wallenberg syndrome, despite the fact that the brainstem, especially the lower medulla, modulates sympathetic and parasympathetic activity. In the case reported here, a 45-year-old man was admitted with clinical symptoms of Wallenberg syndrome, including right sided hemiparesis secondary to dissection of the right vertebral artery. During the following days he experienced several spells of self limiting cardiac arrests, which made the implantation of a pacemaker necessary...
2009: BMJ Case Reports
Andrius Macas, Tomas Bukauskas, Ilona Šuškevičienė, Giedrė Bakšytė, Linas Pieteris, Tomas Tamošiūnas, Audra Mundinaitė, Remigijus Žaliūnas
UNLABELLED: Acute myocardial infarction complicated by cardiogenic shock is one of the main reasons of death in severely ill patients. One of the main indications for intra-aortic balloon counterpulsation is acute myocardial infarction complicated by cardiogenic shock. Aortic counterpulsation is associated with the risk of several important complications: bleeding, thrombosis, thrombocytopenia, limb ischemia, and aortic wall damage. The analysis of complications is necessary to better understand the course of myocardial infarction using aortic counterpulsation and to reduce the risk of complications...
2011: Medicina
V Rey, C Cereda, P Michel
No abstract text is available yet for this article.
2009: BMJ Case Reports
A D'aloia, E Vizzardi, E Antonioli, E Chiari, A Curnis, L Dei Cas
Various cardiac arrhythmias and conduction defects have been described in patients with mitral valve prolapse. We describe a case of a young woman affected by a mitral valve prolapse, involving the posterior mitral leaflet, with mild mitral regurgitation and an episode of syncope due to asystolia. It is hoped that this short communication will once again focus attention on the as yet unexplained association between mitral valve prolapse and various cardiac conduction disorders.
November 2010: Cardiovascular Journal of Africa
Anne Lise Olsen, Rene Mathiasen, Niels Henrik Rasmussen, Finn Ursin Knudsen
INTRODUCTION: The aim of this study was to investigate the long-term prognosis for children with severe breath-holding spells (BHS). MATERIAL AND METHODS: The study was a retrospective cohort study. Data from the medical records of all patients with severe BHS admitted during a ten-year period were recorded and a questionnaire was sent to the families. A matched group of adolescents with febrile convulsions served as controls (n = 289). RESULTS: A total of 85 out of 115 families (73...
November 2010: Danish Medical Bulletin
Sami Pakarinen, Lauri Toivonen
Automated functions of cardiac pacemakers correcting bradycardia provide the possibility to evaluate the utility of cardiac pacing and the patient's cardiac rhythm even over an extended period of time. Application of arrhythmia pacemaker therapy to the prevention of sudden death in high-risk patients has been started without limiting it to the prevention of recurrence of asystolia. Treatment of cardiac insufficiency with cardiac resynchronization therapy has established itself in a proportion of those having severe cardiac insufficiency...
2010: Duodecim; Lääketieteellinen Aikakauskirja
Rodolfo P Moreno, Juan C Vassallo, Silvia S Sáenz, Ana C Blanco, Daniel Allende, José L Araguas, Santiago Ayala Torales, Edgardo Banille, Amanda M Berrueta, Patricia Capocasa, César G Caprotta, Guillermo E Moreno, Hilda S Pérez, Liliana Porta, Gabriela Rodríguez, Marcelo Rojo
INTRODUCTION: The cardiopulmonary resuscitation (CPR) is a common setting in the pediatric intensive care unit (PICU). There are very few reports or publications that evaluate the form of CPR administered in children. OBJECTIVES: 1) Identify the etiology and epidemiology of the CPR in the PICU. 2) Describe how to conduct CPR. 3) Describe the drugs used. 4) Knowing the patient outcomes. 5) Knowing CPR training of physicians in the PICU. PATIENTS AND METHODS: All children with cardiopulmonary arrest who were resuscitated in the PICU between 01/04/2004- 31/03/2005...
June 2010: Archivos Argentinos de Pediatría
H-J Trappe
Bradycardic (heart rate<50/min) and tachycardic heart rhythm disturbances (100/min) require rapid therapeutic strategies. Supraventricular tachycardias (SVT) are sinus tachycardia, atrial tachycardia, AV-nodal reentrant tachycardia and tachycardia due to accessory pathways. Mostly SVT are characterized by small QRS complexes (QRS width<0.12 ms). It is essential to evaluate the arrhythmia history, to perform a good physical examination and to exactly analyze the 12-lead electrocardiogram. An exact diagnosis is then possible in >90% of SVT patients...
August 2010: Der Internist
Cigdem Ozkara, Baris Metin, Serdar Kucukoglu
The clinical presentation of epilepsy and syncope can be confusingly similar. We present a patient with reflex syncopal episodes that mimic seizures using video-EEG recordings. During the episodes, head/eye deviations, automatisms and dystonic movements, suggesting an epileptic seizure, were observed. The EEG revealed diffuse slow waves when the patient lost consciousness and complete cessation of the cerebral activity occurred when the dystonic movements started. On ECG recordings, bradycardia, followed by complete asystolia lasting for 40 seconds, was observed...
December 2009: Epileptic Disorders: International Epilepsy Journal with Videotape
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