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https://www.readbyqxmd.com/read/29351897/transitions-between-circulatory-states-after-out-of-hospital-cardiac-arrest-protocol-for-an-observational-prospective-cohort-study
#1
Halvor Langeland, Daniel Bergum, Magnus Løberg, Knut Bjørnstad, Jan Kristian Damås, Tom Eirik Mollnes, Nils-Kristian Skjærvold, Pål Klepstad
BACKGROUND: The post cardiac arrest syndrome (PCAS) is responsible for the majority of in-hospital deaths following cardiac arrest (CA). The major elements of PCAS are anoxic brain injury and circulatory failure. OBJECTIVE: This study aimed to investigate the clinical characteristics of circulatory failure and inflammatory responses after out-of-hospital cardiac arrest (OHCA) and to identify patterns of circulatory and inflammatory responses, which may predict circulatory deterioration in PCAS...
January 19, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29351018/the-behavior-and-reproductive-physiology-of-a-solitary-progressive-provisioning-vespid-wasp-evidence-for-a-solitary-cycle-origin-of-reproductive-castes
#2
Hans C Kelstrup, Klaus Hartfelder, Tiago Falcon Lopes, Theresa C Wossler
The emergence of queens and workers from solitary antecedents mark a major evolutionary transition in the history of life. The solitary progressive provisioning wasp Synagris cornuta, a member of the subfamily Eumeninae (basal to eusocial vespid wasps), alternates between behavioral states characterized as queenlike and worker-like. Akin to a queen in eusocial wasps, a S. cornuta female initiates construction of a cell into which she oviposits and then, similar to a worker, cares for the brood as it develops...
February 2018: American Naturalist
https://www.readbyqxmd.com/read/29350577/serial-palliative-performance-scale-assessment-in-a-university-general-hospital-a-pilot-study
#3
Rafael Barone de Medeiros, Ana Maria Nunes de Faria Stamm, Rachel Duarte Moritz, Paulo Fontoura Freitas, Lara Patrícia Kretzer, Juliana Vieira Gomes
BACKGROUND: Serial Palliative Performance Scale (PPS) assessments may predict functional decline and prognosis in cancer and noncancer patients and help with end-of-life decision making. OBJECTIVE: To evaluate the functional status of using serial PPS assessments of patients being assisted in collaboration with the palliative care team (PCT). DESIGN: Prospective cohort pilot study. MEASUREMENTS: The sample consisted of 64 cancer and noncancer inpatients being assisted in collaboration with the PCT during the period from 2012 to 2016 (included 12 months)...
January 19, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29350459/nourish-t-targeting-caregivers-to-improve-health-behaviors-in-pediatric-cancer-survivors-with-obesity
#4
Marilyn Stern, Jennifer Bleck, Linda J Ewing, Esther Davila, Courtney Lynn, Gregory Hale, Suzanne Mazzeo
BACKGROUND: Obesity rates in pediatric cancer survivors (PCS) are alarmingly high. Although healthy lifestyle changes may prevent future health complications, promoting healthy behaviors in PCS is challenging, and few interventions have successfully addressed this issue. PROCEDURE: This randomized control trial evaluated the feasibility and preliminary effectiveness of a parent-focused six-session intervention, NOURISH-T (Nourishing Our Understanding of Role Modeling to Improve Support and Health for Healthy Transitions), compared with enhanced usual care (EUC) on the outcomes of caregiver and PCS anthropometric measurements, eating behaviors, and physical activity...
January 19, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29350384/the-importance-of-psychosocial-factors-in-management-of-pulmonary-arterial-hypertension-patients
#5
Maria A Sobczak-Kaleta, Adam Torbicki, Jarosław D Kasprzak
Pulmonary arterial hypertension (PAH) is significantly reshaping personal and professional lives of patients due to its chronic nature, varying clinical profile and uncertain perspectives of treatment. PAH is at this time an incurable disease, which requires to consider not only strictly medical dimension, but also the psychosocial aspects of care. This paper discusses therefore the psychological problems most commonly reported by PAH patients. It reviews the instruments used to assess them. We describe the relationships between the quality of life and depressive symptoms and the physical activity of the PAH patients, which have deep treatment-related consequences...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29349042/an-optimized-targeted-next-generation-sequencing-approach-for-sensitive-detection-of-single-nucleotide-variants
#6
S Stasik, C Schuster, C Ortlepp, U Platzbecker, M Bornhäuser, J Schetelig, G Ehninger, G Folprecht, C Thiede
Monitoring of minimal residual disease (MRD) has become an important clinical aspect for early relapse detection during follow-up care after cancer treatment. Still, the sensitive detection of single base pair point mutations via Next-Generation Sequencing (NGS) is hampered mainly due to high substitution error rates. We evaluated the use of NGS for the detection of low-level variants on an Ion Torrent PGM system. As a model case we used the c.1849G > T (p.Val617Phe) mutation of the JAK2-gene. Several reaction parameters (e...
May 2018: Biomolecular Detection and Quantification
https://www.readbyqxmd.com/read/29348476/animal-models-of-obesity-and-diabetes-mellitus
#7
REVIEW
Maximilian Kleinert, Christoffer Clemmensen, Susanna M Hofmann, Mary C Moore, Simone Renner, Stephen C Woods, Peter Huypens, Johannes Beckers, Martin Hrabe de Angelis, Annette Schürmann, Mostafa Bakhti, Martin Klingenspor, Mark Heiman, Alan D Cherrington, Michael Ristow, Heiko Lickert, Eckhard Wolf, Peter J Havel, Timo D Müller, Matthias H Tschöp
More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the continued use of animal models to discover, validate and optimize novel therapeutics for their safe use in humans. In order to improve the transition from bench to bedside, researchers must not only carefully select the appropriate model but also draw the right conclusions...
January 19, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29347908/management-and-outcomes-of-patients-presenting-with-sepsis-and-septic-shock-to-the-emergency-department-during-nursing-handover-a-retrospective-cohort-study
#8
Sami Alsolamy, Atheer Al-Sabhan, Najla Alassim, Musharaf Sadat, Eman Al Qasim, Hani Tamim, Yaseen M Arabi
BACKGROUND: Clinical handover is an important process for the transition of patient-care responsibility to the next healthcare provider, but it may divert the attention of the team away from active patients. This is challenging in the Emergency Department (ED) because of highly dynamic patient conditions and is likely relevant in conditions that requires time-sensitive therapies, such as sepsis. We aimed to examine the management and outcomes of patients presenting with sepsis and septic shock to the ED during nursing handover...
January 18, 2018: BMC Emergency Medicine
https://www.readbyqxmd.com/read/29347862/survey-of-the-awareness-of-adult-rheumatologists-regarding-transitional-care-for-patients-with-juvenile-idiopathic-arthritis-in-japan
#9
Toshihiro Matsui, Takumi Matsumoto, Fumio Hirano, Fumika Tokunaga, Keisuke Okamoto, Shigeto Tohma, Tomohiro Morio, Hitoshi Kohsaka, Masaaki Mori
OBJECTIVES: To understand the current status of adult rheumatology care for patients who had previously had juvenile idiopathic arthritis (JIA) (excluding systemic JIA), and to identify issues interfering with the transition from pediatric to adult care in Japan. METHODS: Questionnaire-based survey among 30 adult rheumatologists. RESULTS: Eighty-seven percent of adult rheumatologists responded that they had provided medical care to adults who had had JIA; 44% of them had felt hesitation or anxiety when providing such care...
January 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29347849/joint-pain-within-adult-middle-aged-women-attending-a-community-clinic-in-a-peri-urban-area-in-south-africa-a-cross-sectional-survey
#10
Roline Barnes, Jennifer Jelsma, Romy Parker
BACKGROUND: This study aimed to investigate the prevalence of joint pain in women between the ages of 40 and 64 years who attended a community clinic in the Free State to provide micro-information for health care planners. METHODS: A sample of convenience was utilized in the cross-sectional survey. Health care workers were recruited to conduct the survey. Outcome measures included the Community-Oriented-Programme-For-The-Control-Of-Rheumatic-Disease questionnaire and European Quality of Life - 5 Dimensions health related quality of life measure...
January 19, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29347719/effect-of-polymer-network-on-thermodynamic-stability-and-switching-behavior-of-the-smectic-c_-%C3%AE-phase
#11
Magdalena Knapkiewicz, Mariola Sądej, Wojciech Kuczyński, Adam Rachocki
A polymer-stabilized liquid crystal based on 4^{'}-(octyloxy)biphenyl-4-carboxylate 2-fluoro-4-((octyl-2-yloxy)carbonyl)phenyl (D16) and 1,6 hexanediol diacrylate as a monomer was prepared by in situ photopolymerization. The selected antiferroelectric liquid crystal contains a fast-switching smectic C_{α}^{*} phase (SmC_{α}^{*}), and the influence of the polymer network on the thermodynamic stability of this phase and its switching behavior under applying time-dependent electric field were studied. Using dielectric spectroscopy and polarizing microscopy, the liquid crystal materials were characterized, and subsequently with the use of the reversal current method (RCM) the current response, especially from the SmC_{α}^{*} phase was carefully analyzed...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346691/the-impact-of-near-peer-teaching-on-medical-students-transition-to-clerkships
#12
Alexander C Knobloch, Christy J W Ledford, Sean Wilkes, Adam K Saperstein
BACKGROUND AND OBJECTIVES: The transition to clerkships is one of the most challenging times during medical school. To help students better cope, many schools have established transition-to-clerkship curricula. Such curricula may optimally prepare students through increasing their self-efficacy and response efficacy. We hypothesized that a small-group, near-peer-led format would be ideally suited to help students achieve these outcomes. METHODS: During process improvement for a transition-to-clerkship curriculum, we conducted an informal focus group and subsequent survey of postclerkship students to guide curricular innovation, including incorporation of third- and fourth-year students as near-peer instructors in a seminar format...
January 2018: Family Medicine
https://www.readbyqxmd.com/read/29346008/follow-up-care-provider-preferences-of-adolescent-and-young-adult-cancer-survivors
#13
Joemy M Ramsay, Karely Mann, Sapna Kaul, Eduardo R Zamora, Rochelle R Smits-Seemann, Anne C Kirchhoff
PURPOSE: To explore the experiences and perspectives of adolescent and young adult (AYA) cancer survivors regarding patient-provider relationships and their preferences surrounding type of healthcare provider for follow-up care. METHODS: We recruited AYA cancer survivors who were diagnosed between the ages of 15 and 39 using the Utah Cancer Registry. Twenty-eight survivors participated in six focus groups held between March and May of 2015 in Salt Lake City and St...
January 18, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29345497/experiences-of-menopause-self-management-strategies-for-menopausal-symptoms-and-perceptions-of-health-care-among-immigrant-women-a-systematic-review
#14
K A Stanzel, K Hammarberg, J Fisher
OBJECTIVE: To systematically review the published literature relating to experiences of menopause, self-management strategies for menopausal symptoms and health-care needs among immigrant women. METHODS: A systematic literature search of English-language publications was performed using Medline, Embase, PsychInfo, Cinahl and Scopus. Twenty-four papers reporting on 19 studies met our inclusion criteria and investigated immigrant women's experiences of menopause and/or their self-management strategies for menopausal symptoms and/or their perceptions of menopause-specific health care...
January 18, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29345256/caregiver-perspectives-on-communication-during-hospitalization-at-an-academic-pediatric-institution-a-qualitative-study
#15
Lauren G Solan, Andrew F Beck, Stephanie A Shardo, Hadley S Sauers-Ford, Jeffrey M Simmons, Samir S Shah, Susan N Sherman
OBJECTIVE: Communication among those involved in a child's care during hospitalization can mitigate or exacerbate family stress and confusion. As part of a broader qualitative study, we present an in-depth understanding of communication issues experienced by families during their child's hospitalization and during the transition to home. METHODS: Focus groups and individual interviews stratified by socioeconomic status included caregivers of children recently discharged from a children's hospital after acute illnesses...
January 18, 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29345243/electronic-and-mechanical-response-of-graphene-on-batio-sub-3-sub-at-martensitic-phase-transitions
#16
Tim Verhagen, Vaclav Vales, Martin Kalbac, Jana Vejpravova
Graphene is extremely sensitive to optical, electrical and mechanical stimuli, which cause a significant variation of the band structure, thus physiochemical properties. In our work, we report on changes of strain and doping in graphene grown by chemical vapor deposition (CVD) and transferred onto a BaTiO3(100) (BTO) single-crystal. The BTO is known as a ferroelectric material, which undergoes several thermoelastic martensitic phase transitions when it is cooled from 300 K to 10K. In order to enhance the very weak Raman signal of the graphene monolayer (ML) on the BTO, a 15 nm thin gold layer was deposited on top of the graphene ML to benefit from the surface enhanced Raman scattering (SERS)...
January 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29344338/current-best-practice-in-the-management-of-turner-syndrome
#17
REVIEW
Roopa Kanakatti Shankar, Philippe F Backeljauw
Turner syndrome (TS) is characterized by partial or complete loss of the second X-chromosome in phenotypic females resulting in a constellation of clinical findings that may include lymphedema, cardiac anomalies, short stature, primary ovarian failure and neurocognitive difficulties. Optimizing health care delivery is important to enable these individuals achieve their full potential. We review the current best practice management recommendations for individuals with TS focusing on the latest consensus opinion in regard to genetic diagnosis, treatment of short stature, estrogen supplementation, addressing psychosocial issues, as well screening for other comorbidities...
January 2018: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29343977/cost-effectiveness-analysis-of-six-therapies-for-the-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia
#18
James C Ulchaker, Melissa S Martinson
Objective: To conduct a cost-effectiveness analysis from payers' perspectives of six treatments for lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) and to examine positioning of these modalities in the marketplace for the best use of health care funds and quality-of-life benefits for patients. Methods: The economic analysis was conducted with a Markov model to compare combination prescription drug therapy (ComboRx), minimally invasive therapies (MITs) including convective radiofrequency (RF) water vapor thermal therapy (Rezūm®), conductive RF thermal therapy (Prostiva®), and prostatic urethral lift (UroLift®), and invasive surgical procedures including photovaporization of the prostate (Greenlight® PVP) and transurethral resection of the prostate (TURP)...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29343948/types-and-delivery-of-emotional-support-to-promote-linkage-and-engagement-in-hiv-care
#19
Christa L Cook, Shantrel Canidate, Nicole Ennis, Robert L Cook
Purpose: Despite recommendations for early entry into human immunodeficiency virus (HIV) care, many people diagnosed with HIV delay seeking care. Multiple types of social support (ie, cognitive, emotional, and tangible) are often needed for someone to transition into HIV care, but a lack of emotional support at diagnosis may be the reason why some people fail to stay engaged in care. Thus, the purpose of this study was to identify how people living with HIV conceptualized emotional support needs and delivery at diagnosis...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29341985/dexmedetomidine-as-single-continuous-sedative-during-noninvasive-ventilation-typical-usage-hemodynamic-effects-and-withdrawal
#20
Brittany L Shutes, Samantha W Gee, Cheryl L Sargel, Kelsey A Fink, Joseph D Tobias
OBJECTIVES: Dexmedetomidine use in pediatric critical care is increasing. Its prolonged effects as a single continuous agent for sedation are not well described. The aim of the current study was to describe prolonged dexmedetomidine therapy without other continuous sedation, specifically the hemodynamic effects, discontinuation strategies, and risk factors for withdrawal. DESIGN: Retrospective chart review. SETTING: Large, single-center, quaternary care pediatric academic institution...
January 16, 2018: Pediatric Critical Care Medicine
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