Read by QxMD icon Read


Leila Pourtalebi Jahromi, Zahra Sasanipour, Amir Azadi
Alzheimer's disease (AD) is a very prevalent and burdensome disease of elderlies but albeit extensive studies, mechanisms underlying its pathology and consequently its definite treatment is ambiguous. Intra and extra-cellular aggregation of abnormal proteins and impaired autophagy machinery, two closely related events taking place in AD brains proposed to be directly controlled by mTOR signaling pathway. On the other hand, tramadol that is a very well tolerated opioid analgesic has been revealed to inhibit mTOR upstream controllers through interaction with specific types of muscarinic, serotonergic, nicotinic and NMDA receptors, although it seems to induce the opposite effect via µ-opioid receptor...
January 2018: Medical Hypotheses
Ravit Malishev, Shira Shaham-Niv, Sukhendu Nandi, Sofiya Kolusheva, Ehud Gazit, Raz Jelinek
Bacoside-A, a family of compounds extracted from the Bacopa monniera plant, is a folk-medicinal substance believed to exhibit therapeutic properties, particularly enhancing cognitive functions and improving memory. We show that bacoside-A exerted significant inhibitory effects upon cytotoxicity, fibrillation, and particularly membrane interactions of amyloid-beta (1-42) (Aβ42), the peptide playing a prominent role in Alzeheimer's disease progression and toxicity. Specifically, preincubation of bacoside-A with Aβ42 significantly reduced cell toxicity and inhibited fibril formation both in buffer solution and, more significantly, in the presence of membrane vesicles...
April 19, 2017: ACS Chemical Neuroscience
Drazenka Ostojić, Domagoj Vidović, Ana Baceković, Petrana Brecić, Vlado Jukić
Alzheimer's dementia (AD) is the most common neurodegenerative disorder, which affects 30 million people worldwide. With aging of the population, it is becoming an increasing problem in Croatia. Alzheimer's dementia represents not only problem for the patient but affects the patients' caregivers as well. Caring for a patient with AD carries a significant physical, socioeconomic and psychological burden. Previous studies have shown an increased risk of physical and psychiatric illness. The aim of our study was to evaluate the prevalence and intensity of anxious and depressive symptoms in caregivers of AD patients treated at Vrapce University Psychiatric Hospital in Zagreb...
March 2014: Acta Clinica Croatica
James M Brimson, Tewin Tencomnao
Rhinacanthus nasutus (L.) Kurz (Acanthaceae) is an herb native to Thailand and Southeast Asia, known for its antioxidant properties. Hypoxia leads to an increase in reactive oxygen species in cells and is a leading cause of neuronal damage. Cell death caused by hypoxia has been linked with a number of neurodegenerative diseases including some forms of dementia and stroke, as well as the build up of reactive oxygen species which can lead to diseases such as Huntington's disease, Parkinson's disease and Alzeheimer's disease...
July 26, 2011: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Fabrice Gzil
This paper reviews and discusses the two opposing interpretations which have been given of the emergence of Alzheimer's disease (AD) in the medical literature (1906-1911). The commonest interpretation is that Kraepelin coined the eponym in order to describe a disease that had been discovered by Alzheimer. In the last years, however, a growing number of authors argued that Alzheimer and Kraepelin did not discover but create AD, that they did not proceed like botanists cataloguing species in an exotic garden but rather like sculptors carving shapes out of formless matter...
October 2007: Histoire des Sciences Médicales
Akinori Miyashita, Hiroyuki Arai, Takashi Asada, Masaki Imagawa, Etsuro Matsubara, Mikio Shoji, Susumu Higuchi, Katsuya Urakami, Akiyoshi Kakita, Hitoshi Takahashi, Shinichi Toyabe, Kohei Akazawa, Ichiro Kanazawa, Yasuo Ihara, Ryozo Kuwano
Alzheimer's disease (AD), the most common form of dementia in the elderly, was found to exhibit a trend toward a higher risk in females than in males through epidemiological studies. Therefore, we hypothesized that gender-related genetic risks could exist. To reveal the ones for late-onset AD (LOAD), we extended our previous genetic work on chromosome 10q (genomic region, 60-107 Mb), and single nucleotide polymorphism (SNP)-based genetic association analyses were performed on the same chromosomal region, where the existence of genetic risk factors for plasma Abeta42 elevation in LOAD was implied on a linkage analysis...
December 1, 2007: Human Molecular Genetics
Valentino Laquintana, Nunzio Denora, Angela Lopedota, Hiromi Suzuki, Makoto Sawada, Mariangela Serra, Giovanni Biggio, Andrea Latrofa, Giuseppe Trapani, Gaetano Liso
The aim of this work was to develop new fluorescent probes for the localization and function of the peripheral benzodiazepine receptor (PBR). This receptor is primarily expressed on the mitochondria, and it is overexpressed in a variety of different states including glioma, breast cancer, Alzeheimer's disease, and activated microglia. For the mentioned purpose, imidazopyridine and imidazopyrimidine compounds 5-20 were synthesized, and their affinity for PBR was determined. Although some intrinsically fluorescent imidazopyrimidine compounds 12-20 possess good binding affinity, they cannot be used for visualizing PBR due to their unfavorable fluorescence characteristics...
September 2007: Bioconjugate Chemistry
Ryozo Kuwano, Akinori Miyashita, Hiroyuki Arai, Takashi Asada, Masaki Imagawa, Mikio Shoji, Susumu Higuchi, Katsuya Urakami, Akiyoshi Kakita, Hitoshi Takahashi, Tamao Tsukie, Shinichi Toyabe, Kohei Akazawa, Ichiro Kanazawa, Yasuo Ihara et al.
The apolipoprotein E (APOE) gene has been consistently shown to be a major genetic risk factor; however, all cases of Alzheimer's disease (AD) cannot be attributed to the epsilon4 variant of APOE, because about half of AD patients have the APOE-epsilon3*3 genotype. To identify an additional genetic risk factor(s), we performed large-scale single nucleotide polymorphism (SNP)-based association analysis of 1526 late-onset AD patients and 1666 control subjects in a Japanese population. We prepared two independent sets consisting of exploratory and validation samples, respectively, with only the APOE-epsilon3*3 genotype, and first carried out genotyping for the exploratory set with 1206 SNPs in the region between 60 and 107 Mb on chromosome 10q that is implicated by linkage studies as containing an AD susceptibility locus...
July 1, 2006: Human Molecular Genetics
Ezra Mulugeta, Evert Karlsson, Atiqul Islam, Raj Kalaria, Halinder Mangat, Bengt Winblad, Abdu Adem
We assessed muscarinic M(1), M(2) and M(4) receptor subtypes in the hippocampus of Alzheimer's and control brains by receptor autoradiography using ligands such as [(125)I]muscarinic toxin-1 ([(125)I]MT-1, M(1) selective), [(3)H]AFDX-384 (M(2) partially selective) and [(125)I]muscarinic toxin 4 ([(125)I]M(4) toxin-1, M(4) selective). Our results revealed a significant decrease in muscarinic M(4) receptor binding in the dentate gyrus and CA4 regions of brain sections from Alzheimer's patients compared to controls...
January 17, 2003: Brain Research
W P Esler, M S Wolfe
The amyloid beta-peptide (Abeta) is a principal component of the cerebral plaques found in the brains of patients with Alzeheimer's disease (AD). This insoluble 40- to 42-amino acid peptide is formed by the cleavage of the Abeta precursor protein (APP). The three proteases that cleave APP, alpha-, beta-, and gamma-secretases, have been implicated in the etiology of AD. beta-Secretase is a membrane-anchored protein with clear homology to soluble aspartyl proteases, and alpha-secretase displays characteristics of certain membrane-tethered metalloproteases...
August 24, 2001: Science
R Prior, D D'Urso, R Frank, I Prikulis, G Pavlakovic
Cerebral amyloid angiopathy (CAA) is a neuropathological feature of Alzeheimer's disease and an important cause of cerebral haemorrhage in the elderly. CAA is characterized by the deposition of Alzheimer amyloid beta protein (A beta) in cerebral and leptomeningeal vessel walls. In order to study the effect of cerebrovascular A beta deposits in vivo, living canine leptomeninges obtained from old dogs affected by CAA were analysed by confocal laser scanning microscopy after immunofluorescence staining for A beta and viability staining with fluorescein diacetate (FDA)...
January 31, 1996: Neuroreport
F I Perez, D A Stump, J R Gay, V R Hart
A consistent feature in dementia is an overall intellectual deterioration. The present study investigated the intellectual performance of patients with Alzeheimer's disease (AD) and multi-infarct dementia (MID) using the Wechsler Adult Intelligence Scale (WAIS). For reliability and generality purposes two independent samples of patients were collected. Significant differences in Education Level (EDU) and Performance IQ (PIQ) were obtained for the first sample, with the AD group having a significantly higher EDU level...
August 1976: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
C W Putnam, K A Porter, T E Starzl
Six baboons of varying weights and estimated ages had complete portal diversion. All animals became emaciated and lost hair. Five of the 6 developed hepatic encephalopathy so serious that it either killed them or required their sacrifice after an average of 109 days. One exceptional animal which lived for 208 days without encephalopathy had markedly elevated blood ammonia levels. In one brain that was examined, greatly increased numbers of Alzeheimer's Type II astrocytes were diffusely distributed in the cerebral cortex...
August 1976: Annals of Surgery
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"