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https://www.readbyqxmd.com/read/29454028/fabricating-3d-printed-orally-disintegrating-printlets-using-selective-laser-sintering
#1
Fabrizio Fina, Christine M Madla, Alvaro Goyanes, Jiaxin Zhang, Simon Gaisford, Abdul W Basit
Selective laser sintering (SLS) is a three-dimensional printing (3DP) technology employed to manufacture plastic, metallic or ceramic objects. The aim of this study was to demonstrate the feasibility of SLS to fabricating novel solid dosage forms with accelerated drug release properties, and with a view to create orally disintegrating formulations. Two polymers (hydroxypropyl methylcellulose (HPMC E5) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon ® VA 64)) were separately mixed with 5% paracetamol (used as a model drug) and 3% Candurin ® gold sheen colorant; the powder mixes were subjected to SLS printing resulting in the manufacture of printlets (3DP tablets)...
February 14, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29446873/laser-stimulating-st36-with-optical-fiber-induce-blood-component-changes-in-mice-a-raman-spectroscopy-study
#2
Heng Zhang, Zhenyi Chen, Jiping Wu, Na Chen, Wenjie Xu, Taihao Li, Shupeng Liu
ST36 is a commonly-used acupoint in traditional Chinese medicine (TCM) for treatment of inflammations, pains and gastrointestinal disturbs. For decades,the low power laser acupuncture has been widely applied as an alternative therapy to traditional metal needle acupuncture and achieved relatively fine therapeutic effect for ST36-related symptoms with reduction of uncomfortableness and infection risks. However its disadvantages of low penetrativity and lack of manipulation skills limit its potential performance...
February 15, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29439254/inhibition-of-suicidal-erythrocyte-death-by-indirubin-3-monoxime
#3
Chunqiu Liu, Peipei Jiang, Yuanhong Xu, Meijuan Zheng, Jinpin Qiao, Xueyong Zhou, Dake Huang, Maohong Bian
BACKGROUND/AIMS: Qing Dai is a prized traditional Chinese medicine whose major component, indirubin, and its derivative, indirubin-3'-monoxime (IDM), have inhibitory effects on the growth of many human tumor cells and pronounced anti-leukemic activities. However, the effects of IDM on mature human erythrocytes are unclear. This study aimed to evaluate the potential impact of IDM on erythrocytes and the mechanisms underlying that impact. METHODS: Utilizing flow cytometry and confocal laser scanning microscopy, phosphatidylserine exposure at the cell surface was estimated by annexin V-fluorescein isothiocyanate (FITC)...
February 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29433686/gastrodia-elata-alleviates-mutant-huntingtin-aggregation-through-mitochondrial-function-and-biogenesis-mediation
#4
Chuen-Lin Huang, Kaw-Chen Wang, Ying-Chen Yang, Chun-Tang Chiou, Chia-Hui Tan, Yun-Lian Lin, Nai-Kuei Huang
BACKGROUND: According to the Compendium of Materia Medica, Gastrodia elata (GE) Blume is a top-grade herbal medicine frequently used to treat dizziness, headaches, tetanus, and epilepsy, suggesting that it affects neurological functions. Although studies have supported its effects in preventing diverse neurodegenerations such as Huntington's disease (HD), its mechanisms require further investigation. PURPOSE: To investigate the ability of the molecular mechanism of GE to prevent mutant huntingtin (mHTT) protein aggregation by focusing on mitochondrial function and biogenesis, which have been proposed as the therapeutic targets of HD...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29423897/the-role-of-diet-in-glaucoma-a-review-of-the-current-evidence
#5
REVIEW
Adi M Al Owaifeer, Abdulaziz A Al Taisan
Intraocular pressure (IOP) reduction by medications, laser, or surgery remains the mainstay of treatment in glaucoma. However, the role of complementary and alternative medicine (CAM) in glaucoma has received great interest from both patients and ophthalmologists. Previous evidence suggests that diet, a major domain of CAM, can influence an individual's IOP level. Furthermore, certain dietary components have been linked to the incidence and progression of glaucoma. In this review, we aim to provide a summary of the current evidence regarding the role of obesity, certain dietary components, and dietary supplements in glaucoma...
February 8, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29420882/multiplex-immuno-maldi-tof-ms-for-targeted-quantification-of-protein-biomarkers-and-their-proteoforms-related-to-inflammation-and-renal-dysfunction
#6
Jie Gao, Klaus Meyer, Katrin Borucki, Per Magne Ueland
Circulating proteins are widely used as biomarkers in clinical applications for the diagnosis, prediction and treatment of numerous diseases. Immunoassays are the most common technologies for quantification of protein biomarkers and exist in various formats. Traditional immunoassays offer sensitive and fast analyses, but cannot differentiate between proteoforms. Protein micro-heterogeneity, mainly due to post-translational modification, has been recognized as fingerprint for different pathologies, and knowledge about proteoforms is an important step towards personalized medicine...
February 8, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29411432/laser-irradiation-of-metal-oxide-films-and-nanostructures-applications-and-advances
#7
REVIEW
Haribabu Palneedi, Jung Hwan Park, Deepam Maurya, Mahesh Peddigari, Geon-Tae Hwang, Venkateswarlu Annapureddy, Jong-Woo Kim, Jong-Jin Choi, Byung-Dong Hahn, Shashank Priya, Keon Jae Lee, Jungho Ryu
Recent technological advances in developing a diverse range of lasers have opened new avenues in material processing. Laser processing of materials involves their exposure to rapid and localized energy, which creates conditions of electronic and thermodynamic nonequilibrium. The laser-induced heat can be localized in space and time, enabling excellent control over the manipulation of materials. Metal oxides are of significant interest for applications ranging from microelectronics to medicine. Numerous studies have investigated the synthesis, manipulation, and patterning of metal oxide films and nanostructures...
February 7, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29411402/safety-tolerability-and-efficacy-evaluation-of-the-slimme-device-for-circumference-reduction
#8
Giovanni Ferrando
OBJECTIVE: To assess the short- and long-term thermal impact of subclinical and clinical regimens of a single, non-invasive uniform ultrasound treatment session on subcutaneous adipose tissue (SAT). STUDY DESIGN: Prospective, open-label, single-arm, split-side study. METHODS: Patients (n = 17) were subjected to uniform ultrasound treatment, delivered in a single session with the SlimME device. The device was set to one of four treatment regimens, which differed in their durations and energy fluences during the raise and maintenance phases...
February 7, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29407750/inhibitory-effects-of-%C3%AE-caryophyllene-on-streptococcus-mutans-biofilm
#9
Hyun-Jun Yoo, Su-Kyung Jwa
OBJECTIVE: The biofilm of Streptococcus mutans is associated with induction of dental caries. Also, they produce glucan as an extracellular polysaccharide through glucosyltransferases and help the formation of cariogenic biofilm. β-caryophyllene has been used for therapeutic agent in traditional medicine and has antimicrobial activity. The purpose of this study was to investigate the effect of β-caryophyllene on S. mutans biofilm and the expression of biofilm-related factor. DESIGN: The susceptibility assay of S...
February 3, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29403184/fractional-co-2-laser-vs-fractional-co-2-with-topical-platelet-rich-plasma-in-the-treatment-of-acne-scars-a-split-face-comparison-trial
#10
Bikash R Kar, Chinmoy Raj
Background: It is a challenge to treat acne scars and a multimodal combination approach is necessary. While fractional CO 2 lasers (FCLs) are an established treatment option, the role of platelet-rich plasma (PRP) in the treatment of acne scars is not established though it is being used extensively in other fields of medicine owing to its healing properties. We combined the two methods to assess the proposed synergistic action on acne scars. Aims and Objectives: To evaluate the effect of FCL alone vs FCL combined with PRP on the quality of acne scars...
July 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29401762/broadband-2-%C3%A2%C2%B5m-emission-on-silicon-chips-monolithically-integrated-holmium-lasers
#11
Nanxi Li, Emir Salih Magden, Zhan Su, Neetesh Singh, Alfonso Ruocco, Ming Xin, Matthew Byrd, Patrick T Callahan, Jonathan D B Bradley, Christopher Baiocco, Diedrik Vermeulen, Michael R Watts
Laser sources in the mid-infrared are of great interest due to their wide applications in detection, sensing, communication and medicine. Silicon photonics is a promising technology which enables these laser devices to be fabricated in a standard CMOS foundry, with the advantages of reliability, compactness, low cost and large-scale production. In this paper, we demonstrate a holmium-doped distributed feedback laser monolithically integrated on a silicon photonics platform. The Al2O3:Ho3+ glass is used as gain medium, which provides broadband emission around 2 µm...
February 5, 2018: Optics Express
https://www.readbyqxmd.com/read/29399314/therapeutic-and-analgesic-efficacy-of-laser-in-conjunction-with-pharmaceutical-therapy-for-trigeminal-neuralgia
#12
Hooman Ebrahimi, Shamsolmoulouk Najafi, Mina Khayamzadeh, Amirabbas Zahedi, Atossa Mahdavi
Introduction: Trigeminal neuralgia (TN) is the most common neuralgia in the head and neck region and a common cause of orofacial pain. It is routinely treated with carbamazepine. Laser, acupuncture and radiofrequency are among other treatment modalities for this condition. This study sought to assess the efficacy of laser therapy in conjunction with carbamazepine for treatment of TN. Methods: A total of 30 patients who met the inclusion criteria were divided into 2 groups of cases and controls (n=15) by double blind randomized controlled clinical trial...
2018: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29399302/laser-application-in-iran-urology-a-narrative-review
#13
REVIEW
Mohammad Reza Razzaghi, Morteza Fallah Karkan, Saleh Ghiasy, Babak Javanmard
The usage of laser in medicine is not recent, and its history in urology goes back to 40 years ago. For the last 2 decades, common uses of laser have been treatments of subjects with urolithiasis, bladder tumors, benign prostatic enlargement, lesions of the genitalia and urinary tract strictures. To evaluate laser application in urology in Iran, we reviewed all of the Iranian literature on the topic. This study was designed to retrieve all studies on laser application in urology in Iran, regardless of publication status or language, covering years 1990-2017...
2018: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29384405/the-clinical-effectiveness-and-cost-effectiveness-of-fractional-co2-laser-in-acne-scars-and-skin-rejuvenation-a-meta-analysis-and-economic-evaluation
#14
Fereshteh Ansari, Fatemeh Sadeghi-Ghyassi, Barmak Yaaghoobian
INTRODUCTION: Fractional CO2 has many indications in medicine including in treatment of acne scars and rejuvenation. The aim of this study was to evaluate the safety, efficacy, and cost-effectiveness of Fractional CO2 Laser in comparison with other methods of rejuvenation and acne scar treatment. MATERIALS AND METHODS: Several databases including Medline, OVID, EMBASE, CINHAL, SCOPUS, Web of science, CRD, and Cochrane were searched. After conducting the search and evaluation of selected publications, critical appraisal was done and eligible studies were accepted for inclusion in the systematic review...
January 31, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29378379/-biofabrication-new-approaches-for-tissue-regeneration
#15
Raymund E Horch, Annika Weigand, Harald Wajant, Jürgen Groll, Aldo R Boccaccini, Andreas Arkudas
BACKGROUND: The advent of Tissue Engineering (TE) in the early 1990ies was fostered by the increasing need for functional tissue and organ replacement. Classical TE was based on the combination of carrier matrices, cells and growth factors to reconstitute lost or damaged tissue and organs. Despite considerable results in vitro and in experimental settings the lack of early vascularization has hampered its translation into daily clinical practice so far. A new field of research, called "biofabrication" utilizing latest 3D printing technologies aims at hierarchically and spatially incorporating different cells, biomaterials and molecules into a matrix to alleviate a directed maturation of artificial tissue...
January 29, 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29376616/-laser-therapy-for-mens-infertility-part-2-systematic-review-of-clinical-trials
#16
O I Apolikhin, S V Moskvin
Male infertility is a multifactorial syndrome associated with a wide range of pathological conditions affecting both the sexual and other body systems: endocrine, nervous, blood, and immune. Laser therapy is a form of modern physiotherapy that applies low-intensity laser irradiation (LILI) in various parts of the body. It is widely used in all areas of modern medicine due to its high efficiency, ease of use, the absence of contraindications and side effects. The authors reviewed the results of 171 studies investigating laser therapy, of which 93 were experimental (20 in Russian and 73 international publications), four clinical and experimental (all in Russian), 74 clinical (73 in Russian and 1 in English)...
December 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29362943/laser-assisted-liposuction-lal-versus-traditional-liposuction-systematic-review
#17
REVIEW
Danilo Pereira-Netto, Juan Carlos Montano-Pedroso, Ana Laura E Silva Aidar, Wagner Luis Marson, Lydia Masako Ferreira
INTRODUCTION: Liposuction is the most performed surgical procedure in Brazil and the second in the world. In recent years, new technologies have been developed in an attempt to improve liposuction, such as laser. The objective of this study is to evaluate the efficacy and safety of laser-assisted liposuction (LAL) compared to traditional liposuction through a systematic review of the literature. METHOD: The search strategy used was the combination of the descriptors [lasers (MeSH Terms)] and (lipectomy [MeSH Terms]) in the PubMed database...
January 23, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29356026/light-emitting-diodes-in-dermatology-a-systematic-review-of-randomized-controlled-trials
#18
Jared Jagdeo, Evan Austin, Andrew Mamalis, Christopher Wong, Derek Ho, Daniel Siegel
OBJECTIVE: In dermatology, patient and physician adoption of light-emitting diode (LED) medical technology continues to grow as research indicates that LEDs may be used to treat skin conditions. The goal of this systematic review is to critically analyze published randomized controlled trials (RCTs) and provide evidence-based recommendations on the therapeutic uses of LEDs in dermatology based on published efficacy and safety data. METHODS: A systematic review of the published literature on the use of LED treatments for skin conditions was performed on September 13th 2017...
January 22, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29355413/treatment-of-carious-lesions-using-self-assembling-peptides
#19
M Alkilzy, R M Santamaria, J Schmoeckel, C H Splieth
Modern approaches in caries treatment involve lesion management without tissue removal. Regenerative medicine focuses on replacing damaged tissues with biologically similar tissues. This article discusses the scientific evidence and clinical results for self-assembling peptides in modern caries management. The biomimetic remineralization promoted by self-assembling peptide P11-4 has been proven in vitro as an effective therapy for initial caries. P11-4 was rationally designed to promote formation of hydroxyapatite on its surface...
February 2018: Advances in Dental Research
https://www.readbyqxmd.com/read/29349512/photobiomodulation-induces-in-vitro-re-epithelialization-via-nitric-oxide-production
#20
Manuela Rizzi, Mario Migliario, Stelvio Tonello, Vincenzo Rocchetti, Filippo Renò
Photobiomodulation is a widely used tool in regenerative medicine thanks to its ability to modulate a plethora of physiological responses. Wound re-epithelialization is strictly regulated by locally produced chemical mediators, such as nitric oxide (NO), a highly reactive free radical generated by the nitric oxide synthase (NOS) enzymatic family. In this study, it has been hypothesized that a 980-nm low-level laser stimulation could increase NO production in human keratinocytes and that such event might be directly related to the re-epithelialization process...
January 18, 2018: Lasers in Medical Science
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