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Laser medicine

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No abstract text is available yet for this article.
April 2018: Lasers in Surgery and Medicine
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No abstract text is available yet for this article.
April 2018: Lasers in Surgery and Medicine
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Lasers in Surgery and Medicine
Meena Siddiqui, Ahhyun S Nam, Serhat Tozburun, Norman Lippok, Cedric Blatter, Benjamin J Vakoc
Existing three-dimensional optical imaging methods excel in controlled environments but are difficult to deploy over large, irregular and dynamic fields. This has limited imaging in areas such as material inspection and medicine. To better address these applications, we developed methods in optical coherence tomography (OCT) to efficiently interrogate sparse scattering fields, i.e., those in which most locations (voxels) do not generate meaningful signal. Frequency comb sources are used to superimpose reflected signals from equispaced locations through optical subsampling...
2018: Nature Photonics
Jarne M van Hattem, Tessa J C Langeveld, Sylvia M Bruisten, Marion Kolader, Martin P Grobusch, Henry J C de Vries, Godelieve J de Bree
OVERVIEW: We describe the first case of a cutaneous ulcer caused by Haemophilus ducreyi imported from Indonesia to the Netherlands. Skin infections caused by H. ducreyi are uncommon in travellers and have been described in just a few case reports and were all contracted on the Pacific Islands. THE CASE: A 22-year-old healthy male visited the Center of Tropical Medicine and Travel Medicine in February 2017 with a cutaneous ulcer of the right lateral malleolus 4 weeks after returning from Indonesia (Seram and Ambon Islands)...
April 2018: PLoS Neglected Tropical Diseases
Tuangsit Wataganara, Arundhati Gosavi, Katika Nawapun, Pradip D Vijayakumar, Nisarat Phithakwatchara, Mahesh Choolani, Lin Lin Su, Arijit Biswas, Citra N Z Mattar
Fetoscopic laser coagulation of arterio-venous anastomoses (AVA) in a monochorionic placenta is the standard of care for twin-twin transfusion syndrome (TTTS), but is technically challenging and can lead to significant complications. Acquiring and maintaining the necessary surgical skills require consistent practice, a critical caseload, and time. Training on realistic surgical simulators can potentially shorten this steep learning curve and enables several proceduralists to acquire procedure-specific skills simultaneously...
March 21, 2018: Journal of Visualized Experiments: JoVE
Sumbla Sheikh, Alexander Sturzu, Hubert Kalbacher, Thomas Nagele, Christopher Weidenmaier, Marius Horger, Christian Schwentner, Ulrike Ernemann, Stefan Heckl
Curcumin, as the main ingredient of the curcuma spice has increasingly become the target of scientific research. The turmeric root which the spice is obtained from has been widely used in traditional medicine and scientific studies found anti-inflammatory, anti-cancer, anti-angiogenic effects as well as antibacterial properties for curcumin. Recently, curcumin has gathered interest as potential therapeutic agent in the research on Alzheimer's disease. A consistent problem in the investigative and therapeutic applications of curcumin is its poor solubility in aqueous solutions...
April 5, 2018: Current Pharmaceutical Design
Lizette Anayo, Anette Magnussen, Alexis Perry, Mark Wood, Alison Curnow
OBJECTIVES: Non-melanoma skin cancers are the most frequently occurring type of cancer worldwide. They can be effectively treated using topical dermatological photodynamic therapy (PDT) employing protoporphyrin IX (PpIX) as the active photosensitising agent as long as the disease remains superficial. Novel iron chelating agents are being investigated to enhance the effectiveness and extend the applications of this treatment modality, as limiting free iron increases the accumulation of PpIX available for light activation and thus cell kill...
March 31, 2018: Lasers in Surgery and Medicine
Yiwei Zhou, Yong Hu, Wenjie Sun, Shiyi Lu, Chao Cai, Chen Peng, Jing Yu, Rachela Popovtzer, Mingwu Shen, Xiangyang Shi
Development of versatile nanoscale platforms for cancer diagnosis and therapy is of great importance for applications in translational medicine. In this work, we present the use of γ-polyglutamic acid (γ-PGA) nanogels (NGs) to load polypyrrole (PPy) for thermal/photoacoustic (PA) imaging and radiotherapy (RT)-sensitized tumor photothermal therapy (PTT). First, a double emulsion approach was used to prepare the cystamine dihydrochloride (Cys)-crosslinked γ-PGA NGs. Next, the crosslinked NGs served as a reactor to be filled with pyrrole monomers that were subjected to in-situ oxidation polymerization in the existence of Fe(III) ions...
March 30, 2018: Biomacromolecules
Ravi Jain, Gerardo Moreno Arias, Pablo Naranjo, Max Murison, Jose Luis López Estebaranz, Alina Fratila, Welf Prager, Carlos Guillén Barona, Michael Weidmann, Serge Dahan, Hugues Cartier, Gerhard Sattler, Maurizio Podda
INTRODUCTION: A variety of topical anesthetic creams are available to reduce pain associated with dermatological procedures. Pliaglis is a self-occluding eutectic mixture of lidocaine and tetracaine. STUDY OBJECTIVES: To evaluate the post-marketing safety profile of Pliaglis and efficacy in terms of pain reduction, product satisfaction, and daily practice use prior to pre-defined dermatological procedures. METHODS: A prospective, non-interventional study conducted at 44 sites in four European countries; 581 patients were treated prior to dermatological procedures such as pulsed-dye laser therapy, laser-assisted hair removal, non-ablative laser resurfacing, dermal filler injections, and vascular access...
April 1, 2018: Journal of Drugs in Dermatology: JDD
Megha K Trivedi, Suzana S Bosanac, Raja K Sivamani, Larissa N Larsen
As we gain a greater understanding of acne pathogenesis, both new agents as well as new uses for established drugs are being considered for the treatment of acne vulgaris. Multiple clinical trials assessing new formulations or combinations of established acne treatments have been conducted, and novel uses of antimicrobials such as modified diallyl disulfide oxide and nitric oxide are being assessed in clinical trials. There are also a multitude of new therapies currently being studied that target the inflammatory cascade of acne pathogenesis, including sebosuppressive and anti-inflammatory phytochemicals, and  small molecule inhibitors targeting sebaceous glands and enzymes, among others...
March 29, 2018: American Journal of Clinical Dermatology
Susanne Staehlke, Henrike Rebl, Birgit Finke, Petra Mueller, Martina Gruening, J Barbara Nebe
Background: Biomaterial modifications-chemical and topographical-are of particular importance for the integration of materials in biosystems. Cells are known to sense these biomaterial characteristics, but it has remained unclear which physiological processes bio modifications trigger. Hence, the question arises of whether the dynamic of intracellular calcium ions is important for the characterization of the cell-material interaction. In our prior research we could demonstrate that a defined geometrical surface topography affects the cell physiology; this was finally detectable in a reduced intracellular calcium mobilization after the addition of adenosine triphosphate (ATP)...
2018: Cell & Bioscience
Tadasuke Ohnishi, Mitsumasa Hida, Yukio Nakamura, Chikamune Wada
[Purpose] It is clinically important to accurately evaluate the alignment of hindfoot alignment from the body surface in weight-bearing position. In general, measurement is carried out using a goniometer, but the measurement with goniometer requires experience, and the reliability in this measurement is also in question. Therefore, it is necessary to establish a clinical measurement method to replace the goniometer. As a solution, we devised a hindfoot alignment measurement method with laser beam (HAML), which measures hindfoot alignment along the body surface using a laser beam...
March 2018: Journal of Physical Therapy Science
Lothar Koch, Andrea Deiwick, Annika Franke, Kristin Schwanke, Axel Haverich, Robert Zweigerdt, Boris N Chichkov
Research on human induced pluripotent stem cells (hiPSCs) is one of the fastest growing fields in biomedicine. Generated from patient's own somatic cells, hiPSCs can be differentiated towards all functional cell types and returned to the patient without immunological concerns. 3D printing of hiPSCs could enable generation of functional organs for replacement therapies or realization of organ-on-chip systems for individualized medicine. 
 Printing of living cells was demonstrated with immortalized cell lines, primary cells, and adult stem cells with different printing technologies and biomaterials...
March 26, 2018: Biofabrication
Dana Akilbekova, Madina Shaimerdenova, Salimgerey Adilov, Berillo Dmitriy
The chitosan and gelatine are commonly used biopolymers for the tissue engineering applications. In the previous methods for the cryogels synthesis, multistep preparation methods using toxic cross-linking agents such as glutaraldehyde are reported. Here, we present a two-step preparation method of gelatin macroporous cryogels and one-step preparation method of chitosan or gelatin cryogels. The physico-chemical properties of obtained scaffolds were characterized using FTIR, zeta potential, SEM and laser confocal microscopy...
March 22, 2018: International Journal of Biological Macromolecules
Jonathan C Hibbard, Jonathan S Friedstat, Sonia M Thomas, Renee E Edkins, C Scott Hultman, Michael R Kosorok
BACKGROUND/AIMS: Laser treatment of burns scars is considered by some providers to be standard of care. However, there is little evidence-based research as to the true benefit. A number of factors hinder evaluation of the benefit of laser treatment. These include significant heterogeneity in patient response and possible delayed effects from the laser treatment. Moreover, laser treatments are often provided sequentially using different types of equipment and settings, so there are effectively a large number of overall treatment options that need to be compared...
March 1, 2018: Clinical Trials: Journal of the Society for Clinical Trials
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Lasers in Surgery and Medicine
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Lasers in Surgery and Medicine
Steven Shanks, Gerry Leisman
Research into photobiomodulation reveals beneficial effects of light therapy for a rapidly expanding list of medical conditions and illnesses. Although it has become more widely accepted by the mainstream medicine, the effects and mechanisms of action appear to be poorly understood. The therapeutic benefits of photobiomodulation using low-energy red lasers extend far beyond superficial applications, with a well-described physics allowing an understanding of how red lasers of certain optimum intensities may cross the cranium...
March 24, 2018: Advances in Experimental Medicine and Biology
Yogini Jaiswal, Zhitao Liang, Alan Ho, Hubiao Chen, Leonard Williams, Zhongzhen Zhao
Achyranthes bidentata and Achyranthes aspera are saponin and steroid rich medicinal plants, used extensively for therapeutic treatments in Traditional Chinese Medicine (TCM) and Ayurveda. A. bidentata is reported to be one of the rare and extensively exploited medicinal plant species that face the issue of being endangered. Finding qualitative substitute with identical phyto-constituents contributing to similar composition and pharmacological benefits will help in reducing the burden of exploitation of the natural habitats of such plants...
February 2018: Journal of Pharmaceutical Analysis
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