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https://www.readbyqxmd.com/read/29221036/direct-inscription-of-bragg-gratings-into-coated-fluoride-fibers-for-widely-tunable-and-robust-mid-infrared-lasers
#1
Gayathri Bharathan, Robert I Woodward, Martin Ams, Darren D Hudson, Stuart D Jackson, Alex Fuerbach
We report the development of a widely tunable all-fiber mid-infrared laser system based on a mechanically robust fiber Bragg grating (FBG) which was inscribed through the polymer coating of a Ho3+-Pr3+ co-doped double clad ZBLAN fluoride fiber by focusing femtosecond laser pulses into the core of the fiber without the use of a phase mask. By applying mechanical tension and compression to the FBG while pumping the fiber with an 1150 nm laser diode, a continuous wave (CW) all-fiber laser with a tuning range of 37 nm, centered at 2870 nm, was demonstrated with up to 0...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29204310/laser-emission-imaging-of-nuclear-biomarkers-for-high-contrast-cancer-screening-and-immunodiagnosis
#2
Yu-Cheng Chen, Xiaotian Tan, Qihan Sun, Qiushu Chen, Wenjie Wang, Xudong Fan
Detection of nuclear biomarkers such as nucleic acids and nuclear proteins is critical for early-stage cancer diagnosis and prognosis. Conventional methods relying on morphological assessment of cell nuclei in histopathology slides may be subjective, whereas colorimetric immunohistochemical and fluorescence-based imaging are limited by strong light absorption, broad-emission bands and low contrast. Here, we describe the development and use of a scanning laser-emission-based microscope that maps lasing emissions from nuclear biomarkers in human tissues...
2017: Nature Biomedical Engineering
https://www.readbyqxmd.com/read/29204250/generation-and-role-of-reactive-oxygen-and-nitrogen-species-induced-by-plasma-lasers-chemical-agents-and-other-systems-in-dentistry
#3
REVIEW
Nayansi Jha, Jae Jun Ryu, Eun Ha Choi, Nagendra Kumar Kaushik
The generation of reactive oxygen and nitrogen species (RONS) has been found to occur during inflammatory procedures, during cell ischemia, and in various crucial developmental processes such as cell differentiation and along cell signaling pathways. The most common sources of intracellular RONS are the mitochondrial electron transport system, NADH oxidase, and cytochrome P450. In this review, we analyzed the extracellular and intracellular sources of reactive species, their cell signaling pathways, the mechanisms of action, and their positive and negative effects in the dental field...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29200730/comparative-proteomic-analysis-of-three-gelatinous-chinese-medicines-and-their-authentications-by-tryptic-digested-peptides-profiling-using-matrix-assisted-laser-desorption-ionization-time-of-flight-time-of-flight-mass-spectrometry
#4
Huan Yang, Jie Zheng, Hai-Yan Wang, Nan Li, Ya-Ya Yang, Yu-Ping Shen
Background: Gelatinous Chinese medicines (GCMs) including Asini Corii Colla, Testudinis Carapacis ET Plastri Colla, and Cervi Cornus Colla, were made from reptile shell or mammalian skin or deer horn, and consumed as a popular tonic, as well as hemopoietic and hemostatic agents. Misuse of them would not exert their functions, and fake or adulterate products have caused drug market disorder and affected food and drug safety. GCMs are rich in denatured proteins, but insufficient in available DNA fragments, hence commonly used cytochrome c oxidase I barcoding was not successful for their authentication...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29198447/fabrication-and-evaluation-of-magnetic-phosphodiesterase-5-linked-nanoparticles-as-adsorbent-for-magnetic-dispersive-solid-phase-extraction-of-inhibitors-from-chinese-herbal-medicine-prior-to-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight
#5
Yi Tao, Xianghui Gu, Weidong Li, Baochang Cai
In the present study, the preparation of the magnetic phosphodiesterase-5 linked Fe3O4@ SiO2 nanoparticles was successfully achieved by amide reaction and the magnetic phosphodiesterase-5 linked Fe3O4@SiO2 nanoparticles were evaluated as a new adsorbent for magnetic dispersive solid-phase extraction of ligands from medicinal plant samples before the analysis by UHPLC-Q-TOF/MS. The prepared phosphodiesterase-5 linked Fe3O4@SiO2 nanoparticles were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, vibration sample magnetometer and potential laser particle size analyzer...
November 27, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29195356/a-new-instrument-of-vuv-laser-desorption-ionization-mass-spectrometry-imaging-with-micrometer-spatial-resolution-and-low-level-of-molecular-fragmentation
#6
Jia Wang, Feng Liu, Yuxiang Mo, Zhaoying Wang, Sichun Zhang, Xinrong Zhang
Mass spectrometry imaging (MSI) has important applications in material research, biology, and medicine. The MSI method based on UV laser desorption/ionization (UVLDI) can obtain images of intact samples, but has a high level of molecular fragmentation. In this work, we report a new MSI instrument that uses a VUV laser (125.3 nm) as a desorption/ionization source to exploit its advantages of high single photon energy and small focus size. The new instrument was tested by the mass spectra of Nile red and FGB (Fibrinogen beta chain) samples and mass spectrometric images of a fly brain section...
November 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29193393/modified-first-or-second-cervical-nerve-transplantation-technique-for-the-treatment-of-recurrent-laryngeal-neuropathy-in-horses
#7
F Rossignol, O Brandenberger, J D Perkins, J-P Marie, C Mespoulhès-Rivière, N G Ducharme
BACKGROUND: In horses, the only established method for reinnervation of the larynx is the nerve-muscle pedicle implantation, whereas in human medicine, direct nerve implantation is a standard surgical technique for selective laryngeal reinnervation in patients suffering from bilateral vocal fold paralysis. OBJECTIVES: (1) To describe a modified first or second cervical nerve transplantation technique for the treatment of recurrent laryngeal neuropathy (RLN) in horses and (2) evaluate the outcomes of reinnervation using direct nerve needle-stimulation of the first cervical nerve and exercising endoscopy before and after surgery...
November 28, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29189945/could-adverse-effects-and-complications-of-selective-laser-trabeculoplasty-be-decreased-by-low-power-laser-therapy
#8
REVIEW
Alexandre de Carvalho Mendes Paiva, Adenilson de Souza da Fonseca
Selective laser trabeculoplasty (SLT) has been used for treatment of primary open-angle glaucoma, ocular hypertension, pigmenter and pseudoexfoliative glaucoma being considered a low-risk procedure. Therefore, transitory and permanent adverse effects have been reported, including corneal changes, subclinical edema, and reduction in endothelial cells and in central corneal thickness. Despite rarer, serious corneal complications after SLT can be permanent and lead to visual impairment, central corneal haze, opacity and narrowing...
November 30, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29185012/systems-biology-of-the-imidia-biobank-from-organ-donors-and-pancreatectomised-patients-defines-a-novel-transcriptomic-signature-of-islets-from-individuals-with-type-2-diabetes
#9
Michele Solimena, Anke M Schulte, Lorella Marselli, Florian Ehehalt, Daniela Richter, Manuela Kleeberg, Hassan Mziaut, Klaus-Peter Knoch, Julia Parnis, Marco Bugliani, Afshan Siddiq, Anne Jörns, Frédéric Burdet, Robin Liechti, Mara Suleiman, Daniel Margerie, Farooq Syed, Marius Distler, Robert Grützmann, Enrico Petretto, Aida Moreno-Moral, Carolin Wegbrod, Anke Sönmez, Katja Pfriem, Anne Friedrich, Jörn Meinel, Claes B Wollheim, Gustavo B Baretton, Raphael Scharfmann, Everson Nogoceke, Ezio Bonifacio, Dorothée Sturm, Birgit Meyer-Puttlitz, Ugo Boggi, Hans-Detlev Saeger, Franco Filipponi, Mathias Lesche, Paolo Meda, Andreas Dahl, Leonore Wigger, Ioannis Xenarios, Mario Falchi, Bernard Thorens, Jürgen Weitz, Krister Bokvist, Sigurd Lenzen, Guy A Rutter, Philippe Froguel, Manon von Bülow, Mark Ibberson, Piero Marchetti
AIMS/HYPOTHESIS: Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for Diabetes: Improving beta-cell function and identification of diagnostic biomarkers for treatment monitoring in Diabetes (IMIDIA) consortium ( www.imidia.org ) established a comprehensive, unique multicentre biobank of human islets and pancreas tissues from organ donors and metabolically phenotyped pancreatectomised patients (PPP)...
November 28, 2017: Diabetologia
https://www.readbyqxmd.com/read/29179738/laser-modified-titanium-surfaces-enhance-the-osteogenic-differentiation-of-human-mesenchymal-stem-cells
#10
Tatiana A B Bressel, Jana Dara Freires de Queiroz, Susana Margarida Gomes Moreira, Jéssyca T da Fonseca, Edson A Filho, Antônio Carlos Guastaldi, Silvia Regina Batistuzzo de Medeiros
BACKGROUND: Titanium surfaces have been modified by various approaches with the aim of improving the stimulation of osseointegration. Laser beam (Yb-YAG) treatment is a controllable and flexible approach to modifying surfaces. It creates a complex surface topography with micro and nano-scaled patterns, and an oxide layer that can improve the osseointegration of implants, increasing their usefulness as bone implant materials. METHODS: Laser beam irradiation at various fluences (132, 210, or 235 J/cm2) was used to treat commercially pure titanium discs to create complex surface topographies...
November 28, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29172501/combined-pc-and-hmme-for-breast-cancer-treatment-via-photosensitizers-modified-fe3o4-nanoparticles-inhibiting-the-proliferation-and-migration-of-mcf-7-cells
#11
Shi-Wei Du, Ling-Kun Zhang, Kaibin Han, Shaoping Chen, Zhuoyan Hu, Wuya Chen, Kaikai Hu, Liang Yin, Baoyan Wu, Yan-Qing Guan
Photodynamic therapy (PDT), combining the laser and photosensitizers to kill tumor cells, has the potential to address many currently medical requirements. In this study, magnetic Fe3O4 nanoparticles were firstly employed as cores, and modified with oleic acid (OA) and 3-triethoxysilyl-1-Propanamine. Then, the photosensitizers phycocyanin (PC) and hematoporphyrin monomethyl ether (HMME), which might be able to stimulate the cell release of ROS after the irradiation of near infrared (NIR) laser, were grafted on the surface of such nanoparticles...
November 27, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29172133/cellular-imaging-and-bactericidal-mechanism-of-green-synthesized-silver-nanoparticles-against-human-pathogenic-bacteria
#12
Sathish Sundar Dhilip Kumar, Nicolette Nadene Houreld, Eve M Kroukamp, Heidi Abrahamse
In recent years, silver nanoparticles (AgNPs) have attracted significant attention in medicinal, biomedical, and pharmaceutical research owing to their valuable physicochemical and antibacterial properties. Leaf sap extract (LSE) from Aloe arborescens can be used as an active ingredient for different biological applications, including wound healing. In this study, we have investigated the use of LSE from A. arborescens as a reducing, stabilizing and capping agent to produce AgNPs during the so called "green synthesis" (G-AgNPs)...
November 3, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29165472/intracellular-delivery-of-more-than-one-protein-with-spatio-temporal-control
#13
Miguel M Lino, Susana Simões, Sónia Pinho, Lino Ferreira
Transient, non-integrative modulation of cell function by intracellular delivery of proteins has high potential in cellular reprogramming, gene editing and therapeutic medicine applications. Unfortunately, the capacity to deliver multiple proteins intracellularly with temporal and spatial control has not been demonstrated. Here, we report a near infrared (NIR) laser-activatable nanomaterial that allows for precise control over the release of two proteins from a single nanomaterial. The nanomaterial is formed by gold nanorods (AuNRs) modified with single stranded DNA (ssDNA) to which complementary DNA-conjugated proteins are hybridized...
November 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/29158030/the-role-of-ayurveda-management-in-preventing-surgical-site-infections-instead-of-surgical-antibiotic-prophylaxis
#14
Subhash Yadav, Sanjay Jain, Jatinder Chaudhary, Rahul Bansal, Manoj Sharma
It is probably for the first time in the history of modern surgery that Benign Prostate Hyperplasia (BPH) surgery which belongs to 'clean contaminated' class and requires at least 3 doses of prophylactic antibiotic as per recommendations by American Urology Association, was done without the use of any as the patient had a history of severe intolerance to them. The case was an 83 year old male patient presenting with acute urinary retention. He was a known case of BPH being managed continuously on Ayurvedic therapy for many years...
November 17, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29152907/hierarchical-multicomponent-inorganic-metamaterials-intrinsically-driven-self-assembly-at-the-nanoscale
#15
REVIEW
Igor Levchenko, Kateryna Bazaka, Michael Keidar, Shuyan Xu, Jinghua Fang
Increasingly intricate in their composition and structural organization, hierarchical multicomponent metamaterials with nonlinear spatially reconfigurable functionalities challenge the intrinsic constraints of natural materials, revealing tremendous potential for the advancement of biochemistry, nanophotonics, and medicine. Recent breakthroughs in high-resolution nanofabrication utilizing ultranarrow, precisely controlled ion or laser beams have enabled assembly of architectures of unprecedented structural and functional complexity, yet costly, time- and energy-consuming high-resolution sequential techniques do not operate effectively at industry-required scale...
November 20, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29152831/laser-treatment-of-cutaneous-angiokeratomas-a-systematic-review
#16
REVIEW
Jannett Nguyen, Lance W Chapman, Dorota Z Korta, Christopher B Zachary
Angiokeratomas can present therapeutic challenges, especially in cases of extensive lesions, where traditional surgical methods carry high risks of scarring and hemorrhage. Argon, pulsed dye (PDL), neodymium-doped yttrium aluminum garnet (Nd:YAG), copper vapor, potassium titanyl phosphate, carbon dioxide, and erbium-doped yttrium aluminum garnet (Er:YAG) lasers have emerged as alternative options. To review the use and efficacy of lasers in treating angiokeratomas. A PubMed search identified randomized clinical trials, cohort studies, case series, and case reports involving laser treatment of cutaneous angiokeratomas...
November 19, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/29149812/architectures-and-mechanical-properties-of-drugs-and-complexes-of-surface-active-compounds-at-air-water-and-oil-water-interfaces
#17
Dipak K Sarker
BACKGROUND: Drugs can represents a multitude of compounds from proteins and peptides, such as growth hormones and insulin and on to simple organic molecules such as flurbiprofen, ibuprofen and lidocaine. Given the chemical nature of these compounds two features are always present. A portion or portions of the molecule that has little affinity for apolar surfaces and media and the opposite a series of part or one large part that has considerable affinity for hydrophilic, polar or charged media and surfaces...
November 17, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29149145/endoscopic-epidural-laser-decompression-versus-transforaminal-epiduroscopic-laser-annuloplasty-for-lumbar-disc-herniation-a-prospective-randomized-trial
#18
Chang Hong Park, Sang Ho Lee
BACKGROUND: Lumbar radicular pain often results from lumbar disc herniation, spinal stenosis, or degenerative spondylolisthesis. Minimally invasive disc decompression procedures, such as nucleo-annuloplasty or epiduroscopic neural decompression by laser, have been devised to treat such pain. OBJECTIVE: The short-term outcomes of disc decompression by endoscopic epidural laser decompression (EELD) or transforaminal epiduroscopic laser annuloplasty (TELA) were compared in patients with lumbar radicular pain due to disc herniation...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29135155/-laser-therapy-for-male-infertility-part-1-etiology-and-pathogenesis-experimental-studies
#19
O I Apolikhin, S V Moskvin
Male infertility is associated with a wide range of pathological conditions affecting both the sexual and other body systems: endocrine, nervous, blood, and immune. Laser therapy is a form of modern physiotherapy that applies low-intensity laser radiation in various parts of the body. It is widely used in all areas of modern medicine due to its high efficiency, ease of use, the absence of contraindications and side effects. The authors reviewed the results of 171 studies investigating laser therapy, of which 93 were experimental (20 in Russian and 73 international publications), 4 clinical and experimental (all in Russian), 74 clinical (73 in Russian and 1in English)...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29130347/editorial-comment-on-end-2017-0641-ra-r1
#20
Joel Gustavo Gómez-Núñez
The manuscript by Matlaga et al titled "Ureteroscopic Laser Lithotripsy: A Review of Dusting Versus Fragmentation With Extraction" was first intended for a meta-analysis publication, but because limited data published, it became an interesting review article focused in the current debate about which of the so described laser urinary lithotripsy "Fragmentation with Extraction" and "Dusting" techniques is better. Authors do an effort to homologize terminology and nomenclature and list the most efficient energy settings used in clinical scenario on the "Fragmentation with Extraction" [(Frequency 12-15 Hz (< 30 watt laser) >50Hz (100/120 watt laser) / Energy 0...
November 12, 2017: Journal of Endourology
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