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https://www.readbyqxmd.com/read/28436954/optimized-expression-based-microdissection-of-formalin-fixed-lung-cancer-tissue
#1
Markus Grafen, Thurid R Hofmann, Andreas H Scheel, Julia Beck, Alexander Emmert, Stefan Küffer, Bernhard C Danner, Ekkehard Schütz, Reinhardt Büttner, Andreas Ostendorf, Philipp Ströbel, Hanibal Bohnenberger
Analysis of specific DNA alterations in precision medicine of tumors is crucially important for molecular targeted treatments. Lung cancer is a prototypic example and one of the leading causes of cancer-related deaths worldwide. One major technical problem of detecting DNA alterations in tissue samples is cellular heterogeneity, that is, mixture of tumor and normal cells. Microdissection is an important tool to enrich tumor cells from heterogeneous tissue samples. However, conventional laser capture microdissection has several disadvantages like user-dependent selection of regions of interest (ROI), high costs for dissection systems and long processing times...
April 24, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28429764/fabrication-characterization-and-biological-evaluation-of-anti-her2-indocyanine-green-doxorubicin-encapsulated-peg-b-plga-copolymeric-nanoparticles-for-targeted-photochemotherapy-of-breast-cancer-cells
#2
Yu-Hsiang Lee, Da-Sheng Chang
In this study, we aimed to develop anti-human epidermal growth factor receptor 2 (HER2) indocyanine green (ICG)-doxorubicin (DOX)-encapsulated polyethylene glycol-poly(lactic-co-glycolic acid) diblock copolymeric nanoparticles (HIDPPNPs) to explore the co-administration of phototherapy and chemotherapy for HER2-overexpressing breast cancer, a highly aggressive and medicine-resistant breast carcinoma. The HIDPPNPs were fabricated using a solvent evaporation technique followed by carbodiimide-mediated antibody conjugation on the nanoparticle surface...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28412273/efficient-inhibition-of-influenza-a-viral-replication-in-cells-by-deoxyribozymes-delivered-by-nanocomposites
#3
Marina Repkova, Asya Levina, Boris Chelobanov, Zinfer Ismagilov, Natalia Shatskaya, Sergei Baiborodin, Ekaterina Filippova, Natalia Mazurkova, Valentina Zarytova
Nucleic-acid-based drugs are a promising class of novel therapeutics; however, their use in medicine is widely limited because of insufficient delivery into cells. This article proposes a new delivery strategy of nucleic acid fragments into cells as components of TiO2-based nanocomposites. For the first time, unmodified Dz molecules were non-covalently immobilized on TiO2 nanoparticles precovered with polylysine (TiO2•PL) with the formation of (TiO2•PL)•Dz nanocomposites. DNAzymes in the proposed nanocomposites were shown to retain their ability to cleave the RNA target in a cell-free system with the same selectivity as unbound Dz molecules...
April 12, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28411385/news-announcements-american-society-for-laser-medicine-and-surgery-inc
#4
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28400686/convergence-of-minds-for-better-patient-outcome-in-intensive-care-unit-infections
#5
Chand Wattal, Yash Javeri, Neeraj Goel, Debashish Dhar, Sonal Saxena, Sarman Singh, Jaswinder Kaur Oberoi, B K Rao, Purva Mathur, Vikas Manchanda, Vivek Nangia, Arti Kapil, Ashok Rattan, Supradip Ghosh, Omender Singh, Vinod Singh, Iqbal Kaur, Sanghamitra Datta, Sharmila Sen Gupta
BACKGROUND: There is emergence of resistance to the last-line antibiotics such as carbapenems in Intensive Care Units (ICUs), leaving little effective therapeutic options. Since there are no more newer antibiotics in the armamentarium in the near future, it has become imperative that we harness the interdisciplinary knowledge for the best clinical outcome of the patient. AIMS: The aim of the conference was to utilize the synergies between the clinical microbiologists and critical care specialists for better patient care and clinical outcome...
March 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28393856/toward-a-scientific-understanding-of-the-effectiveness-material-basis-and-prescription-compatibility-of-a-chinese-herbal-formula-dan-hong-injection
#6
Panlin Li, Weiwei Su, Sha Yun, Yiqiu Liao, Yinyin Liao, Hong Liu, Peibo Li, Yonggang Wang, Wei Peng, Hongliang Yao
Since traditional Chinese medicine (TCM) is a complex mixture of multiple components, the application of methodologies for evaluating single-components Western medicine in TCM studies may have certain limitations. Appropriate strategies that recognize the integrality of TCM and connect to TCM theories remain to be developed. Here we use multiple unique approaches to study the scientific connotation of a TCM formula Dan-hong injection (DHI) without undermining its prescription integrity. The blood circulation improving and healing promoting effects of DHI were assessed by a qi stagnation blood stasis rat model and a mouse model of laser irradiation induced cerebral microvascular thrombosis...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28390830/bmajpla2-ii-a-basic-lys49-phospholipase-a2-homologue-from-bothrops-marajoensis-snake-venom-with-parasiticidal-potential
#7
Amy N Grabner, Jorge Alfonso, Anderson M Kayano, Leandro S Moreira-Dill, Ana Paula de A Dos Santos, Cleópatra A S Caldeira, Juliana C Sobrinho, Ana Gómez, Fernando P Grabner, Fabio F Cardoso, Juliana Pavan Zuliani, Marcos R M Fontes, Daniel C Pimenta, Celeste Vega Gómez, Carolina B G Teles, Andreimar M Soares, Leonardo A Calderon
Snake venoms contain various proteins, especially phospholipases A2 (PLA2s), which present potential applications in diverse areas of health and medicine. In this study, a new basic PLA2 from Bothrops marajoensis with parasiticidal activity was purified and characterized biochemically and biologically. B. marajoensis venom was fractionated through cation exchange followed by reverse phase chromatographies. The isolated toxin, BmajPLA2-II, was structurally characterized with MALDI-TOF (Matrix-assisted laser desorption/ionization-time of flight) mass spectrometry, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), followed by two-dimensional electrophoresis, partial amino acid sequencing, an enzymatic activity assay, circular dichroism, and dynamic light scattering assays...
April 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28374298/peri-procedure-laser-scar-therapy-protocol-a-pilot-survey-of-plastic-surgeons-practices
#8
Michael Mirmanesh, Zachary Borab, Madeleine Gantz, Pirko Maguina
BACKGROUND: Scar management using laser phototherapy continues to evolve as it gains wide acceptance among patients and providers. Despite widespread use of laser therapy, there are no guidelines or consensus published regarding optimal pre- and post-procedure patient management. Our objective is to gain insight into the best laser practices; we decided to poll colleagues nationwide. METHODS: An online survey was distributed to members of the American Society of Plastic Surgeons...
April 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28370223/novel-assessment-tool-based-on-laser-speckle-contrast-imaging-to-diagnose-severe-ischemia-in-the-lower-limb-for-patients-with-peripheral-arterial-disease
#9
Sotaro Katsui, Yoshinori Inoue, Kimihiro Igari, Takahiro Toyofuku, Toshifumi Kudo, Hiroyuki Uetake
OBJECTIVE: We propose a new assessment tool to diagnose severe ischemia of the lower limb in peripheral arterial disease, using laser speckle contrast imaging to evaluate heating-induced microcirculatory fluctuations in the proximal and distal sites of the dorsal foot. STUDY DESIGN: A cross-sectional study. METHODS: We recorded the slope describing the behavior of perfusion values (decrease or plateau) following the initial, heating-induced increase in perfusion in 63 feet of patients with clinical signs of peripheral arterial disease...
April 2, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28366365/intraocular-lens-power-calculations-in-eyes-with-previous-hyperopic-laser-in-situ-keratomileusis-or-photorefractive-keratectomy
#10
Eric B Hamill, Li Wang, Hayley K Chopra, Warren Hill, Douglas D Koch
PURPOSE: To evaluate the accuracy of 7 intraocular lens (IOL) calculation formulas in patients with previous hyperopic laser in situ keratomileusis (LASIK) or excimer laser photorefractive keratectomy (PRK). DESIGN: Retrospective case series. SETTING: Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, and private practice, Mesa, Arizona, USA. METHODS: The 7 formulas evaluated were the adjusted Atlas 0-3, Masket, Modified Masket, Haigis-L, Shammas-PL, Barrett True-K, and Barrett True-K No-History...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28366363/comparison-of-clinical-outcomes-between-wavefront-optimized-versus-corneal-wavefront-guided-transepithelial-photorefractive-keratectomy-for-myopic-astigmatism
#11
Ikhyun Jun, David Sung Yong Kang, Jerry Tan, Jin Young Choi, Woon Heo, Joo Young Kim, Min Goo Lee, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To evaluate and compare the clinical outcomes, including visual acuity, refractive errors, and aberrations, between aberration-free transepithelial photorefractive keratectomy (PRK) and corneal wavefront-guided transepithelial PRK in eyes with myopic astigmatism. SETTING: Yonsei University College of Medicine and Eyereum Eye Clinic, Seoul, South Korea. DESIGN: Retrospective comparative case series. METHODS: Patients with myopic astigmatism were treated with aberration-free transepithelial PRK or corneal wavefront-guided transepithelial PRK using a 1050 Hz high-repetition excimer laser...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28364326/of-cytometry-stem-cells-and-fountain-of-youth
#12
REVIEW
Dariusz Galkowski, Mariusz Z Ratajczak, Janusz Kocki, Zbigniew Darzynkiewicz
Outlined are advances of cytometry applications to identify and sort stem cells, of laser scanning cytometry and ImageStream imaging instrumentation to further analyze morphometry of these cells, and of mass cytometry to classify a multitude of cellular markers in large cell populations. Reviewed are different types of stem cells, including potential candidates for cancer stem cells, with respect to their "stemness", and other characteristics. Appraised is further progress in identification and isolation of the "very small embryonic-like stem cells" (VSELs) and their autogenous transplantation for tissue repair and geroprotection...
March 31, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28362634/site-selective-conjugation-of-an-anticoagulant-aptamer-to-recombinant-albumins-and-maintenance-of-neonatal-fc-receptor-binding
#13
Julie Schmøkel, Anders Voldum, Georgia Tsakiridou, Matthias Kuhlmann, Jason Cameron, Esben S Sørensen, Jesper Wengel, Kenneth A Howard
Aptamers are an attractive molecular medicine that offers high target specificity. Nucleic acid-based aptamers, however, are prone to nuclease degradation and rapid renal excretion that require blood circulatory half-life extension enabling technologies. The long circulatory half-life, predominately facilitated by engagement with the cellular recycling neonatal Fc receptor (FcRn), and ligand transport properties of albumin promote it as an attractive candidate to improve the pharmacokinetic profile of aptamers...
May 19, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28346749/news-announcements-american-society-for-laser-medicine-and-surgery-inc
#14
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28335189/synergistic-antibacterial-effects-of-nanoparticles-encapsulated-with-scutellaria-baicalensis-and-pure-chlorhexidine-on-oral-bacterial-biofilms
#15
Ken Cham-Fai Leung, Chaminda Jayampath Seneviratne, Xuan Li, Ping Chung Leung, Clara Bik San Lau, Chi-Hin Wong, Ka Yan Pang, Chun Wai Wong, Elaine Wat, Lijian Jin
Scutellariabaicalensis (SB) is a traditional Chinese medicine for treating infectious and inflammatory diseases. Our recent study shows potent antibacterial effects of nanoparticle-encapsulated chlorhexidine (Nano-CHX). Herein, we explored the synergistic effects of the nanoparticle-encapsulated SB (Nano-SB) and Nano-CHX on oral bacterial biofilms. Loading efficiency of Nano-SB was determined by thermogravimetric analysis, and its releasing profile was assessed by high-performance liquid chromatographyusing baicalin (a flavonoid compound of SB) as the marker...
April 7, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28328287/photobiomodulation-with-non-thermal-lasers-mechanisms-of-action-and-therapeutic-uses-in-dermatology-and-aesthetic-medicine
#16
Mark Nestor, Anneke Andriessen, Brian Berman, Bruce E Katz, Dore Gilbert, David J Goldberg, Michael H Gold, Robert S Kirsner, Paul Z Lorenc
BACKGROUND: Non-thermal laser therapy in dermatology, is a growing field in medical technology by which therapeutic effects are achieved by exposing tissues to specific wavelengths of light. OBJECTIVES: The purpose of this review was to gain a better understanding of the science behind non-thermal laser and the evidence supporting its use in dermatology. METHODS: A group of dermatologists and surgeons recently convened to review the evidence supporting the use of non-thermal laser for body sculpting, improving the appearance of cellulite, and treating onychomycosis...
February 17, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28323640/a-micro-scale-printable-nanoclip-for-electrical-stimulation-and-recording-in-small-nerves
#17
Charles A Lissandrello, Winthrop F Gillis, Jun Shen, Ben W Pearre, Flavia Vitale, Matteo Pasquali, Bradley J Holinski, Daniel J Chew, Alice E White, Timothy J Gardner
OBJECTIVE: The vision of bioelectronic medicine is to treat disease by modulating the signaling of visceral nerves near various end organs. In small animal models, the nerves of interest can have small diameters and limited surgical access. New high-resolution methods for building nerve interfaces are desirable. In this study, we present a novel nerve interface and demonstrate its use for stimulation and recording in small nerves. APPROACH: We design and fabricate micro-scale electrode-laden nanoclips capable of interfacing with nerves as small as 50 µm in diameter...
March 21, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28317678/quality-of-vision-after-wavefront-guided-laser-in-situ-keratomileusis-or-photorefractive-keratectomy-contralateral-eye-evaluation
#18
Michele D Lee, Edward E Manche
PURPOSE: To compare quality of vision between laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK). SETTING: Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA. DESIGN: Prospective randomized case series. METHODS: Patients had refractive surgery, with 1 eye treated with LASIK and the other with PRK. Eyes were randomized for dominance. The patients completed a questionnaire assessing quality of vision in each eye at the initial visit and 1, 3, 6, and 12 months postoperatively...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28316193/-clinical-study-on-the-corneal-epithelial-dysfunction-after-cataract-extraction
#19
J H Qu, Z Q Wang, Y Zhang, X G Sun
Objective: To study the clinical manifestations, diagnosis and treatment of corneal epithelial dysfunction after cataract extraction. Methods: Fifteen cases diagnosed as corneal epithelial dysfunction after cataract extraction between November 2014 and September 2016 were retrospectively analyzed, mainly including clinical manifestations, characteristics of morphological changes imaged by in vivo laser confocal microscopy, management and therapeutic effects. Results: There were 6 (40%) males and 9 (60%) females with an average age of 66±7 years (59 to 86 years)...
March 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28315493/an-osteogenesis-angiogenesis-stimulation-artificial-ligament-for-anterior-cruciate-ligament-reconstruction
#20
Hong Li, Jinyan Li, Jia Jiang, Fang Lv, Jiang Chang, Shiyi Chen, Chengtie Wu
To solve the poor healing of polyethylene terephthalate (PET) artificial ligament in bone tunnel, copper-containing bioactive glass (Cu-BG) nanocoatings on PET artificial ligaments were successfully prepared by pulsed laser deposition (PLD). It was hypothesized that Cu-BG coated PET (Cu-BG/PET) grafts could enhance the in vitro osteogenic and angiogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) and in vivo graft-bone healing after anterior cruciate ligament (ACL) reconstruction in a goat model...
March 14, 2017: Acta Biomaterialia
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