Leonard L de Boer, Lesley Vanes, Serena Melgrati, Joshua Biggs O'May, Darryl Hayward, Paul C Driscoll, Jason Day, Alexander Griffiths, Renata Magueta, Alexander Morrell, James I MacRae, Robert Köchl, Victor L J Tybulewicz
Migration of T cells is essential for their ability to mount immune responses. Chemokine-induced T cell migration requires WNK1, a kinase that regulates ion influx into the cell. However, it is not known why ion entry is necessary for T cell movement. Here we show that signaling from the chemokine receptor CCR7 leads to activation of WNK1 and its downstream pathway at the leading edge of migrating CD4+ T cells, resulting in ion influx and water entry by osmosis. We propose that WNK1-induced water entry is required to swell the membrane at the leading edge, generating space into which actin filaments can polymerize, thereby facilitating forward movement of the cell...
December 6, 2023: Nature Communications