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Routine outcome monitoring

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https://www.readbyqxmd.com/read/29791916/diclofenac-sodium-3-in-hyaluronic-acid-2-5-gel-significantly-diminishes-the-actinic-keratosis-area-and-severity-index
#1
Lutz Schmitz, Girish Gupta, Marc Hanno Segert, Ricarda Kost, Julia Sternberg, Thilo Gambichler, Eggert Stockfleth, Thomas Dirschka
BACKGROUND/AIMS: Actinic keratosis area and severity index (AKASI) is a new assessment tool to quantify the severity of actinic damage on the head. Thus far, it has not been evaluated in monitoring the efficacy of field-directed topical treatments in actinic keratosis (AK) in routine clinical practice. Thus, the aim of this study was to determine treatment outcomes by using AKASI 3 months after the initiation of topical application of diclofenac sodium 3% in hyaluronic acid 2.5% gel (DFS) in patients with AKs on the head...
May 23, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29791482/impact-of-high-versus-low-dose-neuromuscular-blocking-agent-administration-on-unplanned-30-day-readmission-rates-in-retroperitoneal-laparoscopic-surgery
#2
Martijn Boon, Chris Martini, H Keri Yang, Shuvayu S Sen, Rob Bevers, Michiel Warlé, Leon Aarts, Marieke Niesters, Albert Dahan
Recent data shows that a neuromuscular block (NMB) induced by administration of high doses of rocuronium improves surgical conditions in certain procedures. However, there are limited data on the effect such practices on postoperative outcomes. We performed a retrospective analysis to compare unplanned 30-day readmissions in patients that received high-dose versus low-dose rocuronium administration during general anesthesia for laparoscopic retroperitoneal surgery. This retrospective cohort study was performed in the Netherlands in an academic hospital where routine high-dose rocuronium NMB has been practiced since July 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29790303/association-between-reappearance-of-myeloperoxidase-antineutrophil-cytoplasmic-antibody-and-relapse-in-antineutrophil-cytoplasmic-antibody-associated-vasculitis-subgroup-analysis-of-nationwide-prospective-cohort-studies
#3
Haruki Watanabe, Ken-Ei Sada, Yoshinori Matsumoto, Masayoshi Harigai, Koichi Amano, Hiroaki Dobashi, Shouichi Fujimoto, Joichi Usui, Kunihiro Yamagata, Tatsuya Atsumi, Shogo Banno, Takahiko Sugihara, Yoshihiro Arimura, Seiichi Matsuo, Hirofumi Makino
OBJECTIVE: The aim of this study was to evaluate clinical links between levels of myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA) and relapse in patients with ANCA-associated vasculitis (AAV) using a data set from two nationwide prospective cohort studies. METHODS: From the cohort studies, 477 MPO-ANCA positive patients, who achieved remission during the 6 months after remission induction therapy, were enrolled. We measured MPO-ANCA levels at months 0, 3, 6, 12, 18, 24, and at the time of relapse...
May 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29790212/dopamine-in-transplantation-written-off-or-comeback-with-novel-indication
#4
REVIEW
Peter Schnuelle, Urs Benck, Benito A Yard
Renal-dose dopamine has fallen out of favor in the intensive care unit (ICU) during past years due to its ineffectiveness to prevent impending or to ameliorate overt renal failure in the critically ill. By contrast, growing evidence indicates that low-dose dopamine administered to the stable organ donor after brain death confirmation improves the clinical course of transplanted organs after kidney and heart transplantation. Ensuring a thorough monitoring for potential circulatory side effects, employment of dopamine at a dose of 4 μg/kg per minute is safe in the deceased donor...
May 23, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29783912/utilizing-clinical-pharmacist-specialist-to-manage-hepatitis-c-virus-patients-on-direct-acting-antiviral-therapy
#5
Lena A Mikolas, Kimberly Jacques, Mostaqul Huq, Charles Krasner, Scott E Mambourg
OBJECTIVES: To evaluate outcomes of a clinical pharmacist specialist (CPS)-managed hepatitis C virus (HCV) treatment clinic (HCVTC) in treating HCV-infected veterans with direct-acting antivirals (DAAs). METHODS: We established a CPS-managed HCVTC under a collaborative practice agreement with our infectious disease physician (IDP). A total of 132 veterans were treated between November 1, 2014, and November 30, 2015. The CPS engaged in pretreatment screening, drug selection, patient education, medication counseling, drug therapy monitoring, drug utilization review, addressing issues on drug adherence, and routine and posttreatment follow-up of patients to assess sustained virologic response (SVR) after 12 weeks of treatment...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29782891/review-article-a-translational-view-of-cells-secretome-analysis-from-untargeted-proteomic-to-potential-circulating-biomarkers
#6
REVIEW
Sandra I Anjo, Bruno Manadas
The identification of circulating biomarkers capable of being used as routine for diagnosis, prognosis, risk stratification and therapeutic monitoring is still the major aim at clinical proteomics. However, the direct search in blood samples or other clinical relevant biofluids is frequently associated with technical limitations that makes the biomarker discovery process extremely difficult when using these types of samples. In this sense, the use of different approaches, such as the analysis of cells' secretomes, can be an important and promising complementary method for the identification and pre-selection of potential circulating biomarkers...
May 18, 2018: Biochimie
https://www.readbyqxmd.com/read/29780917/advanced-pigment-dispersion-glaucoma-secondary-to-phakic-intraocular-collamer-lens-implant
#7
Clara Ye, Cajal K Patel, Anna C Momont, Yao Liu
Purpose: We report a case of pigment dispersion glaucoma secondary to uncomplicated phakic intraocular collamer lens (ICL) (Visian ICL™, Staar Inc., Monrovia, CA) implant that resulted in advanced visual field loss. Observations: A 50-year-old man presented for routine follow-up status post bilateral phakic intraocular collamer lens (ICL) placement 8 years earlier. He was incidentally found to have a decline in visual acuity from an anterior subcapsular cataract and elevated intraocular pressure (IOP) in the left eye...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29778620/-factors-associated-with-non-conversion-of-the-direct-smear-after-the-initial-phase-of-anti-tuberculous-treatment-a-study-undertaken-in-three-tuberculosis-management-centres-in-south-benin
#8
G Agodokpessi, A P Wachinou, B Awanou, M Gninafon
The objective of this work was to describe the profile of routinely managed tuberculosis patients whose sputum smear did not become negative after the initial phase of anti-tuberculous treatment and to analyze the factors associated with this. With this aim a cross-sectional, retrospective, descriptive and analytical study was carried out in a population of adults with pulmonary tuberculosis (PTB) between 2013 and 2014 in three cities in southern Benin (Cotonou, Porto-Novo and Abomey). The data of the patients who did not convert (PTB +) were compared with those who did (PTB-)...
May 16, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29777380/investigating-the-prognostic-ability-of-health-related-quality-of-life-on-survival-a-prospective-cohort-study-of-adults-with-lung-cancer
#9
Laura C Pinheiro, Bryce B Reeve
BACKGROUND: Health-related quality of life (HRQOL) is an important predictor for overall survival (OS). To date, no studies compared associations between HRQOL assessed before and after a cancer diagnosis for OS. Our objectives were to (1) investigate associations between HRQOL changes and OS and (2) identify the best HRQOL assessment time point to predict OS. METHODS: We used the Surveillance, Epidemiology and End Results linked with the Medicare Health Outcomes Survey data...
May 18, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29774052/therapeutic-drug-monitoring-of-vedolizumab-in-inflammatory-bowel-disease-current-data-and-future-directions
#10
REVIEW
Mark G Ward, Miles P Sparrow, Xavier Roblin
The introduction of vedolizumab, a lymphocyte adhesion inhibitor, has expanded the relatively limited therapeutic armamentarium available for Crohn's disease and ulcerative colitis. Despite its effectiveness, both primary nonresponse and secondary loss of response to vedolizumab do occur, as is observed with the use of anti-tumour necrosis factor (TNF) therapy. Further, in a proportion, onset of efficacy may be relatively slow. A large body of data support an exposure-response relationship with anti-TNF drug levels, which has led to therapeutic drug monitoring becoming incorporated into everyday clinical management...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29773575/measuring-physical-activity-with-implanted-cardiac-devices-a-systematic-review
#11
Lindsey Rosman, Rachel Lampert, Samuel F Sears, Matthew M Burg
BACKGROUND: Physical activity is predictive of cardiovascular outcomes in patients with cardiovascular implantable electronic devices, yet it is not regularly assessed in routine care. Current-generation cardiovascular implantable electronic devices, however, continuously monitor patient activity through a built-in accelerometer, which provides new opportunities to remotely assess patient activity, detect changes in clinical status, and incorporate these data in risk stratification models...
May 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29772118/proms-for-pain-in-adult-cancer-patients-a-systematic-review-of-measurement-properties
#12
REVIEW
Asma A Abahussin, Robert M West, David C Wong, Lucy E Ziegler
CONTEXT: Pain is one of the most devastating symptoms for cancer patients. One-third of patients who experience pain do not receive effective treatment. A key barrier to effective pain management is lack of routine measurement and monitoring of pain. Patient-Reported Outcome Measures (PROMs) are recommended for measuring cancer pain. However, evidence to guide the selection of the most appropriate measure to identify and monitor cancer pain is limited. A systematic review of measurement properties of PROMs for pain in cancer patients is needed to identify the best validated measure for adoption to an electronic platform...
May 17, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29766322/microdaimon-study-microcirculatory-daily-monitoring-in-critically-ill-patients-a-prospective-observational-study
#13
Claudia Scorcella, Elisa Damiani, Roberta Domizi, Silvia Pierantozzi, Stefania Tondi, Andrea Carsetti, Silvia Ciucani, Valentina Monaldi, Mara Rogani, Benedetto Marini, Erica Adrario, Rocco Romano, Can Ince, E Christiaan Boerma, Abele Donati
BACKGROUND: Until now, the prognostic value of microcirculatory alterations in critically ill patients has been mainly evaluated in highly selected subgroups. Aim of this study is to monitor the microcirculation daily in mixed group of Intensive Care Unit (ICU)-patients and to establish the association between (the evolution of) microcirculatory alterations and outcome. METHODS: This is a prospective longitudinal observational single-centre study in adult patients admitted to a 12-bed ICU in an Italian teaching hospital...
May 15, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29763267/top-20-research-studies-of-2017-for-primary-care-physicians
#14
Mark H Ebell, Roland Grad
Based on systematic surveillance of more than 110 medical journals, 247 studies met criteria as POEMs (patient-oriented evidence that matters) in 2017. Members of the Canadian Medical Association identified 20 of these POEMs as most relevant to practice. This article reviews the clinical questions and bottom-line answers from these studies. Blood pressure should be measured after a period of rest, using a bare arm, and orthostatic blood pressure is more predictive when measured after one minute of standing rather than three minutes...
May 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29759221/simultaneous-determination-of-total-dissolved-nitrogen-and-total-dissolved-phosphorus-in-natural-waters-with-an-on-line-uv-and-thermal-digestion
#15
Kunning Lin, Junxian Pei, Peicong Li, Jian Ma, Quanlong Li, Dongxing Yuan
A flow injection method combined with an on-line UV and thermal digestion for simultaneous determination of total dissolved nitrogen (TDN) and total dissolved phosphorus (TDP) in natural waters was established in this study. A novel flow manifold made the proposed system compact and automatic. The conversion rates of various nitrogen and phosphorus compounds to their nitrate and phosphate forms with different digestion models and different concentrations were well investigated using the flow injection technique...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29759082/barriers-to-identifying-eating-disorders-in-pregnancy-and-in-the-postnatal-period-a-qualitative-approach
#16
Amanda Bye, Jill Shawe, Debra Bick, Abigail Easter, Megan Kash-Macdonald, Nadia Micali
BACKGROUND: Eating Disorders (ED) are mental health disorders that typically effect women of childbearing age and are associated with adverse maternal and infant outcomes. UK healthcare guidance recommends routine enquiry for current and past mental illness in antenatal and postnatal care for all women, and that pregnant women with a known ED are offered enhanced monitoring and support. Midwives and health visitors are ideally placed to identify and support women with ED as they are often the primary point of contact during the antenatal and postnatal periods...
May 15, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29752666/lung-water-assessment-from-gravimetry-to-wearables
#17
Frederic Michard
Several techniques are now available to detect and quantify pulmonary edema, from the laboratory postmortem method (gravimetry) to non-invasive wearable sensors. In critically ill patients with adult respiratory distress syndrome (ARDS), computed tomography scans are often performed to visualize lung lesions and quantify lung aeration, but their value seems somewhat limited to quantify pulmonary edema on a routine basis and of course to track changes with therapy. In this context, transpulmonary thermodilution is a convenient technique...
May 11, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29747588/construction-and-pilot-test-of-a-set-of-indicators-to-assess-the-implementation-and-effectiveness-of-the-who-safe-childbirth-checklist
#18
Pedro J Saturno-Hernández, María Fernández-Elorriaga, Ismael Martínez-Nicolás, Ofelia Poblano-Verástegui
BACKGROUND: The World Health Organization (WHO) launched the "Safe Childbirth Checklist (SCC) Collaboration" in 2012. The SCC is designed to contribute to quality care by providing reminders of evidence-based practices for the prevention and management of the leading causes of maternal and neonatal morbidity and mortality. However, indicators to monitor the implementation and effectiveness of the SCC have not been defined. This study aimed to produce and pilot test a set of valid, reliable and feasible indicators to assess the implementation and effectiveness of the SCC, with an emphasis on best practices...
May 10, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29739288/how-has-the-presence-of-zimbabwe-s-victim-friendly-court-and-relevant-child-protection-policy-and-legal-frameworks-affected-the-management-of-intrafamilial-child-sexual-abuse-in-zimbabwe-the-case-of-marondera-district
#19
Anthony Shuko Musiwa
The study intended to assess, based on the perceptions of Victim-Friendly Court (VFC) professionals in Marondera District in Zimbabwe, how the presence of the VFC and relevant child protection policy and legal frameworks has affected the management of Intrafamilial Child Sexual Abuse (ICSA) in Zimbabwe. Sem-istructured questionnaires were administered to 25 professionals from 13 VFC agencies in Marondera, while one-on-one semi-structured interviews were conducted with 15 key informants who included five ICSA survivors and their respective five caregivers as well as five key community child protection committee members...
June 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29739110/comparison-of-new-liquid-chromatography-mass-spectrometry-method-and-enzyme-multiplied-immunoassay-technique-for-routine-therapeutic-drug-monitoring-of
#20
Guiyan Yuan, Huanjun Liu, Abdul S Shaikh, Rui Zhang, Pingli Li, Benjie Wang, Ruichen Guo
BACKGROUND: Therapeutic drug monitoring of vancomycin is very valuable due to the good correlation between trough levels and clinical outcome. Therefore, it is important to accurately determine the concentration of vancomycin in patient plasma for adequate dose-adjustment. The objective of this study was to develop a new liquid chromatography-mass spectrometry (LC-MS) method for determination of vancomycin in patient plasma and compare the results with those obtained from enzyme-multiplied immunoassay technique (EMIT)...
March 1, 2018: Clinical Laboratory
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