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Routine outcome monitoring

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https://www.readbyqxmd.com/read/28723520/bone-scan-index-as-an-imaging-biomarker-in-metastatic-castration-resistant-prostate-cancer-a-multicentre-study-based-on-patients-treated-with-abiraterone-acetate-zytiga-in-clinical-practice
#1
Mariana Reza, Mattias Ohlsson, Reza Kaboteh, Aseem Anand, Ingela Franck-Lissbrant, Jan-Erik Damber, Anders Widmark, Camilla Thellenberg-Karlsson, Lars Budäus, Thomas Steuber, Till Eichenauer, Per Wollmer, Lars Edenbrandt, Elin Trägårdh, Anders Bjartell
BACKGROUND: Abiraterone acetate (AA) prolongs survival in metastatic castration-resistant prostate cancer (mCRPC) patients. To measure treatment response accurately in bone, quantitative methods are needed. The Bone Scan Index (BSI), a prognostic imaging biomarker, reflects the tumour burden in bone as a percentage of the total skeletal mass calculated from bone scintigraphy. OBJECTIVE: To evaluate the value of BSI as a biomarker for outcome evaluation in mCRPC patients on treatment with AA according to clinical routine...
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28717121/impact-of-doppler-ultrasound-on-diagnosis-and-therapy-control-of-lienalis-steal-syndrome-after-liver-transplantation
#2
Eva M Teegen, Timm Denecke, Rosa B Schmuck, Robert Öllinger, Dominik Geisel, Johann Pratschke, Sascha S Chopra
BACKGROUND Lienalis steal syndrome is a rare complication after orthotopic liver transplantation leading to severe complications. Routine duplex sonography allows early and safe detection of lienalis steal syndrome and secondarily helps to monitor the outcome by evaluating the hemodynamics. MATERIAL AND METHODS This analysis included eight patients who after orthotopic liver transplantation needed splenic artery embolization due to lienalis steal syndrome. Lienalis steal syndrome was assumed in case of elevated transaminases, bilirubinemia or persistent ascites, and the absence of further pathologies...
July 18, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28716434/training-midwives-to-perform-basic-obstetric-point-of-care-ultrasound-in-rural-areas-using-a-tablet-platform-and-mobile-phone-transmission-technology-a-wfumb-coe-project
#3
Sudhir Vinayak, Joyce Sande, Harvey Nisenbaum, Christian Pállson Nolsøe
Point-of-care ultrasound (POCUS) has become a topical subject and can be applied in a variety of ways with differing outcomes. The cost of all diagnostic procedures including obstetric ultrasound examinations is a major factor in the developing world and POCUS is only useful if it can be equated to good outcomes at a lower cost than a routine obstetric examination. The aim of this study was to assess a number of processes including accuracy of images and reports generated by midwives, performance of a tablet-sized ultrasound scanner, training of midwives to complete ultrasounds, teleradiology solution transmissions of images via internet, review of images by a radiologist, communication between midwife and radiologist, use of this technique to identify high-risk patients and improvement of the education and teleradiology model components...
July 14, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28716027/cytomegalovirus-viraemia-and-mortality-in-renal-transplant-recipients-in-the-era-of-antiviral-prophylaxis-lessons-from-the-western-australian-experience
#4
Linda A Selvey, Wai H Lim, Peter Boan, Ramyasuda Swaminathan, Claudia Slimings, Amy E Harrison, Aron Chakera
BACKGROUND: Cytomegalovirus (CMV) establishes a lifelong infection that is efficiently controlled by the immune system; this infection can be reactivated in case of immunosuppression such as following solid organ transplantation. CMV viraemia has been associated with CMV disease, as well as increased mortality and allograft failure. Prophylactic antiviral medication is routinely given to renal transplant recipients, but reactivation during and following cessation of antiviral prophylaxis is known to occur...
July 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28710245/abciximab-induced-acute-profound-thrombocytopenia-postpercutaneous-coronary-intervention
#5
Todd Golden, Sehem Ghazala, Rita Wadeea, Shilpa Junna
Abciximab (c7E3 Fab) is one of the three potent intravenous glycoprotein IIb/IIIa receptor inhibitors (along with eptifibatide and tirofiban) that have shown significant positive outcomes when used in patients with intracoronary thrombus. However, major side effects have been reported with its use including hypotension, major bleeding and thrombocytopenia. This case is a 53-year-old man presenting with acute chest pain diagnosed with non-ST-elevation myocardial infarction, who underwent percutaneous coronary intervention with abciximab and heparin infusion and developed acute profound thrombocytopenia (platelet count <20,000/L) within 9 hours of infusion...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28708103/pharmacogenomics-of-targeted-agents-for-personalization-of-colorectal-cancer-treatment
#6
REVIEW
Alessia Bignucolo, Elena De Mattia, Erika Cecchin, Rossana Roncato, Giuseppe Toffoli
The use of targeted agents in the treatment of metastatic colorectal cancer (CRC) has improved patient outcomes. Anti-epidermal growth factor receptor (anti-EGFR) agents (cetuximab and panitumumab) and antiangiogenic molecules (bevacizumab, regorafeninb, ramucirumab, and aflibercept) have been successfully integrated into clinical practice. Other drugs have been designed to target additional deregulated pathways in CRC, such as MAPK (mitogen-activated protein kinase)/PI3K-AKT (phosphatidylinositol-3-kinase-AKT serine/threonine kinase)/mTOR (mammalian target of rapamycin), HER-2 and 3 ( human epidermal growth factor receptor-2 and -3), and BRAF...
July 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28704949/surrendered-and-stray-dogs-in-australia-estimation-of-numbers-entering-municipal-pounds-shelters-and-rescue-groups-and-their-outcomes
#7
Diana Chua, Jacquie Rand, John Morton
There is no national system for monitoring numbers of dogs entering municipal council pounds and shelters in Australia, or their outcomes. This limits understanding of the surrendered and stray dog issue, and prevents the evaluation of management strategies. We aimed to estimate these in 2012-2013. Dog intake and outcome data were collected for municipal councils and animal welfare organizations using annual reports, publications, primary peer-reviewed journal articles, websites and direct correspondence. More comprehensive data were obtained for New South Wales, Victoria, South Australia and Australian Capital Territory, whereas it was necessary to impute some or all data for Western Australia, Northern Territory, Queensland and Tasmania, as data were incomplete/unavailable...
July 12, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28694568/the-role-of-routine-measurement-of-intra-abdominal-pressure-in-preventing-abdominal-compartment-syndrome
#8
G Raghavendra Prasad, J V Subba Rao, Amtul Aziz, T M Rashmi
INTRODUCTION: Abdomen, a closed compartment, is prone to raised intra-abdominal pressure (IAP) in the postoperative period. After a critical value of ≥ 15 cm of water, IAP produces abdominal compartment syndrome (ACS). ACS leads to reduced venous return, reduced cardiac output, and domino effect of organ dysfunction, leading to death. Hence, it is the need of hour to monitor IAP to pick up intra-abdominal hypertension (IAH) and ACS. This routine facilitates early institution of treatment measures...
July 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28690088/a-cluster-randomized-trial-to-estimate-the-effect-of-mobile-screening-and-treatment-feedback-on-hba1c-and-diabetes-related-complications-in-tshwane-primary-health-care-clinics-south-africa
#9
Elizabeth Melanie Webb, Paul Rheeder
AIM AND OBJECTIVES: Our study had two primary objectives. The first was to evaluate the effect of an expert review with an individualised patient management plan on change in HbA1c. The second was to determine whether a mobile screening unit would increase the proportion of patients screened for glycaemic and lipid control, as well as diabetic complications as compared to the standard guideline-driven clinic care. METHODS: We conducted a cluster-randomised trial and enrolled 599 diabetic patients from twelve primary health care clinics in the Tshwane district of South Africa...
July 6, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28682924/lamotrigine-drug-interactions-in-combination-therapy-and-the-influence-of-therapeutic-drug-monitoring-on-clinical-outcomes-of-adult-patients
#10
Milan Grundmann, Blanka Koristkova, Hana Brozmanova, Ivana Kacirova
BACKGROUND: The aim was to study the impact of therapeutic drug monitoring (TDM) on patients on lamotrigine (LTG) therapy and the evaluation of possible drug interactions, especially in triple antiepileptic drug combinations. METHODS: During the period of 2001-2014, 3118 pre-dose samples were taken from 1137 patients >15 years of age as part of their routine TDM. Drug interactions were evaluated using calculation of LTG clearance. RESULTS: Valproic acid (VPA) decreased LTG clearance by 66% in bitherapy, and by 35% and 31% in triple therapy with carbamazepine (CBZ) and phenytoin (PHT) respectively...
July 3, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28681500/continuous-support-for-women-during-childbirth
#11
REVIEW
Meghan A Bohren, G Justus Hofmeyr, Carol Sakala, Rieko K Fukuzawa, Anna Cuthbert
BACKGROUND: Historically, women have generally been attended and supported by other women during labour. However, in hospitals worldwide, continuous support during labour has often become the exception rather than the routine. OBJECTIVES: The primary objective was to assess the effects, on women and their babies, of continuous, one-to-one intrapartum support compared with usual care, in any setting. Secondary objectives were to determine whether the effects of continuous support are influenced by:1...
July 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28681281/population-health-outcomes-of-a-student-led-free-health-clinic-for-an-underserved-population-a-naturalistic-study
#12
Cynthia M Stuhlmiller, Barry Tolchard
There are a number of hard to reach and underserved communities who experience inadequate health care. In Australia, the Aboriginal and Torres Strait Islanders peoples experience low life expectancy, higher levels for chronic disease and elevated smoking and drinking. These problems are further exacerbated when living in regional and rural Australia and poverty. There are growing concerns over helping such groups in order to close the health disparity gap. A student-led clinic (SLC) was developed to address clinical placement shortages while providing free health and social services in an underserved community in regional Australia...
July 5, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28680343/current-biochemical-monitoring-and-risk-management-of-immunosuppressive-therapy-after-transplantation
#13
Aleksandra Catić-Đorđević, Tatjana Cvetković, Nikola Stefanović, Radmila Veličković-Radovanović
Immunosuppressive drugs play a crucial role in the inhibition of immune reaction and prevention of graft rejection aswell as in the pharmacotherapy of autoimmune disorders. Effective immunosuppression should provide an adequate safety profile and improve treatment outcomes and the patients' quality of life. High-risk transplant recipients may be identified, but a definitive prediction model has still not been recognized. Therapeutic drug monitoring (TDM) for immunosuppressive drugs is an essential, but at the same time insufficient tool due to low predictability of drug exposition and marked pharmacokinetic variability...
January 2017: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28675078/evaluation-of-the-parkinson-s-kinetigraph-in-monitoring-and-managing-parkinson-s-disease
#14
Parisa Farzanehfar, Malcolm Horne
While objective measurement is routine in clinical care of most conditions, this has not been the case for Parkinson's Disease. Recent innovations make objective measurement in Parkinson's Disease possible and its utility and how this should be assessed is discussed here. Areas covered: Whilst therapies are effective in Parkinson's Disease, symptoms fluctuate in relation to treatment over the course of the day. Objective measurement makes it possible to assess symptom control, whether treatment is required and whether it achieved control...
July 4, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28673958/identifying-primary-care-quality-indicators-for-people-with-serious-mental-illness-a-systematic-review
#15
Christoph Kronenberg, Tim Doran, Maria Goddard, Tony Kendrick, Simon Gilbody, Ceri R Dare, Lauren Aylott, Rowena Jacobs
BACKGROUND: Serious mental illness (SMI) - which comprises long-term conditions such as schizophrenia, bipolar disorder, and other psychoses - has enormous costs for patients and society. In many countries, people with SMI are treated solely in primary care, and have particular needs for physical care. AIM: The objective of this study was to systematically review the literature to create a list of quality indicators relevant to patients with SMI that could be captured using routine data, and which could be used to monitor or incentivise better-quality primary care...
July 3, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28669391/rates-of-serum-level-determinations-of-antiepileptic-drugs-in-accord-with-guidelines-a-clinical-study-at-a-tertiary-center
#16
REVIEW
A Hanin, R Tubiana, M Bedouet, A Gales, N Zahr, A Liou, S Dupont
OBJECTIVE: To compare our rates of appropriate therapeutic drug monitoring (TDM) with those defined in the French guidelines for measuring drug levels of antiepileptic drugs (AEDs) during the pre- and post-medical/pharmaceutical interventional periods. METHODS: This study was prospectively carried out at a tertiary center (epilepsy unit of the Pitié-Salpêtrière Hospital in Paris) between 2013 and 2016 over three time periods. Criteria for appropriateness were those stated in the current French guidelines...
June 29, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28666310/effectiveness-of-self-management-support-in-maintenance-haemodialysis-patients-with-hypertension-a-pilot-cluster-randomized-controlled-trial
#17
Baoyan Huang, Zheng Li, Ying Wang, Jinghua Xia, Tao Shi, Jingmei Jiang, Nolan T Marie, Xuemei Li, Sagar U Nigwekar, Limeng Chen
BACKGROUND: Uncontrolled hypertension is an independent risk factor for cardiovascular disease and is the leading cause of mortality in haemodialysis patients. The aim of this study was to examine the effectiveness of self-management support SMS) for blood pressure (BP) control and health behaviors. METHODS: We conducted a cluster randomized controlled trial (RCT) in which 90 adult haemodialysis patients were assigned to either an SMS or common intervention (CI) group...
June 30, 2017: Nephrology
https://www.readbyqxmd.com/read/28666173/linking-routinely-collected-social-work-education-and-health-data-to-enable-monitoring-of-the-health-and-health-care-of-school-aged-children-in-state-care-looked-after-children-in-scotland-a-national-demonstration-project
#18
D Clark, A King, K Sharpe, G Connelly, L Elliott, L M D Macpherson, A D McMahon, I Milligan, P Wilson, D I Conway, R Wood
BACKGROUND AND OBJECTIVES: Children in state care ('looked after children') have poorer health than children who are not looked after. Recent developments in Scotland and elsewhere have aimed to improve services and outcomes for looked after children. Routine monitoring of the health outcomes of looked after children compared to those of their non-looked after peers is currently lacking. Developing capacity for comparative monitoring of population-based outcomes based on linkage of routinely collected administrative data has been identified as a priority...
June 27, 2017: Public Health
https://www.readbyqxmd.com/read/28665250/prognostic-value-of-changes-in-brain-tissue-oxygen-pressure-before-and-after-decompressive-craniectomy-following-severe-traumatic-brain-injury
#19
Santiago T Lubillo, Dácil M Parrilla, José Blanco, Jesús Morera, Jaime Dominguez, Felipe Belmonte, Patricia López, Ismael Molina, Candelaria Ruiz, Francisco J Clemente, Daniel A Godoy
OBJECTIVE In severe traumatic brain injury (TBI), the effects of decompressive craniectomy (DC) on brain tissue oxygen pressure (PbtO2) and outcome are unclear. The authors aimed to investigate whether changes in PbtO2 after DC could be used as an independent prognostic factor. METHODS The authors conducted a retrospective, observational study at 2 university hospital ICUs. The study included 42 patients who were admitted with isolated moderate or severe TBI and underwent intracranial pressure (ICP) and PbtO2 monitoring before and after DC...
June 30, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28661946/correlations-between-hourly-pupillometer-readings-and-intracranial-pressure-values
#20
Molly McNett, Cristina Moran, Clare Janki, Anastasia Gianakis
INTRODUCTION: Automated pupillometry is emerging as a mainstay in neurocritical care primarily because it overcomes limitations of manual pupillary examinations. Although several recent studies show improved assessment accuracy with a pupillometer, few investigate clinical use, specifically how well parameters correlate with multimodality monitoring and outcomes. The primary aim of this study was to examine correlations between serial pupillometer readings and intracranial pressure (ICP) values among neurocritically ill patients...
August 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
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