Dongcheng Zhou, Yuhui Yang, Jiajia Chen, Jiaqi Zhou, Jianfeng He, Danyong Liu, Anyuan Zhang, Bixian Yuan, Yuxin Jiang, Weiyi Xia, Ronghui Han, Zhengyuan Xia
The hearts of subjects with diabetes are vulnerable to ischemia-reperfusion injury (IRI). In contrast, experimentally rodent hearts have been shown to be more resistant to IRI at the very early stages of diabetes induction than the heart of the non-diabetic control mice, and the mechanism is largely unclear. Ferroptosis has recently been shown to play an important role in myocardial IRI including that in diabetes, while the specific mechanisms are still unclear. Non-diabetic control (NC) and streptozotocin-induced diabetic (DM) mice were treated with the antioxidant N-acetylcysteine (NAC) in drinking water for 4 week starting at 1 week after diabetes induction...
April 22, 2024: Cardiovascular Toxicology