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https://www.readbyqxmd.com/read/29913541/cost-effectiveness-of-carbetocin-versus-oxytocin-for-prevention-of-postpartum-hemorrhage-resulting-from-uterine-atony-in-women-at-high-risk-for-bleeding-in-colombia
#1
Yaneth Gil-Rojas, Pieralessandro Lasalvia, Fabián Hernández, Camilo Castañeda-Cardona, Diego Rosselli
OBJECTIVE:  To assess the cost-effectiveness of carbetocin versus oxytocin for prevention of postpartum hemorrhage (PPH) due to uterine atony after vaginal delivery/cesarean section in women with risk factors for bleeding. METHODS:  A decision tree was developed for vaginal delivery and another one for cesarean, in which a sequential analysis of the results was obtained with the use of carbetocin and oxytocin for prevention of PPH and related consequences. A third-party payer perspective was used; only direct medical costs were considered...
May 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29913537/evaluation-of-the-utility-of-von-willebrand-factor-propeptide-in-the-differential-diagnosis-of-von-willebrand-disease-and-acquired-von-willebrand-syndrome
#2
Francesca Stufano, Marco Boscarino, Paolo Bucciarelli, Luciano Baronciani, Alberto Maino, Giovanna Cozzi, Flora Peyvandi
An increased von Willebrand factor propeptide (VWFpp) to VWF antigen (VWF:Ag) ratio (VWFpp/VWF:Ag) indicates an enhanced clearance of VWF. This finding has been described in von Willebrand disease (VWD) and in acquired von Willebrand syndrome (AVWS). A distinction between these two diseases, one congenital and the other acquired, is primarily based on family and personal history of bleeding. However, if this information is scanty, the diagnosis might be challenging due to the lack of an effective diagnostic biomarker...
June 18, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29913536/hemostasis-in-the-very-young
#3
Gili Kenet, Assaf Arie Barg, Ulrike Nowak-Göttl
Hemostasis is a dynamic process that starts in utero. The coagulation system evolves with age, as evidenced by marked physiological differences in the concentration of the majority of hemostatic proteins in early life compared with adulthood. This concept, known as "developmental hemostasis," has important biological and clinical implications. Overall, impaired platelet function, along with physiologically reduced levels of vitamin K-dependent and contact coagulation factors, may cause poorer clot firmness even in healthy neonates...
June 18, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29913529/a-pilot-study-evaluating-cerebral-vasculitis-in-kawasaki-s-disease
#4
Jung Sook Yeom, Young Hye Cho, Chung Mo Koo, Jin Su Jun, Ji Sook Park, Eun Sil Park, Ji-Hyun Seo, Jae-Young Lim, Hyang-Ok Woo, Hee-Shang Youn
Cerebral vasculitis is thought to be a possible underlying mechanism of severe neurological complications of Kawasaki's disease (KD), such as cerebral infarct or aneurysm rupture. To evaluate the intracranial inflammatory response in patients with acute-stage KD, we measured the levels of cytokines (interleukin [IL]-6 and tumor necrosis factor [TNF]-α) and pentraxin-3 (PTX3) in the cerebrospinal fluid of patients with KD ( n  = 7) and compared the levels to those of the age- and sex-matched febrile control patients (bacterial meningitis [ n  = 5], enteroviral meningitis [ n  = 10], nonspecific viral illness without central nervous system involvement [ n  = 10])...
June 18, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29913483/the-associations-between-the-growth-hormone-insulin-like-growth-factor-1-axis-adiponectin-resistin-and-metabolic-profile-in-children-with-growth-hormone-deficiency-before-and-during-growth-hormone-treatment
#5
Ewelina Witkowska-Sędek, Małgorzata Rumińska, Anna Stelmaszczyk-Emmel, Anna Majcher, Beata Pyrżak
This study investigated associations between the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis, adiponectin, resistin and metabolic profile in 47 GH-deficient children before and during 12 months of GH treatment. 23 short age-matched children without growth hormone deficiency (GHD) or any genetic or chronic disorders were recruited as controls at baseline. Metabolic evaluation included measurements of adiponectin, resistin, IGF-1, total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, insulin, glycated haemoglobin (HbA1c), thyroid stimulating hormone (TSH) and free thyroxine (free T4) concentrations...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29913459/clinical-characteristics-and-prognosis-of-pregnancy-associated-breast-cancer-poor-survival-of-luminal-b-subtype
#6
Soo Youn Bae, Seung Pil Jung, Eun Sung Jung, Sung Min Park, Se Kyung Lee, Jong Han Yu, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam
BACKGROUND: Pregnancy-associated breast cancer (PABC) is rare and is generally defined as breast cancer diagnosed during pregnancy or within 1 year of delivery. The average ages of marriage and childbearing are increasing, and PABC is expected to also increase. This study is intended to increase understanding of the characteristics of PABC. METHODS: A database of 2,810 patients with breast cancer diagnosed when they were less than 40 years of age was reviewed. The clinicopathological factors and survival of PABC (40 patients) were compared to those of patients with young breast cancer (YBC, non-pregnant or over 12 months after delivery; 2,770 patients)...
June 18, 2018: Oncology
https://www.readbyqxmd.com/read/29913446/segmentation-of-dilated-hemorrhoidal-veins-in-hemorrhoidal-disease
#7
Lucio Díaz-Flores, Ricardo Gutiérrez, Miriam González-Gómez, Pino García, Francisco J Sáez, Lucio Díaz-Flores, José Luis Carrasco, Juan F Madrid
Vein segmentation is a vascular remodeling process mainly studied in experimental conditions and linked to hemodynamic factors, with clinical implications. The aim of this work is to assess the morphologic characteristics, associated findings, and mechanisms that participate in vein segmentation in humans. To this end, we examined 156 surgically obtained cases of hemorrhoidal disease. Segmentation occurred in 65 and was most prominent in 15, which were selected for serial sections, immunohistochemistry, and immunofluorescence procedures...
June 18, 2018: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29913445/disparities-in-the-presentation-and-management-of-cutaneous-melanoma-that-required-admission
#8
Zaid Al-Qurayshi, Sudesh Srivastav, Alun Wang, Erin Boh, John Hamner, Mohamed Hassan, Emad Kandil
OBJECTIVE: In this study, we aimed to examine the association of demographic and socioeconomic factors with cutaneous melanoma that required admission. METHODS: A cross-sectional study utilizing the Nationwide Inpatient Sample database, 2003-2009, was merged with County Health Rankings Data. RESULTS: A total of 2,765 discharge -records were included. Men were more likely to have melanoma in the head, neck, and trunk regions (p < 0.001), while extremities melanoma was more common in women (p < 0...
June 18, 2018: Oncology
https://www.readbyqxmd.com/read/29913444/stimulation-of-eryptosis-by-afatinib
#9
Abdulla Al Mamun Bhuyan, Florian Lang
BACKGROUND/AIMS: The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor afatinib is primarily utilized for the treatment of non-small cell lung carcinoma. The drug is at least partially effective by triggering suicidal tumor cell death. Side effects of afatinib treatment include anemia. At least in theory, afatinib induced anemia could be secondary to stimulation of suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913442/associations-of-pulmonary-fibrosis-with-peripheral-blood-th1-th2-cell-imbalance-and-ebf3-gene-methylation-in-uygur-pigeon-breeder-s-lung-patients
#10
Chao Wu, Zujin Luo, Baosen Pang, Wenyi Wang, Mingqin Deng, Rong Jin, Xirennayi Muhataer, Yafang Li, Qifeng Li, Xiaohong Yang
Background/Aims Pigeon breeder's lung (PBL) results from Th1/Th2 cell imbalance. B cells inhibit the immune activity of Th1, and EBF3 is a key B cell factor. This study explored the relationship between EBF3 and Th1/Th2 imbalance in chronic PBL cases complicated with pulmonary fibrosis (PF). Methods Twenty Uygur PBL+PF patients, 20 pigeon breeders without PBL or PF, and 20 healthy individuals without pigeon breeding history constituted the patient I, negative control, and normal control groups, respectively...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913437/thymoquinone-attenuates-myocardial-ischemia-reperfusion-injury-through-activation-of-sirt1-signaling
#11
Yunyang Lu, Yingda Feng, Dan Liu, Zhiran Zhang, Kai Gao, Wei Zhang, Haifeng Tang
BACKGROUND/AIMS: Myocardial ischemia/reperfusion (MI/R) injury is a leading factor responsible for damage in myocardial infarction, resulting in additional injury to cardiac tissues involved in oxidative stress, inflammation, and apoptosis. Thymoquinone (TQ), the main constituent of Nigella sativa L. seeds, has been reported to possess various biological activities. However, few reports regarding myocardial protection are available at present. Therefore, this study was conducted aiming to investigate the protective effect of TQ against MI/R injury and to clarify its potential mechanism...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913436/nefa-sensitive-orai1-expression-in-regulation-of-de-novo-lipogenesis
#12
Bingbing Zhang, Wei Yang, Ying Zou, Ming Li, Han Guo, Hongyou Zhang, Cheng Xia, Chuang Xu
BACKGROUND/AIMS: Non-esterified fatty acids (NEFAs) are important inducers of inflammatory responses and hepatic lipid accumulation, which lead to non-alcoholic fatty liver disease (NAFLD). High plasma NEFA is found in NAFLD patients, and associated with metabolic syndrome and type-2 diabetes. NFκB is known to upregulate Orai1, the Ca2+ channel responsible for store-operated Ca2+ entry. The present study explored the role of NEFA-sensitive NFκB-dependent Orai1 expression in the regulation of lipid synthesis...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913434/factors-influencing-child-protection-professionals-decision-making-and-multidisciplinary-collaboration-in-suspected-abusive-head-trauma-cases-a-qualitative-study
#13
Laura E Cowley, Sabine Maguire, Daniel M Farewell, Harriet D Quinn-Scoggins, Matthew O Flynn, Alison M Kemp
Clinicians face unique challenges when assessing suspected child abuse cases. The majority of the literature exploring diagnostic decision-making in this field is anecdotal or survey-based and there is a lack of studies exploring decision-making around suspected abusive head trauma (AHT). We aimed to determine factors influencing decision-making and multidisciplinary collaboration in suspected AHT cases, amongst 56 child protection professionals. Semi-structured interviews were conducted with clinicians (25), child protection social workers (10), legal practitioners (9, including 4 judges), police officers (8), and pathologists (4), purposively sampled across southwest United Kingdom...
June 15, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29913432/transcriptome-analysis-reveals-novel-insights-into-the-response-of-low-dose-benzo-a-pyrene-exposure-in-male-tilapia
#14
Reyna Cristina Colli-Dula, Xiefan Fang, David Moraga-Amador, Nacira Albornoz-Abud, Roberto Zamora-Bustillos, Ana Conesa, Omar Zapata-Perez, Diego Moreno, Emanuel Hernandez-Nuñez
Despite a wide number of toxicological studies that describe benzo[a]pyrene (BaP) effects, the metabolic mechanisms that underlie these effects in fish are largely unknown. Of great concern is the presence of BaP in aquatic systems, especially those in close proximity to human activity leading to consumption of potentially contaminated foods. BaP is a known carcinogen and it has been reported to have adverse effects on the survival, development and reproduction of fish. The purpose of this study was to investigate if a low dose of BaP can alter genes and key metabolic pathways in the liver and testis in male adult tilapia, and whether these could be associated with biological endpoints disruption...
June 8, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29913428/preformed-and-induced-mechanisms-underlies-the-differential-responses-of-prunus-rootstock-to-hypoxia
#15
María J Rubio-Cabetas, Clara Pons, Beatriz Bielsa, María L Amador, Cristina Marti, Antonio Granell
Analysis of the transcriptomic changes produced in response to hypoxia in root tissues from two rootstock Prunus genotypes differing in their sensitivity to waterlogging: resistant Myrobalan 'P.2175' (P. cerasifera Erhr.), and sensitive 'Felinem' hybrid [P. amygdalus Batsch × P. persica (L.) Batsch] revealed alterations in both metabolism and regulatory processes. Early hypoxia response in both genotypes is characterized by a molecular program aimed to adapt the cell metabolism to the new conditions. Upon hypoxia conditions, tolerant Myrobalan represses first secondary metabolism gene expression as a strategy to prevent the waste of resources/energy, and by the up-regulation of protein degradation genes probably leading to structural adaptations to long-term response to hypoxia...
June 9, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29913415/reduction-in-co-2-emissions-in-roro-pax-ports-equipped-with-automatic-mooring-systems
#16
REVIEW
Emma Díaz-Ruiz-Navamuel, Andrés Ortega Piris, Carlos A Pérez-Labajos
Faced with the unavoidable reality of the emission of pollutant gases by vessels both while sailing and when performing in-port manoeuvres, the international community has devised an extensive set of rules to limit greenhouse gas emissions and the emission of other pollutants which are bad for our health. In order to make these reductions in the emissions, the areas addressed are the engine regime or speed control, the quality of the fuel used, the state of conservation of the vessel and its hull or the time taken to perform the manoeuvres of mooring and unmooring...
June 14, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29913413/shipping-pollution-emission-associated-with-increased-cardiovascular-mortality-a-time-series-study-in-guangzhou-china
#17
Hualiang Lin, Jun Tao, Zhengmin Min Qian, Zengliang Ruan, Yanjun Xu, Jian Hang, Xiaojun Xu, Tao Liu, Yuming Guo, Weilin Zeng, Jianpeng Xiao, Lingchuan Guo, Xing Li, Wenjun Ma
Substantial evidence has linked short-term exposure to ambient fine particulate matter (PM2.5 ) with increased cardiovascular mortality, however, the specific chemical constituent and emission source responsible for this effect remained largely unclear. A time series Poisson model was employed to quantify the association of cardiovascular mortality with two sets of shipping pollution emission: nickel (Ni), vanadium (V) (the indices of shipping emission) and estimated shipping emission using a source apportionment approach in Guangzhou, China in 2014...
June 12, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29913403/jnk-stat-signalling-pathway-is-involved-in-fluoride-induced-follicular-developmental-dysplasia-in-female-mice
#18
Wen-Peng Zhao, Hong-Wei Wang, Jing Liu, Pan-Pan Tan, Lin Lin, Bian-Hua Zhou
Excessive fluoride (F) intake decreases the development of potential oocytes by inducing oxidative stress and apoptosis in female mice in our previous study. This study aims to investigate the underlying mechanisms of F-induced follicular developmental dysplasia. Pathomorphological changes in the ovary tissues were observed under light and transmission electron microscopes. DNA damage and proliferation in granulosa cells were analysed by TUNEL staining and BrdU measurement. The protein expression of cell proliferation related regulatory factors including JNK, STAT3, STAT5, CDK2, CDK4, PCNA and Ki67 in the ovary tissues was measured by immunohistochemistry and Western blot analyses...
June 12, 2018: Chemosphere
https://www.readbyqxmd.com/read/29913390/orexin-a-prevents-degradation-of-the-articular-matrixes-in-human-primary-chondrocyte-culture
#19
Dong Wang, Hui Ren, Chunlong Li, Fanghe Liu, Guangzhi Wang, Fengjun Shi, Yuanxin Sun
Excessive production of pro-inflammatory cytokines such as interleukin-1β (IL-1β) plays a key role in the pathophysiological development of osteoarthritis (OA). Orexin A is an important peptide of hypothalamic origin, which has displayed its multiple biological functions in several chronic diseases via activation of its specific G-protein coupled receptors, orexin-1 receptor (OX1R) and orexin-2 receptor (OX2R). In this study, we aimed to characterize the protective effects of orexin A against IL-1β-induced degradation of articular cartilage matrixes in human chondrocytes...
June 15, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29913387/nitrogen-sources-and-cycling-revealed-by-dual-isotopes-of-nitrate-in-a-complex-urbanized-environment
#20
Anand Archana, Benoit Thibodeau, Naomi Geeraert, Min Nina Xu, Shuh-Ji Kao, David M Baker
Elevated nutrient inputs have led to increased eutrophication in coastal marine ecosystems worldwide. An understanding of the relative contribution of different nutrient sources is imperative for effective water quality management. Stable isotope values of nitrate (δ15 NNO3- , δ18 ONO3- ) can complement conventional water quality monitoring programs to help differentiate natural sources of NO3 - from anthropogenic inputs and estimate the processes involved in N cycling within an ecosystem. We measured nutrient concentrations, δ15 NNO3- , and δ18 ONO3- in 76 locations along a salinity gradient from the lower end of the Pearl River Estuary, one of China's largest rivers discharging into the South China Sea, towards the open ocean...
June 5, 2018: Water Research
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