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factor IIV

Christina D Kay, Michael Seidenberg, Sally Durgerian, Kristy A Nielson, J Carson Smith, John L Woodard, Stephen M Rao
INTRODUCTION: Intraindividual variability (IIV) in motor performance has been shown to predict future cognitive decline. The apolipoprotein E-epsilon 4 (APOE-ε4) allele is also a well-established risk factor for memory decline. Here, we present novel findings examining the influence of the APOE-ε4 allele on the performance of asymptomatic healthy elders in comparison to individuals with amnestic MCI (aMCI) on a fine motor synchronization, paced finger-tapping task (PFTT). METHOD: Two Alzheimer's disease (AD) risk groups, individuals with aMCI (n = 24) and cognitively intact APOE-ε4 carriers (n = 41), and a control group consisting of cognitively intact APOE-ε4 noncarriers (n = 65) completed the Rey Auditory Verbal Learning Test and the PFTT, which requires index finger tapping in synchrony with a visual stimulus (interstimulus interval = 333 ms)...
January 4, 2017: Journal of Clinical and Experimental Neuropsychology
Manel Aouri, Catalina Barcelo, Monia Guidi, Margalida Rotger, Matthias Cavassini, Cédric Hizrel, Thierry Buclin, Laurent A Decosterd, Chantal Csajka
Rilpivirine (RPV), the latest nonnucleoside reverse transcriptase inhibitor active against HIV-1, is prescribed in a standard dosage of 25 mg once a day in combination with emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF). The aim of this observational study was to characterize the RPV pharmacokinetic profile, to quantify interpatient variability, and to identify potential factors that could influence drug exposure. RPV concentration data were collected from HIV-infected patients as part of routine therapeutic drug monitoring performed in our center (Laboratory of Clinical Pharmacology)...
January 2017: Antimicrobial Agents and Chemotherapy
Aitor Nogales, Kai Huang, Caroline Chauché, Marta L DeDiego, Pablo R Murcia, Colin R Parrish, Luis Martínez-Sobrido
Canine Influenza Virus (CIV) H3N8 is the causative agent of canine influenza, a common and contagious respiratory disease of dogs. Currently, only inactivated influenza vaccines (IIVs) are available for the prevention of CIV H3N8. However, live-attenuated influenza vaccines (LAIVs) are known to provide better immunogenicity and protection efficacy than IIVs. Influenza NS1 is a virulence factor that offers an attractive target for the preparation of attenuated viruses as LAIVs. Here we generated recombinant H3N8 CIVs containing truncated or a deleted NS1 protein to test their potential as LAIVs...
October 14, 2016: Virology
Victor Mangas-Sanjuan, Sarin Colon-Useche, Isabel Gonzalez-Alvarez, Marival Bermejo, Alfredo Garcia-Arieta
The objective is to compare the performance of dissolution-profile comparison methods when f 2 is inadequate due to high variability. The 90% confidence region of the Mahalanobis distance and the 90% bootstrap confidence interval (CI) of the f 2 similarity factor (f 2-bootstrap) were explored. A modification of the Mahalanobis distance (new D-Mahalanobis) in which those points >85% were not taken into account for calculation was also used. A population kinetic approach in NONMEM was used to simulate dissolution profiles with the first-order or Weibull kinetic models...
2016: AAPS Journal
Min Z Levine, Judith M Martin, F Liaini Gross, Stacie Jefferson, Kelly Stefano Cole, Crystal Ann Archibald, Mary Patricia Nowalk, Michael Susick, Krissy Moehling, Sarah Spencer, Jessie R Chung, Brendan Flannery, Richard K Zimmerman
Human influenza A(H3N2) viruses that predominated during the moderately severe 2014-2015 influenza season differed antigenically from the vaccine component, resulting in reduced vaccine effectiveness (VE). To examine antibody responses to 2014-2015 inactivated influenza vaccine (IIV) and live-attenuated influenza vaccine (LAIV) among children and adolescents, we collected sera before and after vaccination from 150 children aged 3 to 17 years enrolled at health care facilities. Hemagglutination inhibition (HI) assays were used to assess the antibody responses to vaccine strains...
October 2016: Clinical and Vaccine Immunology: CVI
Annemieke J M Nieuweboer, Ellen S de Morrée, Anne-Joy M de Graan, Alex Sparreboom, Ronald de Wit, Ron H J Mathijssen
Docetaxel is a frequently used chemotherapeutic agent in the treatment of solid cancers. Because of the large inter-individual variability (IIV) in the pharmacokinetics (PK) of docetaxel, it is challenging to determine the optimal dose in individual patients in order to achieve optimal efficacy and acceptable toxicity. Despite the established correlation between systemic docetaxel exposure and efficacy, the precise factors influencing docetaxel PK are not yet completely understood. This review article highlights currently known factors that influence docetaxel PK, and focusses on those that are clinically relevant...
July 2015: Cancer Treatment Reviews
M J Sanchez
Contents-This report presents national estimates of the prevalance and severity cf periodontal disease among youths aged 12-17 years in the United States according, to race, sex, age, and other selected demographic characteristics. The severity and prevalance of periodontal disease were measured by the Periodontal Index (PI). A correlation analysis of the interrelation of the PI and selected demographic variables is also included. Background and Source of Data-During 1966-70 the Division of Health Examination Statistics conducted a survey of the health uf the Nation's youth...
June 1974: Vital and Health Statistics. Series 11, Data From the National Health Survey
Erin E Morgan, Katie L Doyle, Arpi Minassian, Brook L Henry, William Perry, Thomas D Marcotte, Steven Paul Woods, Igor Grant
Methamphetamine (MA) dependence is associated with executive dysfunction, but no studies have evaluated MA-related elevations in neurocognitive intraindividual variability (IIV), an expression of cognitive dyscontrol linked to poor daily functioning in populations with frontal systems injury. We examined IIV during a vigilance task in a well-characterized sample of 35 MA-dependent (MA+) and 55 non-MA using comparison participants (MA-) as part of a larger neuropsychological battery that included self-report and performance-based measures of everyday functioning...
December 15, 2014: Psychiatry Research
Debjani Das, Xiaoyun Tan, Allison A M Bielak, Nicolas Cherbuin, Simon Easteal, Kaarin J Anstey
Genetic differences play a significant role in generating individual differences in cognitive abilities. Studies have linked common polymorphisms (valine to methionine substitution; VAL/MET) in the catechol-O-methyltransferase (COMT) and brain-derived neurotrophic factor (BDNF) to cognitive differences between individuals. However, not all studies support these associations and hence, the impact of these polymorphisms on cognition is unclear. Here, we investigated the effect of COMT VAL158MET and BDNF VAL66MET polymorphisms and their interaction on cognitive performance measured longitudinally over 8 years in a population-based sample of older adults (60-64 years at baseline; n = 400)...
June 2014: Psychology and Aging
Oneeb Majid, Anubha Gupta, Larisa Reyderman, Martin Olivo, Ziad Hussein
Pharmacometric investigation of eribulin was undertaken in patients with metastatic breast cancer (MBC) and other advanced solid tumors. A population pharmacokinetic (PK) model used data combined from seven phase 1 studies (advanced solid tumors; n = 129), and one phase 2 (MBC; n = 211), and one phase 3 study (MBC; n = 173). Phase 3 data were also used in a PK/pharmacodynamic (PD) model of efficacy and tumor response (sum of longest diameters of target lesions). All analyses used NONMEM 7.2. Eribulin PK, described by a dose-independent, three-compartment model with allometric relationship for body weight, was similar for all tumor types...
October 2014: Journal of Clinical Pharmacology
Erjian Wang, Dongwoo Kang, Kyun-Seop Bae, Margaret A Marshall, Dmitri Pavlov, Kourosh Parivar
Tremelimumab, a fully human monoclonal antibody specific for human cytotoxic T-lymphocyte-associated antigen 4, has been studied in clinical trials. We have reported the results of population pharmacokinetics for tremelimumab in 654 metastatic melanoma patients. Population estimates (inter-individual variability [IIV]) for pharmacokinetic parameters in a final model were clearance (CL), 0.26 L/day (31.8%) and central volume of distribution, 3.97 L (20.4%). CL was faster in males, patients with higher values of creatinine clearance and endogenous immunoglobulin, and patients with relatively poor baseline prognostic factors...
October 2014: Journal of Clinical Pharmacology
Yang He, Janice E Brunstrom-Hernandez, Liu Lin Thio, Shellie Lackey, Deborah Gaebler-Spira, Maxine M Kuroda, Elaine Stashinko, Alexander H Hoon, Jilda Vargus-Adams, Richard D Stevenson, Stephanie Lowenhaupt, John F McLaughlin, Ana Christensen, Nienke P Dosa, Maureen Butler, Aloysia Schwabe, Christina Lopez, Desiree Roge, Diane Kennedy, Ann Tilton, Linda E Krach, Andrew Lewandowski, Hongying Dai, Andrea Gaedigk, J Steven Leeder, William J Jusko
OBJECTIVE: To characterize the population pharmacokinetics (PK) of oral baclofen and assess impact of patient-specific covariates in children with cerebral palsy (CP) in order to support its clinical use. SUBJECTS DESIGN: Children (2-17 years of age) with CP received a dose of titrated oral baclofen from 2.5 mg 3 times a day to a maximum tolerated dose of up to 20 mg 4 times a day. PK sampling followed titration of 10-12 weeks. Serial R- and S-baclofen plasma concentrations were measured for up to 16 hours in 49 subjects...
May 2014: Journal of Pediatrics
Deborah Finkel, Nancy L Pedersen
Intraindividual variability (IIV) in reaction time has been related to cognitive decline, but questions remain about the nature of this relationship. Mean and range in movement and decision time for simple reaction time were available from 241 individuals aged 51-86 years at the fifth testing wave of the Swedish Adoption/Twin Study of Aging. Cognitive performance on four factors was also available: verbal, spatial, memory, and speed. Analyses indicated that range in reaction time could be used as an indicator of IIV...
2014: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
Vincenza Tarantino, Simone Cutini, Carla Mogentale, Patrizia Silvia Bisiacchi
Although it is widely known that high intra-individual variability (IIV) is a key characteristic of attention deficit/hyperactivity disorder (ADHD), a detailed exploration of the IIV pattern during the time course of a cognitive task has never been carried out. In this study, 30 children with ADHD and 30 controls, were administered the Conners' Continuous Performance Task (CPT-II). The across-block individual performance of the groups was analyzed using an ex-Gaussian approach, which enabled a clearer understanding of how individual response times (RTs) fluctuate during a task in comparison with conventional measures of central tendency...
August 2013: Journal of the International Neuropsychological Society: JINS
Michelle Phillips, Peter Rogers, Judy Haworth, Antony Bayer, Andrea Tales
Compared to cognitively healthy ageing (CH), intra-individual variability in reaction time (IIV(RT)), a behavioural marker of neurological integrity, is commonly reported to increase in both Alzheimer's disease (AD) and mild cognitive impairment (MCI). It varies in MCI with respect to whether it represents the pro-dromal stages of dementia or not; being greatest in those most likely to convert. Abnormal IIV(RT) in MCI therefore represents a potential measure of underlying functional integrity that may serve to differentiate MCI from CH and to help identify those patients for whom MCI is the result of a progressive pathological process...
2013: PloS One
Alison L Sukits, Robert D Nebes, April J Chambers, Aaron Ledgerwood, Edythe M Halligan, Subashan Perera, Rakié Cham
As humans age, the amount of intra-individual variability (IIV) present in both their gait and their cognitive performance tends to increase. Both gait and cognitive IIV are associated with attentional control and with cerebrovascular disease, suggesting that the IIV in gait and cognitive function should be strongly correlated in the elderly. In this study temporal gait variability was determined from a 60-second period of walking. Cognitive variability was determined from two decision-time tasks assessing inhibition...
2014: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
J G Coen van Hasselt, Anubha Gupta, Ziad Hussein, Jos H Beijnen, Jan H M Schellens, Alwin D R Huitema
AIMS: Eribulin mesilate is an inhibitor of microtubule dynamics that is approved for the treatment of late-stage metastatic breast cancer. Neutropenia is one of the major dose-limiting adverse effects of eribulin. The objective of this analysis was to develop a population pharmacokinetic-pharmacodynamic model for eribulin-associated neutropenia. METHODS: A combined data set of 12 phase I, II and III studies for eribulin mesilate was analysed. The population pharmacokinetics of eribulin was described using a previously developed model...
September 2013: British Journal of Clinical Pharmacology
Susan Vandermorris, Kelly J Murphy, Angela K Troyer
Age-related elevations in cognitive intraindividual variability (IIV) have been linked to reduced executive control associated with decline in frontal lobe function. However, the theoretical conceptualization of IIV in cognitive aging may be constrained by limited study of the extent to which age-related elevations in IIV may be observed on cognitive processes sensitive to aging, but not primarily reliant on frontal systems. To address this empirical gap, the present study investigated age-related differences in IIV on two associative memory tasks...
2013: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
Hadis Rastad, Narges Khanjani, Behjat Kalantari Khandani
BACKGROUND: In the Middle East, including Iran, breast cancer is the most frequent malignancy among women. Without treatment, a malignant breast tumor advances in stage, diminishing a woman's chances of survival. In this study we aimed to gain insight into the causes of delay in seeking treatment in patients with breast cancer. METHODS: The participants in this qualitative, content analysis study were 10 women in whom a diagnosis of breast cancer in the stages of II b, III or IIV had been made...
2012: Asian Pacific Journal of Cancer Prevention: APJCP
Han Ro, Sang-Il Min, Jaeseok Yang, Kyung Chul Moon, Yon Su Kim, Sang Joon Kim, Curie Ahn, Jongwon Ha
BACKGROUND: Wide variation in tacrolimus concentrations and low tacrolimus exposure have been reported to be associated with poor renal graft outcomes in non-Asians. The CYP3A5 polymorphism is a representative genetic factor that might affect this association, together with environmental factors. We investigated whether tacrolimus variability or the mean tacrolimus trough concentration can influence kidney allograft outcomes in Asians and whether the CYP3A5 polymorphism (rs776746) can affect this relationship...
December 2012: Therapeutic Drug Monitoring
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