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https://www.readbyqxmd.com/read/28449508/avoiding-completion-pneumonectomy-by-omentopexy-for-bronchial-dehiscence
#1
Takuro Miyazaki, Naoya Yamasaki, Tomoshi Tsuchiya, Keitaro Matsumoto, Ryotaro Kamohara, Go Hatachi, Shigekazu Hidaka, Takeshi Nagayasu
A 56-year-old man underwent right upper sleeve lobectomy with mediastinal lymph node dissection after induction chemoradiotherapy (CRT) for advanced non-small cell lung cancer (NSCLC). The patient developed anastomotic dehiscence 11 days postoperatively. A fistula measuring 10 mm in diameter was found around the transition region between cartilage and membranous portions of the bronchus. To avoid completion right pneumonectomy, omentopexy was performed to cover the bronchial dehiscence and facilitate healing...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449393/a-phase-1-study-of-the-c-met-inhibitor-tivantinib-arq197-in-children-with-relapsed-or-refractory-solid-tumors-a-children-s-oncology-group-study-phase-1-and-pilot-consortium-trial-advl1111
#2
James I Geller, John P Perentesis, Xiaowei Liu, Charles G Minard, Rachel A Kudgus, Joel M Reid, Elizabeth Fox, Susan M Blaney, Brenda J Weigel
BACKGROUND: The c-Met receptor tyrosine kinase is dysregulated in many pediatric cancers. Tivantinib is an oral small molecule that inhibits the c-Met receptor tyrosine kinase. A phase 1 and pharmacokinetic (PK) trial evaluating tivantinib was conducted in children with relapsed/refractory solid tumors. METHODS: Oral tivantinib capsules were administered twice daily with food, continuously in 28-day cycles. Dose levels 170, 200, and 240 mg/m(2) /dose were evaluated using a rolling-six design (Part A)...
April 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28449369/exposure-to-the-insecticide-endosulfan-induces-liver-morphology-alterations-and-oxidative-stress-in-fruit-eating-bats-artibeus-lituratus
#3
Jerusa Maria Oliveira, Alessandro Brinati, Liany Divina Lima Miranda, Danielle Barbosa Morais, José Cola Zanuncio, Reggiani Vilela Gonçalves, Maria do Carmo Gouveia Peluzio, Mariella Bontempo Freitas
Exposure to pesticides may increase the generation of reactive oxygen species (ROS), leading to oxidation of cell membrane lipids and proteins. Although fruit bats are potentially exposed to pesticides during their entire lifespan, the impacts of this exposure are still poorly investigated. We examined the effects of low, commercially recommended concentrations (0, 1.05 and 2.1 g/l) of an organochlorine insecticide endosulfan (EDS) formulation on oxidative responses in the liver and kidneys of Neotropical fruit bats (Artibeus lituratus), as well as possible liver morphological alterations following a 35-day oral exposure...
April 27, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28449222/tspan33-is-expressed-in-transitional-and-memory-b-cells-but-is-not-responsible-for-high-adam10-expression
#4
César Augusto Pérez-Martínez, José Luis Maravillas-Montero, Iván Meza-Herrera, Felipe Vences-Catalán, Albert Zlotnik, Leopoldo Santos-Argumedo
Tetraspanins are a family of transmembrane proteins that form membrane microdomains. They play important roles in migration, adhesion, and other cellular processes. TspanC8, a subfamily of tetraspanins, were found to associate and promote ADAM10 trafficking and cell surface localization. One of its members, Tspan33, is expressed in activated B cells. Using RT-PCR and flow cytometry, we analyzed the pattern of expression of Tspan33 in B cells from healthy donors. We found Tspan33 expression in early and late stages of B cell development...
April 27, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28449117/the-lxr-ligand-t0901317-acutely-inhibits-insulin-secretion-by-affecting-mitochondrial-metabolism
#5
Jonas Maczewsky, Jelena Sikimic, Cita Bauer, Peter Krippeit-Drews, Carmen Wolke, Uwe Lendeckel, Winfried Barthlen, Gisela Drews
The role of liver X receptor (LXR) in pancreatic beta-cell physiology and pathophysiology is still unclear. It has been postulated that chronic LXR activation in beta-cells induces lipotoxicity, a key step in the development of beta-cell dysfunction which accompanies type-2 diabetes mellitus. In most of these studies, the LXR ligand T0901317 has been administered chronically in the µmolar range to study the significance of LXR activation.In the present study, we have evaluated acute effects of T0901317 on stimulus-secretion coupling of beta-cells...
April 25, 2017: Endocrinology
https://www.readbyqxmd.com/read/28449081/the-coxiella-burnetii-type-ivb-secretion-system-t4bss-component-dota-is-released-secreted-during-infection-of-host-cells-and-during-in-vitro-growth-in-a-t4bss-dependent-manner
#6
Brandon E Luedtke, Saugata Mahapatra, Erika I Lutter, Edward I Shaw
Coxiella burnetii is a Gram-negative intracellular pathogen and is the causative agent of the zoonotic disease Q-fever. To cause disease, C. burnetii requires a functional type IVB secretion system (T4BSS) to transfer effector proteins required for the establishment and maintenance of a membrane bound parasitophorous vacuole (PV) and further modulation of host cell process. However, it is not clear how the T4BSS interacts with the PV membrane since neither a secretion pilus nor an extracellular pore forming apparatus has not been described...
April 25, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28449070/in-situ-screening-for-postsynaptic-cell-adhesion-molecules-during-synapse-formation
#7
Takeshi Uemura, Tomoko Shiroshima, Asami Maeda, Misato Yasumura, Takashi Shimada, Yuko Fukata, Masaki Fukata, Tomoyuki Yoshida
Neuronal synapse formation is regulated by pre- and postsynaptic cell adhesion molecules. Presynaptic neurexins (NRXNs) and receptor protein tyrosine phosphatases (RPTPs; PTPδ, PTPσ, and LAR in mammals) can induce postsynaptic differentiation through the interaction with various postsynaptic cell adhesion molecules. Here, we developed a novel in situ screening method to identify postsynaptic membranous proteins involved in synaptogenesis. Magnetic beads coated with the extracellular domains of NRXN1β(-S4) and PTPδ-A6 variants preferentially induced excitatory postsynaptic differentiation on the beads' surface when co-cultured with cortical neurons...
April 25, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28449039/polyphyllin-i-induces-g2-m-phase-arrest-and-apoptosis-in-u251-human-glioma-cells-via-mitochondrial-dysfunction-and-the-jnk-signaling-pathway
#8
Jiaxin Liu, Yueting Zhang, Li Chen, Fei Yu, Xiaojin Li, Dan Tao, Jianhua Zhao, Shuai Zhou
Glioblastoma is the most aggressive brain tumor, and its prognosis remains poor. Therefore, novel therapeutic strategies are needed for glioma therapy. Polyphyllin I (PPI), a bioactive constituent extracted from Paris polyphylla, was reported to have anti-tumor activity. However, the detailed mechanism for this activity remains unclear. Here, we investigated the inhibitory effects of PPI on glioma cells and its mechanisms in vitro. U251 cells were treated with various concentrations of PPI (2-9 μM) for 24 to 72 h...
April 26, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28448961/supported-binary-liposome-vesicle-gold-nanoparticle-for-enhanced-label-free-dna-and-protein-sensing
#9
Divya Karutha Pandian, Venkataraman Dharuman
Supported binary liposome mixture of cationic liposome N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium propane (DOTAP) and the zwitterionic liposome 1,2-Dioleoyl-sn-Glycero-3-Phosphoethanolamine (DOPE) were tethered on thiol monolayers in the absence and presence of gold nanoparticle to enhance sensor stability and sensitivity for label free DNA and protein sensing for the first time. Cysteamine hydrochloride (Cyst), 3-Mercaptopropionic acid (MPA), 11-Mercaptoundecanoic acid (MUDA) and 11-amino-1-undecane thiol (AUT) monolayers were used as tethers on gold surfaces...
April 20, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28448930/determining-equilibrium-partition-coefficients-between-lipid-protein-and-polydimethylsiloxane-for-highly-hydrophobic-organic-contaminants-using-preloaded-disks
#10
Yuanyuan Pei, Huizhen Li, Jing You
Bioaccumulation of hydrophobic organic contaminants is of great concern and understanding their partitioning to biological phases is crucial for estimating their bioaccumulation potential. The estimation, however, was of large uncertainty for highly hydrophobic organic contaminants (HHOCs) with log KOW>9 due to the challenge of quantifying their water concentrations. In the present study, partition coefficients between polydimethylsiloxane (PDMS) and storage lipid (KSL,PDMS), membrane lipid (KML,PDMS) and protein (Kpro,PDMS) were measured for 21 polychlorinated biphenyls (PCBs), 14 polybrominated diphenyl ethers (PBDEs), dechlorane plus (DP) and decabromodiphenyl ethane (DBDPE), covering log KOW from 5...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448874/regulation-and-roles-of-cd26-dppiv-in-hematopoiesis-and-diseases
#11
REVIEW
Zeynab Aliyari Serej, Abbas Ebrahimi Kalan, Ahmad Mehdipour, Hojjatollah Nozad Charoudeh
Dipeptidyl peptidase IV (DPPIV),(1) on the surface of certain cells, where it is also referred to as CD26, is involved in a vast majority of biological and pathological processes. CD26/DPPIV function contributes to cancer and tumor metastasis as well as inhibition of its expression which alters the expression of immune response-related genes. CD26/DPPIV is a widely distributed multifunctional integral membrane and secreted protein that is defined as early predictive biomarker in HIV, cancer and autoimmunity diseases like diabetes and multiple sclerosis...
April 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28448865/glycolipids-from-spinach-suppress-lps-induced-vascular-inflammation-through-enos-and-nk-%C3%AE%C2%BAb-signaling
#12
Masakazu Ishii, Tatsuo Nakahara, Daisuke Araho, Juri Murakami, Masahiro Nishimura
Glycolipids are the major constituent of the thylakoid membrane of higher plants and have a variety of biological and pharmacological activities. However, anti-inflammatory effects of glycolipids on vascular endothelial cells have not been elucidated. Here, we investigated the effect of glycolipids extracted from spinach on lipopolysaccharides (LPS)-induced endothelial inflammation and evaluated the underlying molecular mechanisms. Treatment with glycolipids from spinach had no cytotoxic effects on cultured human umbilical vein endothelial cells (HUVECs) and significantly blocked the expression of LPS-induced interleukin (IL)-6, monocyte chemoattractant protein-1 (MCP-1), vascular cell adhesion molecule-1 (VCAM-1), and intracellular adhesion molecule-1 (ICAM-1) in them...
April 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28448835/continuous-production-of-polymer-nanoparticles-using-a-membrane-based-flow-cell
#13
Zhengnan Yang, Dona Foster, Ali Dhinojwala
We demonstrate the surfactant-free production of polymer nanoparticles using a continuous membrane-based tangential flow cell. Co-current streams of water and polymethylmethacrylate (PMMA)/acetone/water solution were separated by a porous regenerated cellulose (RC) membrane. The water concentration in the PMMA solution was adjusted so that as additional water diffused through the RC membrane, the PMMA solution composition crossed the two phase boundary to precipitate PMMA nanoparticles. The size of these nanoparticles varied with the concentration of the PMMA feed and the amount of water diffusing across the membrane...
April 17, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28448828/note-on-in-situ-scanning-transmission-electron-microscopy-study-of-liquid-samples
#14
Nan Jiang
Liquid cell (scanning) transmission electron microscopy has been developed rapidly, using amorphous SiNx membranes as electron transparent windows. The current interpretations of electron beam effects are mainly based on radiolytic processes. In this note, additional effects of the electric field due to electron-beam irradiation are discussed. The electric field can be produced by the charge accumulation due to the emission of secondary and Auger electrons. Besides various beam-induced phenomena, such as nanoparticle precipitation and gas bubble formation and motion, two other effects need to be considered; one is the change of Gibbs free energy of nucleation and the other is the violation of Brownian motion due to ion drifting driven by the electric field...
April 19, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28448816/protective-effect-of-artemisinin-on-chronic-alcohol-induced-liver-damage-in-mice
#15
Xiaoyan Zhao, Liqing Wang, Hao Zhang, Duoduo Zhang, Zhihao Zhang, Jie Zhang
The liver disease related to chronic alcohol consumption is one of the leading causes of death for alcoholics. The efficient drug to ameliorate the alcoholic liver injury was needed urgently. The present study was performed to investigate whether artemisinin possessed the protective effect against chronic alcohol consumption. 50 male Kunming mice were divided into 5 groups: control group (C): 10ml/kg saline+10ml/kg saline, alcohol group (A): 10ml/kg 56%(v/v) alcohol+10ml/kg saline, low dose group of artemisinin (L): 10ml/kg 56%(v/v) alcohol+30mg/kg/day artemisinin, medium dose group of artemisinin (M): 10ml/kg 56%(v/v) alcohol+60mg/kg/day artemisinin, high dose group of artemisinin (H): 10ml/kg 56%(v/v) alcohol+120mg/kg/day artemisinin...
April 13, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28448737/involvement-of-arhgef10-gef-for-rhoa-in-rab6-rab8-mediating-membrane-traffic
#16
Satoshi Shibata, Yui Teshima, Kenta Niimi, Shinobu Inagaki
Small GTPases play crucial roles in the maintenance of a homeostatic environment and appropriate movements of the cell. In these processes, the direct or indirect interaction between distinct small GTPases could be required for regulating mutual signaling pathways. In our recent study, ARHGEF10, known as a guanine nucleotide exchange factor (GEF) for RhoA, was indicated to interact with Rab6A and Rab8A, which are known to function in the exocytotic pathway, and colocalized with these Rabs at exocytotic vesicles...
April 27, 2017: Small GTPases
https://www.readbyqxmd.com/read/28448716/phosphorylation-weakens-but-does-not-inhibit-membrane-binding-and-clustering-of-k-ras4b
#17
Si-Yu Zhang, Benjamin Sperlich, Fang-Yi Li, Samy Al-Ayoubi, Hong-Xue Chen, YuFen Zhao, Yan-Mei Li, Katrin Weise, Roland Winter, Yong-Xiang Chen
K-Ras4B is one of the most frequently mutated Ras isoforms in cancers. The signaling activity of K-Ras4B depends on its localization to the plasma membrane (PM), which is mainly mediated by its polybasic farnesylated C-terminus. On top of the constitutive cycles that maintain the PM enrichment of K-Ras4B, conditional phosphorylation at Ser181 located within this motif has been found to be involved in regulating K-Ras4B's cell distribution and signaling activity. However, discordant observations have undermined our understanding of the role this phosphorylation plays...
April 27, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28448640/mapping-of-the-lassa-virus-lamp1-binding-site-reveals-unique-determinants-not-shared-by-other-old-world-arenaviruses
#18
Hadar Israeli, Hadas Cohen-Dvashi, Anastasiya Shulman, Amir Shimon, Ron Diskin
Cell entry of many enveloped viruses occurs by engagement with cellular receptors, followed by internalization into endocytic compartments and pH-induced membrane fusion. A previously unnoticed step of receptor switching was found to be critical during cell entry of two devastating human pathogens: Ebola and Lassa viruses. Our recent studies revealed the functional role of receptor switching to LAMP1 for triggering membrane fusion by Lassa virus and showed the involvement of conserved histidines in this switching, suggesting that other viruses from this family may also switch to LAMP1...
April 27, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28448603/evaluation-of-immunogenicity-and-protective-efficacy-of-recombinant-outer-membrane-proteins-of-haemophilus-parasuis-serovar-5-in-a-murine-model
#19
Miao Li, Ru-Jian Cai, Shuai Song, Zhi-Yong Jiang, Yan Li, Hong-Chao Gou, Pin-Pin Chu, Chun-Ling Li, Hua-Ji Qiu
Glässer's disease is an economically important infectious disease of pigs caused by Haemophilus parasuis. Few vaccines are currently available that could provide effective cross-protection against various serovars of H. parasuis. In this study, five OMPs (OppA, TolC, HxuC, LppC, and HAPS_0926) identified by bioinformatic approaches, were cloned and expressed as recombinant proteins. Antigenicity of the purified proteins was verified through Western blotting, and primary screening for protective potential was evaluated in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28448589/morpho-physiological-analysis-of-tolerance-to-aluminum-toxicity-in-rice-varieties-of-north-east-india
#20
Jay Prakash Awasthi, Bedabrata Saha, Preetom Regon, Smita Sahoo, Umakanta Chowra, Amit Pradhan, Anupam Roy, Sanjib Kumar Panda
Aluminum (Al) is the third most abundant metal in earth crust, whose chemical form is mainly dependent on soil pH. The most toxic form of Al with respect to plants is Al3+, which exists in soil pH <5. Acidic soil significantly limits crop production mainly due to Al3+ toxicity worldwide, impacting approximately 50% of the world's arable land (in North-Eastern India 80% soil are acidic). Al3+ toxicity in plants ensues root growth inhibition leading to less nutrient and water uptake impacting crop productivity as a whole...
2017: PloS One
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