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https://www.readbyqxmd.com/read/29135773/tree-based-claims-algorithm-for-measuring-pretreatment-quality-of-care-in-medicare-disabled-hepatitis-c-patients
#1
Viktor V Chirikov, Fadia T Shaya, Ebere Onukwugha, C Daniel Mullins, Susan dosReis, Charles D Howell
BACKGROUND: To help broaden the use of machine-learning approaches in health services research, we provide an easy-to-follow framework on the implementation of random forests and apply it to identify quality of care (QC) patterns correlated with treatment receipt among Medicare disabled patients with hepatitis C virus (HCV). METHODS: Using Medicare claims 2006-2009, we identified 1936 patients with 6 months continuous enrollment before HCV diagnosis. We ran a random forest on 14 pretreatment QC indicators, extracted the forest's representative tree, and aggregated its terminal nodes into 4 QC groups predictive of treatment...
December 2017: Medical Care
https://www.readbyqxmd.com/read/29134483/evaluating-the-impact-of-dyslexia-laws-on-the-identification-of-specific-learning-disability-and-dyslexia
#2
B Anne Barber Phillips, Timothy N Odegard
Dyslexia is a specific learning disability that impacts word reading accuracy and/or reading fluency. Over half of the states in the USA have passed legislation intended to promote better identification of individuals with dyslexia. To date, no study has been conducted to investigate the potential impact of state laws on the identification of specific learning disability (SLD), and limited data has been presented on the rate at which students in public school settings are identified with dyslexia. The first aim of the current study was to determine if any detectable changes in the identification rates of SLD have occurred in states implementing dyslexia laws because most states do not report number of students identified as dyslexic but rather those students identified with an SLD...
November 13, 2017: Annals of Dyslexia
https://www.readbyqxmd.com/read/29134479/take-flight-the-evolution-of-an-orton-gillingham-based-curriculum
#3
Jeremiah J Ring, Karen J Avrit, Jeffrey L Black
Thirty years ago in this journal, Aylett Royall Cox reported on the development of Alphabetic Phonics, a revision of the existing Orton Gillingham treatment for children with dyslexia. This paper continues that discussion and reports on the evolution of that curriculum as it is represented in a comprehensive dyslexia treatment program informed by intervention research. The paper describes the curriculum and reports data from a hospital-based learning disabilities clinic that provides qualified support for treatment efficacy and the value of added comprehension instruction...
November 13, 2017: Annals of Dyslexia
https://www.readbyqxmd.com/read/29133437/abnormal-microglia-and-enhanced-inflammation-related-gene-transcription-in-mice-with-conditional-deletion-of-ctcf-in-camk2a-cre-expressing-neurons
#4
Bryan E McGill, Ruteja A Barve, Susan E Maloney, Amy Strickland, Nicholas Rensing, Peter Wang, Michael Wong, Richard Head, David F Wozniak, Jeffrey Milbrandt
CCCTC-binding factor (CTCF) is an 11 zinc finger DNA-binding domain protein that regulates gene expression by modifying three dimensional chromatin structure. Human mutations in CTCF cause intellectual disability and autistic features. Knocking out Ctcf in mouse embryonic neurons is lethal by neonatal age, but the effects of CTCF deficiency in postnatal neurons are less well studied. We knocked out Ctcf postnatally in glutamatergic forebrain neurons under the control of Camk2a-CreCtcf(loxP/loxP) ;Camk2a-Cre+ (Ctcf CKO) mice of both sexes were viable and exhibited profound deficits in spatial learning/memory, impaired motor co-ordination, and decreased sociability by 4 months of age...
November 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29128904/pharmacological-rescue-of-hippocampal-fear-learning-deficits-in-fragile-x-syndrome
#5
Luis A Martinez, Maria Victoria Tejada-Simon
Fragile X Syndrome (FXS) is the leading cause of autism spectrum disorder and intellectual disability and results from loss of Fragile X mental retardation protein (FMRP). In neurons, FMRP controls the translation of synaptic plasticity proteins that are implicated in learning and memory. FMRP also regulates development- and experience-dependent actin cytoskeleton remodeling within dendritic spines through the small Rho GTPase Rac1. Modulation of Rac1 activity is critical during synaptic plasticity as well as learning and memory...
November 11, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29128445/the-promise-of-induced-pluripotent-stem-cells-for-neurodevelopmental-disorders
#6
REVIEW
Katrin Linda, Carol Fiuza, Nael Nadif Kasri
A major challenge in clinical genetics and medicine is represented by genetically and phenotypically highly diverse neurodevelopmental disorders, like for example intellectual disability and autism. Intellectual disability is characterized by substantial limitations in cognitive function and adaptive behaviour. At the cellular level, this is reflected by deficits in synaptic structure and plasticity and therefore has been coined as a synaptic disorder or "synaptopathy". In this review, we summarize the findings from recent studies in which iPSCs have been used to model specific neurodevelopmental syndromes, including Fragile X syndrome, Rett syndrome, Williams-Beuren syndrome and Phelan-McDermid syndrome...
November 8, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29124944/human-rights-of-refugee-survivors-of-sexual-and-gender-based-violence-with-communication-disability
#7
Julie Marshall, Helen Barrett
Article 19 of the Universal Declaration of Human Rights (United Nations, 1948 ) states that all people have the right to seek, receive and impart information using any means. Ensuring that people with communication disability achieve this right is inherently challenging. For people with communication disability, who are refugee-survivors of sexual and gender-based violence (SGBV), additional human rights are challenged, including the right to education, protection from discrimination, a safe place to live, security of person and legal protection...
November 10, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29122542/twin-twin-transfusion-syndrome-what-we-have-learned-from-clinical-trials
#8
REVIEW
Fatiha Djaafri, Julien Stirnemann, Imen Mediouni, Claire Colmant, Yves Ville
Monochorionic twin pregnancies are at increased risk for adverse outcome compared to dichorionic twin pregnancies and singletons. Monochorionic-specific complications include twin-twin transfusion syndrome (TTTS), twin anemia-polycythemia sequence, single intrauterine fetal demise and its consequences on the co-twin, and selective intrauterine growth restriction. Whereas the natural history of monochorionic-specific complications carries a high risk of fetal death or severe neurologic disability, a framework now exists, based on well-designed clinical trials, for optimal treatment of these entities...
November 6, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29121825/the-impact-of-staff-training-on-special-educational-needs-professionals-attitudes-toward-and-understanding-of-applied-behavior-analysis
#9
Sinéad Smyth, Benjamin E Reading, Claire McDowell
BACKGROUND: Research-based evidence points to the efficacy and value of applied behavior analysis (ABA) in meeting the needs of individuals with learning disabilities and autism. Nonetheless, public, government, and professional perception of ABA can be negative. The current study was designed to measure the impact of a short intervention on professionals' attitudes toward, and knowledge of, ABA. METHOD: Teachers and classroom assistants from two separate schools for children with severe learning difficulties completed a self-report survey on knowledge of and attitudes toward ABA...
January 1, 2017: Journal of Intellectual Disabilities: JOID
https://www.readbyqxmd.com/read/29120714/functional-magnetic-resonance-imaging-to-assess-neuroadaptation-to-multifocal-intraocular-lenses
#10
Andreia M Rosa, Ângela C Miranda, Miguel M Patrício, Colm McAlinden, Fátima L Silva, Miguel Castelo-Branco, Joaquim N Murta
PURPOSE: To evaluate the use of functional magnetic resonance imaging (MRI) to assess neuroadaptation to multifocal intraocular lenses (IOLs). SETTING: Faculty of Medicine, University of Coimbra, Coimbra, Portugal. DESIGN: Prospective case study. METHODS: Patients with bilateral diffractive IOL implantation after cataract surgery had functional MRI at postoperative intervals of 3 weeks and 6 months. A nonintervention control group was included as proof of concept...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29119424/health-literacy-assessment-in-adults-with-neurofibromatosis-electronic-and-short-form-measurement-using-fcchl-and-health-litt
#11
Vanessa L Merker, Sarah McDannold, Eric Riklin, Mojtaba Talaei-Khoei, Monica R Sheridan, Justin T Jordan, Scott R Plotkin, Ana-Maria Vranceanu
Determining health literacy level is an important prerequisite for effective patient education. We assessed multiple dimensions of health literacy and sociodemographic predictors of health literacy in patients with neurofibromatosis. In 86 individuals with a confirmed diagnosis of neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), or schwannomatosis, we assessed health literacy status using two HL tools-the adapted functional, communicative, and critical health literacy scale (adapted FCCHL) and health literacy assessment using talking touchscreen technology (Health LiTT)...
November 8, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29119105/a-rare-variant-in-pgap2-causes-autosomal-recessive-hyperphosphatasia-with-mental-retardation-syndrome-with-a-mild-phenotype-in-heterozygous-carriers
#12
Yonatan Perez, Ohad Wormser, Yair Sadaka, Ruth Birk, Ginat Narkis, Ohad S Birk
Mutations in genes involved in the biosynthesis of the glycosylphosphatidylinositol (GPI) anchor cause autosomal recessive glycosylation defects, with a wide phenotypic spectrum of intellectual disability, seizures, minor facial dysmorphism, hypotonia, and elevated serum alkaline phosphatase. We now describe consanguineous Bedouin kindred presenting with an autosomal recessive syndrome of intellectual disability and elevated serum alkaline phosphatase. Genome-wide linkage analysis identified 6 possible disease-associated loci...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29118725/cognitive-and-neural-correlates-of-mathematical-giftedness-in-adults-and-children-a-review
#13
REVIEW
Timothy Myers, Emma Carey, Dénes Szűcs
Most mathematical cognition research has focused on understanding normal adult function and child development as well as mildly and moderately impaired mathematical skill, often labeled developmental dyscalculia and/or mathematical learning disability. In contrast, much less research is available on cognitive and neural correlates of gifted/excellent mathematical knowledge in adults and children. In order to facilitate further inquiry into this area, here we review 40 available studies, which examine the cognitive and neural basis of gifted mathematics...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29117264/obesity-and-the-burden-of-health-risks-among-the-elderly-in-ghana-a-population-study
#14
Godfred O Boateng, Ellis A Adams, Mavis Odei Boateng, Isaac N Luginaah, Mary-Margaret Taabazuing
BACKGROUND: The causes and health risks associated with obesity in young people have been extensively documented, but elderly obesity is less well understood, especially in sub-Saharan Africa. This study examines the relationship between obesity and the risk of chronic diseases, cognitive impairment, and functional disability among the elderly in Ghana. It highlights the social and cultural dimensions of elderly obesity and discusses the implications of related health risks using a socio-ecological model...
2017: PloS One
https://www.readbyqxmd.com/read/29115755/nurses-as-participants-in-research-an-evaluation-of-recruitment-techniques
#15
Lauretta Luck, Harrison Ng Chok, Lesley Wilkes
BACKGROUND: Recruitment and retention of participants, as well as response rates, can be challenging in nursing research. This can be because of the questions asked; the choice of methodology; the methods used to collect data; the characteristics of potential participants; the sample size required; and the duration of the study. Additionally, conducting research with nurses as participants presents several issues for them, including the time needed to participate in the research, the competing commitments for clinical practice, the political and environmental climate, and recruitment itself...
September 19, 2017: Nurse Researcher
https://www.readbyqxmd.com/read/29111462/successful-treatment-of-multifactorial-chronic-daily-headaches-at-an-interdisciplinary-chronic-pain-program-a-case-study
#16
Sarah A Mihalov, Karina Bouffard, Jeffrey R Cara
Chronic daily headaches (CDH) are common, disabling, and difficult to treat. We report a case of a patient with complex medical history experiencing multifactorial CDH referred for and eventually enrolled in an interdisciplinary chronic pain program. Focusing on enhancing the patient's function while minimizing the use of medications and invasive procedures, this comprehensive rehabilitation intervention consists of diverse treatment approaches, including cognitive-behavioral therapy, physical and occupational therapy, and medical interventions...
October 27, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29110906/memory-focused-interventions-for-people-with-cognitive-disorders-a-systematic-review-and-meta-analysis-of-randomized-controlled-studies
#17
Hui-Ling Yang, Pi-Tuan Chan, Pi-Chen Chang, Huei-Ling Chiu, Shu-Tai Sheen Hsiao, Hsin Chu, Kuei-Ru Chou
BACKGROUND: A better understanding of people with cognitive disorders improves performance on memory tasks through memory-focused interventions are needed. OBJECTIVES: The purpose of this study was to assess the effect of memoryfocused interventions on cognitive disorders through a meta-analysis. DESIGN: Systematic review and meta-analysis. DATA SOURCES: The online electronic databases PubMed, the Cochrane Library, Ovid-Medline, CINHAL, PsycINFO, Ageline, and Embase (up to May 2017) were used in this study...
August 20, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29110728/how-a-diverse-research-ecosystem-has-generated-new-rehabilitation-technologies-review-of-nidilrr-s-rehabilitation-engineering-research-centers
#18
REVIEW
David J Reinkensmeyer, Sarah Blackstone, Cathy Bodine, John Brabyn, David Brienza, Kevin Caves, Frank DeRuyter, Edmund Durfee, Stefania Fatone, Geoff Fernie, Steven Gard, Patricia Karg, Todd A Kuiken, Gerald F Harris, Mike Jones, Yue Li, Jordana Maisel, Michael McCue, Michelle A Meade, Helena Mitchell, Tracy L Mitzner, James L Patton, Philip S Requejo, James H Rimmer, Wendy A Rogers, W Zev Rymer, Jon A Sanford, Lawrence Schneider, Levin Sliker, Stephen Sprigle, Aaron Steinfeld, Edward Steinfeld, Gregg Vanderheiden, Carolee Winstein, Li-Qun Zhang, Thomas Corfman
Over 50 million United States citizens (1 in 6 people in the US) have a developmental, acquired, or degenerative disability. The average US citizen can expect to live 20% of his or her life with a disability. Rehabilitation technologies play a major role in improving the quality of life for people with a disability, yet widespread and highly challenging needs remain. Within the US, a major effort aimed at the creation and evaluation of rehabilitation technology has been the Rehabilitation Engineering Research Centers (RERCs) sponsored by the National Institute on Disability, Independent Living, and Rehabilitation Research...
November 6, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29107851/are-wisc-iq-scores-in-children-with-mathematical-learning-disabilities-underestimated-the-influence-of-a-specialized-intervention-on-test-performance
#19
Katharina Lambert, Birgit Spinath
BACKGROUND: Intelligence measures play a pivotal role in the diagnosis of mathematical learning disabilities (MLD). Probably as a result of math-related material in IQ tests, children with MLD often display reduced IQ scores. However, it remains unclear whether the effects of math remediation extend to IQ scores. AIMS: The present study investigated the impact of a special remediation program compared to a control group receiving private tutoring (PT) on the WISC IQ scores of children with MLD...
October 28, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29104930/brain-and-behavioral-assessment-of-executive-functions-for-self-regulating-levels-of-language-in-reading-brain
#20
Virginia W Berninger, Todd L Richards, Robert D Abbott
This brief research report examines brain-behavioral relationships specific to levels of language in the complex reading brain. The first specific aim was to examine prior findings for significant fMRI connectivity from four seeds (left precuneus, left occipital temporal, left supramarginal, left inferior frontal) for each of four levels of language-subword, word (word-specific spelling or affixed words), syntax (with and without homonym foils or affix foils), and multi-sentence text to identify significant fMRI connectivity (a) unique to the lower level of language when compared to the immediately higher adjacent level of language across subword-word, word-syntax, and syntax-text comparisons; and (b) involving a brain region associated with executive functions...
November 2017: Journal of Nature and Science
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