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https://www.readbyqxmd.com/read/28943415/management-of-blood-blister-like-aneurysms-of-the-internal-carotid-artery-lessons-learned-from-direct-clipping-in-22-cases
#1
Zheng Liu, Shangming Zhang, Shousen Wang, Qizuan Chen
OBJECTIVE: To present a case series of blood blister-like aneurysms (BBAs) of the internal carotid artery (ICA) and an assessment of diagnosis and treatment options, attempting to identify surgical or endovascular management of BBAs with a low complication rate and a functional outcome. METHODS: A retrospective analysis including diagnosis and treatment options of BBAs of the ICA was performed of patients treated for BBAs at Fuzhou General Hospital from January 2008 to September 2016...
September 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28943107/analyses-of-sustained-vowels-in-down-syndrome-ds-a-case-study-using-spectrograms-and-perturbation-data-to-investigate-voice-quality-in-four-adults-with-ds
#2
Tracy Jeffery, Stuart Cunningham, Sandra P Whiteside
OBJECTIVES: Automatic acoustic measures of voice quality in people with Down syndrome (DS) do not reliably reflect perceived voice qualities. This study used acoustic data and visual spectral data to investigate the relationship between perceived voice qualities and acoustic measures. STUDY DESIGN: Participants were four young adults (two males, two females; mean age 23.8 years) with DS and severe learning disabilities, at least one of whom had a hearing impairment...
September 21, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28940883/development-of-a-battery-of-tests-to-measure-attitudes-and-intended-behaviours-of-dental-students-towards-people-with-disability-or-those-in-marginalised-groups
#3
D Faulks, A Dougall, G Ting, T Ari, J Nunn, C Friedman, J John, B Daly, V Roger-Leroi, J T Newton
INTRODUCTION: Recommended curricula in Special Care Dentistry (SCD) outline learning objectives that include the domain of attitudes and behaviours, but these are notoriously difficult to measure. The aims of this study were (i) to develop a test battery comprising adapted and new scales to evaluate values, attitudes and intentions of dental students towards people with disability and people in marginalised groups and (ii) to determine reliability (interitem consistency) and validity of the scales within the test battery...
September 22, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/28939535/reading-difficulties-and-the-pediatric-ophthalmologist
#4
EDITORIAL
Sheryl M Handler, Walter M Fierson
Approximately 20% of children have dyslexia, a language-based reading disability. A variation in language processing in the brain leads to a deficit in phonological (auditory) processing, which leads to problems in learning to read, write, and spell. Myths continue to exist regarding dyslexia and vision, and although eye and vision problems may coexist with dyslexia, they are not more prevalent than in the general population. Rarely vision problems may make reading at near very difficult and may masquerade as a learning problem or attention deficit disorder/attention deficit hyperactivity disorder...
September 19, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28937789/identifying-dyslexia-risk-in-student-athletes-a-preliminary-protocol-for-concussion-management
#5
Rebecca Wiseheart, Robin Wellington
Learning disability (LD) has been identified as a potential risk factor for protracted recovery from a sport-related concussion, yet students with LD are rarely included in concussion research. Here, we draw special attention to dyslexia, a common but often underdiagnosed LD. Reading and learning problems commonly associated with dyslexia are often masked by protective factors, such as high verbal ability or general intelligence. Hence, high-achieving individuals with dyslexia may not be identified as being in a high-risk category...
September 22, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28936422/forgotten-excluded-or-included-students-with-disabilities-a-case-study-at-the-university-of-mauritius
#6
Sameerchand Pudaruth, Rajendra P Gunputh, Upasana G Singh
BACKGROUND: Students with disabilities in the tertiary education sector are more than a just a phenomenon, they are a reality. In general, little attention is devoted to their needs despite the fact that they need more care and attention. OBJECTIVES: This paper, through a case study at the University of Mauritius, sought to answer some pertinent questions regarding students with disabilities. Does the University of Mauritius have sufficient facilities to support these students? Are students aware of existing facilities? What additional structures need to be put in place so that students with any form of disability are neither victimised, nor their education undermined? Are there any local laws about students with disabilities in higher education? METHOD: To answer these questions and others, an online questionnaire was sent to 500 students and the responses were then analysed and discussed...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28936361/relationships-between-eye-movements-during-sentence-reading-comprehension-word-spelling-and-reading-and-dti-and-fmri-connectivity-in-students-with-and-without-dysgraphia-or-dyslexia
#7
Kevin Yagle, Todd Richards, Katie Askren, Zoe Mestre, Scott Beers, Robert Abbott, William Nagy, Peter Boord, Virginia Berninger
While eye movements were recorded and brains scanned, 29 children with and without specific learning disabilities (SLDs) decided if sentences they read (half with only correctly spelled words and half with homonym foils) were meaningful. Significant main effects were found for diagnostic groups (non-SLD control, dysgraphia control, and dyslexia) in total fixation (dwell) time, total number of fixations, and total regressions in during saccades; the dyslexia group had longer and more fixations and made more regressions in during saccades than either control group...
January 2017: Journal of Systems and Integrative Neuroscience
https://www.readbyqxmd.com/read/28935587/glutamatergic-synapses-in-neurodevelopmental-disorders
#8
REVIEW
Edoardo Moretto, Luca Murru, Giuseppe Martano, Jenny Sassone, Maria Passafaro
Neurodevelopmental disorders (NDDs) are a group of diseases whose symptoms arise during childhood or adolescence and that impact several higher cognitive functions such as learning, sociability and mood. Accruing evidence suggests that a shared pathogenic mechanism underlying these diseases is the dysfunction of glutamatergic synapses. We summarize present knowledge on autism spectrum disorders (ASD), intellectual disability (ID), Down syndrome (DS), Rett syndrome (RS) and attention-deficit hyperactivity disorder (ADHD), highlighting the involvement of glutamatergic synapses and receptors in these disorders...
September 18, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28933956/relationship-between-reading-and-long-term-storage-and-retrieval-glr-in-college-students
#9
Maria Jesus Avitia, Alan S Kaufman, Melissa Bray, James C Kaufman
The purpose of this study was to (a) identify the relationship between specific types of reading ability, different forms of learning, and long-term memory and retrieval (Glr); and then (b) to determine the degree to which self-assessed reading ability and a Glr measure could predict objective reading ability. College students were administered three different reading assessments from the Kaufman Test of Educational Achievement, Second Edition (KTEA-II): word reading, reading comprehension, and nonsense word decoding...
September 21, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28931509/development-and-validation-of-qmortality-risk-prediction-algorithm-to-estimate-short-term-risk-of-death-and-assess-frailty-cohort-study
#10
Julia Hippisley-Cox, Carol Coupland
Objectives To derive and validate a risk prediction equation to estimate the short term risk of death, and to develop a classification method for frailty based on risk of death and risk of unplanned hospital admission.Design Prospective open cohort study.Participants Routinely collected data from 1436 general practices contributing data to QResearch in England between 2012 and 2016. 1079 practices were used to develop the scores and a separate set of 357 practices to validate the scores. 1.47 million patients aged 65-100 years were in the derivation cohort and 0...
September 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28931311/validating-the-unicef-washington-group-child-functioning-module-for-fijian-schools-to-identify-seeing-hearing-and-walking-difficulties
#11
Beth Sprunt, Monsurul Hoq, Umesh Sharma, Manjula Marella
PURPOSE: This study investigated the seeing, hearing and walking questions of the UNICEF/Washington Group Child Functioning Module and the inter-rater reliability between teachers and parents as proxy respondents. METHODS: Cross-sectional diagnostic accuracy study, two-gate design with representative sampling, comparing Module responses to reference standard assessments for 472 primary aged students in Fiji. Receiver operating characteristic curves were constructed to determine the area under the curve and optimal cut-off points...
September 20, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28931075/excitability-is-increased-in-hippocampal-ca1-pyramidal-cells-of-fmr1-knockout-mice
#12
M Angeles Luque, Pablo Beltran-Matas, M Carmen Marin, Blas Torres, Luis Herrero
Fragile X syndrome (FXS) is caused by a failure of neuronal cells to express the gene encoding the fragile mental retardation protein (FMRP). Clinical features of the syndrome include intellectual disability, learning impairment, hyperactivity, seizures and anxiety. Fmr1 knockout (KO) mice do not express FMRP and, as a result, reproduce some FXS behavioral abnormalities. While intrinsic and synaptic properties of excitatory cells in various part of the brain have been studied in Fmr1 KO mice, a thorough analysis of action potential characteristics and input-output function of CA1 pyramidal cells in this model is lacking...
2017: PloS One
https://www.readbyqxmd.com/read/28929902/neurochemical-changes-underpinning-the-development-of-adjunct-therapies-in-recovery-after-stroke-a-role-for-gaba
#13
Ainslie Johnstone, Jacob M Levenstein, Emily L Hinson, Charlotte J Stagg
Stroke is a leading cause of long-term disability, with around three-quarters of stroke survivors experiencing motor problems. Intensive physiotherapy is currently the most effective treatment for post-stroke motor deficits, but much recent research has been targeted at increasing the effects of the intervention by pairing it with a wide variety of adjunct therapies, all of which aim to increase cortical plasticity, and thereby hope to maximize functional outcome. Here, we review the literature describing neurochemical changes underlying plasticity induction following stroke...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28927869/what-have-we-learned-from-best
#14
Cornelia F Allaart, Iris M Markusse, Willem F Lems
BACKGROUND: How have the long term outcomes of RA improved in the last decade? METHODS: Patients with DMARD naïve RA were randomized to 4 treatment strategies: 1. sequential DMARD monotherapy, 2. step-up combination therapy, 3. initial combination therapy including prednisone or 4. including infliximab. Treatment-to-target was aimed at DAS≤2.4 (three-monthly calculations). Functional ability (HAQ), radiologic damage progression (Sharp/vanderHeijde Score) and overall survival were reported...
September 16, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28927322/-it-s-important-that-we-learn-too-empowering-parents-to-facilitate-participation-in-physical-activity-for-children-and-youth-with-disabilities
#15
Claire E Willis, Siobhan Reid, Catherine Elliott, Astrid Nyquist, Reidun Jahnsen, Michael Rosenberg, Sonya Girdler
AIM: The actions and behaviors of parents have been identified as key factors that influence a child's participation in physical activity. However, there is limited knowledge of how parents can be supported to embody facilitative roles. This study aimed to explore how an ecological intervention encourages parents of children with disabilities to develop as facilitators, to enable ongoing physical activity participation in a child's local environment. METHODS: A qualitative design using grounded theory was employed...
September 20, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28923375/the-feldenkrais-method-improves-functioning-and-body-balance-in-people-with-intellectual-disability-in-supported-employment-a-randomized-clinical-trial
#16
Jon Torres-Unda, Vanesa Polo, Iratxe Dunabeitia, Iraia Bidaurrazaga-Letona, María García-Gil, Ana Rodriguez-Larrad, Jon Irazusta
Loss of functioning and age-related health problems tend to appear earlier in individuals with intellectual disability (ID) than in their non-disabled peers. The Feldenkrais method (FM) is a movement-based form of learning that enhances body balance and physical functioning. We carried out an intervention based on Awareness Through Movement, a form of the FM. Thirty-two middle-aged (48.94±6.01years old) adults with ID who were in supported employment were recruited and randomly assigned to the experimental group (EG) or control group (CG)...
September 15, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28918392/cnvs-affecting-cancer-predisposing-genes-cpgs-detected-as-incidental-findings-in-routine-germline-diagnostic-chromosomal-microarray-cma-testing
#17
Josie Innes, Lisa Reali, Jill Clayton-Smith, Georgina Hall, Derek Hk Lim, George J Burghel, Kim French, Unzela Khan, Daniel Walker, Fiona Lalloo, D Gareth R Evans, Dominic McMullan, Eamonn R Maher, Emma R Woodward
BACKGROUND: Identification of CNVs through chromosomal microarray (CMA) testing is the first-line investigation in individuals with learning difficulties/congenital abnormalities. Although recognised that CMA testing may identify CNVs encompassing a cancer predisposition gene (CPG), limited information is available on the frequency and nature of such results. METHODS: We investigated CNV gains and losses affecting 39 CPGs in 3366 pilot index case individuals undergoing CMA testing, and then studied an extended cohort (n=10 454) for CNV losses at 105 CPGs and CNV gains at 9 proto-oncogenes implicated in inherited cancer susceptibility...
September 16, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28917696/brain-mapping-in-multiple-sclerosis-lessons-learned-about-the-human-brain
#18
REVIEW
Massimo Filippi, Paolo Preziosa, Maria A Rocca
The application of structural and functional magnetic resonance imaging (MRI) techniques in patients with multiple sclerosis (MS) has certainly helped to improve our understanding of the mechanisms responsible for clinical disability and cognitive impairment in this condition. The numerous studies performed in MS patients have also provided many lessons on the structure-function relationships in the human brain, which could be applied to healthy subjects and to patients affected by other neurological conditions...
September 13, 2017: NeuroImage
https://www.readbyqxmd.com/read/28915930/predicting-activities-of-daily-living-for-cancer-patients-using-an-ontology-guided-machine-learning-methodology
#19
Hua Min, Hedyeh Mobahi, Katherine Irvin, Sanja Avramovic, Janusz Wojtusiak
BACKGROUND: Bio-ontologies are becoming increasingly important in knowledge representation and in the machine learning (ML) fields. This paper presents a ML approach that incorporates bio-ontologies and its application to the SEER-MHOS dataset to discover patterns of patient characteristics that impact the ability to perform activities of daily living (ADLs). Bio-ontologies are used to provide computable knowledge for ML methods to "understand" biomedical data. RESULTS: This retrospective study included 723 cancer patients from the SEER-MHOS dataset...
September 16, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28914735/palliative-care-in-neuromuscular-diseases
#20
Marianne de Visser, David J Oliver
PURPOSE OF REVIEW: Palliative care is an approach that improves the quality of life of patients and their families facing the problem associated with life-threatening illness. Neuromuscular disorders (NMDs) are characterized by progressive muscle weakness, leading to pronounced and incapacitating physical disabilities. Most NMDs are not amenable to curative treatment and would thus qualify for palliative care. Amyotrophic lateral sclerosis is a relentlessly progressive disease, which leads to death about 2 years after onset due to respiratory muscle weakness...
September 13, 2017: Current Opinion in Neurology
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