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https://www.readbyqxmd.com/read/28540246/serious-complications-of-collagenase-clostridium-histiolyticum-injection-for-peyronie-s-disease-more-than-meets-the-eye
#1
EDITORIAL
Christopher Hobaugh, Alexander W Pastuszak
No abstract text is available yet for this article.
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28540240/collagenase-clostridium-hystolyticum-in-the-management-of-peyronie-s-disease
#2
EDITORIAL
Sun Tae Ahn, Du Geon Moon
No abstract text is available yet for this article.
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28522935/penile-ossification-a-reconstructive-challenge
#3
Arthi Satyanarayan, Nirmish Singla, Allen F Morey
Penile ossification is a rare condition that occurs most commonly in acquired cases of penile deformity. We report the case of a 43-year-old man with Peyronie disease who was incidentally found to have significant ossified tissue in his penile corpora during complex placement of an inflatable penile prosthesis (IPP). His clinical course was later complicated by impending distal extrusion of his IPP laterally, necessitating corporoplasty. Penile ossification remains a poorly understood, unusual entity that may pose a reconstructive challenge for urologists...
2017: Reviews in Urology
https://www.readbyqxmd.com/read/28502596/safety-profile-of-collagenase-clostridium-histolyticum-stratified-by-degree-of-penile-curvature-in-patients-with-peyronie-s-disease
#4
Wayne J G Hellstrom, Ronny B W Tan, Genzhou Liu
OBJECTIVE: To examine the safety of collagenase clostridium histolyticum (CCH) in adult males with penile curvature deformity <30°. Collagenase clostridium histolyticum is indicated for treatment of Peyronie's disease (PD) in adult males with palpable plaque and a penile curvature deformity ≥30° at start of therapy; however, during treatment, patients may receive CCH injections when penile curvature deformity is <30°. MATERIALS AND METHODS: Patients who received ≥2 CCH treatment cycles in 2 phase 3 studies (IMPRESS I and II) were included...
May 10, 2017: Urology
https://www.readbyqxmd.com/read/28483591/self-reported-clinical-meaningfulness-early-in-the-treatment-course-predicts-objective-outcomes-in-men-undergoing-collagenase-clostridium-histolyticum-injections-for-peyronie-s-disease
#5
Matthew J Ziegelmann, Boyd R Viers, Brian D Montgomery, Mary E Westerman, Joshua B Savage, Landon W Trost
OBJECTIVE: To compare perceived meaningfulness early in the course of collagenase clostridium histolyticum (CCH) with final outcomes in order to evaluate its utility as a predictor of efficacy. METHODS: A registry of patients undergoing CCH from March 2014 to September 2016 was maintained. Patients were recommended to complete four injection-cycles. After each cycle, patients completed a questionnaire that included, "If you stopped at this point, would you consider this a meaningful improvement for you?" Curve assessments were performed prior to and at therapy completion...
May 5, 2017: Urology
https://www.readbyqxmd.com/read/28482350/does-transfer-capacitive-resistive-energy-has-a-therapeutic-effect-on-peyronie-s-disease-randomized-single-blind-sham-controlled-study-on-96-patients-fast-pain-relief
#6
Carlo Pavone, Salvatore Romeo, Francesco D'Amato, Manuela Usala, Giulia Letizia Mauro, Giovanni Caruana
Background/Aims/Objectives: We have investigated the clinical and physiological effects of Transfer Capacitive Resistive Energy (TCARE) therapy on men with Peyronie's disease (PD). METHODS: Ninety-six men with PD have been randomized in a 2:1 ratio to receive 3 sessions of TCARE therapy or sham therapy. Pain, penile curvature and erectile function have been assessed before the first treatment and up to 9 months after the end of treatment, using the Visual Analogue Scale for the pain, a goniometer to measure the degree of curvature using at-home photography and an International Index of Erectile Function (IIEF-5) questionnaire...
May 9, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28460995/three-dimensional-photography-for-quantitative-assessment-of-penile-volume-loss-deformities-in-peyronie-s-disease
#7
Ezra J Margolin, Carrie M Mlynarczyk, John P Mulhall, Doron S Stember, Peter J Stahl
BACKGROUND: Non-curvature penile deformities are prevalent and bothersome manifestations of Peyronie's disease (PD), but the quantitative metrics that are currently used to describe these deformities are inadequate and non-standardized, presenting a barrier to clinical research and patient care. AIM: To introduce erect penile volume (EPV) and percentage of erect penile volume loss (percent EPVL) as novel metrics that provide detailed quantitative information about non-curvature penile deformities and to study the feasibility and reliability of three-dimensional (3D) photography for measurement of quantitative penile parameters...
April 28, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28454897/collagenase-clostridium-histolyticum-in-the-treatment-of-urologic-disease-current-and-future-impact
#8
REVIEW
Andrew T Gabrielson, Jonathan T Spitz, Wayne J G Hellstrom
INTRODUCTION: Peyronie's disease (PD) is a connective tissue disorder resulting in the abnormal accumulation of type I to III collagen, fibrin, and disorganized elastic fibers in the tunica albuginea of the penis. Many medical and non-pharmacologic modalities have been used in the treatment of PD; however, these approaches have proved largely ineffective, with surgery being the only definitive treatment. Intralesional injection of collagenase Clostridium histolyticum (CCH) has recently become the gold standard for minimally invasive treatment of PD, and studies have suggested the role of CCH could expand to the treatment of other urologic conditions such as urethral stricture disease...
April 25, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28403604/ultrasound-findings-of-ruptured-peyronie-s-plaque-case-report-and-review-of-the-literature
#9
Lucio Dell'Atti, Andrea Benedetto Galosi
We present here a rare case of rupture of tunica albuginea and corpus cavernosum, in the site of a Peyronie's plaque, which happened in a 61- year-old man during a vacuum cleaner masturbation. Ultrasound study showed an irregular hyperechoic defect at the cavernosal rupture site in correspondence of the Peyronie's plaque. The hematoma was evacuated, partially plaque excised, and the tear repaired. Ultrasonography is an ideal technique for evaluating patients with penile trauma and can be routinely used in an emergency...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28395998/changes-in-the-effects-of-peyronie-s-disease-after-treatment-with-collagenase-clostridium-histolyticum-male-patients-and-their-female-partners
#10
Irwin Goldstein, L Dean Knoll, Larry I Lipshultz, Ted Smith, Gregory J Kaufman, Chris G McMahon
INTRODUCTION: Collagenase Clostridium histolyticum (CCH) intralesional injection was efficacious for the management of Peyronie's disease (PD) in the double-blinded, randomized, placebo-controlled Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies I and II (IMPRESS I and II). Little is known about the consequences of PD or treatment on the sexual partners of affected men. AIM: To assess the safety and efficacy of CCH treatment in men who received placebo in the IMPRESS I or II study and to evaluate the men's PD symptoms and partner bother as reported by female sexual partners...
April 5, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28359407/role-of-interleukin-6-and-pentraxin-3-as-an-early-marker-in-peyronie-s-disease
#11
Arda Atar, Alev Kural, Gurkan Yenice, Ilker Comez, Volkan Tugcu
Inflammation is mechanistically involved in the development of Peyronie's disease (PD). The aim of this study is to assess the relevance of serum pentraxin 3 (PTX3) and interleukin-6 (IL-6) concentrations in PD. The study enrolled 40 patients with PD in the acute phase and 40 healthy controls. Plasma PTX3 and IL-6 concentrations were evaluated in 40 patients in the acute phase of PD and 40 healthy controls by enzyme-linked immunosorbent assay. Serum concentrations of both PTX3 and IL-6 were significantly higher in the PD patients than in the control group (p=0...
April 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28347795/clinical-experience-with-penile-traction-therapy-among-men-undergoing-collagenase-clostridium-histolyticum-for-peyronie-s-disease
#12
Matthew J Ziegelmann, Boyd R Viers, Brian D Montgomery, Ross A Avant, Joshua B Savage, Landon W Trost
OBJECTIVES: To evaluate the outcomes in men undergoing Collagenase Clostridium histolyticum (CCH) with concurrent penile traction therapy (PTT) for the treatment of Peyronie's Disease (PD). METHODS: We identified patients treated with CCH between March 2014 and July 2016. Patients were recommended to perform modeling and PTT between injection series. A final curve assessment was performed after patients completed CCH. A prospective database was maintained, including patient reported frequency and duration of PTT...
March 24, 2017: Urology
https://www.readbyqxmd.com/read/28280315/collagenase-clostridium-histolyticum-in-the-treatment-of-peyronie-s-disease-patient-selection-and-perspectives
#13
REVIEW
Paige K Kuhlmann, Kenneth J DeLay, James Anaissie, Wayne Jg Hellstrom, Faysal A Yafi
The safety and efficacy of the use of collagenase Clostridium histolyticum (CCH) for the treatment of Peyronie's disease has been confirmed over the past several years. However, identification of the ideal patient population for use of this treatment is not well established. Multiple studies have attempted to delineate various patient-specific factors that may predict response to treatment with CCH, with the intent of enhancing patient selection. To date, these include baseline curvature severity, duration of disease, disease phase at presentation, plaque calcification, baseline erectile function, plaque size, age, comorbid diabetes, previous penile trauma, responsiveness to first treatment cycle, baseline penile shortening or pain, prior treatment with intralesional injection, compliance with plaque modeling, and atypical curvature...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28274142/stem-cell-therapy-for-the-treatment-of-peyronie-s-disease
#14
Athanasios Dellis, Athanasios Papatsoris
Like other fibrotic diseases, the cause of Peyronie's disease (PD) is still obscure. Since there is now increasing evidence for the role of Mesenchymal Stem Cells (MSCs) as potential treatment to fibrosis, it is crucial to determine their possible efficacy in the treatment of PD. Areas covered: In this review, the authors summarize the emerging data and published studies regarding the use of SCs for the treatment of PD. The authors provide particular focus on the three-first experimental studies for the use of SCs in rat models as well as the sole two studies undertaken in humans...
April 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28268167/low-intensity-extracorporeal-shockwave-therapy-in-sexual-medicine-a%C3%A2-questionnaire-based-assessment-of-knowledge-clinical-practice-patterns-and-attitudes-in-sexual-medicine-practitioners
#15
Mikkel Fode, Lior Lowenstein, Yacov Reisman
INTRODUCTION: Low-intensity extracorporeal shockwave therapy (LI-ESWT) has emerged as a treatment option for male sexual dysfunction. However, results have been contradictory. AIM: To investigate the knowledge, practice patterns, and attitudes regarding LI-ESWT among experts in sexual medicine. METHODS: A study-specific questionnaire was handed out at the 18th Congress for the European Society for Sexual Medicine. Participants were queried on their knowledge about LI-ESWT and about their use of the equipment...
March 4, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28262100/sexual-rehabilitation-after-treatment-for-prostate-cancer-part-2-recommendations-from-the-fourth-international-consultation-for-sexual-medicine-icsm-2015
#16
Andrea Salonia, Ganesh Adaikan, Jacques Buvat, Serge Carrier, Amr El-Meliegy, Kostas Hatzimouratidis, Andrew McCullough, Abraham Morgentaler, Luiz Otavio Torres, Mohit Khera
INTRODUCTION: Sexual dysfunction is common in patients after radical prostatectomy (RP) for prostate cancer. AIM: To provide the International Consultation for Sexual Medicine (ICSM) 2015 recommendations concerning management strategies for post-RP erectile function impairment and to analyze post-RP sexual dysfunction other than erectile dysfunction. METHODS: A literature search was performed using Google and PubMed database for English-language original and review articles published up to August 2016...
March 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28258933/contemporary-review-of-grafting-techniques-for-the-surgical-treatment-of-peyronie-s-disease
#17
REVIEW
Georgios Hatzichristodoulou, Daniar Osmonov, Hubert Kübler, Wayne J G Hellstrom, Faysal A Yafi
INTRODUCTION: Peyronie's disease (PD) is a benign fibrotic disorder of the tunica albuginea of the penis, which can cause penile pain, curvature, shortening, erectile dysfunction, and psychological distress. Surgery is indicated when penile curvature prevents satisfactory sexual intercourse. Plaque incision or excision with grafting has been suggested as an option in patients with a penile curvature greater than 60°, a shortened penis, and/or an hourglass or complex deformity. AIM: To provide an overview of recent studies reporting outcomes of grafting techniques and to report advances in the development of new grafting materials for PD surgery...
February 28, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28247636/-using-cell-technologies-to-treat-urologic-diseases
#18
P V Glybochko, Yu V Olefir, Yu G Alyaev, D V Butnaru, E A Bezrukov, A A Chaplenko, T M Zharikova
Stem and progenitor cells being introduced into the body have the ability to stimulate regeneration of tissues and organs by differentiating into specialized cells. Stem cell therapy is used in urology to treat various disorders, including erectile dysfunction, urinary incontinence, Peyronies disease, and male infertility. This review presents the results of international preclinical and clinical research on stem cell based medications for treating the above diseases. The most promising appears to be the use of adipose tissue-derived mesenchymal stem cells...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28217460/collagenase-clostridium-histolyticum-intralesional-injections-for-the-treatment-of-peyronie-s-disease-a-safety-profile
#19
EDITORIAL
Sylvia Yan, Tet Yap, Suks Minhas
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217459/complications-and-other-concerns-with-intralesional-injection-therapy-with-collagenase-clostridium-histolyticum-for-peyronie-s-disease
#20
EDITORIAL
Laurence A Levine
No abstract text is available yet for this article.
February 2017: Translational Andrology and Urology
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