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L Deville, M Konan, A Hij, L Goldwirt, O Peyrony, F Fieux, P Faure, I Madelaine, S Villiers, D Farge-Bancel, C Frère
Direct oral anticoagulants (DAOC) are indicated for the treatment of venous thromboembolism and the prevention of stroke or systemic embolism in patients with non-valvular atrial fibrillation. Given their advantages and friendly use for patient, the prescription of long term DOAC therapy has rapidly increased both as first line treatment while initiating anticoagulation and as a substitute to vitamins K antagonist (VKA) in poorly controlled patients. However, DOAC therapy can also be associated with significant bleeding complications, and in the absence of specific antidote at disposal, treatment of serious hemorrhagic complications under DOAC remains complex...
July 2016: Current Research in Translational Medicine
Allen F Morey
No abstract text is available yet for this article.
November 2016: Journal of Urology
Oliver Kayes, Rauf Khadr
Peyronie's disease remains an under-reported and debilitating problem which can result in significant physical and psychological symptoms for some men. The classic symptom complex includes penile curvature, penile plaque, and penile pain. Men can also present with erectile dysfunction, penile instability, and penile shortening, alongside feelings of low mood/libido, dysmorphobia, and low self-esteem. This review highlights the current key publications in the medical literature and provides updates on new clinical therapies whilst postulating about potential future treatments on the horizon...
2016: F1000Research
Fábio de Oliveira Vilar, Flávia Cristina Morone Pinto, Amanda Vasconcelos Albuquerque, Ana Gabriela Santos Martins, Luiz Alberto Pereira de Araújo, José Lamartine de Andrade Aguiar, Salvador Vilar Correia Lima
PURPOSE: This study was to confirm the safety and efficacy of BC dressing when used in surgical male wound healing at the urogenital area. METHODS: Open, non-controlled clinical study of phase II. A total of 141 patients, among those children, adolescents and adults with hypospadias (112), epispadias (04), phymosis (13) and Peyronie's disease (12) that had a BC dressing applied over the operated area after surgery. A written informed consent was obtained from all participants...
September 20, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Allen D Seftel
No abstract text is available yet for this article.
October 2016: Journal of Urology
Allen D Seftel
No abstract text is available yet for this article.
October 2016: Journal of Urology
Allen D Seftel
No abstract text is available yet for this article.
October 2016: Journal of Urology
Gregory A Joice, Arthur L Burnett
Peyronie's disease (PD) is a debilitating condition of the penis that leads to significant pain, erectile dysfunction, and emotional distress in men. PD is likely underreported due to lack of knowledge of the disease and the absence of well-established available treatments. Surgical treatment can lead to sustained improvements, but is often associated with penile shortening and places the patient at risk for perioperative morbidity. Nonsurgical management has been studied for several years as an alternative to surgery for men with PD...
August 2016: World Journal of Men's Health
Amanda B Reed-Maldonado, Tom F Lue
No abstract text is available yet for this article.
August 23, 2016: European Urology
Faysal A Yafi, Georgios Hatzichristodoulou, Kenneth J DeLay, Wayne J G Hellstrom
INTRODUCTION: Peyronie's disease (PD) is a wound-healing disorder of the tunica albuginea often associated with penile deformity. Less commonly, patients with PD might display atypical presentations such as ventral curvature, hourglass deformity, significantly shortened penis, and/or multiplanar curvature. AIM: To review the available literature on the prevalence of and management options for atypical PD. METHODS: A literature review was performed through PubMed from 1982 through 2016 regarding atypical PD...
August 17, 2016: Sexual Medicine Reviews
J C Angulo, I Arance, M M de Las Heras, E Meilán, C Esquinas, E M Andrés
CONTEXT: The low-intensity shockwave (LISW) therapy is a recently developed modality for treating erectile dysfunction. OBJECTIVE: To assess the efficacy of LISW therapy for treating erectile dysfunction as described in the literature. ACQUISITION OF EVIDENCE: Two independent reviewers identified studies eligible for a systematic review and meta-analysis of various sources written in English and Spanish, using the databases of PubMed, EMBASE and Web of Science...
August 9, 2016: Actas Urologicas Españolas
P Vicini, S Di Nicola, G Antonini, E De Berardinis, V Gentile, F De Marco
We present the use of a modified corporoplasty, based on geometrical principles, to determine the exact site for the incision in the tunica or plaque and the exact amount of albuginea for overlaying to correct with extreme precision the different types of congenital or acquired penile curvature due to Peyronie's disease. To describe our experience with a new surgical procedure for the enhancement of penile curvature avoiding any overcorrection or undercorrection. Between March 2004 and April 2013, a total of 74 patients underwent the geometrical modified corporoplasty...
August 11, 2016: International Journal of Impotence Research
J Vinay, J Sarquella, J Sanchez, F Algaba, I Gallegos, E Ruiz-Castañe, C Palma
OBJECTIVES: Animal models have shown that erectile dysfunction is associated with adipocyte accumulation under tunica albugínea, which could be involved in venous leakage and loss of penile rigidity. In the current sudy, we compared the histology of the penile sub-albuginean region of drug-refractory erectile dysfunction patients undergoing penile prosthesis implantation with potent patients with Peyronie's disease undergoing curvature correction procedures. MATERIALS AND METHODS: Seventeen refractory erectile dysfunction patients and fourteen potent patients with Peyronie's disease were recruited...
August 2, 2016: Actas Urologicas Españolas
Gianni Paulis, Gennaro Romano, Andrea Paulis
Peyronie's disease (PD) is a chronic inflammatory disease involving the tunica albuginea of the penis. Erectile dysfunction (ED) is a possible invalidating symptom of PD. The aim of this study was to evaluate the prevalence, psychological impact, and risk factors of ED in patients with PD. The study was conducted by carrying out a retrospective analysis of the clinical records of 309 patients with PD who visited our andrology clinic. All patients underwent the following tests: body mass index, common blood tests and hormone assays, questionnaire for erectile function assessment, dynamic penile color Doppler ultrasonography, imaging of the penis at maximum erection with photographic poses according to Kelâmi, psychosexual impact evaluation with PD Questionnaire (symptom bother score), evaluation of depression symptoms with the Patient Health Questionnaire-9, and evaluation of the intensity of penile pain with the pain intensity numeric rating scale...
2016: Research and Reports in Urology
A Silva-Garretón, D Santillán, D Chávez, A Gioielli, G Rey-Valzacchi, O Layús, G Gueglio
INTRODUCTION: Plaque and bovine pericardium graft surgery is a useful tool for treating Peyronie's disease. OBJECTIVE: To determine patient satisfaction following this operation. MATERIALS AND METHODS: This was a retrospective, observational and descriptive study. We collected data from the medical records of patients who underwent surgery between 2004 and 2015 and were evaluated through a postoperative satisfaction questionnaire. RESULTS: Twenty-eight operations were performed...
July 25, 2016: Actas Urologicas Españolas
Louis A Aliperti, Akanksha Mehta
Peyronie's disease is a collagen wound healing disorder of the penis that negatively affects the quality of life of afflicted men. According to the 2015 AUA Consensus Guidelines on Peyronie's Disease, minimally invasive intralesional therapies and surgical intervention form the basis of contemporary therapy for this disorder. These therapeutic options, along with selected portions of the guidelines, are explored in this review.
September 2016: Current Urology Reports
Jin-hong Li, Jiu-hong Yuan
Peyronie's disease is characterized by local fibrosis of the tunica albuginea and relatively rare clinically. Few relevant basic researches could be retrieved, which might be attributed to the absence of a robust animal model of the disease as well as to its rareness. At present, some animal models available for Peyronie's disease have their own merits and demerits. TGF-β1-induced and Fibrin-induced models are lack of penile curvature and calcification/ossification. A surgical model might be established for the acute phase of the disease...
May 2016: Zhonghua Nan Ke Xue, National Journal of Andrology
Edoardo Pescatori, Giovanni Alei, Gabriele Antonini, Antonio Avolio, Carlo Bettocchi, Marco Bitelli, Francesco Boezio, Tommaso Cai, Enrico Caraceni, Maurizio Carrino, Fulvio Colombo, Enrico Conti, Antonio Corvasce, Federico Dehò, Stefano Fiordelise, Nicola Ghidini, Emilio Italiano, Giuseppe La Pera, Giovanni Liguori, Carlo Maretti, Nicola Mondaini, Alessandro Natali, Carlo Negro, Alessandro Palmieri, Fabrizio Palumbo, Matteo Paradiso, Massimo Polito, Diego Pozza, Mauro Silvani, Aldo Tamai, Massimiliano Timpano, Lilia Utizi, Francesco Varvello, Patrizio Vicini, Antonio Vitarelli, Giorgio Franco
OBJECTIVES: The Italian Society of Andrology, i.e. "Società Italiana di Andrologia" (S.I.A.), launched on December 2014 a prospective, multicenter, monitored and internal review board approved Registry for penile implants, the "INSIST-ED" (Italian Nationwide Systematic Inventarisation of Surgical Treatment for ED) Registry. Purpose of this first report is to present a baseline data analysis of the characteristics of penile implant surgery in Italy. MATERIAL AND METHODS: The INSIST-ED Registry is open to all surgeons implanting penile prostheses (all brands, all models) in Italy, providing anonymous patient, device, surgical procedure, outcome, follow-up data, for both first and revision surgeries...
2016: Archivio Italiano di Urologia, Andrologia
Andrea Fabiani, Lucilla Servi, Fabrizio Fioretti, Valentina Maurelli, Flavia Tombolini, Alessandra Filosa, Alessandro Zucchi, Gianni Paulis, Gabriele Mammana
AIM: Peyronie's Disease (PD) is an under reported acquired benign condition that, at the moment, is not curable with medical therapy. Surgery represent the gold standard of treatment. Surgical approaches are several and they consist in "plication techniques" or plaque incision/excision with grafting of resulting albuginea defect. Among grafting procedures, albuginea defect substitution with autologous materials demonstrated over the years not inferior results respect to heterologous grafts...
2016: Archivio Italiano di Urologia, Andrologia
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