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https://www.readbyqxmd.com/read/29928188/rare-incidence-of-acute-liver-injury-with-potassium-para-aminobenzoate-introduction
#1
Layth Al Attar, Wiliam Kilgore
Acute liver injury is an alarming condition, as it may lead to a devastating outcome. Of the many causes of acute liver injury, review of medications is crucial to identifying the cause of the injury. Some commonly used medications may unpredictably be the underlying cause of liver injury. We present a case of Peyronie's disease treated with potassium para-aminobenzoate that developed acute liver injury. After starting the new treatment, the patient complained of right upper quadrant pain. He was found to have elevated liver enzymes...
May 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29908867/plaque-calcification-an-important-predictor-of-collagenase-clostridium-histolyticum-treatment-outcomes-for-men-with-peyronie-s-disease
#2
Kevin Wymer, Matthew Ziegelmann, Joshua Savage, Tobias Kohler, Landon Trost
OBJECTIVE: To compare outcomes of men with or without calcified plaques undergoing collagenase clostridium histolyticum (CCH) injections for Peyronie's Disease (PD) and identify predictors of CCH success. MATERIAL AND METHODS: From March 2014 through January 2017, data were prospectively collected on 192 patients who underwent 1-4 cycles of CCH for the treatment of PD. Of these, 115 completed ≥2 CCH cycles and had data on curvature assessment. The primary outcome was the percentage of men with >20% improvement in composite curvature...
June 14, 2018: Urology
https://www.readbyqxmd.com/read/29891411/understanding-the-role-of-adenosine-receptors-in-the-myofibroblast-transformation-in-peyronie-s-disease
#3
Marta Mateus, Marcus M Ilg, William J Stebbeds, Nim Christopher, Asif Muneer, David J Ralph, Selim Cellek
BACKGROUND: Peyronie's disease (PD) is a chronic fibrotic disease of the penis affecting a significant number of men worldwide without effective medical treatments. Myofibroblasts are pivotal in the pathogenesis of PD. Adenosine and adenosine receptors have been suggested to be involved in the pathophysiology of fibrosis. AIM: To understand the role of adenosine receptors in myofibroblast transformation in PD. METHODS: Fibroblasts were isolated from the non-PD tunica albuginea (TA) tissue and PD plaque tissue and were transformed into myofibroblasts using transforming growth factor (TGF)-β1...
June 8, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29888556/phosphodiesterase-5-in-men-with-vasculogenic-and-post-radical-prostatectomy-erectile-dysfunction-is-there-a-molecular-difference
#4
Serkan Karakus, Biljana Musicki, Arthur L Burnett
OBJECTIVES: To clarify the molecular basis of penile erection at the human level and distinguish mechanisms underlying vasculogenic and post-radical prostatectomy (post-RP) erectile dysfunction (ED) subtypes. PATIENTS AND METHODS: Erectile tissue was obtained from men without histories of ED who underwent penile surgery for Peyronie's disease (control, n=5) and with ED who underwent penile prosthesis implantation (n=17). ED was categorized into vasculogenic (n=8) and post-RP (n=9) subtypes...
June 11, 2018: BJU International
https://www.readbyqxmd.com/read/29880823/patient-s-choice-of-health-information-and-treatment-modality-for-peyronie-s-disease-a-long-term-assessment
#5
Georgios Hatzichristodoulou
No abstract text is available yet for this article.
June 8, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29861359/five-things-i-wish-i-would-have-known-earlier-in-my-career-lessons-learned-in-peyronie-s-disease-surgery
#6
Tom F Lue, Alan W Shindel
No abstract text is available yet for this article.
May 31, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29861353/response-and-rebuttal-to-editorial-comment-a-comparative-study-between-2-different-grafts-used-as-patches-after-plaque-incision-and-inflatable-penile-prosthesis-implantation-for-end-stage-peyronie-s-disease
#7
Mirko Preto, Giulio Garaffa, Marco Falcone, Paolo Gontero, Luigi Rolle
No abstract text is available yet for this article.
May 31, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29850357/erosive-arthritis-fibromatosis-and-keloids-a-rare-dermatoarthropathy
#8
Fawad Aslam, Jonathan A Flug, Yousif Yonan, Shelley S Noland
Polyfibromatosis is a rare disease characterized by fibrosis manifesting in different locations. It is commonly characterized by palmar fibromatosis (Dupuytren's contracture) in variable combinations with plantar fibromatosis (Ledderhose's disease), penile fibromatosis (Peyronie's disease), knuckle pads, and keloids. There are only three reported cases of polyfibromatosis and keloids with erosive arthritis. We report one such case and review the existing literature on this rare syndrome.
2018: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/29806152/reduction-in-peyronie-s-like-plaque-size-using-a-vacuum-erection-device-in-a-rat-model-of-peyronie-s-disease-via-the-tgf-%C3%AE-smad-signalling-pathway
#9
Jinhong Li, Shuzhen Wang, Feng Qin, Mengli Zhu, Xuanhe You, Changjing Wu, Fudong Fu, Jiuhong Yuan
Peyronie's disease (PD) is a fibrotic disorder of the tunica albuginea (TA). This study aimed to determine the therapeutic effects of a vacuum erection device (VED) in an animal model of PD and explore the possible mechanisms. Twenty-seven male Sprague-Dawley rats were used. The sham group (group A) (N = 9) received a 50-μl-saline vehicle injection into the TA, while the remaining 18 rats (groups B and C) received a TGF-β1 injection into the TA. The treatment group (group C) underwent VED therapy for 10 days after the TGF-β1 injection...
May 28, 2018: Andrologia
https://www.readbyqxmd.com/read/29803354/editorial-comment-on-a-comparative-study-between-two-different-grafts-used-as-patches-after-plaque-incision-and-inflatable-penile-prosthesis-implantation-for-end-stage-peyronie-s-disease
#10
https://www.readbyqxmd.com/read/29803353/editorial-comment-on-penile-prosthesis-implantation-in-patients-with-peyronie-s-disease-results-of-the-propper-study-demonstrate-a-decrease-in-patient-reported-depression
#11
https://www.readbyqxmd.com/read/29803352/increased-risk-of-incident-disease-in-men-with-peyronie-s-disease-analysis-of-u-s-claims-data
#12
Alexander W Pastuszak, Katherine M Rodriguez, Zachary J Solomon, Taylor P Kohn, Larry I Lipshultz, Michael L Eisenberg
BACKGROUND: The subsequent health risks associated with Peyronie's disease (PD) are unknown. AIM: This cohort study assesses the risk of developing auto-immune conditions and common chronic health conditions after a diagnosis of PD. We hypothesize that an increase in auto-immune disease will be evident in men with PD, as has been suggested in smaller studies. METHODS: We determined the longitudinal incidence of 13 auto-immune diseases and 25 common chronic conditions in a cohort from the Truven Health Analytics (Ann Arbor, Michigan, USA) database from 2007-2013...
June 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29802005/surgical-outcomes-of-plaque-excision-and-grafting-and-supplemental-tunica-albuginea-plication-for-treatment-of-peyronie-s-disease-with-severe-compound-curvature
#13
Alexander K Chow, Steven A Sidelsky, Laurence A Levine
BACKGROUND: There are limited data in the literature that describe the management of Peyronie's disease (PD) with severe compound curvature, which often requires additional straightening procedures after plaque excision and grafting (PEG) to achieve functional penile straightening (<20 degrees). AIM: This study highlights the clinical distinction and our experience with men with PD and severe compound curvature treated with PEG and supplemental tunica albuginea plication (TAP)...
May 22, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29800632/characterization-of-septal-and-punctate-scarring-in-peyronie-s-disease
#14
Nahid Punjani, Noah Stern, Gerald Brock
OBJECTIVE: To characterize patients with isolated septal scarring (ISS) and punctate scarring (PS) in Peyronie's disease (PD) and to highlight the importance of duplex ultrasonography in the workup of patients with PD. MATERIALS AND METHODS: Data from all men undergoing duplex ultrasonography at London Health Sciences Center for PD or erectile dysfunction over a 3-year period were retrospectively reviewed. RESULTS: Our cohort included 722 patients with duplex ultrasound...
May 22, 2018: Urology
https://www.readbyqxmd.com/read/29795531/patient-s-choice-of-health-information-and-treatment-modality-for-peyronie-s-disease-a-long-term-assessment
#15
Raevti Bole, Matthew Ziegelmann, Ross Avant, Brian Montgomery, Tobias Kohler, Landon Trost
Despite various Peyronie's disease (PD) treatment options, the literature is sparse regarding patient preference for available therapies. Our data explore resource and treatment choices made by PD men following diagnosis. A survey was mailed to 719 randomly selected PD men evaluated at our institution from 1990-2012. Questions included evaluation of treatments and preferred information resources. Results were summarized as a descriptive report with statistical analyses performed as indicated. A total of 162 men (median age 65) responded with median PD duration of 9...
May 25, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29795530/the-relationship-between-penile-deformity-age-psychological-bother-and-erectile-dysfunction-in-a-sample-of-men-with-peyronie-s-disease-pd
#16
Andrea Burri, Hartmut Porst
The aim of the present study was to investigate which PD specific factors (e.g., degree of penile curvature, levels of pain) cause most distress and to further explore whether there are specific subgroups of patients that report particularly high levels of psychological distress. Data were available for N = 119 men with a clinical diagnosis of PD presenting at a private Uro-Andrology in Germany. The strongest complaint of men with PD was being bothered by the look of the penis as opposed to being distressed by the pain (3...
May 25, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29792593/2018-canadian-urological-association-guideline-for-peyronie-s-disease-and-congenital-penile-curvature
#17
Anthony J Bella, Jay C Lee, Ethan D Grober, Serge Carrier, Francois Benard, Gerald B Brock
No abstract text is available yet for this article.
May 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29791971/predictors-of-treatment-success-after-collagenase-clostridium-histolyticum-injection-for-peyronie-s-disease-development-of-a-nomogram-from-a-multicentre-single-arm-non-placebo-controlled-clinical-study
#18
Andrea Cocci, Giorgio Ivan Russo, Alberto Briganti, Andrea Salonia, Giovanni Cacciamani, Marco Capece, Marco Falcone, Massimiliano Timpano, Gianmartin Cito, Paolo Verze, Bruno Giammusso, Giuseppe Morgia, Vincenzo Mirone, Andrea Minervini, Mauro Gacci, Tommaso Cai, Sergio Serni, Marco Carini, Gianluca Giubilei, Nicola Mondaini
OBJECTIVE: To build-up a nomogram able to predict treatment success after Collagenase clostridium histolyticum (CCH) for Peyronie's disease (PD). MATERIAL AND METHODS: From November 2016 to November 2017, we enrolled 135 patients with PD in a multicentre single-arm prospective study. All patients enrolled had a treatment with CCH. Success of therapy was defined as a penile curvature decrease of at least 20 degrees from baseline curvature. Treatment satisfaction was assessed using a scale from 1 to 10 and high satisfaction was arbitral defined as a score ≥8...
May 23, 2018: BJU International
https://www.readbyqxmd.com/read/29774446/contemporary-review-of-peyronie-s-disease-treatment
#19
REVIEW
Edward Capoccia, Laurence A Levine
PURPOSE: To analyze the literature on the current treatment options for Peyronie's disease (PD). RECENT FINDINGS: Intracavernosal injection therapy using collagenase clostridium histolyticum (CCH) has been widely adopted since its FDA approval in 2013. Based on the current evidence, it appears to be moderately efficacious for men with mild curvatures. Although a recent study has shown similar outcomes using a modified protocol requiring fewer injections, CCH remains an expensive medication...
May 17, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29768978/levels-of-serum-trace-elements-in-patients-with-peyronie
#20
Mustafa Gunes, Rahmi Aslan, Recep Eryılmaz, Halit Demir, Kerem Taken
AIM: The etiology of the disease of Peyronie is not certainly known. However, penile micro traumas are thought to be important in the pathogenesis of Peyronie's disease (PD) in genetically predisposed individuals. In this study, we aimed to determine the relationship of some trace element and heavy metals with PD. MATERIAL AND METHODS: Thirty Peyronie patients and 26 healthy volunteers were included in the study. In individuals in both groups, levels of serum trace elements (Manganese [Mn], Cu, Cobalt (Co), zinc [Zn], Cd, and iron [Fe]) were determined separately by Atomic Absorption Spectrophotometer method in Yüzüncü Yıl University Central Research Laboratory...
May 17, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
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