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https://www.readbyqxmd.com/read/29780797/pilot-efficacy-of-a-drivefocus%C3%A2-intervention-on-the-driving-performance-of-young-drivers
#1
Liliana Alvarez, Sherrilene Classen, Shabnam Medhizadah, Melissa Knott, Wenqing He
Road traffic injuries are the leading cause of death for youth between the ages of 15 and 29 around the world. A need remains for evidence-based interventions that can improve the underlying skills of young drivers, including hazard perception and anticipation. This pilot study investigated the preliminary impact of a six session DriveFocus™ intervention on the ability of young novice drivers (mean age = 18.6, SD = 2.12) to detect (visual scanning), and respond (adjustment to stimuli) to critical roadway information...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29769567/genomic-alterations-of-ground-glass-nodular-lung-adenocarcinoma
#2
Hyun Lee, Je-Gun Joung, Hyun-Tae Shin, Duk-Hwan Kim, Yujin Kim, Hojoong Kim, O Jung Kwon, Young Mog Shim, Ho Yun Lee, Kyung Soo Lee, Yoon-La Choi, Woong-Yang Park, D Neil Hayes, Sang-Won Um
In-depth molecular pathogenesis of ground-glass nodular lung adenocarcinoma has not been well understood. The objectives of this study were to identify genomic alterations in ground-glass nodular lung adenocarcinomas and to investigate whether viral transcripts were detected in these tumors. Nine patients with pure (n = 4) and part-solid (n = 5) ground-glass nodular adenocarcinomas were included. Six were females with a median age of 58 years. We performed targeted exon sequencing and RNA sequencing...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29765142/targeted-deep-sequencing-of-gastric-marginal-zone-lymphoma-identified-alterations-of-traf3-and-tnfaip3-that-were-mutually-exclusive-for-malt1-rearrangement
#3
Jiyeon Hyeon, Boram Lee, So-Hyun Shin, Hae Yong Yoo, Seok Jin Kim, Won Seog Kim, Woong-Yang Park, Young-Hyeh Ko
Gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue is a distinct entity in that Helicobacter pylori infection plays the most important causative role in the development of the disease. To investigate the genomic alteration in gastric marginal zone lymphoma that was resistant to the H. pylori eradication therapy, we analyzed 19 cases of the gastric marginal zone lymphoma using fluorescence in situ hybridization for MALT1, BCL10 rearrangement, and targeted sequencing using an Illumina platform...
May 15, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29764465/traditional-knowledge-and-cultural-importance-of-borassus-aethiopum-mart-in-benin-interacting-effects-of-socio-demographic-attributes-and-multi-scale-abundance
#4
Kolawolé Valère Salako, Francisco Moreira, Rodrigue Castro Gbedomon, Frédéric Tovissodé, Achille Ephrem Assogbadjo, Romain Lucas Glèlè Kakaï
BACKGROUND: Eliciting factors affecting distribution of traditional knowledge (TK) and cultural importance of plant resources is central in ethnobiology. Socio-demographic attributes and ecological apparency hypothesis (EAH) have been widely documented as drivers of TK distribution, but their synergistic effect is poorly documented. Here, we focused on Borassus aethiopum, a socio-economic important agroforestry palm in Africa, analyzing relationships between the number of use-reports and cultural importance on one hand, and informant socio-demographic attributes (age category and gender) on the other hand, considering the EAH at multi-scale contexts...
May 15, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29763879/plant-and-vegetation-functional-responses-to-cumulative-high-nitrogen-deposition-in-rear-edge-heathlands
#5
Angela Taboada, Javier Calvo-Fernández, Elena Marcos, Leonor Calvo
Elevated atmospheric nitrogen (N) deposition is a major driver of change, altering the structure/functioning of nutrient-poor Calluna vulgaris-heathlands over Europe. These effects amply proven for north-western/central heathlands may, however, vary across the ecosystem's distribution, especially at the range limits, as heathlands are highly vulnerable to land-use changes combined with present climate change. This is an often overlooked and greatly understudied aspect of the ecology of heathlands facing global change...
May 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29756121/critically-dysregulated-signaling-pathways-and-clinical-utility-of-the-pathway-biomarkers-in-lymphoid-malignancies
#6
REVIEW
Rui-Fang Sun, Qian-Qian Yu, Ken H Young
Accumulating evidence confirmed that many dysregulated signaling pathways and aberrant genetic alterations contribute to the oncogenesis and heterogeneity of lymphoid malignancies. Therapeutically targeting dysregulating signaling pathways and their hidden oncogenic biomarkers are becoming available, but did not show desired therapeutic effect in current clinical practice. It is meaningful to further understand the underlying mechanisms of the dysregulated signaling pathways and to address the potential utility of pathway-related biomarkers...
March 2018: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29752319/misdiagnosis-of-li-fraumeni-syndrome-in-a-patient-with-clonal-hematopoiesis-and-a-somatic-tp53-mutation
#7
Rachel L Mitchell, Cory Kosche, Kelly Burgess, Shreya Wadhwa, Lela Buckingham, Ritu Ghai, Jacob Rotmensch, Oleksandra Klapko, Lydia Usha
Li-Fraumeni syndrome (LFS) is a rare genetic disorder that confers a high risk of developing certain malignancies at a young age. It is caused by germline mutations in the TP53 gene and is typically diagnosed by sequencing this gene in blood cells. The presence of a mutation in approximately half of the DNA reads (allelic fraction of 50%) is an indicator of a germline mutation, such as that in LFS. Clonal hematopoiesis (CH) is an expansion of a hematopoietic clone containing a somatic driver mutation with a low allelic fraction, usually not more than 10% to 20%...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29748910/does-the-increase-in-ambient-co-2-concentration-elevate-allergy-risks-posed-by-oak-pollen
#8
Kyu Rang Kim, Jae-Won Oh, Su-Young Woo, Yun Am Seo, Young-Jin Choi, Hyun Seok Kim, Wi Young Lee, Baek-Jo Kim
Oak pollen is a major respiratory allergen in Korea, and the distribution of oak trees is expected to increase by ecological succession and climate change. One of the drivers of climate change is increasing CO2 , which is also known to amplify the allergy risk of weed pollen by inducing elevated allergenic protein content. However, the impact of CO2 concentration on tree pollen is not clearly understood due to the experimental difficulties in carrying out extended CO2 treatment. To study the response of pollen production of sawtooth oak trees (Quercus acutissima) to elevated levels of ambient CO2 , three open-top chambers at the National Institute of Forest Science in Suwon, Korea were utilized with daytime (8 am-6 pm) CO2 concentrations of ambient (× 1...
May 10, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29738538/the-hypoxia-inducible-factor-erythropoietin-epo-epo-receptor-pathway-is-disturbed-in-a-rat-model-of-chronic-kidney-disease-related-anemia
#9
Daniel Landau, Lital London, Inbar Bandach, Yael Segev
OBJECTIVES: Anemia is a known driver for hypoxia inducible factor (HIF) which leads to increased renal erythropoietin (EPO) synthesis. Bone marrow (BM) EPO receptor (EPOR) signals are transduced through a JAK2-STAT5 pathway. The origins of anemia of chronic kidney disease (CKD) are multifactorial, including impairment of both renal EPO synthesis as well as intestinal iron absorption. We investigated the HIF- EPO- EPOR axis in kidney, BM and proximal tibia in anemic juvenile CKD rats. METHODS: CKD was induced by 5/6 nephrectomy in young (20 days old) male Sprague-Dawley rats while C group was sham operated...
2018: PloS One
https://www.readbyqxmd.com/read/29734959/calculation-of-the-age-of-the-first-infection-for-skin-sores-and-scabies-in-five-remote-communities-in-northern-australia
#10
M J Lydeamore, P T Campbell, W Cuningham, R M Andrews, T Kearns, D Clucas, R Gundjirryirr Dhurrkay, J Carapetis, S Y C Tong, J M McCaw, J McVernon
Prevalence of skin sores and scabies in remote Australian Aboriginal communities remains unacceptably high, with Group A Streptococcus (GAS) the dominant pathogen. We aim to better understand the drivers of GAS transmission using mathematical models. To estimate the force of infection, we quantified the age of first skin sores and scabies infection by pooling historical data from three studies conducted across five remote Aboriginal communities for children born between 2001 and 2005. We estimated the age of the first infection using the Kaplan-Meier estimator; parametric exponential mixture model; and Cox proportional hazards...
May 8, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29725049/macroecology-and-macroevolution-of-the-latitudinal-diversity-gradient-in-ants
#11
Evan P Economo, Nitish Narula, Nicholas R Friedman, Michael D Weiser, Benoit Guénard
The latitudinal diversity gradient-the tendency for more species to occur toward the equator-is the dominant pattern of life on Earth, yet the mechanisms responsible for it remain largely unexplained. Recently, the analysis of global data has led to advances in understanding, but these advances have been mostly limited to vertebrates and trees and have not provided consensus answers. Here we synthesize large-scale geographic, phylogenetic, and fossil data for an exemplar invertebrate group-ants-and investigate whether the latitudinal diversity gradient arose due to higher rates of net diversification in the tropics, or due to a longer time period to accumulate diversity due to Earth's climatic history...
May 3, 2018: Nature Communications
https://www.readbyqxmd.com/read/29724720/setd2-haploinsufficiency-for-microtubule-methylation-is-an-early-driver-of-genomic-instability-in-renal-cell-carcinoma
#12
Yun Chen Chiang, In Young Park, Esteban A Terzo, Durga Nand Tripathi, Frank M Mason, Catherine C Fahey, Menuka Karki, Charles B Shuster, Bo Hwa Sohn, Pratim Chowdhury, Reid T Powell, Ryoma Ohi, Yi-Hsuan Tsai, Aguirre A de Cubas, Abid Khan, Ian Davis, Brian D Strahl, Joel S Parker, Ruhee Dere, Cheryl Lyn Walker, W Kimryn Rathmell
Loss of the short arm of chromosome 3 (3p) occurs early in >95% of clear cell renal cell carcinoma (ccRCC). Nearly ubiquitous 3p loss in ccRCC suggests haploinsufficiency for 3p tumor suppressors as early drivers of tumorigenesis. We previously reported methyltransferase SETD2, which trimethylates H3 histones on lysine 36 (H3K36me3) and is located in the 3p deletion, to also trimethylate microtubules on lysine 40 (αTubK40me3) during mitosis, with αTubK40me3 required for genomic stability. We now show that mono-allelic, Setd2-deficient cells retaining H3K36me3 but not αTubK40me3 exhibit a dramatic increase in mitotic defects and micronuclei count with increased viability compared to bi-allelic loss...
May 3, 2018: Cancer Research
https://www.readbyqxmd.com/read/29724181/high-pregnancy-incidence-and-low-contraceptive-use-among-a-prospective-cohort-of-female-entertainment-and-sex-workers-in-phnom-penh-cambodia
#13
Putu Duff, Jennifer L Evans, Ellen S Stein, Kimberly Page, Lisa Maher
BACKGROUND: While HIV and unintended pregnancies are both occupational risks faced by female sex workers, the epidemiology of pregnancy and its drivers in this population remains understudied. This includes Cambodia, where the drivers of pregnancy among female entertainment and sex workers (FESW) remain unknown. The current study aimed to examine factors associated with incident pregnancy, as well as describe contraceptive use among FESW in Phnom Penh, Cambodia. METHODS: This analysis drew from the Young Women's Health Study (YWHS)-2, a 12-month observational cohort of 220 FESW aged 15-29 years, conducted between August 2009 and August 2010...
May 3, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29723735/driver-distraction-by-smartphone-use-whatsapp-in-different-age-groups
#14
C Ortiz, S Ortiz-Peregrina, J J Castro, M Casares-López, C Salas
This paper investigates the effect that texting with WhatsApp, one of the most common applications for instant messaging, exerts on driving performance. Because distracted driving also affects older drivers, who can have seriously compromised vision, we also analysed the associations between visual-function parameters and driving performance. A total of 75 drivers, experienced in sending WhatsApp messages (≥10WhatsApp messages/week), participated in this study and were divided into four age categories. Visual-function tests included contrast sensitivity with and without glare, retinal straylight and objective assessment of optical quality...
April 30, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29722034/surviving-in-the-urban-rural-interface-feeding-and-ranging-behavior-of-brown-howlers-alouatta-guariba-clamitans-in-an-urban-fragment-in-southern-brazil
#15
Fabiana M Corrêa, Óscar M Chaves, Rodrigo C Printes, Helena P Romanowski
Wild primates that live in urban areas face extreme threats that are less frequent in nonurban fragments, such as the presence of dangerous matrix elements (e.g., roads, power lines, buildings, and a high density of domestic dogs near food patches), that could influence their movements, feeding behavior, and survival. However, the scarcity of studies addressing this issue hinders our understanding of the behavioral adjustments that favor the survival of primates in urban areas. For 12 months, we studied a six-individual group of brown howlers (Alouatta guariba clamitans) in an urban fragment to determine (i) their diet richness and its relationships with food availability, (ii) their daily path length (DPL) and the matrix elements used during movement, and (iii) the main ecological drivers of the DPL...
May 2, 2018: American Journal of Primatology
https://www.readbyqxmd.com/read/29717571/cochlear-damage-caused-by-the-striking-noise-of-titanium-head-golf-driver
#16
Yong-Ho Park, Juyong Chung, Min Young Lee, Doh Young Lee, Young Ho Kim
Objectives: To investigate how mouse cochleae are affected by the striking noise of titanium head golf driver. Methods: Thirty-two BALB/c mice (20-22 g) with normal hearing were used. The impact acoustic stimulus generated by the striking of titanium golf driver head was centered around 4.5 kHz with 120.5 dB sound pressure level. The recorded impact noise was provided to mice in two ways with the same exposure time of 288 seconds: 1,440 repetitions and an impact duration of 0...
May 3, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29710657/biogeochemistry-of-natural-ponds-in-agricultural-landscape-lessons-learned-from-modeling-a-kettle-hole-in-northeast-germany
#17
Gabriela Onandia, Gunnar Lischeid, Thomas Kalettka, Andreas Kleeberg, Mohamed Omari, Katrin Premke, George B Arhonditsis
Kettle holes, small shallow ponds of glacial origin, represent hotspots for biodiversity and biogeochemical cycling. They abound in the young moraine landscape of Northeast Germany, potentially modulating element fluxes in a region where intensive agriculture prevails. The Rittgarten kettle hole, with semi-permanent hydroperiod and a surrounding reed belt, can be considered as a representative case study for such systems. Aiming to provide insights into the biogeochemical processes driving nutrient and primary producer dynamics in the Rittgarten kettle hole, we developed a mechanistic model that simulates the carbon, nitrogen, phosphorus and oxygen, phytoplankton, and free-floating macrophyte biomass dynamics...
April 24, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29709730/understanding-the-psychological-precursors-of-young-drivers-willingness-to-speed-and-text-while-driving
#18
Carissa Preece, Angela Watson, Sherrie-Anne Kaye, Judy Fleiter
This study applied the Prototype Willingness Model (PWM) to investigate the factors that may predict young drivers' (non-intentional) willingness to text while driving, text while stopped, and engage in high and low levels of speeding. In addition, the study sought to assess whether general optimism bias would predict young drivers' willingness to text and speed over and above the PWM. Licenced drivers (N = 183) aged 17-25 years (M = 19.84, SD = 2.30) in Queensland, Australia completed an online survey...
April 26, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29709444/food-choice-drivers-in-the-context-of-the-nutrition-transition-in-delhi-india
#19
Claire Bailey, Vandana Garg, Deksha Kapoor, Heather Wasser, Dorairaj Prabhakaran, Lindsay M Jaacks
OBJECTIVE: To understand factors that influence the process of food decision-making among urban Indian women in the context of the nutrition transition. DESIGN: Mixed methods. METHODS: Semistructured interviews and sorting of 12 a priori hypothesized drivers into categories of always, sometimes, and never influencing food choice. SETTING: Delhi, India. PARTICIPANTS: Thirty-eight women aged 20-35 years selected from the roster of a prospective cohort study...
April 27, 2018: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29706226/school-start-times-and-teenage-driver-motor-vehicle-crashes
#20
Robert D Foss, Richard L Smith, Natalie P O'Brien
INTRODUCTION: Shifting school start times to 8:30 am or later has been found to improve academic performance and reduce behavior problems. Limited research suggests this may also reduce adolescent driver motor vehicle crashes. A change in the school start time from 7:30 am to 8:45 am for all public high schools in one North Carolina county presented the opportunity to address this question with greater methodologic rigor. METHOD: We conducted ARIMA interrupted time-series analyses to examine motor vehicle crash rates of high school age drivers in the intervention county and 3 similar comparison counties with comparable urban-rural population distribution...
April 26, 2018: Accident; Analysis and Prevention
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