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young driver

Joseph R Starnes, Purnima Unni, Cherie A Fathy, Kelly A Harms, Shelby R Payne, Dai H Chung
BACKGROUND: Golf cart injuries represent an increasing source of morbidity and mortality in the United States. Characterization of the circumstances of these injuries can inform injury prevention efforts. METHODS: This study retrospectively reviews a prospective trauma registry at a level-one pediatric trauma center for golf cart-related injuries in patients under 18years of age admitted to the hospital between 2008 and 2016. RESULTS: The 40 identified crashes were associated with 82 hospital days, 17 ICU days, and more than $1 million in hospital charges over the study period...
March 2, 2018: American Journal of Emergency Medicine
Jonathan J Rolison, Shirley Regev, Salissou Moutari, Aidan Feeney
What are the main contributing factors to road accidents? Factors such as inexperience, lack of skill, and risk-taking behaviors have been associated with the collisions of young drivers. In contrast, visual, cognitive, and mobility impairment have been associated with the collisions of older drivers. We investigated the main causes of road accidents by drawing on multiple sources: expert views of police officers, lay views of the driving public, and official road accident records. In Studies 1 and 2, police officers and the public were asked about the typical causes of road traffic collisions using hypothetical accident scenarios...
March 9, 2018: Accident; Analysis and Prevention
Takuro Kometani, Kenji Sugio, Atsushi Osoegawa, Takashi Seto, Yukito Ichinose
BACKGROUND: The EML4-ALK fusion gene has recently been identified as a driver mutation in a subset of non-small cell lung cancers. In subsequent studies, EML4-ALK has been detected in a low percentage of patients, and was associated with a lack of EGFR or KRAS mutations, younger age, and adenocarcinoma with acinar histology. Cases with the EML4-ALK fusion gene were examined to clarify the clinicopathological characteristics of young adenocarcinoma patients. METHODS: Between December 1998 and May 2009, 85 patients aged ≤ 50 with lung adenocarcinoma were treated at our hospital...
March 8, 2018: Thoracic Cancer
Presha Rajbhandari, Gonzalo Lopez, Claudia Capdevila, Beatrice Salvatori, Jiyang Yu, Ruth Rodriguez-Barrueco, Daniel Martinez, Mark Yarmarkovich, Nina Weichert-Leahey, Brian J Abraham, Mariano J Alvarez, Archana Iyer, Jo Lynne Harenza, Derek Oldridge, Katleen De Preter, Jan Koster, Shahab Asgharzadeh, Robert C Seeger, Jun S Wei, Javed Khan, Jo Vandesompele, Pieter Mestdagh, Rogier Versteeg, A Thomas Look, Richard A Young, Antonio Iavarone, Anna Lasorella, Jose M Silva, John M Maris, Andrea Califano
High-risk neuroblastomas show a paucity of recurrent somatic mutations at diagnosis. As a result, the molecular basis for this aggressive phenotype remains elusive. Recent progress in regulatory network analysis helped us elucidate disease-driving mechanisms downstream of genomic alterations, including recurrent chromosomal alterations. Our analysis identified three molecular subtypes of high-risk neuroblastomas, consistent with chromosomal alterations, and identified subtype-specific master regulator (MR) proteins that were conserved across independent cohorts...
March 6, 2018: Cancer Discovery
Līva Ābele, Sonja Haustein, Mette Møller, Laila M Martinussen
Young male drivers have lower hazard perception skills (HPS) than older and more experienced drivers and a tendency to overestimate their skills in hazardous situations. Both factors contribute to an over-representation in traffic accidents. Based on a sample of 63 drivers aged 18-24, this study compares the consistency of HPS measured by objective and subjective measures and the link between these measures is the key contribution of the study. Both visible and hidden hazards are included. Objective measures of HPS include responsiveness and eye movements while driving in a driving simulator...
March 1, 2018: Accident; Analysis and Prevention
Susanne N Gröbner, Barbara C Worst, Joachim Weischenfeldt, Ivo Buchhalter, Kortine Kleinheinz, Vasilisa A Rudneva, Pascal D Johann, Gnana Prakash Balasubramanian, Maia Segura-Wang, Sebastian Brabetz, Sebastian Bender, Barbara Hutter, Dominik Sturm, Elke Pfaff, Daniel Hübschmann, Gideon Zipprich, Michael Heinold, Jürgen Eils, Christian Lawerenz, Serap Erkek, Sander Lambo, Sebastian Waszak, Claudia Blattmann, Arndt Borkhardt, Michaela Kuhlen, Angelika Eggert, Simone Fulda, Manfred Gessler, Jenny Wegert, Roland Kappler, Daniel Baumhoer, Stefan Burdach, Renate Kirschner-Schwabe, Udo Kontny, Andreas E Kulozik, Dietmar Lohmann, Simone Hettmer, Cornelia Eckert, Stefan Bielack, Michaela Nathrath, Charlotte Niemeyer, Günther H Richter, Johannes Schulte, Reiner Siebert, Frank Westermann, Jan J Molenaar, Gilles Vassal, Hendrik Witt, Birgit Burkhardt, Christian P Kratz, Olaf Witt, Cornelis M van Tilburg, Christof M Kramm, Gudrun Fleischhack, Uta Dirksen, Stefan Rutkowski, Michael Frühwald, Katja von Hoff, Stephan Wolf, Thomas Klingebiel, Ewa Koscielniak, Pablo Landgraf, Jan Koster, Adam C Resnick, Jinghui Zhang, Yanling Liu, Xin Zhou, Angela J Waanders, Danny A Zwijnenburg, Pichai Raman, Benedikt Brors, Ursula D Weber, Paul A Northcott, Kristian W Pajtler, Marcel Kool, Rosario M Piro, Jan O Korbel, Matthias Schlesner, Roland Eils, David T W Jones, Peter Lichter, Lukas Chavez, Marc Zapatka, Stefan M Pfister
Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into cancer biology. Here we present a comprehensive analysis of genetic alterations in a pan-cancer cohort including 961 tumours from children, adolescents, and young adults, comprising 24 distinct molecular types of cancer. Using a standardized workflow, we identified marked differences in terms of mutation frequency and significantly mutated genes in comparison to previously analysed adult cancers...
February 28, 2018: Nature
Antonin Levy, Corinne Faivre-Finn, Baktiar Hasan, Eleonora De Maio, Anna S Berghoff, Nicolas Girard, Laurent Greillier, Sylvie Lantuéjoul, Mary O'Brien, Martin Reck, Anne-Marie C Dingemans, Silvia Novello, Thierry Berghmans, Benjamin Besse, Lizza Hendriks
BACKGROUND: Brain metastases (BM) are frequent in non-small cell lung cancer (NSCLC) patients, but there is a lack of evidence-based management of this patient group. We aimed to capture a snapshot of routine BM management in Europe to identify relevant research questions for future clinical trials. METHODS: An EORTC Lung Cancer Group (LCG) online survey containing questions on NSCLC BM screening and treatment was distributed between 16/02/17 and 15/06/17 to worldwide EORTC LCG members, and through several European scientific societies in the thoracic oncology field...
February 20, 2018: European Journal of Cancer
Juliana Loureiro Almeida Campos, Elcida de Lima Araújo, Orou G Gaoue, Ulysses Paulino Albuquerque
The use and appropriation of natural resources by human groups may be strongly related to the perception that these groups have of the abundance or scarcity of these resources. Researches on environmental representation can be useful to understand the criteria involved in the selection and use of natural resources, to verify if people realize changes in the availability of these resources and the possible causes of these changes and to elaborate conservation strategies, if necessary. However, if people are not realizing these changes, of if they do not perceive themselves as a cause of such scarcity, the developing of conservation strategies will be very difficult to implement...
February 14, 2018: Science of the Total Environment
Sanghee Moon, Maud Ranchet, Abiodun Emmanuel Akinwuntan, Mark Tant, David Brian Carr, Mukaila Ajiboye Raji, Hannes Devos
BACKGROUND: Adults aged 85 and older, often referred to as the oldest-old, are the fastest-growing segment of the population. The rapidly increasing number of older adults with chronic and multiple medical conditions poses challenges regarding their driving safety. OBJECTIVE: To investigate the effect of advanced age on driving safety in drivers with medical conditions. METHODS: We categorized 3,425 drivers with preexisting medical conditions into four age groups: middle-aged (55-64 years, n = 1,386), young-old (65-74 years, n = 1,013), old-old (75-84 years, n = 803), or oldest-old (85 years and older, n = 223)...
February 14, 2018: Gerontology
Celestin Missikpode, Corinne Peek-Asa, Tracy Young, Cara Hamann
INTRODUCTION: Emergency vehicles, such as police, ambulances, and fire vehicles, need to arrive at the scene of emergencies as quickly as possible, and thus they often travel in emergency mode - using their lights and sirens and often bypassing traffic signals. We examined whether travelling in emergency mode increased crash risk among police, ambulance and fire vehicles. METHODS: We conducted a quasi-induced exposure analysis using data from the Iowa Crash Database for the period of 2005 through 2013...
February 10, 2018: Accident; Analysis and Prevention
Michal Javorka, Fatima El-Hamad, Barbora Czippelova, Zuzana Turianikova, Jana Krohova, Zuzana Lazarova, Mathias Baumert
The objective of this study was to determine the response of heart rate and blood pressure variability (respiratory sinus arrhythmia, baroreflex sensitivity) to orthostatic and mental stress, focussing on causality and the mediating effect of respiration. Seventy-seven healthy young volunteers (46 f, 31 m) aged 18.4 {plus minus} 2.7 years underwent an experimental protocol comprising: supine rest, 45{degree sign} head-up tilt, recovery, and a mental arithmetic task. Heart rate variability and blood pressure variability were analysed in the time and frequency domain and modelled as a multivariate autoregressive process where the respiratory volume signal acted as an external driver...
February 14, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Kayo Fujimoto, Charlene A Flash, Lisa M Kuhns, Ju-Yeong Kim, John A Schneider
OBJECTIVES: Syphilis and HIV epidemics overlap, yet little is known about combined network and behavioural factors that drive syphilis-HIV coinfection. Our study objective was to assess network contexts and sexual behaviours associated with syphilis-HIV co-infection and monoinfection among a particularly vulnerable subgroup: young Black men who have sex with men (YBMSM). To achieve this objective, we examined factors associated with coinfection by each subgroup as classified by syphilis-HIV infection status: (A) HIV monoinfected, (B) syphilis monoinfected and (C) neither syphilis infected nor HIV infected...
February 9, 2018: Sexually Transmitted Infections
George Vlontzos, Leonidas Kyrgiakos, Marie Noelle Duquenne
In this research, the attitude of European young adults (age 18 to 30 years) regarding their consumption of local and traditional products was examined. The survey was conducted on a sample of 836 consumers from seven European countries (Greece, Bulgaria, Romania, Slovenia, Croatia, Denmark and France). Data collection was made by distributing a developed questionnaire through social media and university mail services. Principal Component Analysis (PCA) was used to identify consumer perception comparing the overall sample with two subsets (consumers from Eastern and Western European countries)...
February 12, 2018: Foods (Basel, Switzerland)
Hugo Botha, William G Mantyh, Jonathan Graff-Radford, Mary M Machulda, Scott A Przybelski, Heather J Wiste, Matthew L Senjem, Joseph E Parisi, Ronald C Petersen, Melissa E Murray, Bradley F Boeve, Val J Lowe, David S Knopman, Clifford R Jack, David T Jones
OBJECTIVE: To describe the phenomenon of tau-negative amnestic dementia mimicking Alzheimer disease (AD) clinically and radiologically and to highlight the importance of biomarkers in AD research. METHODS: Eight participants with amnestic mild cognitive impairment or AD dementia were evaluated by a behavioral neurologist and had a standardized neuropsychological battery performed. All participants completed structural (MRI) and molecular (amyloid and tau PET) imaging...
February 7, 2018: Neurology
Julie Marin, Giovanni Rapacciuolo, Gabriel C Costa, Catherine H Graham, Thomas M Brooks, Bruce E Young, Volker C Radeloff, Jocelyn E Behm, Matthew R Helmus, S Blair Hedges
Global variation in species richness is widely recognized, but the explanation for what drives it continues to be debated. Previous efforts have focused on a subset of potential drivers, including evolutionary rate, evolutionary time (maximum clade age of species restricted to a region), dispersal (migration from one region to another), ecological factors and climatic stability. However, no study has evaluated these competing hypotheses simultaneously at a broad spatial scale. Here, we examine their relative contribution in determining the richness of the most comprehensive dataset of tetrapods to our knowledge (84% of the described species), distinguishing between the direct influences of evolutionary rate, evolutionary time and dispersal, and the indirect influences of ecological factors and climatic stability through their effect on direct factors...
February 14, 2018: Proceedings. Biological Sciences
Zubair Ahmed Ratan, Young-Jin Son, Mohammad Faisal Haidere, Bhuiyan Mohammad Mahtab Uddin, Md Abdullah Yusuf, Sojib Bin Zaman, Jong-Hoon Kim, Laila Anjuman Banu, Jae Youl Cho
Bacteria and archaea possess adaptive immunity against foreign genetic materials through clustered regularly interspaced short palindromic repeat (CRISPR) systems. The discovery of this intriguing bacterial system heralded a revolutionary change in the field of medical science. The CRISPR and CRISPR-associated protein 9 (Cas9) based molecular mechanism has been applied to genome editing. This CRISPR-Cas9 technique is now able to mediate precise genetic corrections or disruptions in in vitro and in vivo environments...
2018: Therapeutic Advances in Medical Oncology
Aimee J Palumbo, Melissa R Pfeiffer, Michael R Elliott, Allison E Curry
PURPOSE: In May 2010, New Jersey implemented the first-in-the-nation decal provision to increase intermediate drivers' compliance with Graduated Driver Licensing restrictions and ultimately reduce young driver crashes. We previously found that the provision was associated with a 9.5% decline in crash rates. This study evaluates whether the decal provision was associated with an increase in compliance with passenger and nighttime restrictions. METHODS: We analyzed New Jersey driver licensing and crash data from 2008 through 2012...
February 9, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Jennifer M Whitehill, Rosa Rodriguez-Monguio, Mitchell Doucette, Emily Flom
Driving (DUIM) and riding (RUIM) with a driver under the influence of marijuana increases crash risk. This study assessed risk factors for DUIM and RUIM among ethnically diverse young adults. Randomly selected individuals were surveyed. Multivariable regression was used to assess risk factors associated with DUIM and RUIM. Participants (N = 335, response rate = 34.9%) were 33.7% White non-Hispanic. Reported DUIM and RUIM was not statistically significant by race/ethnicity. Frequency of marijuana use was significantly associated with greater risk of DUIM...
February 12, 2018: Journal of Ethnicity in Substance Abuse
Hyuma Makizako, Hiroyuki Shimada, Ryo Hotta, Takehiko Doi, Kota Tsutsumimoto, Sho Nakakubo, Keitaro Makino
BACKGROUND: Attention and executive function may play an important role in ensuring safe driving as they involve paying attention to complex information and making an instantaneous judgment during driving. We hypothesized that poor performance in attention and executive function may increase the risk of near-miss incidents among older drivers. OBJECTIVE: The aim of this study was to examine associations of current experience of near-miss traffic incidents with attention and executive function among older Japanese drivers...
February 9, 2018: Gerontology
Pamela A Matson, Vivian Towe, Jonathan M Ellen, Shang-En Chung, Susan G Sherman
BACKGROUND: Young men who have been involved with the criminal justice system are more likely to have concurrent sexual partners, a key driver of sexually transmitted infections. The value men place on having sexual relationships to validate themselves may play an important role in understanding this association. METHODS: Data were from a household survey. Young men (N = 132), aged 16 to 24 years, self-reported whether they ever spent time in jail or juvenile detention and if they had sexual partnerships that overlapped in time...
March 2018: Sexually Transmitted Diseases
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