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https://www.readbyqxmd.com/read/29332672/motivational-factors-associated-with-drowsy-driving-behavior-a-qualitative-investigation-of-college-students
#1
Kenneth H Beck, Clark J Lee, Talia Weiner
OBJECTIVES: This qualitative investigation sought to identify the motivational factors that contribute to drowsy driving in college students and to discover important messaging strategies that may help prevent or reduce this behavior in this population. DESIGN: Four focus groups of college students. SETTING: A large university in the Washington, DC, metropolitan area during the Fall 2016 term. PARTICIPANTS: Twenty-six undergraduate students between the ages of 18 and 25 years...
February 2018: Sleep Health
https://www.readbyqxmd.com/read/29330163/affective-stimuli-in-behavioural-interventions-soliciting-for-health-check-up-services-and-the-service-users-socioeconomic-statuses-a-study-at-japanese-pachinko-parlours
#2
Naoki Kondo, Yoshiki Ishikawa
BACKGROUND: Socioeconomically vulnerable people are likely to have more health risks because of inadequate behaviour choices related to chronic social stresses. Brain science suggests that stress causes cognitively biased automatic decision making, preferring instant stress relief and pleasure (eg, smoking, alcohol use and drug abuse) as opposed to reflectively seeking health-maintenance services (eg, health check-ups). As such, hedonic stimuli that nudge people towards preventive actions could reduce health behaviour disparities...
January 12, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29329039/an-investigation-into-the-drivers-of-avolition-in-schizophrenia
#3
Gaurav Suri, Lindsey M Lavaysse, Gerald Young, Craig Moodie, Alen Tersakyan, James J Gross, David E Gard
Over a century of research has documented that avolition is a core symptom in schizophrenia. However, the drivers of avolition remain unclear. Conceptually, there are at least two potential mutually compatible drivers that could cause avolition in schizophrenia. First, people with schizophrenia might have differences in preferences that result in less goal-directed behavior than non-clinical populations (preference-differences). Second, people with schizophrenia might have difficulty translating their preferences into manifest behavior at rates similar to non-clinical populations (psychological-inertia)...
January 6, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29326299/targeting-mutant-kras-with-crispr-cas9-controls-tumor-growth
#4
Hyongbum Henry Kim, Wonjoo Kim, Sangeun Lee, Han Sang Kim, Minjung Song, Yong Hoon Cha, Young-Hoon Kim, Jeonghong Shin, Eun-Seo Lee, Yeonsoo Joo, Jae J Song, Eun Ju Choi, Jae W Choi, Jinu Lee, Moonkyung Kang, Jong In Yook, Min Goo Lee, Yeon-Soo Kim, Soonmyung Paik
KRAS is the most frequently mutated oncogene in human tumors and its activating mutations represents important therapeutic targets. The combination of Cas9 and guide RNA from the CRISPR-Cas system recognizes a specific DNA sequence and makes a double-strand break, which enables editing of the relevant genes. Here we harnessed CRISPR to specifically target mutant KRAS alleles in cancer cells. We screened guide RNAs using a reporter system and validated them in cancer cells after lentiviral delivery of Cas9 and guide RNA...
January 11, 2018: Genome Research
https://www.readbyqxmd.com/read/29324264/driver-education-enhancing-knowledge-of-sleep-fatigue-and-risky-behaviour-to-improve-decision-making-in-young-drivers
#5
Pasquale K Alvaro, Nicole M Burnett, Gerard A Kennedy, William Yu Xun Min, Marcus McMahon, Maree Barnes, Melinda Jackson, Mark E Howard
This study assessed the impact of an education program on knowledge of sleepiness and driving behaviour in young adult drivers and their performance and behaviour during simulated night driving. Thirty-four participants (18-26 years old) were randomized to receive either a four-week education program about sleep and driving or a control condition. A series of questionnaires were administered to assess knowledge of factors affecting sleep and driving before and after the four-week education program. Participants also completed a two hour driving simulator task at 1am after 17 h of extended wakefulness to assess the impact on driving behaviour...
January 8, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29321293/individual-variation-in-reproductive-behaviour-is-linked-to-temporal-heterogeneity-in-predation-risk
#6
Miguel Barbosa, Amy E Deacon, Maria Joao Janeiro, Indar Ramnarine, Michael Blair Morrissey, Anne E Magurran
Variation in predation risk is a major driver of ecological and evolutionary change, and, in turn, of geographical variation in behaviour. While predation risk is rarely constant in natural populations, the extent to which variation in predation risk shapes individual behaviour in wild populations remains unclear. Here, we investigated individual differences in reproductive behaviour in 16 Trinidadian guppy populations and related it to the observed variation in predator biomass each population experienced...
January 10, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29316511/young-africans-social-representations-of-rape-in-their-hiv-related-creative-narratives-2005-2014-rape-myths-and-alternative-narratives
#7
Robyn Singleton, Kate Winskell, Siphiwe Nkambule-Vilakati, Gaëlle Sabben
Sexual violence is both a major human rights issue and an important driver of HIV infection in sub-Saharan Africa. While quantitative indicators of sexual violence have evolved to facilitate cross-national comparison and country-level decision making, qualitative findings typically remain constrained to single sites and populations. We analyzed social representations of sexual violence, specifically rape, in a sample of 1446 narratives about HIV written by young Africans between 2005 and 2014. The narratives were written at 5 discrete time points (2005, 2008, 2011, 2013 and 2014) by equal numbers of males and females aged 10-24 in urban and rural areas of Swaziland, Kenya, South-East Nigeria, Burkina Faso and Senegal...
December 26, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29315530/ecological-drivers-of-soil-microbial-diversity-and-soil-biological-networks-in-the-southern-hemisphere
#8
Manuel Delgado-Baquerizo, Frank Reith, Paul G Dennis, Kelly Hamonts, Jeff R Powell, Andrew Young, Brajesh K Singh, Andrew Bissett
The ecological drivers of soil biodiversity in the Southern Hemisphere remain underexplored. Here, in a continental survey comprising 647 sites, across 58 degrees of latitude between tropical Australia and Antarctica, we evaluated the major ecological patterns in soil biodiversity and relative abundance of ecological clusters within a co-occurrence network of soil bacteria, archaea and eukaryotes. Six major ecological clusters (modules) of co-occurring soil taxa were identified. These clusters exhibited strong shifts in their relative abundances with increasing distance from the equator...
January 9, 2018: Ecology
https://www.readbyqxmd.com/read/29312762/ciliated-muconodular-papillary-tumor-of-the-lung-harboring-braf-v600e-mutation-and-p16ink4a-overexpression-without-proliferative-activity-may-represent-an-example-of-oncogene-induced-senescence
#9
Lucia Kim, Young Sam Kim, Jin Soo Lee, Suk Jin Choi, In Suh Park, Jee Young Han, Joon Mee Kim, Young Chae Chu
Ciliated muconodular papillary tumor (CMPT) is a rare peripheral lung tumor that shows puzzling histologic features encompassing metaplastic and neoplastic nature. This type of tumor is occasionally misdiagnosed as lung adenocarcinoma clinically and pathologically, and its pathogenic mechanism has not been well characterized. We experienced a case of CMPT in a 73-year-old male and performed targeted deep sequencing to characterize its molecular features. The tumor was an ill-defined, subpleural, and non-endobronchial nodule showing glandular and papillary proliferation of mucous cells, ciliated columnar cells, and basal cells without any cytologic atypia...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29306084/traffic-accident-severity-analysis-with-rain-related-factors-using-structural-equation-modeling-a-case-study-of-seoul-city
#10
Jonghak Lee, Junghyo Chae, Taekwan Yoon, Hojin Yang
Weather conditions are strongly correlated with traffic accident severity. In particular, rain-related factors are an important cause of traffic accidents due to the poor visibility and reduced friction resulting from slippery road conditions. This paper presents a systematic approach to analyze the extent to which the rainfall intensity and level of water depth are responsible for traffic accidents using Seoul City, Korea, as a case study. The rainfall and traffic accident data over a nine-year period (from 2007 to 2015) for Seoul were analyzed through Structural Equation Modeling to identify the relationships among variables by handling endogenous and exogenous variables simultaneously...
January 3, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29284669/c-myc-drives-a-subset-of-high-risk-pediatric-neuroblastomas-and-is-activated-through-mechanisms-including-enhancer-hijacking-and-focal-enhancer-amplification
#11
Mark W Zimmerman, Yu Liu, Shuning He, Adam D Durbin, Brian J Abraham, John Easton, Ying Shao, Beisi Xu, Shizhen Zhu, Xiaoling Zhang, Zhaodong Li, Nina Weichert-Leahey, Richard A Young, Jinghui Zhang, A Thomas Look
The amplified MYCN gene serves as an oncogenic driver in approximately 20% of high-risk pediatric neuroblastomas. Here we show that the family member c-MYC is a potent transforming gene in a separate subset of high-risk neuroblastoma cases (~10%), based on (i) its upregulation by focal enhancer amplification or genomic rearrangements leading to enhancer hijacking, and (ii) its ability to transform neuroblastoma precursor cells in a transgenic animal model. The aberrant regulatory elements associated with oncogenic c-MYC activation include focally amplified distal enhancers and translocation of highly active enhancers from other genes to within topologically associating domains containing the c-MYC gene locus...
December 28, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29282818/effect-of-severe-obesity-in-childhood-and-adolescence-on-risk-of-type-2-diabetes-in-youth-and-early-adulthood-in-an-american-indian-population
#12
Stephanie K Tanamas, Sanil P Reddy, Melissa A Chambers, Elena J Clark, Diana L Dunnigan, Robert L Hanson, Robert G Nelson, William C Knowler, Madhumita Sinha
OBJECTIVES: The risk of early-onset type 2 diabetes associated with the severity of obesity in youth is not well understood. This study aims to determine metabolic alterations and type 2 diabetes risk among American Indian children who are obese or severely obese. METHODS: Incidence rates of diabetes before 20 years (youth-onset) and 45 years were computed in 2728 children who were from 5 to <10 years and 4317 adolescents who were from 10 to <18 years without diabetes examined between 1965 and 2007...
December 28, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29282223/combined-mutation-of-apc-kras-and-tgfbr2-effectively-drives-metastasis-of-intestinal-cancer
#13
Eri Sakai, Mizuho Nakayama, Hiroko Oshima, Yuta Kouyama, Atsushi Niida, Satoshi Fujii, Atsushi Ochiai, Keiichi I Nakayama, Koshi Mimori, Yutaka Suzuki, Chang Pyo Hong, Chan-Young Ock, Seong-Jin Kim, Masanobu Oshima
Colorectal cancer (CRC) is driven by the accumulation of driver mutations, but the contributions of specific mutations to different steps in malignant progression is not fully understood. In this study, we generated mouse models harboring different combinations of key CRC driver mutations (Apc, Kras, Tgfbr2, Trp53, Fbxw7) in intestinal epithelial cells to comprehensively investigate their roles in the development of primary tumors and metastases. Apc∆716 mutation caused intestinal adenomas and combination with Trp53R270H mutation or Tgfbr2 deletion induced submucosal invasion...
December 27, 2017: Cancer Research
https://www.readbyqxmd.com/read/29281098/origin-of-new-genes-after-zygotic-genome-activation-in-vertebrate
#14
Hai-Bo Xu, Yong-Xin Li, Yan Li, Newton O Otecko, Ya-Ping Zhang, Bingyu Mao, Dong-Dong Wu
New genes are drivers of evolutionary innovation and phenotypic evolution. Expression of new genes in early development raises the possibility that new genes could originate and be recruited for functions in embryonic development, but this remains undocumented. Here, based on temporal gene expression at different developmental stages in Xenopus tropicalis, we found that young protein-coding genes were significantly enriched for expression in developmental stages occurring after the midblastula transition (MBT), and displayed a decreasing trend in abundance in the subsequent stages after MBT...
December 21, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29278378/modelling-the-transmission-dynamics-and-control-of-mumps-in-mainland-china
#15
Yong Li, Xianning Liu, Lianwen Wang
Mumps is a common childhood viral disease and children have been vaccinated throughout the world since 1967. The incidence of mumps has increased with more than 300,000 young people infected with mumps annually in mainland China since 2005. Therefore, we designed and analyzed long-term mumps surveillance data in an SVEILR (susceptible-vaccinated-exposed-severely infectious-mildly infectious-recovered) dynamic transmission model with optimized parameter values to describe the dynamics of mumps infections in China...
December 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29277384/effectiveness-of-visual-warnings-on-young-drivers-hazard-anticipation-and-hazard-mitigation-abilities
#16
Foroogh Hajiseyedjavadi, Tingru Zhang, Ravi Agrawal, Michael Knodler, Donald Fisher, Siby Samuel
Previous studies have demonstrated that young drivers fail both to scan for and mitigate latent hazards mostly due to their cluelessness. This study aims to investigate whether these skills could be improved by providing young drivers with alerts in advance of the upcoming threat using a driving simulator experiment. In particular, the warning was presented on the head-up displays (HUD) either 2 s, 3 s or 4 s in advance of a latent threat. The hazard anticipation, hazard mitigation and attention maintenance performance of forty-eight young drivers aged 18-25 was evaluated across eight unique scenarios either in the presence or in the absence of latent threat alerts displayed on a HUD...
December 22, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29276613/vita-activa-in-biotechnology-what-we-do-with-fungi-and-what-fungi-do-with-us
#17
EDITORIAL
Martin Weinhold, Edeltraud Mast-Gerlach, Vera Meyer
Filamentous fungi are fascinating microorganisms. One of the reasons why it is so worthwhile to take a closer look at them is their capacity to produce secondary metabolites. Some of these substances have the potential to be of great use for mankind, such as it was the case with penicillin and its discovery in 1928. Almost a century later, the situation in healthcare could possibly turn back to the state before the development of the first antibiotics. Due to an overuse of antibiotics we are facing a surge of multiresistant bacteria that are not inhibited by any of the currently known drugs...
2017: Fungal Biology and Biotechnology
https://www.readbyqxmd.com/read/29259322/hubness-of-strategic-planning-and-sociality-influences-depressive-mood-and-anxiety-in-college-population
#18
Je-Yeon Yun, Yoobin Choi, Yoonhee Kwon, Hwa Young Lee, Soo-Hee Choi, Joon Hwan Jang
Depressive mood and anxiety can reduce cognitive performance. Conversely, the presence of a biased cognitive tendency may serve as a trigger for depressive mood-anxiety. Previous studies have largely focused on group-wise correlations between clinical-neurocognitive variables. Using network analyses for intra-individual covariance, we sought to decipher the most influential clinical-neurocognitive hub in the differential severity of depressive-anxiety symptoms in a college population. Ninety college students were evaluated for depressive-anxiety symptoms, Minnesota multiphasic personality inventory-2(MMPI-2), and neuro-cognition...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29258295/therapeutic-targeting-of-ependymoma-as-informed-by-oncogenic-enhancer-profiling
#19
Stephen C Mack, Kristian W Pajtler, Lukas Chavez, Konstantin Okonechnikov, Kelsey C Bertrand, Xiuxing Wang, Serap Erkek, Alexander Federation, Anne Song, Christine Lee, Xin Wang, Laura McDonald, James J Morrow, Alina Saiakhova, Patrick Sin-Chan, Qiulian Wu, Kulandaimanuvel Antony Michaelraj, Tyler E Miller, Christopher G Hubert, Marina Ryzhova, Livia Garzia, Laura Donovan, Stephen Dombrowski, Daniel C Factor, Betty Luu, Claudia L L Valentim, Ryan C Gimple, Andrew Morton, Leo Kim, Briana C Prager, John J Y Lee, Xiaochong Wu, Jennifer Zuccaro, Yuan Thompson, Borja L Holgado, Jüri Reimand, Susan Q Ke, Adam Tropper, Sisi Lai, Senthuran Vijayarajah, Sylvia Doan, Vaidehi Mahadev, Ana Fernandez Miñan, Susanne N Gröbner, Matthias Lienhard, Marc Zapatka, Zhiqin Huang, Kenneth D Aldape, Angel M Carcaboso, Peter J Houghton, Stephen T Keir, Till Milde, Hendrik Witt, Yan Li, Chao-Jun Li, Xiu-Wu Bian, David T W Jones, Ian Scott, Sheila K Singh, Annie Huang, Peter B Dirks, Eric Bouffet, James E Bradner, Vijay Ramaswamy, Nada Jabado, James T Rutka, Paul A Northcott, Mathieu Lupien, Peter Lichter, Andrey Korshunov, Peter C Scacheri, Stefan M Pfister, Marcel Kool, Michael D Taylor, Jeremy N Rich
Genomic sequencing has driven precision-based oncology therapy; however, the genetic drivers of many malignancies remain unknown or non-targetable, so alternative approaches to the identification of therapeutic leads are necessary. Ependymomas are chemotherapy-resistant brain tumours, which, despite genomic sequencing, lack effective molecular targets. Intracranial ependymomas are segregated on the basis of anatomical location (supratentorial region or posterior fossa) and further divided into distinct molecular subgroups that reflect differences in the age of onset, gender predominance and response to therapy...
December 20, 2017: Nature
https://www.readbyqxmd.com/read/29248095/new-findings-on-child-marriage-in-sub-saharan-africa
#20
Suzanne Petroni, Mara Steinhaus, Natacha Stevanovic Fenn, Kirsten Stoebenau, Amy Gregowski
Despite increasing global attention and commitments by countries to end the harmful practice of child marriage, each year some 15 million girls marry before the age of 18. The preponderance of the evidence produced historically on child marriage comes from South Asia, where the vast majority of child brides live. Far less attention has been paid to child marriage in sub-Saharan Africa, where prevalence rates remain high. The International Center for Research on Women (ICRW) recently conducted research in Kenya, Senegal, Uganda, and Zambia to contribute to greater understanding of the drivers of child marriage in each of these contexts...
September 2017: Annals of Global Health
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