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https://www.readbyqxmd.com/read/29679838/medico-legal-investigation-in-an-explicable-case-of-congenital-central-hypoventilation-syndrome-due-to-a-rare-variant-of-the-phox2b-gene
#1
Francesco Ventura, Rosario Barranco, Tiziana Bachetti, Paolo Nozza, Ezio Fulcheri, Antonella Palmieri, Isabella Ceccherini
The heterozygous PHOX2B gene mutation is related to congenital central hypoventilation syndrome (CCHS). It is characterized by defective autonomous nervous system development leading to inadequate breathing response to hypoxia and hypercapnia, leading to hypoventilation especially during non-REM sleep, but also during waking in the more severe cases. Herein we report a case of sudden death in a 28-day-old child. The mother reported the infant was found lying on her own bed in the prone position. The infant was wearing a romper and lying in her crib without any blanket or other objects...
April 17, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29679623/hyperglycemia-in-pregnancy-and-its-implications-for-a-woman-s-future-risk-of-cardiovascular-disease
#2
REVIEW
Ravi Retnakaran
It is well established that gestational diabetes mellitus (GDM) identifies a population of women who are at risk of ultimately developing type 2 diabetes (T2DM) later in life. Moreover, this relationship extends across the full spectrum of hyperglycemia in pregnancy, with lesser degrees of gestational dysglycemia identifying a proportionate gradient of future risk of T2DM. Importantly, a growing body of evidence suggests that an analogous relationship exists between hyperglycemia in pregnancy and a woman's long-term risk of cardiovascular disease (CVD), as well...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29678946/prenatal-antibiotic-exposure-and-childhood-asthma-a-population-based-study
#3
Keely Loewen, Barret Monchka, Salaheddin M Mahmud, Geert 't Jong, Meghan B Azad
Antibiotic use during infancy alters gut microbiota and immune development and is associated with an increased risk of childhood asthma. The impact of prenatal antibiotic exposure is unclear. We sought to characterise the association between prenatal antibiotic exposure and childhood asthma.We performed a population-based cohort study using prescription records, hospitalization records, and physician billing claims from 213,661 mother-child dyads born in Manitoba, Canada from 1996-2012. Associations were determined using Cox regression, adjusting for maternal asthma, postnatal antibiotics, and other potential confounders...
April 20, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29678929/antibiotic-use-after-removal-of-penicillin-allergy-label
#4
David Vyles, Asriani Chiu, John Routes, Mariana Castells, Elizabeth J Phillips, Jennifer Kibicho, David C Brousseau
BACKGROUND: Penicillin allergy is commonly reported in the pediatric emergency department. We previously performed 3-tier penicillin allergy testing on children with low-risk symptoms, and 100% tolerated a penicillin challenge without an allergic reaction. We hypothesized that no serious allergic reactions would occur after re-exposure to penicillin and that prescription practices would change after testing. METHODS: We performed a follow-up case series of 100 children whose test results were negative for penicillin allergy...
April 20, 2018: Pediatrics
https://www.readbyqxmd.com/read/29678804/feasibility-and-acceptability-of-a-web-based-treatment-with-telephone-support-for-postpartum-women-with-anxiety-randomized-controlled-trial
#5
Miriam T Ashford, Ellinor K Olander, Heather Rowe, Jane Rw Fisher, Susan Ayers
BACKGROUND: Postpartum anxiety can have adverse effects on the mother and child if left untreated. Time constraints and stigma are common barriers to postpartum treatment. Web-based treatments offer potential flexibility and anonymity. What Am I Worried About (WaWa) is a self-guided treatment based on cognitive-behavioral and mindfulness principles for women experiencing postpartum anxiety. WaWa was developed in Australia and consists of 9 modules with optional weekly telephone support...
April 20, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29678098/improving-patient-experience-in-a-children-s-hospital-new-digital-services-for-children-and-their-families
#6
Nina Karisalmi, Johanna Kaipio, Pekka Lahdenne
Digital services are increasingly being developed for the healthcare sector. In Finland, the five university hospitals in 2016 launched a virtual hospital platform, Healthvillage.fi that includes several portals. The aim of this study is to explore the needs of children and their families related to digital services in the context of a children's hospital in Finland. Two methods were used to examine the needs and expectations of children and their families: a web-based survey for parents and video diaries for children...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678068/a-mobile-early-stimulation-program-to-support-children-with-developmental-delays-in-brazil
#7
Raquel da Luz Dias, Kátia Cristina Correa Guimarães Silva, Marcela Raquel de Oliveira Lima, João Guilherme Bezerra Alves, Syed Sibte Raza Abidi
Developmental delay is a deviation development from the normative milestones during the childhood and it may be caused by neurological disorders. Early stimulation is a standardized and simple technique to treat developmental delays in children (aged 0-3 years), allowing them to reach the best development possible and to mitigate neuropsychomotor sequelae. However, the outcomes of the treatment depending on the involvement of the family, to continue the activities at home on a daily basis. To empower and educate parents of children with neurodevelopmental delays to administer standardized early stimulation programs at home, we developed a mobile early stimulation program that provides timely and evidence-based clinical decision support to health professionals and a personalized guidance to parents about how to administer early stimulation to their child at home...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677412/gunderkids-design-of-a-clinical-care-management-program-for-parents-with-substance-abuse-and-their-newborn-children-with-a-focus-on-preventing-child-abuse
#8
Ann E Budzak-Garza, Allison L Allmon Dixson, Renee A Holzer, Kaitlin E Lillard-Pierce, Carolynn J Devine
BACKGROUND: In response to an increased need to care for babies born to mothers with substance abuse issues, we developed GunderKids, a care management program that provides integrated medical care beyond standard-of-care, well-child appointments for these socially complex families. METHODS: The program incorporates frequent visits to the pediatrician and the care team, which includes pediatric nurses, a pediatric social worker, and a child psychologist. Enrollment is voluntary...
March 2018: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29676618/cancer-risk-from-paediatric-computed-tomography-scanning-implications-for-radiation-protection-in-medicine
#9
A Kesminiene, E Cardis
The use of computed tomography (CT) imaging is clearly beneficial for millions of patients. However, the potential adverse health effects, particularly cancer, of ionising radiation exposure from CT early in life are an issue of growing concern in the radiological protection, medical, and public health communities. Although efforts to quantify these effects have been conducted, the precision and accuracy of reported risks needs confirmation. EPI-CT, a European collaborative epidemiological study, was set up to quantify risks from paediatric CT to optimise paediatric diagnostic protocol...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29675588/parenting-a-child-with-phenylketonuria-an-investigation-into-the-factors-that-contribute-to-parental-distress
#10
Olivia Ambler, Emma Medford, Dougal J Hare
Phenylketonuria (PKU) is an inherited metabolic condition that can lead to the onset of intellectual disabilities if not strictly managed through a low-protein diet. Parents are responsible for supervising their child's treatment for PKU, which may impact on their experience of distress. This cross-sectional study aimed to identify the factors that contribute to distress in parents who care for a child with PKU, distinct from parents in the general population. Thirty-eight parents of children and adolescents with PKU and 32 parents in the general population completed the questionnaires measuring parental psychological resilience, child behaviour problems, perceived social support and distress...
April 20, 2018: JIMD Reports
https://www.readbyqxmd.com/read/29675076/abrus-precatorius-poisoning-and-central-pontine-myelinolysis
#11
Sumantra Sarkar, Kaushambi Basu, Jayati Das, Supratim Datta
Accidental poisoning with Abrus precatorius (AP) can rarely produce neurological complication due to its toxic principle "Abrin". The authors report such a case in a 2-year old child, who subsequently developed central pontine myelinolysis, an association, to the best of the author's knowledge, has never been reported in literature.
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29675071/pediatric-head-injury-a-study-of-403-cases-in-a-tertiary-care-hospital-in-a-developing-country
#12
Abrar Ahad Wani, Arif Hussain Sarmast, Muzaffar Ahangar, Nayil Khursheed Malik, Sarabjit Singh Chhibber, Sajad Hussain Arif, Altaf Umar Ramzan, Bashir Ahmed Dar, Zulfiqar Ali
Introduction: Traumatic brain injury (TBI) in children is a significant cause of morbidity and mortality worldwide. Falls are the most common type of injury, followed by motor vehicle-related accidents and child abuse. Aims and Objectives: The aim and objective of this study was to elucidate the various modes of injury, prognostic factors, complications, incidence of various modes of injury, and outcome in TBI in pediatric population. Materials and Methods: Patients with TBI, 18 years or less in age, managed in our Department of Neurosurgery, over a period of 2 years, were studied prospectively...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29674988/a-virtual-object-location-task-for-children-gender-and-videogame-experience-influence-navigation-age-impacts-memory-and-completion-time
#13
David Rodriguez-Andres, Magdalena Mendez-Lopez, M-Carmen Juan, Elena Perez-Hernandez
The use of virtual reality-based tasks for studying memory has increased considerably. Most of the studies that have looked at child population factors that influence performance on such tasks have been focused on cognitive variables. However, little attention has been paid to the impact of non-cognitive skills. In the present paper, we tested 52 typically-developing children aged 5-12 years in a virtual object-location task. The task assessed their spatial short-term memory for the location of three objects in a virtual city...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29674984/rhythm-and-melody-tasks-for-school-aged-children-with-and-without-musical-training-age-equivalent-scores-and-reliability
#14
Kierla Ireland, Averil Parker, Nicholas Foster, Virginia Penhune
Measuring musical abilities in childhood can be challenging. When music training and maturation occur simultaneously, it is difficult to separate the effects of specific experience from age-based changes in cognitive and motor abilities. The goal of this study was to develop age-equivalent scores for two measures of musical ability that could be reliably used with school-aged children (7-13) with and without musical training. The children's Rhythm Synchronization Task (c-RST) and the children's Melody Discrimination Task (c-MDT) were adapted from adult tasks developed and used in our laboratories...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29674310/the-interactive-child-distress-screener-development-and-preliminary-feasibility-testing
#15
Sonja March, Jamin Day, Kirsty Zieschank, Michael Ireland
BACKGROUND: Early identification of child emotional and behavioral concerns is essential for the prevention of mental health problems; however, few suitable child-reported screening measures are available. Digital tools offer an exciting opportunity for obtaining clinical information from the child's perspective. OBJECTIVE: The aim of this study was to describe the initial development and pilot testing of the Interactive Child Distress Screener (ICDS). The ICDS is a Web-based screening instrument for the early identification of emotional and behavioral problems in children aged between 5 and 12 years...
April 19, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29674290/the-impact-of-patterns-of-trauma-exposure-among-low-income-children-with-and-without-histories-of-child-maltreatment
#16
Abigail L Rosen, Elizabeth D Handley, Dante Cicchetti, Fred A Rogosch
Previous research has revealed a large prevalence of trauma experienced by children, creating high risk for the development of psychopathology. Research investigating the negative impacts of child maltreatment and other traumas has typically examined these experiences individually, controlling for co-occurring traumas, or has combined these experiences into a general variable of risk, thereby obscuring the complex relationships among environmental traumas and maltreatment. The current study expands on previous research by elucidating relationships between multiple contexts of overlapping traumas and maltreatment experienced by children, and by categorizing how these experiences join together to impact internalizing and externalizing symptomatology...
April 16, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29674194/resting-state-functional-connectivity-in-children-born-from-gestations-complicated-by-preeclampsia-a-pilot-study-cohort
#17
Lauren E Mak, B Anne Croy, Vanessa Kay, James N Reynolds, Matthew T Rätsep, Nils D Forkert, Graeme N Smith, Angelina Paolozza, Patrick W Stroman, Ernesto A Figueiró-Filho
BACKGROUND: Individuals (PE-F1s) born from preeclampsia (PE)-complicated pregnancies have elevated risks for cognitive impairment. Intervals of disturbed maternal plasma angiokines precede clinical signs of PE. We hypothesized pan-blastocyst dysregulation of angiokines underlies altered PE-F1 brain vascular and neurological development. This could alter brain functional connectivity (FC) patterns at rest. MATERIALS AND METHODS: Resting-state functional MRI datasets of ten, matched child pairs (5 boys and 5 girls aged 7-10 years of age) from PE or control pregnancies were available for study...
February 7, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29673875/intervention-strategies-to-improve-nutrition-and-health-behaviours-before-conception
#18
REVIEW
Mary Barker, Stephan U Dombrowski, Tim Colbourn, Caroline H D Fall, Natasha M Kriznik, Wendy T Lawrence, Shane A Norris, Gloria Ngaiza, Dilisha Patel, Jolene Skordis-Worrall, Falko F Sniehotta, Régine Steegers-Theunissen, Christina Vogel, Kathryn Woods-Townsend, Judith Stephenson
The nutritional status of both women and men before conception has profound implications for the growth, development, and long-term health of their offspring. Evidence of the effectiveness of preconception interventions for improving outcomes for mothers and babies is scarce. However, given the large potential health return, and relatively low costs and risk of harm, research into potential interventions is warranted. We identified three promising strategies for intervention that are likely to be scalable and have positive effects on a range of health outcomes: supplementation and fortification; cash transfers and incentives; and behaviour change interventions...
April 16, 2018: Lancet
https://www.readbyqxmd.com/read/29673873/before-the-beginning-nutrition-and-lifestyle-in-the-preconception-period-and-its-importance-for-future-health
#19
REVIEW
Judith Stephenson, Nicola Heslehurst, Jennifer Hall, Danielle A J M Schoenaker, Jayne Hutchinson, Janet E Cade, Lucilla Poston, Geraldine Barrett, Sarah R Crozier, Mary Barker, Kalyanaraman Kumaran, Chittaranjan S Yajnik, Janis Baird, Gita D Mishra
A woman who is healthy at the time of conception is more likely to have a successful pregnancy and a healthy child. We reviewed published evidence and present new data from low-income, middle-income, and high-income countries on the timing and importance of preconception health for subsequent maternal and child health. We describe the extent to which pregnancy is planned, and whether planning is linked to preconception health behaviours. Observational studies show strong links between health before pregnancy and maternal and child health outcomes, with consequences that can extend across generations, but awareness of these links is not widespread...
April 16, 2018: Lancet
https://www.readbyqxmd.com/read/29673720/-study-of-parental-bonding-in-childhood-in-children-and-adolescents-with-anorexia-nervosa
#20
A M H Albinhac, F A M Jean, M P Bouvard
INTRODUCTION: Anorexia nervosa constitutes a severe and complex eating disorder occurring principally in adolescence. It is one of the most deadly psychiatric disorders. Considering the multifactorial nature of anorexia nervosa, the important place of the family and the growing interest in the theory of attachment in eating disorders, parental bonding is questioned in anorexia nervosa. The main study goal is to analyze parental bonding in a population of children and adolescents with anorexia nervosa...
April 16, 2018: L'Encéphale
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