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Bourbon virus

Hiroko Ejiri, Chang-Kweng Lim, Haruhiko Isawa, Ryosuke Fujita, Katsunori Murota, Tomomi Sato, Daisuke Kobayashi, Miki Kan, Masashi Hattori, Toshiya Kimura, Yukie Yamaguchi, Mutsuyo Takayama-Ito, Madoka Horiya, Guillermo Posadas-Herrera, Shohei Minami, Ryusei Kuwata, Hiroshi Shimoda, Ken Maeda, Yukie Katayama, Tetsuya Mizutani, Masayuki Saijo, Koki Kaku, Hiroto Shinomiya, Kyoko Sawabe
The genus Thogotovirus, as represented by Thogoto virus and Dhori virus, comprises a group of arthropod-borne viruses, most members of which are transmitted by ticks. Here we report the genetic and biological characterization of a new thogotovirus, designated Oz virus (OZV), isolated from the hard tick Amblyomma testudinarium in Ehime, Japan. OZV efficiently replicated and induced a cytopathic effect in Vero cells, from which enveloped pleomorphic virus particles were formed by budding. OZV could also replicate in BHK-21 and DH82 cells and caused high mortality in suckling mice after intracerebral inoculation...
March 13, 2018: Virus Research
Harry M Savage, Marvin S Godsey, Nicholas A Panella, Kristen L Burkhalter, Justin Manford, Ingrid C Trevino-Garrison, Anne Straily, Savannah Wilson, Jaden Bowen, Ram K Raghavan
Bourbon virus (Family Orthomyxoviridae: Genus Thogotovirus) was first isolated from a human case-patient residing in Bourbon County, Kansas, who subsequently died. Before becoming ill in late spring of 2014, the patient reported several tick bites. In response, we initiated tick surveillance in Bourbon County and adjacent southern Linn County during spring and summer of 2015. We collected 20,639 host-seeking ticks representing four species from 12 sites. Amblyomma americanum (L.) (Acari: Ixodidae) and Dermacentor variabilis (Say) (Acari: Ixodidae) accounted for nearly all ticks collected (99...
January 20, 2018: Journal of Medical Entomology
Harry M Savage, Kristen L Burkhalter, Marvin S Godsey, Nicholas A Panella, David C Ashley, William L Nicholson, Amy J Lambert
Bourbon virus (BRBV) was first isolated in 2014 from a resident of Bourbon County, Kansas, USA, who died of the infection. In 2015, an ill Payne County, Oklahoma, resident tested positive for antibodies to BRBV, before fully recovering. We retrospectively tested for BRBV in 39,096 ticks from northwestern Missouri, located 240 km from Bourbon County, Kansas. We detected BRBV in 3 pools of Amblyomma americanum (L.) ticks: 1 pool of male adults and 2 pools of nymphs. Detection of BRBV in A. americanum, a species that is aggressive, feeds on humans, and is abundant in Kansas and Oklahoma, supports the premise that A...
December 2017: Emerging Infectious Diseases
Steven J Schweon
No abstract text is available yet for this article.
April 2016: Nursing
Pedro F C Vasconcelos, Charles H Calisher
In addition to individual or clusters of cases of human infections with arboviruses, the past 15 years has seen the emergence of newly recognized arboviruses and the re-emergence of others. Mentioned in this brief summary are Bourbon, Cache Valley, chikungunya, Heartland, Itaqui, Mayaro, Oropouche, Powassan, and Zika viruses, the latter being a remarkable occurrence.
May 2016: Vector Borne and Zoonotic Diseases
Sofia C Carvalhana, Jorge Leitão, Ana C Alves, Mafalda Bourbon, Helena Cortez-Pinto
BACKGROUND AND AIMS: The prevalence of anti-HCV and HBsAg in Portugal has been shown to be elevated in high-risk groups, such as intravenous drug-users and incarcerated individuals. However, in the general population, prevalence remains largely unknown. The aims of this study were to estimate the prevalence of anti-HCV and HBsAg in the general Portuguese population and identify associated risk factors. MATERIALS AND METHODS: We carried out a nationwide, population-based cross-sectional study of adults resident in mainland Portugal...
June 2016: European Journal of Gastroenterology & Hepatology
Amy J Lambert, Jason O Velez, Aaron C Brault, Amanda E Calvert, Lesley Bell-Sakyi, Angela M Bosco-Lauth, J Erin Staples, Olga I Kosoy
BACKGROUND: In June of 2014, a previously healthy man from Kansas with a recent history of tick exposure died from complications related to an illness marked by fever, thrombocytopenia and leukopenia. An isolate was derived from the blood of this patient during the course of diagnostic testing. This isolate was subsequently identified as a novel orthomyxovirus of the genus Thogotovirus by next generation sequencing and was named Bourbon virus after the patient's county of residence. OBJECTIVES: To support research and diagnostic aims, we provide a basic description of Bourbon virus at both the molecular and serological levels...
December 2015: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Dezheng Zhao, Liuliang Qin, Pierre-Marie Bourbon, Lauralee James, Harold F Dvorak, Huiyan Zeng
Low-level basal vascular permeability (BVP) provides nutrients to normal tissues, and increased vascular permeability is characteristic of inflammation and cancer. We recently reported that VEGF-A, a potent vascular permeabilizing and angiogenic factor, exerts much of its angiogenic activity by up-regulating expression of TR3/Nur77, an orphan nuclear transcription factor, in vascular endothelial cells (EC). To determine whether TR3/Nur77 had a more general role in regulating vascular permeability, we found that histamine, serotonin, and platelet-activating factor, small molecule vascular permeabilizing agents, also increased TR3/Nur77 expression acutely in EC...
July 19, 2011: Proceedings of the National Academy of Sciences of the United States of America
Emmanuelle Fleurence, Christel Riviere, Thierry Lacaze-Masmonteil, Marie-Laure Franco-Motoya, Paul Waszak, Jacques Bourbon, Olivier Danos, Anne-Marie Douar, Christophe Delacourt
Transient local overexpression of genes that promote lung defense or repair may help to protect or promote alveolar development in premature neonates. We showed that the use of adenoviral vectors in neonates was limited by the induction of lung growth disorders. In the present work we compare the efficiency of gene transfer to the neonatal lung by three adeno-associated viral vectors: rAAV1, rAAV2, and rAAV5. Transduction efficiency was first measured in vitro, by infecting A549 immortalized human lung epithelial cells, and primary epithelial and mesenchymal cells isolated from human fetal lung...
November 2005: Human Gene Therapy
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