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Bourbon virus

Steven J Schweon
No abstract text is available yet for this article.
April 2016: Nursing
Pedro F C Vasconcelos, Charles H Calisher
In addition to individual or clusters of cases of human infections with arboviruses, the past 15 years has seen the emergence of newly recognized arboviruses and the re-emergence of others. Mentioned in this brief summary are Bourbon, Cache Valley, chikungunya, Heartland, Itaqui, Mayaro, Oropouche, Powassan, and Zika viruses, the latter being a remarkable occurrence.
May 2016: Vector Borne and Zoonotic Diseases
Sofia C Carvalhana, Jorge Leitão, Ana C Alves, Mafalda Bourbon, Helena Cortez-Pinto
BACKGROUND AND AIMS: The prevalence of anti-HCV and HBsAg in Portugal has been shown to be elevated in high-risk groups, such as intravenous drug-users and incarcerated individuals. However, in the general population, prevalence remains largely unknown. The aims of this study were to estimate the prevalence of anti-HCV and HBsAg in the general Portuguese population and identify associated risk factors. MATERIALS AND METHODS: We carried out a nationwide, population-based cross-sectional study of adults resident in mainland Portugal...
June 2016: European Journal of Gastroenterology & Hepatology
Amy J Lambert, Jason O Velez, Aaron C Brault, Amanda E Calvert, Lesley Bell-Sakyi, Angela M Bosco-Lauth, J Erin Staples, Olga I Kosoy
BACKGROUND: In June of 2014, a previously healthy man from Kansas with a recent history of tick exposure died from complications related to an illness marked by fever, thrombocytopenia and leukopenia. An isolate was derived from the blood of this patient during the course of diagnostic testing. This isolate was subsequently identified as a novel orthomyxovirus of the genus Thogotovirus by next generation sequencing and was named Bourbon virus after the patient's county of residence. OBJECTIVES: To support research and diagnostic aims, we provide a basic description of Bourbon virus at both the molecular and serological levels...
December 2015: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Dezheng Zhao, Liuliang Qin, Pierre-Marie Bourbon, Lauralee James, Harold F Dvorak, Huiyan Zeng
Low-level basal vascular permeability (BVP) provides nutrients to normal tissues, and increased vascular permeability is characteristic of inflammation and cancer. We recently reported that VEGF-A, a potent vascular permeabilizing and angiogenic factor, exerts much of its angiogenic activity by up-regulating expression of TR3/Nur77, an orphan nuclear transcription factor, in vascular endothelial cells (EC). To determine whether TR3/Nur77 had a more general role in regulating vascular permeability, we found that histamine, serotonin, and platelet-activating factor, small molecule vascular permeabilizing agents, also increased TR3/Nur77 expression acutely in EC...
July 19, 2011: Proceedings of the National Academy of Sciences of the United States of America
Emmanuelle Fleurence, Christel Riviere, Thierry Lacaze-Masmonteil, Marie-Laure Franco-Motoya, Paul Waszak, Jacques Bourbon, Olivier Danos, Anne-Marie Douar, Christophe Delacourt
Transient local overexpression of genes that promote lung defense or repair may help to protect or promote alveolar development in premature neonates. We showed that the use of adenoviral vectors in neonates was limited by the induction of lung growth disorders. In the present work we compare the efficiency of gene transfer to the neonatal lung by three adeno-associated viral vectors: rAAV1, rAAV2, and rAAV5. Transduction efficiency was first measured in vitro, by infecting A549 immortalized human lung epithelial cells, and primary epithelial and mesenchymal cells isolated from human fetal lung...
November 2005: Human Gene Therapy
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