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osteochondral allograft

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https://www.readbyqxmd.com/read/29792070/chondral-delamination-of-fresh-osteochondral-allografts-after-implantation-in-the-knee-a-matched-cohort-analysis
#1
Ryan C Rauck, Dean Wang, Matthew Tao, Riley J Williams
Introduction Delamination of the chondral surface of an osteochondral allograft (OCA) from the underlying cancellous bone has been described as a mode of failure after implantation in the knee. Our hypothesis was that increased storage time of the OCA is associated with increased risk of graft delamination after implantation. Methods Prospective data on 13 patients with evidence of OCA delamination identified on magnetic resonance imaging or during subsequent surgery from 2000 to 2015 were reviewed. A cohort of 33 patients without evidence of graft delamination were then matched to the delamination group based on recipient age, sex, body mass index (BMI), and chondral defect location...
May 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29777422/patellofemoral-cartilage-repair
#2
REVIEW
Alexandre Barbieri Mestriner, Jakob Ackermann, Andreas H Gomoll
PURPOSE OF REVIEW: This review provides an overview of well-established and newly developed cartilage repair techniques for cartilage defects in the patellofemoral joint (PFJ). An algorithm will be presented for approaching cartilage defects considering the distinct anatomy of both the patellar and trochlear articular surfaces. RECENT FINDINGS: Recent studies on cartilage repair in the PFJ have demonstrated improved outcomes in an attempt to delay or obviate the need for arthroplasty, and improve symptoms in young patients...
May 18, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29768019/does-anterior-cruciate-ligament-reconstruction-affect-the-outcome-of-osteochondral-allograft-transplantation-a-matched-cohort-study-with-a-mean-follow-up-of-6-years
#3
Luís E P Tírico, Julie C McCauley, Pamela A Pulido, William D Bugbee
BACKGROUND: Few studies have evaluated the influence of anterior cruciate ligament (ACL) reconstruction on the outcome of cartilage repair. Hypothesis/Purpose: The purpose was to investigate the association between ACL reconstruction and functional outcomes after osteochondral allograft (OCA) transplantation. The hypothesis was that patients treated with OCA transplantation who had a history of ACL reconstruction would have inferior clinical outcomes and lower osteochondral graft survivorship when compared with a matched group of patients undergoing OCA transplantation without a history of ACL reconstruction...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29741957/effects-of-proud-large-osteochondral-plugs-on-contact-forces-and-knee-kinematics-a-robotic-study
#4
Peter Z Du, Keith L Markolf, Daniel V Boguszewski, Kent T Yamaguchi, Christopher J Lama, David R McAllister, Kristofer J Jones
BACKGROUND: Osteochondral allograft (OCA) transplantation is used to treat large focal femoral condylar articular cartilage defects. A proud plug could affect graft survival by altering contact forces (CFs) and knee kinematics. HYPOTHESIS: A proud OCA plug will significantly increase CF and significantly alter knee kinematics throughout controlled knee flexion. STUDY DESIGN: Controlled laboratory study. METHODS: Human cadaver knees had miniature load cells, each with a 20-mm-diameter cylinder of native bone/cartilage attached at its exact anatomic position, installed in both femoral condyles at standardized locations representative of clinical defects...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29697499/management-of-articular-cartilage-defects-in-the-glenohumeral-joint
#5
Adam J Seidl, Matthew J Kraeutler
Articular cartilage defects are not often encountered in the glenohumeral joint. These lesions are typically found in patients with shoulder trauma, recurrent instability, or previous surgical treatment. Diagnosis can be difficult; these defects are often found incidentally during arthroscopic or open surgical management of other pathology. Initial management of isolated glenohumeral chondral defects is nonsurgical and includes physical therapy and/or corticosteroid injections. If nonsurgical treatment is unsuccessful, patients may undergo surgery...
April 24, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29691831/osteochondral-tissue-engineering-translational-research-and-turning-research-into-products
#6
Victoria Spencer, Erica Illescas, Lorenzo Maltes, Hyun Kim, Vinayak Sathe, Syam Nukavarapu
Osteochondral (OC) defect repair is a significant clinical challenge. Osteoarthritis results in articular cartilage/subchondral bone tissue degeneration and tissue loss, which in the long run results in cartilage/ostecochondral defect formation. OC defects are commonly approached with autografts and allografts, and both these options have found limitations. Alternatively, tissue engineered strategies with biodegradable scaffolds with and without cells and growth factors have been developed. In order to approach regeneration of complex tissues such as osteochondral, advanced tissue engineered grafts including biphasic, triphasic, and gradient configurations are considered...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29675506/large-osteochondral-allografts-of-the-knee-surgical-technique-and-indications
#7
REVIEW
Gabriele Pisanu, Umberto Cottino, Federica Rosso, Davide Blonna, Antonio Giulio Marmotti, Corrado Bertolo, Roberto Rossi, Davide E Bonasia
Large osteochondral allograft (OCA) transplant has become a valid alternative to restore articular surface in challenging articular lesions in young and active patients, either in primary or in revision procedures. Several studies support the effectiveness and safety of OCA, but costs and graft availability limit their use. The indications are the treatment of symptomatic full-thickness cartilage lesions greater than 3 cm 2 , deep lesions with subchondral damage, or revision procedures when a previous treatment has failed...
March 2018: Joints
https://www.readbyqxmd.com/read/29669383/total-knee-arthroplasty-versus-osteochondral-allograft-prevalence-and-risk-factors-following-tibial-plateau-fractures
#8
Lasun O Oladeji, Tina K Dreger, Eli L Pratte, Charles A Baumann, James P Stannard, David A Volgas, Gregory J Della Rocca, Brett D Crist
Orthopaedic surgeons commonly have the misconception that patients with tibial plateau fractures will likely go on to posttraumatic knee arthritis requiring total knee arthroplasty (TKA). In younger patients, osteochondral allograft (OCA) transplantation is an alternative method to address posttraumatic knee arthritis. The purpose of this study was (1) to identify our institutional failure rate following tibial plateau open reduction and internal fixation (ORIF) (failure was defined as conversion to TKA or OCA); (2) to determine if there are patient- or injury-related risk factors predictive of failure; and (3) to characterize differences between patients treated with TKA versus those treated with OCA transplantation...
April 18, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29659379/bony-reconstruction-of-the-anterior-glenoid-rim
#9
Laurent B Willemot, Bassem T Elhassan, Olivier Verborgt
Recurrent anterior shoulder instability is associated with glenohumeral bone loss. Glenoid deficiency compromises the concavity-compression mechanism. Medial Hill-Sachs lesions can result in an off-track humeral position. Anterior glenoid reconstruction or augmentation prevents recurrence by addressing the pathomechanics. In Bristow and Latarjet procedures, the coracoid process is harvested for conjoint tendon transfer, capsular reinforcement, and glenoid rim restoration. Complications and the nonanatomic nature of the procedure have spurred research on graft sources...
May 15, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29619397/treatment-of-failed-articular-cartilage-reconstructive-procedures-of-the-knee-a-systematic-review
#10
REVIEW
Joseph D Lamplot, Kevin A Schafer, Matthew J Matava
Background: Symptomatic articular cartilage lesions of the knee are common and are being treated surgically with increasing frequency. While many studies have reported outcomes following a variety of cartilage restoration procedures, few have investigated outcomes of revision surgery after a failed attempt at cartilage repair or reconstruction. Purpose: To investigate outcomes of revision cartilage restoration procedures for symptomatic articular cartilage lesions of the knee following a previously failed cartilage reconstructive procedure...
March 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29600684/-current-advances-on-surgical-treatment-for-knee-articular-cartilage-injuries
#11
REVIEW
Long Xin, Chun Zhang, Wei-Xing Xu, Fu-Hua Zhong, Shun-Wu Fan, Zhen-Bin Wang
Chondral injuries are short of self-healing ability and need to surgical repair after articular cartilage injury. Conventional treatment includes debridement and drainage under arthroscope, micro-fracture, osteochondral autograft transplantation (OATS), mosaiplasty and osteochondral allografts (OCA), autologous chondrocyte implantation (ACI). Debridement and drainage could remove pain factor, and has advantages of simple operation, wide clinical application and early clinical effect. Micro-fracture and osteochondral autograft transplantation is suitable for small area of cartilage repair, while the further effect showed that fibrous cartilage permeated by drill could decrease postoperative clinical effect...
March 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29577591/effects-of-antigen-removal-on-a-porcine-osteochondral-xenograft-for-articular-cartilage-repair
#12
Steve Elder, Hudson Chenault, Paul Gloth, Katie Webb, Ruth Recinos, Emily Wright, Dalton Moran, James Butler, Abdolsamad Borazjani, Avery Cooley
Given the limited availability of fresh osteochondral allografts and uncertainty regarding performance of decellularized allografts, this study was undertaken as part of an effort to develop an osteochondral xenograft for articular cartilage repair. The purpose was to evaluate a simple antigen removal procedure based mainly on treatment with SDS and nucleases. Histology demonstrated a preservation of collagenous structure and removal of most nuclei. Immunohistochemistry revealed the apparent retention of α-Gal within osteocyte lacunae unless the tissue underwent an additional α-galactosidase processing step...
March 25, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29573913/fresh-osteochondral-allograft-transplantation-for-treatment-of-large-cartilage-defects-of-the-femoral-head-a-minimum-two-year-follow-up-study-of-twenty-two-patients
#13
Xin Y Mei, Ibrahim S Alshaygy, Oleg A Safir, Allan E Gross, Paul R Kuzyk
BACKGROUND: Controversy remains over the surgical management of large osteochondral lesions of the femoral head in young, active patients. The purpose of this study is to assess midterm clinical and radiographic outcomes after fresh osteochondral allograft transplantation (OAT) for large femoral head lesions at minimum 2-year follow-up. METHODS: A retrospective review of prospectively collected data was performed for 22 patients under the age of 50 years with defined femoral head osteochondral lesions who underwent fresh OAT between 2008 and 2015...
February 9, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29570765/effect-of-bisphosphonate-pretreatment-on-fresh-osteochondral-allografts-analysis-of-in-vitro-graft-structure-and-in-vivo-osseous-incorporation
#14
Drew D Moore, Kevin C Baker, Erin A Baker, Mackenzie M Fleischer, Michael D Newton, Nicholas Barreras, Zachary M Vaupel, Paul T Fortin
Fresh allograft transplantation of osteochondral defects restores functional articular cartilage and subchondral bone; however, rapid loss of chondrocyte viability during storage and osteoclast-mediated bone resorption at the graft-host interface after transplantation negatively impact outcomes. The authors present a pilot study evaluating the in vitro and in vivo impact of augmenting storage media with bisphosphonates. Forty cylindrical osteochondral cores were harvested from femoral condyles of human cadaveric specimens and immersed in either standard storage media or storage media supplemented with nitrogenated or non-nitrogenated bisphosphonates...
March 23, 2018: Orthopedics
https://www.readbyqxmd.com/read/29525030/knee-cartilage-repair-and-restoration-common-problems-and-solutions
#15
REVIEW
Kristina Linnea Welton, Stephanie Logterman, Justin H Bartley, Armando F Vidal, Eric C McCarty
Focal cartilage defects in the knee are commonly found on MRI and arthroscopically. When these lesions are symptomatic and fail nonoperative management several surgical strategies are available. Common surgical techniques include reparative (ie, microfracture) and restorative procedures (ie, autologous chondrocyte implantation, particulated juvenile allograft cartilage, osteochondral autograft transfer, and osteochondral allograft). Each of these surgical procedures have shared and novel complications associated with their use...
April 2018: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/29514363/comparison-of-techniques-for-preimplantation-treatment-of-osteochondral-allograft-bone
#16
Charles A Baumann, John R Baumann, Chantelle C Bozynski, Aaron M Stoker, James P Stannard, James L Cook
Articular defects are a major problem with few effective treatment options. Osteochondral allograft (OCA) transplantation can be an effective treatment; however, lack of OCA bone integration can cause failure. This controlled laboratory study was designed to compare clinically applicable methods for marrow element removal and enhanced delivery of bone marrow aspirate concentrate (BMC) to OCA bone. We hypothesized that compressed carbon dioxide (CO2 ) treatment of OCA bone would result in significantly better marrow element removal, significantly more retention and distribution of viable osteoprogenitor cells, and significantly higher osteoinductive protein elution from OCAs compared with other preimplantation treatments...
March 7, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29442213/elbow-injuries-in-the-adolescent-thrower
#17
REVIEW
Timothy B Griffith, James Kercher, S Clifton Willimon, Crystal Perkins, Xavier A Duralde
PURPOSE OF REVIEW: With an increasing rate of adolescent elbow injuries, especially in throwing athletes, the purpose of this review is to investigate the current literature regarding the diagnosis, treatment, and non-operative and operative outcomes of medial epicondyle fractures, ulnar collateral ligament repair, osteochondritis dissecans of the elbow, and olecranon stress fractures. RECENT FINDINGS: Acceptable outcomes with both non-operative and operative treatments of medial epicondyle fractures have been reported, with surgical indications continuing to evolve...
March 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29441429/three-dimensional-printing-improves-osteochondral-allograft-placement-in-complex-cases
#18
Kelechi R Okoroha, Timothy J Evans, Jeffrey P Stephens, Eric C Makhni, Vasilios Moutzouros
The use of three-dimensional (3D) printing has seen a vast expansion over recent years, with an increased application for its use in orthopaedics. This report details the use of 3D printing technology to aid in the treatment of a medial femoral condyle osteochondral defect in a 26-year-old female who had previously undergone a failed autograft procedure. A preoperative computed tomography scan of the knee and chondral defect was used to generate a 3D printed, one-to-one scale replica of the distal femur. This replica was then used to size a patient-specific allograft plug for the osteochondral transplantation procedure...
February 13, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29430397/multicompartmental-osteochondral-allografts-of-knee-and-concomitant-high-tibial-osteotomy
#19
Jonathan A Godin, Zaamin B Hussain, Anthony Sanchez, George Sanchez, Márcio B Ferrari, Mark E Cinque, Nicholas I Kennedy, Matthew T Provencher
Chondral lesions of the knee can occur secondary to limb malalignment. To address these interrelated problems, a high tibial osteotomy with concomitant osteochondral allograft transfer may be performed. It is important to address these chondral lesions as they often affect the young and active population and cause morbidity in an otherwise healthy population. Although numerous approaches for the treatment of chondral lesions have been described, long-term results demonstrating regeneration of hyaline cartilage have yet to be reported...
October 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29424234/osteochondral-allograft-transplantation-of-the-knee-in-patients-with-an-elevated-body-mass-index
#20
Dean Wang, Brian J Rebolledo, David M Dare, Mollyann D Pais, Matthew R Cohn, Kristofer J Jones, Riley J Williams
Objective To characterize the graft survivorship and clinical outcomes of osteochondral allograft transplantation (OCA) of the knee in patients with an elevated body mass index (BMI). Design Prospective data on 38 consecutive patients with a BMI ≥30 kg/m2 treated with OCA from 2000 to 2015 were reviewed. Complications, reoperations, and patient responses to validated outcome measures were examined. Failures were defined by any removal/revision of the allograft or conversion to arthroplasty. Results Thirty-one knees in 31 patients (mean age, 35...
February 1, 2018: Cartilage
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