keyword
MENU ▼
Read by QxMD icon Read
search

life cycle testing

keyword
https://www.readbyqxmd.com/read/28543963/ageing-is-associated-with-brown-adipose-tissue-remodelling-and-loss-of-white-fat-browning-in-female-c57bl-6-mice
#1
Leidyanne Ferreira Gonçalves, Thaissa Queiroz Machado, Camila Castro-Pinheiro, Nathalia Guimaraes de Souza, Karen Jesus Oliveira, Caroline Fernandes-Santos
Fat storage changes throughout life and affects body metabolism. Ageing impact on brown (BAT) and white adipose tissue (WAT) deserves attention, especially in females, because they are less prone to age-induced weight gain. While in male mice the impact of ageing on adipose tissue remodelling is well characterized, the effects in female mice remain largely unclear. Thus, we investigated BAT and WAT remodelling during ageing in female C57BL/6 mice. At 3 months, body weight was 24 ± 0.3 g (mean±SD), and it increased from 6 to 9 months of age (+20%, P < 0...
May 24, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28535762/gait-initiation-and-termination-strategies-in-patients-with-prader-willi-syndrome
#2
Veronica Cimolin, Nicola Cau, Manuela Galli, Cristina Santovito, Graziano Grugni, Paolo Capodaglio
BACKGROUND: Gait Initiation (GI) is a functional task representing one of the first voluntary destabilizing behaviours observed in the development of a locomotor pattern as the whole body centre of mass transitions from a large to a small base of support. Conversely, Gait Termination (GT) consists in the transition from walking to standing which, in everyday life, is a very common movement. Compared to normal walking, it requires higher control of postural stability. For a safe GT, the forward movement of the body has to be slowed down to achieve a stable upright position...
May 23, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28532427/microrna-275-and-its-target-vitellogenin-2-are-crucial-in-ovary-development-and-blood-digestion-of-haemaphysalis-longicornis
#3
Jiawei Hao, Jin Luo, Ze Chen, Qiaoyun Ren, Jinxia Guo, Xiaocui Liu, Qiuyu Chen, Feng Wu, Zhen Wang, Jianxun Luo, Hong Yin, Hui Wang, Guangyuan Liu
BACKGROUND: The hard tick Haemaphysalis longicornis is widely distributed in eastern Asia, New Zealand and Australia and is considered the major vector of Theileria and Babesia, harmful parasites to humans and animals. Female ticks need successful blood meals to complete the life-cycle. Therefore, elucidation of the underlying molecular mechanisms of H. longicornis development and reproduction is considered important for developing control strategies against the tick and tick-borne pathogens...
May 22, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28530540/novel-n-mustard-benzimidazoles-benzothiazoles-hybrids-synthesis-and-anticancer-evaluation
#4
Dilip P Detroja, Tai-Lin Chen, Yi-Wen Lin, Tsai-Yi Yen, Ming-Hsi Wu, Tung-Hu Tsai, Krunal Maheriya, Rajesh Kakadiya, Te-Chang Lee, Anamik Shah, Tsann-Long Su
BACKGROUND: Bendamustine, an N-mustard-benzoimidazole hybrid conjugate, was recently approved for the treatment of chronic lymphocytic leukemia. However, the short half-life of bendamustine may limit its clinical applications. OBJECTIVE: The purpose of this study is to design and synthesize compounds with a more favorable pharmacokinetic profile. METHODS: We synthesized a series of hybrid molecules comprising a phenyl N-mustard moiety and benzothiazole or benzimidazole scaffold linked via an ureido linker and evaluated their antitumor activity and plasma stability...
May 22, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28527785/the-effectiveness-of-a-fixed-dose-combination-pour-on-formulation-of-1-25-fipronil-and-2-5-fluazuron-against-economically-important-ectoparasites-and-associated-pharmacokinetics-in-cattle
#5
Welber Daniel Zanetti Lopes, Rafael Marin Chiummo, Luis Fernando Vettorato, Daniel de Castro Rodrigues, Rafael Bazaglia Sonada
The present work consisted of eight studies to evaluate the ectoparasiticidal spectrum and determine the pharmacokinetic parameters of a pour-on combination of fipronil 1.25mg/kg+fluazuron 2.5mg/kg for cattle against Rhipicephalus microplus, Haematobia irritans and the larvae of Dermatobia hominis and Cochliomyia hominivorax. The analysis fipronil and fluazuron were performed by liquid chromatography using a mass detector for the detection and quantification of analytes (LC-MS/MS). Additionally, in two of these studies, the animals were artificially infested with R...
May 17, 2017: Parasitology International
https://www.readbyqxmd.com/read/28521532/new-antivirals-for-the-treatment-of-chronic-hepatitis-b
#6
Vincent Soriano, Pablo Barreiro, Laura Benitez, Jose M Peña, Carmen de Mendoza
Current treatment with oral nucleos(t)ides entecavir or tenofovir provide sustained suppression of HBV replication and clinical benefit in most chronic hepatitis B virus (HBV) infected persons. However, HBV rebound generally occurs upon drug discontinuation due to persistence of genomic HBV reservoirs as episomic cccDNA and chromosomic integrated HBV-DNA. There is renewed enthusiasm on HBV drug discovery following recent successes with antivirals for hepatitis C and immunotherapies for some cancers. Areas covered: New drugs that target distinct steps of the HBV life cycle are been developed, including inhibitors of viral entry, new polymerase inhibitors, capsid and assembly inhibitors, virus release blockers, and disruptors of cccDNA formation and transcription...
May 18, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28518406/host-density-increases-parasite-recruitment-but-decreases-host-risk-in-a-snail-trematode-system
#7
J C Buck, R F Hechinger, A C Wood, T E Stewart, A M Kuris, K D Lafferty
Most species aggregate in local patches. High host density in patches increases contact rate between hosts and parasites, increasing parasite transmission success. At the same time, for environmentally-transmitted parasites, high host density can decrease infection risk to individual hosts, because infective stages are divided among all hosts in a patch, leading to safety in numbers. We tested these predictions using the California horn snail, Cerithideopsis californica (=Cerithidea californica), which is the first intermediate host for at least 19 digenean trematode species in California estuaries...
May 18, 2017: Ecology
https://www.readbyqxmd.com/read/28516834/comparison-of-antemortem-and-environmental-samples-for-zebrafish-health-monitoring-and-quarantine
#8
Marcus J Crim, Christian Lawrence, Robert S Livingston, Andrei Rakitin, Shane J Hurley, Lela K Riley
Molecular diagnostic assays offer both exquisite sensitivity and the ability to test a wide variety of sample types. Varioustypes of environmental sample, such as detritus and concentrated water, might provide a useful adjunct to sentinels in routinezebrafish health monitoring. Similarly, antemortem sampling would be advantageous for expediting zebrafish quarantine,without euthanasia of valuable fish. We evaluated the detection of Mycobacterium chelonae, M. fortuitum, M. peregrinum,Pseudocapillaria tomentosa, and Pseudoloma neurophilia in zebrafish, detritus, pooled feces, and filter membranes after filtration of 1000-, 500-, and 150-mL water samples by real-time PCR analysis...
May 17, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28507164/reliability-of-low-power-cycling-efficiency-in-energy-expenditure-phenotyping-of-inactive-men-and-women
#9
Elie-Jacques Fares, Laurie Isacco, Cathriona R Monnard, Jennifer L Miles-Chan, Jean-Pierre Montani, Yves Schutz, Abdul G Dulloo
Standardized approaches to assess human energy expenditure (EE) are well defined at rest and at moderate to high-intensity exercise, but not at light intensity physical activities energetically comparable with those of daily life (i.e., 1.5-4 times the resting EE, i.e., 1.5-4 METs). Our aim was to validate a graded exercise test for assessing the energy cost of low-intensity dynamic work in physically inactive humans, that is, those who habitually do not meet the guidelines for moderate-to-vigorous aerobic physical activity levels...
May 2017: Physiological Reports
https://www.readbyqxmd.com/read/28505574/the-effect-of-insecticides-chlorpyrifos-%C3%AE-cypermethrin-and-imidacloprid-on-primary-dna-damage-tp-53-and-c-myc-structural-integrity-by-comet-fish-assay
#10
Davor Zeljezic, Benjamin Vinkovic, Vilena Kasuba, Nevenka Kopjar, Mirta Milic, Marin Mladinic
In parallel with the continuous use of conventional insecticides, introduction of more environmentally friendly substances continues to grow in modern agriculture. In the present study, we evaluated chlorpyrifos, and imidacloprid and α-cypermethrin as two representatives of green insecticides for their genotoxic activity. We conducted a 14-day treatment in extended human lymphocytes cultures using real life exposure relevant concentrations. An alkaline comet assay was used to detect primary DNA damage. Simultaneously, the effect on the specific action towards the TP 53 and c-Myc genes in terms of fragmentation and copy number were determined...
May 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28505375/between-a-pod-and-a-hard-test-the-deep-evolution-of-amoebae
#11
Seungho Kang, Alexander K Tice, Frederick W Spiegel, Jeffrey D Silberman, Tomáš Pánek, Ivan Cepicka, Martin Kostka, Anush Kosakyan, Daniel M Alcântara, Andrew J Roger, Lora L Shadwick, Alexey Smirnov, Alexander Kudryavstev, Daniel J G Lahr, Matthew W Brown
Amoebozoa is the eukaryotic supergroup sister to Obazoa, the lineage that contains the animals and Fungi, as well as their protistan relatives, and the breviate and apusomonad flagellates. Amoebozoa is extraordinarily diverse, encompassing important model organisms and significant pathogens. Although amoebozoans are integral to global nutrient cycles and present in nearly all environments, they remain vastly understudied. We present a robust phylogeny of Amoebozoa based on broad representative set of taxa in a phylogenomic framework (325 genes)...
May 15, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28504670/longevity-of-major-coenzymes-allows-minimal-de-novo-synthesis-in-microorganisms
#12
Johannes Hartl, Patrick Kiefer, Fabian Meyer, Julia A Vorholt
Coenzymes are vital for cellular metabolism and act on the full spectrum of enzymatic reactions. Intrinsic chemical reactivity, enzyme promiscuity and high flux through their catalytic cycles make coenzymes prone to damage. To counteract such compromising factors and ensure stable levels of functional coenzymes, cells use a complex interplay between de novo synthesis, salvage, repair and degradation. However, the relative contribution of these factors is currently unknown, as is the overall stability of coenzymes in the cell...
May 15, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28500775/vaccines-against-malaria-still-a-long-way-to-go
#13
REVIEW
Kai Matuschewski
Several species of Plasmodium cause a broad spectrum of human disease that range from nausea and fever to severe anemia, cerebral malaria, and multi-organ failure. In malaria-endemic countries continuous exposure to Plasmodium sporozoite inoculations and subsequent blood infections elicit only partial and short-lived immunity, which gradually develops over many years of parasite exposure and multiple clinical episodes. The ambitious goal of malaria vaccinology over the past 70 years has been to develop an immunization strategy that mounts protection superior to naturally acquired immunity...
May 13, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28499032/development-of-a-new-tool-for-systematic-observation-of-nursing-home-resident-and-staff-engagement-and-relationship
#14
A Lynn Snow, M Lindsey Jacobs, Jennifer A Palmer, Patricia A Parmelee, Rebecca S Allen, Nancy J Wewiorski, Michelle M Hilgeman, Latrice D Vinson, Dan R Berlowitz, Anne D Halli-Tierney, Christine W Hartmann
Purpose of Study: To develop a structured observational tool, the Resident-centered Assessment of Interactions with Staff and Engagement tool (RAISE), to measure 2 critical, multi-faceted, organizational-level aspects of person-centered care (PCC) in nursing homes: (a) resident engagement and (b) the quality and frequency of staff-resident interactions. Design and Methods: In this multi-method psychometric development study, we conducted (a) 120 hr of ethnographic observations in one nursing home and (b) a targeted literature review to enable construct development...
May 11, 2017: Gerontologist
https://www.readbyqxmd.com/read/28493897/characterization-of-a-bvg-regulated-fatty-acid-methyl-transferase-in-bordetella-pertussis
#15
Alex Rivera-Millot, Elodie Lesne, Luis Solans, Loic Coutte, Justine Bertrand-Michel, Philippe Froguel, Véronique Dhennin, David Hot, Camille Locht, Rudy Antoine, Françoise Jacob-Dubuisson
The whooping cough agent Bordetella pertussis controls the expression of its large virulence regulon in a coordinated manner through the two-component signal transduction system BvgAS. In addition to the genes coding for bona fide virulence factors, the Bvg regulon comprises genes of unknown function. In this work, we characterized a new Bvg-activated gene called BP2936. Homologs of BP2936 are found in other pathogenic Bordetellae and in several other species, including plant pathogens and environmental bacteria...
2017: PloS One
https://www.readbyqxmd.com/read/28493143/differences-in-the-importance-of-weather-and-weather-based-decisions-among-campers-in-ontario-parks-canada
#16
Micah J Hewer, Daniel J Scott, William A Gough
Parks and protected areas represent an important resource for tourism in Canada, in which camping is a common recreational activity. The important relationship between weather and climate with recreation and tourism has been widely acknowledged within the academic literature. Howbeit, the need for activity-specific assessments has been identified as an on-going need for future research in the field of tourism climatology. Furthermore, very little is known about the interrelationships between personal characteristics and socio-demographics with weather preferences and behavioural thresholds...
May 10, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28488336/hazard-assessment-of-nickel-nanoparticles-in-soil-the-use-of-a-full-life-cycle-test-with-enchytraeus-crypticus
#17
Fátima C F Santos, Susana I L Gomes, Janeck J Scott-Fordsmand, Valéria Freitas Mónica J B
Nanoparticles (NPs) such as nickel (Ni) are widely used in several applications. Nevertheless the environmental effects of NiNPs are still poorly understood. In the present study, the toxicity of NiNPs and NiNO3 was assessed using the standard test species in soil ecotoxicology Enchytraeus crypticus (Oligochaeta) in a Full Life Cycle test, adding the endpoints hatching, growth and time to reach maturity, besides survival and reproduction as in the standard OECD Guideline 220 and/or ISO 16387. Overall, NiNO3 was more toxic than NiNPs and toxicity seemed to occur via different mechanisms...
May 10, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28485975/binder-free-n-and-o-rich-carbon-nanofiber-anodes-for-long-cycle-life-k-ion-batteries
#18
Ryan A Adams, Jia-Min Syu, Yunpu Zhao, Chieh-Tsung Lo, Arvind Varma, Vilas G Pol
Carbon nanofibers produced by electrospinning of polyacrylonitrile polymer and subsequent carbonization were tested as freestanding potassium-ion anodes. The effect of oxygen functionalization on K-ion carbon anode performance was tested for the first time via plasma oxidation of prepared carbon nanofibers. The produced materials exhibited exceptional cycling stability through the amorphous carbon structuring and 1-dimensional architecture accommodating significant material expansion upon K+ intercalation, resulting in a stable capacity of 170 mAh g-1 after 1900 cycles at 1C rate for N-rich carbon nanofibers...
May 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28480095/the-effect-of-lavender-aromatherapy-on-the-pain-severity-of-primary-dysmenorrhea-a-triple-blind-randomized-clinical-trial
#19
R Nikjou, R Kazemzadeh, M Rostamnegad, S Moshfegi, M Karimollahi, H Salehi
BACKGROUND: Primary dysmenorrhea is the most common complaint in adolescents and adult young women that disturbs their daily life performance. AIM: The current study investigated the effect of lavender aromatherapy on pain severity in primary dysmenorrhea. SUBJECTS AND METHODS: This triple-blind randomized clinical trial was conducted on 200 students of Ardabil University of Medical Sciences, Iran. Subjects were allocated randomly into intervention (lavender) and control (placebo) groups...
July 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28476464/environmental-temperature-drastically-affects-flexural-fatigue-resistance-of-nickel-titanium-rotary-files
#20
Nicola Maria Grande, Gianluca Plotino, Enrico Silla, Eugenio Pedullà, Gustavo DeDeus, Gianluca Gambarini, Francesco Somma
INTRODUCTION: The aim of the present study was to analyze how a low environmental temperature can affect the fatigue life of instruments made by different types of heat-treated nickel-titanium alloys. METHODS: The flexural cyclic fatigue of 40 new specimens for each of the following systems was tested for cyclic fatigue resistance: ProTaper Universal F2 (Dentsply Maillefer, Ballaigues, Switzerland), ProTaper Gold F2 (Dentsply Tulsa Dental Specialties, Tulsa, OK), Twisted Files SM2 (SybronEndo, Orange, CA), Mtwo #25...
May 2, 2017: Journal of Endodontics
keyword
keyword
54457
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"