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Sai Prachetan Balguri, Goutham R Adelli, Karthik Yadav Janga, Prakash Bhagav, Soumyajit Majumdar
Ciprofloxacin (CIP) is an antibacterial agent prescribed for the treatment of ocular infections. The objective of the present project is to investigate the effect of surface PEG functionalization of the Nano structured lipid carriers (NLCs) on formulation stability, ocular penetration and distribution. CIP NLCs were tested with different molecular weight (poly ethylene glycol) PEGs ranging from (2K to 20K) grafted onto the phospholipid and with different chain lengths (14-18 carbons) of phospholipids derivatized with PEG-2K...
June 17, 2017: International Journal of Pharmaceutics
Gang-Gang Chong, Yu-Cai He, Qiu-Xiang Liu, Xiao-Qin Kou, Xiao-Jun Huang, Jun-Hua Di, Cui-Luan Ma
In this study, dilute alkali salts (0.6% NaClO, 0.067% Na2S) pretreatment at 10% sulfidity under the autoclave system at 120°C for 40min was used for pretreating bamboo shoot shell (BSS). Furthermore, FT-IR, XRD and SEM were employed to characterize the changes in the cellulose structural characteristics (porosity, morphology, and crystallinity) of the pretreated BSS solid residue. After 72h, the reducing sugars and glucose from the enzymatic in situ hydrolysis of 50g/L pretreated BSS in dilute NaClO/Na2S media could be obtained at 31...
June 1, 2017: Bioresource Technology
Alberto Biavati, Michele Poncini, Arianna Ferrarini, Nicola Favaro, Martina Scarpa, Marta Vallotto
Among the factors that affect the glass surface chemical durability, pH and complexing agents presence in aqueous solution have the main role (1). Glass surface attack can be also related to the delamination issue with glass particles appearance in the pharmaceutical preparation. A few methods to check for glass containers delamination propensity and some control guidelines have been proposed (2,3). The present study emphasizes the possible synergy between a few complexing agents with pH on the borosilicate glass chemical durability...
June 16, 2017: PDA Journal of Pharmaceutical Science and Technology
Laiane Teixeira Sousa Moura, Domenica Palomaris Mariano Souza, Simone Mendonça, José Antônio de Aquino Ribeiro, Luciano Fernandes Sousa, Adriano Tony Ramos, Paulo César Maiorka, Vera Lúcia de Araújo, Viviane Mayumi Maruo
Jatropha curcas cake, a by-product of biodiesel production, is rich in protein and has potential to be used in livestock feed; however, the presence of antinutritional factors and phorbol esters limits its use. Thus, this study investigated toxicological and reproductive effects in male Wistar rats after subchronic exposure to J. curcas cake subjected to detoxification procedures. Rats were divided into seven groups (n = 10) and treated for 60 days. The control group received commercial feed, while experimental groups received a diet containing 5% J...
2017: BioMed Research International
Matheus Albino Souza, Guilherme Lima, Bianca Pazinatto, Karolina Frick Bischoff, Huriel Scartazzini Palhano, Doglas Cecchin
INTRODUCTION: The aim of the present study was to evaluate, in vitro, the influence of the addition of chlorhexidine to photosensitiser in the antimicrobial activity of photodynamic therapy in root canals infected by Enterococcus faecalis. METHODS: the root canals of 50 single-rooted human extracted teeth were enlarged up to a file F3 of Pro-Taper system, autoclaved, inoculated with Enterococcus faecalis and incubated for 14 days. The samples were divided into five groups (n=10) according to the protocol of decontamination: G1 (control group) - no procedure was performed; G2-photosensitiser (0...
June 12, 2017: Photodiagnosis and Photodynamic Therapy
Agnieszka Bus, Agnieszka Karczmarczyk
The research investigated the implementation of suspended reactive filters to support the phosphorus (P) removal efficiency of constructed wetlands (CWs). The reactive material (RM) used in this study was autoclaved aerated concrete (AAC). The laboratory experiment consists of four plastic boxes filled with the volume of 10 L of artificial P solution with three variants of RM mass to volume ratio: 1:1 (g:L), 5:1 (g:L), 10:1 (g:L), and the blind probe 0:1 (g:L) as a reference. AAC of different weights (10, 50 and 100 g) was wrapped in a filter bag, put into boxes, and suspended...
June 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Rameez Ahmad Mir, Piyush Sharma, Om Prakash Pandey
Carbon coated nano molybdenum carbide (Mo2C) has been synthesized at 800 °C through single step reduction route using molybdenum trioxide (MoO3) as a precursor, polypropylene (P.P) as a carbon source and magnesium (Mg) as a catalyst in an autoclave. The synthesized samples were characterized by X-ray diffraction (XRD), thermal analysis techniques (TG/DTA/DTG), field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). Williamson- Hall (W-H) analysis has been done to estimate various parameters like strain, stress and strain energy density...
June 14, 2017: Scientific Reports
Boyang Liu, Yingfeng Shao, Xin Xiang, Fuhua Zhang, Shengchang Yan, Wenge Li
Carbon encapsulated various nanocrystals, including MnS and MnO, Cr2O3, MoO2, Fe7S8 and Fe3O4, ZrO2, are one-step in-situ prepared by a common and simple synthesis approach, respectively. The nanocrystals have an equiaxed morphology and a median size smaller than 30 nm. Tens and hundreds of these nanocrystals are entirely encapsulated by the worm-like amorphous carbon shell. The formation of core-shell structure depends on the strongly exothermic reaction of metal π-complexes with ammonium persulfate in an autoclave below 200 oC...
June 14, 2017: Nanotechnology
Lu Fan, Michael T Brett, Wenju Jiang, Bo Li
The objective of this study was to determine the composition of nitrogen (N) in the effluents of advanced N removal (ANR) wastewater treatment plants (WWTPs). This study also tested two different experimental protocols for determining dissolved N recalcitrance. An analysis of 15 effluent samples from five WWTPs, showed effluent concentrations and especially effluent composition varied greatly from one system to the other, with total nitrogen (TN) ranging between 1.05 and 8.10 mg L(-1). Nitrate (NO3(-)) accounted for between 38 ± 32% of TN, and ammonium accounted for a further 29 ± 28%...
June 7, 2017: Environmental Pollution
Cong-Xiao Cao, Jiayin Yuan, Jin-Pei Cheng, Bao-Hang Han
The unusually broad physical and chemical property window of ionic liquids allows for a wide range of applications, which gives rise to the recent spring-up of ionic liquid-based functional materials. Via solvothermal copolymerization of a monomeric ionic liquid and divinylbenzene in the presence of a tissue paper in autoclave, we fabricated a flexible porous polymer/paper hybrid membrane. The surface areas of the hybrid membranes depend on the weight fraction of the copolymer impregnated inside the tissue paper...
June 8, 2017: Scientific Reports
Eduardo Mariscal Muñoz, Diogo Longhini, Selma Gutierres Antonio, Gelson Luis Adabo
OBJECTIVES: To evaluate the effect of hydrothermal aging (H), mechanical cycling (M), and the combination of hydrothermal plus mechanical cycling (H+M) on biaxial flexural strength (BFS) and microstructure of two monolithic zirconias, indicated for anterior (AMZ) or posterior restorations (PMZ) and a conventional zirconia (IZr). METHODS: Disc specimens of each material (n=12) were submitted to: i) H (8hours in autoclave at 134°C); ii) M (10(6) cycles, at 40% of BFS); and iii) H+M...
June 4, 2017: Journal of Dentistry
Hera Karayanni, Alexandra Meziti, Sofie Spatharis, Savvas Genitsaris, Claude Courties, Konstantinos A Kormas
Microbes are considered to have a global distribution due to their high dispersal capabilities. However, our knowledge of the way geographically distant microbial communities assemble after dispersal in a new environment is limited. In this study, we examined whether communities would converge because similar taxa would be selected under the same environmental conditions, or would diverge because of initial community composition, after artificial dispersal. To this aim, a microcosm experiment was performed, in which the temporal changes in the composition and diversity of different prokaryoplankton assemblages from three distant geographic coastal areas (Banyuls-sur-Mer in northwest Mediterranean Sea, Pagasitikos Gulf in northeast Mediterranean and Woods Hole, MA, USA in the northwest Atlantic), were studied...
June 3, 2017: Microorganisms
Vânia Mayumi Nakajima, Tais Moala, Cintia Rabelo E Paiva Caria, Carolina Soares Moura, Jaime Amaya-Farfan, Alessandra Gambero, Gabriela Alves Macedo, Juliana Alves Macedo
Chronic non-communicable diseases such as obesity are preceded by increased macrophage infiltration in adipose tissue and greater secretion of pro-inflammatory cytokines. We evaluated the anti-inflammatory potential of Biotransformed extract, and two control extracts: In Natura and Autoclaved. The assays were performed using a cellular model with RAW264.7, 3T3-L1 cells, and RAW264.7 and 3T3-L1 co-culture. The innovation of the study was the use of Biotransformed extract, a unique phenolic extract of a bioprocessed citrus residue...
July 2017: Food Research International
Sarah A Bradner, Benjamin P Partlow, Peggy Cebe, Fiorenzo G Omenetto, David L Kaplan
Methods to generate fibers from hydrogels, with control over mechanical properties, fiber diameter and crystallinity, while retaining cytocompatibility and degradability, would expand options for biomaterials. Here we exploited features of silk fibroin protein for the formation of tunable silk hydrogel fibers. The biological, chemical, and morphological features inherent to silk were combined with elastomeric properties gained through enzymatic crosslinking of the protein. Post-processing via methanol and autoclaving provided tunable control of fiber features...
May 27, 2017: Biopolymers
Ana Rey-Rico, Heiko Babicz, Henning Madry, Angel Concheiro, Carmen Alvarez-Lorenzo, Magali Cucchiarini
The aim of this work was to investigate, for the first time, the possibility of using supramolecular polypseudorotaxane gels as scaffolds that can durably deliver rAAV vectors for applications in cartilage regeneration. Dispersions of Pluronic(®) F68 (PF68) or Tetronic(®) 908 (T908) containing either hyaluronic acid (HA) or chondroitin sulfate (CS) were prepared in PBS. Then, alpha-cyclodextrin (αCD) was added to some dispersions to form polypseudorotaxane gels. Polysaccharides and αCD reinforced the viscoelasticity of the gels, which could withstand autoclaving without changes...
May 25, 2017: International Journal of Pharmaceutics
Sanela M Đorđević, Anja Santrač, Nebojša D Cekić, Bojan D Marković, Branka Divović, Tanja M Ilić, Miroslav M Savić, Snežana D Savić
This work aimed to deepen the lately acquired knowledge about parenteral nanoemulsions as carriers for brain delivery of risperidone, a poorly water-soluble antipsychotic drug, through establishing the prospective relationship between their physicochemical, pharmacokinetic, biodistribution, and behavioral performances. For this purpose, two optimized risperidone-loaded nanoemulsions, stabilized by lecithin or lecithin/polysorbate 80 mixture, and costabilized by sodium oleate, were produced by high-pressure homogenization...
May 25, 2017: International Journal of Pharmaceutics
Yeji Kam, Mina Sung, Hoon Cho, Chang-Min Kang, Jungmin Kim, Jong-In Han
Starch-enriched brewery waste (SBW), an unexplored feedstock, was investigated as a nutritious low-cost source for the mixotrophic cultivation of Ettlia sp. YC001 for biodiesel production. Stirring, autoclaving, and sonication were assessed for the SBW, in conjunction with pH. Stirring at 55 °C was found to be the best, in terms of the effectiveness of starch hydrolysis and yeast disintegration as well as cost. The treated solutions were found to support the mixotrophic growth of microalgae: 20 g/L of glucose medium resulted in the highest biomass production of 9...
May 27, 2017: Applied Biochemistry and Biotechnology
Thiago L Marques, Helmar Wiltsche, Joaquim A Nóbrega, Monika Winkler, Günter Knapp
Acid digestion is usually required for metal determination in food samples. However, this step is usually performed in batch mode which is time consuming, labor intensive, and may lead to sample contamination. Flow digestion can overcome these limitations. In this work, the performance of a high-pressure microwave-assisted flow digestion system with a large volume reactor was evaluated for liquid samples high in sugar and fat (fruit juice and milk). The digestions were carried out in a coiled perfluoroalkoxy (PFA) tube reactor (13...
May 26, 2017: Analytical and Bioanalytical Chemistry
Mohammed M Gad, Shaimaa M Fouda, Aws S ArRejaie, Ahmad M Al-Thobity
PURPOSE: Polymerization techniques have been modified to improve physical and mechanical properties of polymethylmethacrylate (PMMA) denture base, as have the laboratory procedures that facilitate denture construction techniques. The purpose of the present study was to investigate the effect of autoclave polymerization on flexural strength, elastic modulus, surface roughness, and the hardness of PMMA denture base resins. MATERIALS AND METHODS: Major Base and Vertex Implacryl heat-polymerized acrylic resins were used to fabricate 180 specimens...
May 22, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
S C Deogade, S S Mantri, S Saxena, K Sumathi
BACKGROUND: Dental undergraduate students work on extracted human teeth in preclinical practical's to learn technical skills before entering the clinics and delivering dental care to the patients. AIM: The aim of the present investigation was to assess the awareness and knowledge toward sterilization/disinfection methods of extracted human teeth in a selected group of Indian dental students. MATERIALS AND METHODS: In this descriptive cross-sectional study, the participants consisted of 2(nd)-, 3(rd)-, 4(th)-, and 5(th)-year dental students...
November 2016: Annals of Medical and Health Sciences Research
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