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https://www.readbyqxmd.com/read/29769782/graft-versus-host-disease-presenting-as-fibrosing-alopecia-in-a-pattern-distribution-a-model-for-pathophysiological-understanding-of-cicatricial-pattern-hair-loss
#1
Hudson Dutra Rezende, Maria Fernanda Reis Gavazzoni Dias, Ralph Michel Trüeb
A case of cutaneous graft versus host disease (GvHD) presenting as fibrosing alopecia in a pattern distribution (FAPD) is discussed, possibly providing a mechanistic model for a better understanding of the pathogenic events underlying cicatricial pattern hair loss. The implication of a follicular inflammation and fibrosis associated with patterned hair loss has emerged from several independent studies. Eventually, Zinkernagel and Trüeb reported a peculiar type of cicatricial pattern hair loss with histopathological features consistent with lichen planopilaris (LPP) associated with androgenetic alopecia (AGA)...
March 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29769090/comparing-morbidities-of-bone-graft-harvesting-from-the-anterior-iliac-crest-and-proximal-tibia-a-retrospective-study
#2
Ying-Cheng Huang, Chun-Yu Chen, Kai-Cheng Lin, Jenn-Huei Renn, Yih-Wen Tarng, Chien-Jen Hsu, Wei-Ning Chang, Shan-Wei Yang
BACKGROUND: The anterior iliac crest (AIC) and proximal tibia (PT) are common donor sites for autologous bone graft harvesting. We compared pain levels at these harvest sites on 1 day, 5 days, 2 weeks, 4 weeks, and 8 weeks post-harvest. METHODS: We retrospectively reviewed 18 patients undergoing autologous bone grafting surgery at a level I trauma center between June 2013 and October 2014. Ten grafts were harvested from the AIC group and eight from the PT group...
May 16, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29768340/the-patient-general-satisfaction-of-mandibular-single-implant-overdentures-and-conventional-complete-dentures-study-protocol-for-a-randomized-crossover-trial
#3
Manabu Kanazawa, Mariko Tanoue, Anna Miyayasu, Shin Takeshita, Daisuke Sato, Mari Asami, Thuy Vo Lam, Khaing Myat Thu, Ken Oda, Yuriko Komagamine, Shunsuke Minakuchi, Jocelyne Feine
BACKGROUND: Mandibular overdentures retained by a single implant placed in the midline of edentulous mandible have been reported to be more comfortable and function better than complete dentures. Although single-implant overdentures are still more costly than conventional complete dentures, there are a few studies which investigated whether mandibular single-implant overdentures are superior to complete dentures when patient general satisfaction is compared. The aim of this study is to assess patient general satisfaction with mandibular single-implant overdentures and complete dentures...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29765210/percutaneous-kyphoplasty-combined-with-zoledronic-acid-infusion-in-the-treatment-of-osteoporotic-thoracolumbar-fractures-in-the-elderly
#4
Chen Shi, Mi Zhang, An-Yuan Cheng, Zi-Feng Huang
Objective: We studied the efficacy of zoledronic acid (ZOL) infusion on radiographic and clinical outcomes after percutaneous kyphoplasty (PKP) for elderly patients with osteoporotic thoracolumbar fractures (osteoporotic vertebral compression fractures [OVCFs]). Materials and methods: We retrospectively analyzed 95 elderly patients (age >65 years) with OVCF. All patients were followed up for 2 years. Thirty-two patients were treated with only once-yearly 5 mg ZOL infusion (ZOL group), 34 patients with only PKP (PKP group) and 29 patients received ZOL infusion 3 days after PKP (PKP+ZOL group)...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29764470/joint-preserving-palliative-surgery-using-self-locking-screws-of-intramedullary-nail-and-percutaneous-cementoplasty-for-proximal-humeral-metastasis-in-the-advanced-cancer-patients
#5
Jong Woong Park, Yong-Il Kim, Hyun Guy Kang, June Hyuk Kim, Han Soo Kim
BACKGROUND: We introduced a palliative joint-preserving surgery using proximal self-locking screws of intramedullary (IM) nail and percutaneous cementoplasty (PC) in patients with proximal humeral metastases, including the head and neck, and evaluated the outcome of the surgical method. METHODS: Twenty-three patients (mean age = 63.0 ± 11.8 years, M:F = 14:9) had IM nailing with a self-locking screw system and PC for the treatment of humeral head and neck metastases...
May 15, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29757601/fluorescence-detection-of-bone-microcracks-using-monophosphonated-carbon-dots
#6
Fatemeh Ostadhossein, Lily Benig, Indu Tripathi, Santosh K Misra, Dipanjan Pan
Phosphonated compounds, in particular, bis-analogs are widely applied in clinical settings for the treatment of severe bone turnovers and recently as imaging probes when conjugated with organic fluorophores. Herein, we introduce a bone seeking luminescent probe that shows high binding affinity towards bone minerals based on monophosphonated carbon dots (CDs). The spheroidal CDs tethered with PEG monophosphates are synthesized in a one pot hydrothermal method and are physico-chemically characterized where the retention of phosphonates is confirmed by 13P NMR and XPS...
May 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29757436/continuous-pth-in-male-mice-causes-bone-loss-because-it-induces-serum-amyloid-a-saa
#7
Shilpa Choudhary, Elizabeth Santone, Yee Sui-Pok, Joseph Lorenzo, Douglas J Adams, Alexandra Goetjen, Mary Beth McCarthy, Augustus D Mazzocca, Carol Pilbeam
Increased bone resorption is considered to explain why intermittent PTH is anabolic for bone but continuous PTH is catabolic. However, when cyclooxygenase-2 (COX2) is absent in mice, continuous PTH becomes anabolic without decreased resorption. In murine bone marrow stromal cells (BMSCs), SAA3, induced in the hematopoietic lineage by the combination of COX2-produced prostaglandin and receptor activator of nuclear factor-κB ligand (RANKL), suppresses PTH-stimulated osteoblast differentiation. To determine if SAA3 inhibits the anabolic effects of PTH in vivo, wild-type (WT) and SAA3 knockout (KO) mice were infused with PTH...
May 10, 2018: Endocrinology
https://www.readbyqxmd.com/read/29753413/development-of-a-step-down-method-for-altering-male-c57bl-6-mouse-housing-density-and-hierarchical-structure-preparations-for-spaceflight-studies
#8
David C Scofield, Jeffrey D Rytlewski, Paul Childress, Kishan Shah, Aamir Tucker, Faisal Khan, Jessica Peveler, Ding Li, Todd O McKinley, Tien-Min G Chu, Debra L Hickman, Melissa A Kacena
This study was initiated as a component of a larger undertaking designed to study bone healing in microgravity aboard the International Space Station (ISS). Spaceflight experimentation introduces multiple challenges not seen in ground studies, especially with regard to physical space, limited resources, and inability to easily reproduce results. Together, these can lead to diminished statistical power and increased risk of failure. It is because of the limited space, and need for improved statistical power by increasing sample size over historical numbers, NASA studies involving mice require housing mice at densities higher than recommended in the Guide for the Care and Use of Laboratory Animals (National Research Council, 2011)...
May 2018: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29752687/a-phase-ii-study-evaluating-the-efficacy-of-zoledronic-acid-in-prevention-of-aromatase-inhibitor-associated-musculoskeletal-symptoms-the-zap-trial
#9
Cesar A Santa-Maria, Aditya Bardia, Amanda L Blackford, Claire Snyder, Roisin M Connolly, John H Fetting, Daniel F Hayes, Stacie C Jeter, Robert S Miller, Anne Nguyen, Katie Quinlan, Gary L Rosner, Shannon Slater, Anna Maria Storniolo, Antonio C Wolff, Jane Zorzi, Nora Lynn Henry, Vered Stearns
PURPOSE: Aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) are common adverse events of AIs often leading to drug discontinuation. We initiated a prospective clinical trial to evaluate whether bisphosphonates are associated with reduced incidence of AIMSS. METHODS: In the single-arm trial, the Zoledronic Acid Prophylaxis (ZAP) trial, we compared the incidence of AIMSS against historical controls from the Exemestane and Letrozole Pharmacogenomics (ELPh) trial...
May 11, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29749729/redox-active-vs-redox-innocent-a-comparison-of-uranium-complexes-containing-diamine-ligands
#10
Scott A Pattenaude, Kimberly C Mullane, Eric J Schelter, Maryline G Ferrier, Benjamin W Stein, Sharon E Bone, Juan S Lezama Pacheco, Stosh A Kozimor, Phillip E Fanwick, Matthias Zeller, Suzanne C Bart
Uranium complexes (Mes DAE)2 U(THF) (1-DAE) and Cp2 U(Mes DAE) (2-DAE) (Mes DAE = [ArN-CH2 CH2 -NAr]; Ar = 2,4,6-trimethylphenyl (Mes)), bearing redox-innocent diamide ligands, have been synthesized and characterized for a full comparison with previously published, redox-active diimine complexes, (Mes DABMe )2 U(THF) (1-DAB) and Cp2 U(Mes DABMe ) (2-DAB) (Mes DABMe = [ArN═C(Me)C(Me)═NAr]; Ar = Mes). These redox-innocent analogues maintain an analogous steric environment to their redox-active ligand counterparts to facilitate a study aimed at determining the differing electronic behavior around the uranium center...
May 11, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29746262/clinical-comparison-of-surgical-constructs-for-anterior-cervical-corpectomy-and-fusion-in-patients-with-cervical-spondylotic-myelopathy-or-ossified-posterior-longitudinal-ligament-a-systematic-review-and-meta-analysis
#11
Timothy R Niedzielak, Joseph Palmer, John P Malloy
STUDY DESIGN: This is a systematic review and meta-analysis. OBJECTIVE: To examine the differences in outcomes among current constructs and techniques for anterior cervical corpectomy and fusion (ACCF) in patients with single or multiple level cervical myelopathy (CM) secondary to cervical spondylosis or ossified posterior longitudinal ligament. SUMMARY OF BACKGROUND DATA: The natural history of CM can be a progressive disease process. In such cases, where surgical decompression is indicated to halt the progression, ACCF is typically chosen for pathology located posterior to the vertebral body...
May 9, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29741923/effect-of-intraoperative-platelet-rich-plasma-treatment-on-postoperative-donor-site-knee-pain-in-patellar-tendon-autograft-anterior-cruciate-ligament-reconstruction-a-double-blind-randomized-controlled-trial
#12
Brian L Walters, David A Porter, Sarah J Hobart, Benjamin B Bedford, Daniel E Hogan, Malachy M McHugh, Devon A Klein, Kendall Harousseau, Stephen J Nicholas
BACKGROUND: Donor site morbidity in the form of anterior knee pain is a frequent complication after bone-patellar tendon-bone (BPTB) autograft anterior cruciate ligament (ACL) reconstruction. Hypothesis/Purpose: The purpose was to examine the effect of the intraoperative administration of platelet-rich plasma (PRP) on postoperative kneeling pain. It was hypothesized that PRP treatment would reduce knee pain. STUDY DESIGN: Randomized controlled trial; Level of evidence, 2...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29738596/relatively-high-complication-and-revision-rates-of-the-mayo-%C3%A2-metaphysical-conservative-femoral-stem-in-young-patients
#13
Tal Frenkel Rutenberg, Yaniv Warshevski, Aviram Gold, Nadav Shasha, Nimrod Snir, Ofir Chechik, Oleg Dolkart, Dynai Eilig, Amir Herman, Ehud Rath, Moti Kramer, Michael Drexler
The Mayo metaphysical conservative femoral stem (Zimmer, Warsaw, Indiana) is a wedge-shaped implant designed to transfer loads proximally, reduce femoral destruction, and enable the preservation of bone stock in the proximal femur. Thus, it is a potentially preferred prosthesis for active, non-elderly patients who may require additional future surgeries. This retrospective case study analyzed the outcomes of consecutive patients who underwent total hip replacements with this stem between May 2001 and February 2013...
May 8, 2018: Orthopedics
https://www.readbyqxmd.com/read/29738034/evaluation-of-prevalence-biochemical-profile-and-drugs-associated-with-chronic-kidney-disease-mineral-and-bone-disorder-in-11-dialysis-centers
#14
Rodrigo Reis Abrita, Beatriz Dos Santos Pereira, Neimar da Silva Fernandes, Renata Abrita, Rosalia Maria Nunes Henriques Huaira, Marcus Gomes Bastos, Natália Maria da Silva Fernandes
INTRODUCTION: The diagnosis and treatment of mineral and bone disorder of chronic kidney disease (CKD-MBD) is a challenge for nephrologists and health managers. The aim of this study was to evaluate the prevalence, biochemical profile, and drugs associated with CKD-MBD. METHODS: Cross-sectional study between July and November 2013, with 1134 patients on dialysis. Sociodemographic, clinical, and laboratory data were compared between groups based on levels of intact parathyroid hormone (iPTH) (< 150, 150-300, 301-600, 601-1000, and > 1001 pg/mL)...
May 7, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29732428/minimum-ten-year-follow-up-of-spinal-stenosis-with-degenerative-spondylolisthesis-treated-with-decompression-and-dynamic-stabilization
#15
Kotryna Veresciagina, Arne Mehrkens, Stefan Schären, Bernhard Jeanneret
Background: The Dynesys system remains the most widely implanted posterior non-fusion pedicle screw system. Various study designs used in investigations with good to excellent short- and mid-term results have been reported in the current literature. However, there is a lack of information concerning long-term outcomes following treatment for spinal stenosis with degenerative spondylolisthesis. Methods: The aim of our study was twofold. Firstly, to assess whether the dynamic stabilization in situ with the Dynesys System without bone grafting provides enough stability to prevent progression of spondylolisthesis and secondarily to maintain significant clinical improvement in a long-term follow-up (FU)...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29730213/comparative-matched-pair-analysis-of-keyhole-bone-plug-technique-versus-arthroscopic-assisted-pullout-suture-technique-for-lateral-meniscal-allograft-transplantation
#16
Yong Gon Koh, Yong Sang Kim, Oh Ryong Kwon, Dong Beom Heo, Dae Hyun Tak
PURPOSE: To compare the clinical outcomes and meniscal extrusion measured by magnetic resonance imaging (MRI) between the keyhole bone-plug technique and arthroscopic-assisted pullout suture technique in lateral meniscal allograft transplantation (MAT). METHODS: Between October 2009 and February 2015, patients who underwent lateral MAT were retrospectively reviewed. The inclusion criteria were patients with symptomatic knees that had undergone total or subtotal meniscectomy who were treated with lateral MAT with a minimum follow-up period of 2 years...
May 2, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29730208/the-effect-of-cartilage-fragments-on-femoral-tunnel-widening-after-anterior-cruciate-ligament-reconstruction-a-prospective-randomized-controlled-study
#17
Chi Zhang, Jun Pan, Jian-De Chen, Yi-Jun Zhang, Peng-Cheng Gu, Xiang-Jin Lin, You-Zhi Cai
PURPOSE: To analyze the effect of cartilage fragments on tunnel widening and tendon-bone integration at 2 years' follow-up after anterior cruciate ligament reconstruction (ACLR). METHODS: A prospective randomized controlled study was performed in 116 patients who underwent ACLR with autologous hamstring tendons augmented with cartilage fragments (study group, n = 56) or without any augmentation (control group, n = 60). All patients were followed up for 25.6 months (range, 24-28 months), and the International Knee Documentation Committee score, Lysholm score, and visual analog scale score were determined...
May 2, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29725706/abaloparatide-exerts-bone-anabolic-effects-with-less-stimulation-of-bone-resorption-related-factors-a-comparison-with-teriparatide
#18
Akito Makino, Hideko Takagi, Yoshimasa Takahashi, Naoki Hase, Hiroyuki Sugiyama, Kei Yamana, Tsunefumi Kobayashi
Abaloparatide (ABL) is a novel synthetic peptide analog of parathyroid hormone-related protein. In previous reports, intermittent ABL administration showed robust bone mineral density (BMD) increase and reduced the incidence of fractures in patients with osteoporosis, while its calcemic effect was reduced, as compared with teriparatide (TPTD), a parathyroid hormone N-terminal fragment. The present study aimed to elucidate the effects of ABL on bone anabolism and bone turnover as compared with TPTD. In ovariectomized (OVX) rats, ABL increased the bone strength and BMD of lumbar spine by intermittent administration similar to TPTD...
May 3, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29724458/interspecific-comparison-of-radiocesium-trophic-transfer-in-two-tropical-fish-species
#19
Simon Pouil, Jean-Louis Teyssié, Scott W Fowler, Marc Metian, Michel Warnau
The trophic transfer of radiocesium (134 Cs) was investigated in two tropical fish, the silver moony Monodactylus argenteus and the spotted scat Scatophagus argus. Juveniles of both species were exposed to dietary 134 Cs using the pulse-chase feeding methodology. The food was brine shrimp (Artemia salina) previously exposed to the dissolved radiotracer. Depuration kinetics of 134 Cs were followed for 45 d. Results showed that Cs was similarly efficiently assimilated by both species (AE > 50%). The estimated trophic transfer factors in the two species ranked from 1 to 2, suggesting that 134 Cs could be biomagnified in both omnivorous species...
April 30, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29724093/the-effect-of-postoperative-use-of-teriparatide-reducing-screw-loosening-in-osteoporotic-patients
#20
Jae Wook Kim, Seung Won Park, Young Baeg Kim, Myeong Jin Ko
Objective: The loosening of pedicle screws (PS) is one of the frequent problems of spinal surgery in the patients with osteoporosis. Previous studies had revealed that intermittent injection of teriparatide could reduce PS loosening by improving bone mass and quality when their patients took parathyroid hormone for a considerable duration before surgery. However, although the teriparatide is usually used after spine surgery in most clinical situations, there was no report on the efficacy of teriparatide treatment started after spine surgery...
May 4, 2018: Journal of Korean Neurosurgical Society
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