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https://www.readbyqxmd.com/read/29157219/a-new-multiple-trauma-model-of-the-mouse
#1
Stefanie Fitschen-Oestern, Sebastian Lippross, Tim Klueter, Matthias Weuster, Deike Varoga, Mersedeh Tohidnezhad, Thomas Pufe, Stefan Rose-John, Hagen Andruszkow, Frank Hildebrand, Nadine Steubesand, Andreas Seekamp, Claudia Neunaber
BACKGROUND: Blunt trauma is the most frequent mechanism of injury in multiple trauma, commonly resulting from road traffic collisions or falls. Two of the most frequent injuries in patients with multiple trauma are chest trauma and extremity fracture. Several trauma mouse models combine chest trauma and head injury, but no trauma mouse model to date includes the combination of long bone fractures and chest trauma. Outcome is essentially determined by the combination of these injuries...
November 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29155001/postoperative-pain-following-posterior-iliac-crest-bone-graft-harvesting-in-spine-surgery-a-prospective-randomized-trial
#2
Evan D Sheha, Dennis S Meredith, Grant D Shifflett, Benjamin T Bjerke, Sravisht Iyer, Jennifer Shue, Joseph Nguyen, Russel C Huang
BACKGROUND CONTEXT: Post-operative pain at the site of bone graft harvest for posterior spine fusion is reported to occur in 6% to 39% of cases. However, the area around the posterior, superior iliac spine is a frequent site of referred pain for many structures. Therefore, many postoperative spine patients may have pain in the vicinity of the posterior iliac crest that may not in fact be caused by bone graft harvesting. The literature may then overestimate the true incidence of postoperative iliac crest pain...
November 14, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29152128/modulation-of-cabozantinib-efficacy-by-the-prostate-tumor-microenvironment
#3
Manisha Tripathi, Srinivas Nandana, Sandrine Billet, Karen A Cavassani, Rajeev Mishra, Leland W K Chung, Edwin M Posadas, Neil A Bhowmick
The tumor microenvironment (TME) is increasingly recognized as the arbiter of metastatic progression and drug resistance in advanced prostate cancer (PCa). Cabozantinib is a potent tyrosine kinase inhibitor (TKI) with reported biological activity in the PCa epithelia, but failed to provide an overall survival benefit in phase 3 clinical trials. However, the promising biologic efficacy of the drug in early trials warranted a better understanding of the mechanism of action, with the goal of improving patient selection for TKI-based therapy such as cabozantinib...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29148312/experimental-analysis-of-the-process-parameters-affecting-bone-burring-operations
#4
Jonathan R Kusins, O Remus Tutunea-Fatan, Louis M Ferreira
The experimental quantification of the process parameters associated with bone burring represents a desirable outcome both from the perspective of an optimized surgical procedure as well as that of a future implementation into the design of closed-loop controllers used in robot-assisted bone removal operations. Along these lines, the present study presents an experimental investigation of the effects that tool type, rotational speed of the tool, depth of cut, feed rate, cutting track overlap, and tool angle (to a total of 864 total unique combinations) have on bone temperature, tool vibration, and cutting forces associated with superficial bone removal operations...
November 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29145343/anterior-release-and-nonstructural-bone-grafting-and-posterior-fixation-for-old-lower-cervical-dislocations-with-locked-facets
#5
Chen Ding, Ting-Kui Wu, Quan Gong, Tao Li, Li-Tai Ma, Bei-Yu Wang, Yu-Xiao Deng, Hao Liu
Lower cervical dislocations are often missed at the time of initial injury for several reasons. The treatment of old facet dislocations of the lower cervical spine is difficult, and the optimal method has not been established. The objective of the present study was to evaluate the clinical outcomes of a surgical technique, anterior release, and nonstructural bone grafting combined with posterior fixation, for the treatment of old lower cervical dislocations with locked facets.This was a retrospective study of 17 patients (13 men and 4 women) with old facet dislocations, who underwent the same surgical treatment at our hospital between April 2010 and January 2016...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144249/effect-of-antiandrogen-aromatase-inhibitor-and-gonadotropin-releasing-hormone-analog-on-adult-height-in-familial-male-precocious-puberty
#6
Ellen Werber Leschek, Armando C Flor, Joy C Bryant, Janet V Jones, Kevin M Barnes, Gordon B Cutler
OBJECTIVE: Antiandrogen, aromatase inhibitor, and gonadotropin-releasing hormone analog (GnRHa) treatment normalizes growth rate and bone maturation and increases predicted adult height (AH) in boys with familial male-limited precocious puberty (FMPP). To evaluate the effect of long-term antiandrogen, aromatase inhibitor, and GnRHa on AH, boys with FMPP who were treated were followed to AH. STUDY DESIGN: Twenty-eight boys with FMPP, referred to the National Institutes of Health, were started on antiandrogen and aromatase inhibitor at 4...
November 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29140383/a-randomized-split-mouth-clinical-trial-on-effectiveness-of-amnion-chorion-membranes-in-alveolar-ridge-preservation-a-clinical-radiologic-and-morphometric-study
#7
Muyeenul Hassan, Sivaraman Prakasam, Carol Bain, Ahmed Ghoneima, Sean Shih-Yao Liu
PURPOSE: Recent case reports suggest that amnion-chorion membranes (ACM) and dense polytetrafluoroethylene membranes (dPTFE) can be left exposed during ridge preservation. The aim of this study was to compare the effectiveness of these membranes in ridge preservation, particularly when they are intentionally left exposed. MATERIALS AND METHODS: A split-mouth, single-blind, randomized trial design was used to compare treatments with the two membranes in 22 nonmolar sites on the same arch...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29137080/a-medium-term-follow-up-of-adult-lumbar-tuberculosis-treating-with-3-surgical-approaches
#8
Qi Hong Zhang, Qiang Guo, Chaofeng Guo, Jianhuang Wu, Jinyang Liu, Qile Gao, Yuxiang Wang
Surgical intervention is an important option for treating lumbar tuberculosis. Previous studies have reported different surgical intervention procedures. To our knowledge, few studies have compared the clinical results of mid-term follow-up of 3 different surgeries in surgical treatment of spinal tuberculosis. This study's purpose is to evaluate the effectiveness of 3 different surgeries for the treatment of lumbar tuberculosis in adult and analyze the mid-term influence of the surgery on quality of life.Between June 2004 and January 2010, a total of 137 adult patients (54 women and 83 men) with lumbar tuberculosis were recruited for this study...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135723/oral-health-related-quality-of-life-after-surgical-treatment-of-osteonecrosis-of-the-jaws
#9
Giacomo Oteri, Francesco Saverio De Ponte, Michele Runci, Matteo Peditto, Antonia Marcianò, Marco Cicciù
The aim of this study is to analyze the clinical outcome and the change in oral-health-related quality of life (QoL) of osteoporotic patients affected by medication-related osteonecrosis of the jaws (MRONJ). Forty-one patients, consecutively treated for a 10-year period, were retrospectively analyzed. All the patients underwent a marginal osseous resective jaw surgery. A clinical 12 months postoperative evaluation has been performed and the complete mucosal healing, the absence of swelling and suppuration, and no signs of disease recurrence were defined like success parameters...
November 9, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29126043/biphasic-bioresorbable-scaffold-trufit-plug-%C3%A2-for-the-treatment-of-osteochondral-lesions-of-talus-6-to-8-year-follow-up
#10
Elvira Di Cave, Pierluigi Versari, Fabio Sciarretta, David Luzon, Lorenzo Marcellini
BACKGROUND: The ideal treatment of osteochondral lesions of the talus (OLT) is debatable. The TruFit plug has been investigated as a potential treatment method for osteochondral defects. This is a biphasic scaffold designed to stimulate cartilage and subchondral bone formation. The purpose of this retrospective study was to investigate the long-term functional and MRI outcomes of the TruFit Plug for the treatment of OLT. METHODS: Twelve consecutive patients treated from March 2007 to April 2009 for OLT were evaluated...
June 3, 2017: Foot
https://www.readbyqxmd.com/read/29125919/autologous-chondrocyte-implantation-sandwich-technique-compared-with-autologous-bone-grafting-for-deep-osteochondral-lesions-in-the-knee
#11
Tom Minas, Takahiro Ogura, Jeff Headrick, Tim Bryant
BACKGROUND: Treating symptomatic osteochondral defects is challenging, especially in young adults with deep (>8-10 mm) empty defects after osteochondritis dissecans (OCD) or collapsed condyles secondary to avascular necrosis (AVN). For this population, osteoarthritis (OA) is inevitable if articular congruence is not restored. PURPOSE: To describe the autologous chondrocyte implantation (ACI) "sandwich" technique with autologous bone grafting (ABG) and compare it with ABG alone for restoration of the osteochondral unit...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29118758/combining-v%C3%AE-9v%C3%AE-2-t-cells-with-a-lipophilic-bisphosphonate-efficiently-kills-activated-hepatic-stellate-cells
#12
Xiaoying Zhou, Yanzheng Gu, Hongying Xiao, Ning Kang, Yonghua Xie, Guangbo Zhang, Yan Shi, Xiaoyu Hu, Eric Oldfield, Xueguang Zhang, Yonghui Zhang
Activated hepatic stellate cells (aHSCs) are now established as a central driver of fibrosis in human liver injury. In the presence of chronic or repeated injury, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) can occur, so there is interest in down-regulating aHSCs activity in order to treat these diseases. Here, we report that Vγ9Vδ2 T cells are reduced in patients with liver cirrhosis, stimulating us to investigate possible interactions between Vγ9Vδ2 T cells and aHSCs. We find that Vγ9Vδ2 T cells kill aHSCs and killing is enhanced when aHSCs are pretreated with BPH-1236, a lipophilic analog of the bone resorption drug zoledronate...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29115583/unfavorable-effect-of-calcitriol-and-its-low-calcemic-analogs-on-metastasis-of-4t1-mouse-mammary-gland-cancer
#13
Artur Anisiewicz, Agata Pawlik, Beata Filip-Psurska, Eliza Turlej, Stanisław Dzimira, Magdalena Milczarek, Katarzyna Gdesz, Diana Papiernik, Joanna Jarosz, Dagmara Kłopotowska, Andrzej Kutner, Andrzej Mazur, Joanna Wietrzyk
Low vitamin D status is considered as a risk factor for breast cancer and has prognostic significance. Furthermore, vitamin D deficiency increases after adjuvant cancer therapy, which alters bone metabolism increasing the risk of osteoporosis. It is now postulated that vitamin D supplementation in breast cancer treatment delays the recurrence of cancer thereby extending survival. We evaluated the impact of calcitriol and its low-calcemic analogs, PRI‑2191 and PRI‑2205, on the tumor growth, angiogenesis, and metastasis of 4T1 mouse mammary gland cancer...
November 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29114326/phosphonic-acid-preparation-and-applications
#14
REVIEW
Charlotte M Sevrain, Mathieu Berchel, Hélène Couthon, Paul-Alain Jaffrès
The phosphonic acid functional group, which is characterized by a phosphorus atom bonded to three oxygen atoms (two hydroxy groups and one P=O double bond) and one carbon atom, is employed for many applications due to its structural analogy with the phosphate moiety or to its coordination or supramolecular properties. Phosphonic acids were used for their bioactive properties (drug, pro-drug), for bone targeting, for the design of supramolecular or hybrid materials, for the functionalization of surfaces, for analytical purposes, for medical imaging or as phosphoantigen...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29113903/long-term-follow-up-of-metastatic-epidural-spinal-cord-compression-mescc-patients-from-breast-cancer-treated-with-surgery-followed-by-radiotherapy
#15
Federico Pessina, Pierina Navarria, Marco Riva, Davide Franceschini, Marco Conti Nibali, Maurizio Fornari, Marta Scorsetti
BACKGROUND: Aim of this study was to evaluate the role of surgery plus radiotherapy in Metastatic Epidural Spinal Cord Compression (MESCC) breast cancer (BC) patients with a follow-up longer than 10 years. METHODS: Twenty-three patients treated between 2004 and 2008 were included. Surgical treatment was performed in patients with good performance status, limited metastatic disease and progressive neurologic deficit and/or intractable pain. RT was performed delivering a median total dose of 30 Gy in 10 fractions...
November 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29110516/minimally-invasive-distal-metatarsal-diaphyseal-osteotomy-dmdo-for-chronic-plantar-diabetic-foot-ulcers
#16
Carlo Biz, Stefano Gastaldo, Miki Dalmau-Pastor, Marco Corradin, Andrea Volpin, Pietro Ruggieri
BACKGROUND: The aims of this prospective study were first to evaluate the safety and effectiveness of minimally invasive distal metatarsal diaphyseal osteotomies (DMDOs) for treating a consecutive series of diabetic patients with chronic plantar diabetic foot ulcers (CPDFUs) and second to assess their clinical-functional and radiographic outcomes. METHODS: A consecutive series of patients affected by diabetes mellitus with CPDFUs, not responsive to previous nonoperative management, underwent DMDO...
November 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29110512/short-term-clinical-and-radiographic-results-of-the-salto-mobile-total-ankle-prosthesis
#17
Dong Dong Wan, Woo Jin Choi, Dong Woo Shim, Yeokgu Hwang, Yoo Jung Park, Jin Woo Lee
BACKGROUND: The mobile-bearing Salto total ankle prosthesis has been reported to have promising outcomes. However, clinical reports on this prosthesis are few, and most have been published by the inventors and disclosed consultants. METHODS: We retrospectively reviewed 59 patients who received Salto prosthesis unilaterally. The average follow-up was 35.9 (range, 6-56) months. Clinical and radiologic results were evaluated. Clinical results were evaluated according to visual analog scale (VAS), American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot score, Ankle Osteoarthritis Scale (AOS) pain and disability score, and ankle range of motion (ROM) in dorsiflexion/plantarflexion...
November 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29097151/a-chemotaxis-model-of-feather-primordia-pattern-formation-during-avian-development
#18
Kevin J Painter, William Ho, Denis J Headon
The orderly formation of the avian feather array is a classic example of periodic pattern formation during embryonic development. Various mathematical models have been developed to describe this process, including Turing/activator-inhibitor type reaction-diffusion systems and chemotaxis/mechanical-based models based on cell movement and tissue interactions. In this paper we formulate a mathematical model founded on experimental findings, a set of interactions between the key cellular (dermal and epidermal cell populations) and molecular (fibroblast growth factor, FGF, and bone morphogenetic protein, BMP) players and a medially progressing priming wave that acts as the trigger to initiate patterning...
October 31, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29095313/treatment-of-type-ii-odontoid-fracture-with-a-novel-technique-titanium-cable-dragged-reduction-and-cantilever-beam-internal-fixation
#19
Ce Zhu, Lei Wang, Hao Liu, Yueming Song, Limin Liu, Tao Li, Quan Gong
Surgical methods for type II odontoid fracture can be classified into 2 main groups: anterior or posterior approach. A more effective way to achieve bone fusion with the lowest possible surgical risk is needed. Therefore, the aim of our study was to describe and evaluate a novel technique, cable-dragged reduction/cantilever beam internal fixation for the treatment of type II odontoid fracture.This was a retrospective study enrolled 34 patients underwent posterior cable-dragged reduction/cantilever-beam internal fixation surgery...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29093779/comparison-of-clinical-and-radiological-outcomes-of-lumbar-interbody-fusion-using-a-combination-of-hydroxyapatite-and-demineralized-bone-matrix-and-autografts-for-lumbar-degenerative-spondylolisthesis
#20
Asrafi Rizki Gatam, Luthfi Gatam, Singkat Dohar Lumban Tobing
Study Design: Prospective, cohort, non-inferiority study. Purpose: This study evaluated the clinical and radiological outcomes of interbody fusion using a combination of demineralized bone matrix (DBM) and hydroxyapatite (HA). Overview of Literature: The use of autografts remains a gold standard in lumbar interbody fusion, but the limited availability and donor site morbidity encourages the use of bone substitutes. In addition to autografts, a combination of HA and DBM is being increasingly use for lumbar interbody fusion...
October 2017: Asian Spine Journal
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