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https://www.readbyqxmd.com/read/28428919/tibial-bone-grafting-for-wrist-reconstruction
#1
Schneider K Rancy, Stephanie D Malliaris, Scott W Wolfe
Background Iliac crest bone graft harvesting is routinely performed for upper extremity orthopedic procedures despite high complication rates associated with sensory nerve injury, hematoma, chronic pain, and fracture. Description of Technique Cancellous bone graft is harvested from the proximal tibia using a medial approach, minimizing donor site morbidity. Patients and Methods A retrospective review was undertaken of 14 patients who underwent cancellous proximal tibia bone graft harvesting to augment healing of wrist reconstruction, with 2 months minimum follow-up...
May 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28428911/early-rehabilitation-of-distal-radius-fractures-stabilized-by-volar-locking-plate-a-prospective-randomized-pilot-study
#2
Stefan Quadlbauer, Christoph Pezzei, Josef Jurkowitsch, Brigitta Kolmayr, Tina Keuchel, Daniel Simon, Thomas Hausner, Martin Leixnering
Background Distal radius fractures are very common and an increased incidence of 50% is estimated by 2030. Therefore, both operative and postsurgical treatment remains pertinent. Main aim in treating intra-articular fractures is to restore the articular surface by internal fixation and early mobilization (EM). Questions/Purposes The purpose of this study was to compare functional results between EM immediately after surgery and 5 weeks of immobilization (IM). Patients and Methods In a randomized prospective study, 30 patients with an isolated distal radius fracture were treated by open reduction and internal fixation using a single volar locking plate excluding bone graft...
May 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28427810/synthesis-of-novel-5-6-dehydrokawain-analogs-as-osteogenic-inducers-and-their-action-mechanisms
#3
Momochika Kumagai, Keisuke Nishikawa, Takashi Mishima, Izumi Yoshida, Masahiro Ide, Keiko Koizumi, Munetomo Nakamura, Yoshiki Morimoto
An imbalance between bone resorption by osteoclasts and bone formation by osteoblasts can cause bone loss and bone-related disease. In a previous search for natural products that increase osteogenic activity, we found that 5,6-dehydrokawain (1) from Alpinia zerumbet promotes osteoblastogenesis. In this study, we synthesized and evaluated series of 5,6-dehydrokawain analogs. Our structure-activity relationships revealed that alkylation of para or meta position of aromatic ring of 1 promote osteogenic activity...
April 6, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28425054/can-a-three-component-prosthesis-be-used-for-conversion-of-painful-ankle-arthrodesis-to-total-ankle-replacement
#4
Markus Preis, Travis Bailey, Lucas S Marchand, Alexej Barg
BACKGROUND: In patients with painful ankle arthrodesis, the surgical treatment is challenging, and may include takedown of ankle arthrodesis and conversion to a total ankle replacement (TAR). This procedure is technically demanding given the altered anatomy after arthrodesis. Few studies have evaluated TAR in the setting of prior arthrodesis. QUESTIONS/PURPOSES: (1) What intraoperative and perioperative complications were observed in patients who underwent conversion of an ankle arthrodesis to a TAR? (2) Was durable fixation achieved at short term, and what was the alignment of the components? (3) What subsequent surgical procedures were performed, including revisions? (4) What improvements were observed in pain, tibiotalar range of motion (ROM), and quality of life? METHODS: Between January 2007 and December 2014, 18 patients with a painful ankle arthrodesis underwent conversion to TAR at our tertiary referral center...
April 19, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28419031/prognostic-factors-affecting-union-after-ulnar-shortening-osteotomy-in-ulnar-impaction-syndrome-a-retrospective-case-control-study
#5
Soo Min Cha, Hyun Dae Shin, Ki Jun Ahn
BACKGROUND: Ulnar shortening osteotomy (USO) is a widely adopted procedure with excellent outcomes. However, delayed union or nonunion has occasionally been observed. The purpose of this retrospective case-control study was to identify variables affecting osseous consolidation after USO in patients with ulnar impaction syndrome. METHODS: The study included 325 patients who had undergone USO between March 2008 and March 2014. We evaluated the association between union and basic demographic factors as well as preoperative pain (assessed on a visual analog scale [VAS]), range of wrist motion, grip strength, and modified Mayo wrist score...
April 19, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28418012/cyp3a4-is-a-crosslink-between-vitamin-d-and-calcineurin-inhibitors-in-solid-organ-transplant-recipients-implications-for-bone-health
#6
REVIEW
A Prytuła, K Cransberg, A Raes
The use of calcineurin inhibitors (CNIs) and vitamin D deficiency may contribute to the pathogenesis of post-transplant bone disease. CNIs and 1,25-dihydroxyvitamin D₃ (1,25(OH)2D3) are substrates of the drug-metabolizing enzyme CYP3A4. This review summarizes the indications for the use of activated vitamin D analogs in post-transplant care and the current knowledge on the impact of CNIs on bone. We searched for clinical evidence of the interaction between CNIs and 1,25(OH)2D3. We also provide an overview of the literature on the interplay between vitamin D metabolism and CYP3A4 in experimental and clinical settings and discuss its possible implications for solid organ transplant recipients...
April 18, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28416835/-polymethylmethacrylate-augmentation-of-bone-cement-injectable-cannulated-pedicle-screws-was-used-to-treat-degenerative-lumbar-scoliosis-with-osteoporosis
#7
H L Sun, C D Li, X W Li, X D Yi, H Liu, H L Lu, H Li, Z R Yu, Y Wang
OBJECTIVE: To describe the application of polymethylmethacrylate (PMMA) augmentation of cement-injectable cannulated pedicle screws for the treatment of degenerative lumbar scoliosis with osteoporosis. METHODS: Retrospective cohort study was used to compare cement injectable cannulated pedicle screws (CICPs) group with PMMA augmentation and control group with traditional method in the correction surgery for Lenke-silva level III and level IV degenerative scoliosis cases with osteoporosis...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28411578/differential-effects-of-low-dose-fludarabine-or-5-fluorouracil-on-the-tumor-growth-and-myeloid-derived-immunosuppression-status-of-tumor-bearing-mice
#8
Manuchehr Abedi-Valugerdi, Wenyi Zheng, Fadwa Benkessou, Ying Zhao, Moustapha Hassan
Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play a key role in the suppression of the innate and adaptive immunity. Chemotherapeutic strategies have been developed to deplete or deactivate MDSCs in different tumor models. The pyrimidine analog, 5-fluorouracil (5-FU) is found to reduce the tumor size by depleting MDSCs. Here, we asked whether the purine analog, fludarabine (Flu), could exert similar effects. Employing a lymphoma model, we demonstrated that in mice with advanced tumors (where MDSC-induced suppression was present), treatment with a single low-dose Flu (25, 50, 100mg/kg) elevated the numbers of splenic MDSCs and serum arginase activity, and simultaneously, increased the tumor growth (only the highest dose)...
April 12, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28408254/midterm-outcomes-of-bone-grafting-in-glenoid-defects-treated-with-reverse-shoulder-arthroplasty
#9
Yaiza Lopiz, Carlos García-Fernández, Alvaro Arriaza, Belen Rizo, Hector Marcelo, Fernando Marco
BACKGROUND: Large glenoid defects are a difficult reconstructive problem for shoulder surgeons. The purpose of this study was to determine the complications, rate of healing, and functional results of glenoid bone grafting in primary or revision surgery with reverse shoulder arthroplasty. METHODS: We retrospectively reviewed 23 patients with glenoid bone loss who underwent primary or revision surgery using a glenoid bone graft with a minimum follow-up of 2 years...
April 10, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28407019/comparison-between-titanium-mesh-and-autogenous-iliac-bone-graft-to-restore-vertebral-height-through-posterior-approach-for-the-treatment-of-thoracic-and-lumbar-spinal-tuberculosis
#10
COMPARATIVE STUDY
Yongjian Gao, Yunsheng Ou, Qianxing Deng, Bin He, Xing Du, Jianxiao Li
OBJECT: To compare the clinical efficacy of titanium mesh cages and autogenous iliac bone graft to restore vertebral height through posterior approach in patients with thoracic and lumbar spinal tuberculosis. METHOD: 59 patients with spinal tuberculosis underwent interbody fusion and internal fixation through posterior approach in our department from January 2011 to December 2013. In group A, 34 patients obtained titanium mesh for the reconstruction of vertebral height, among them 25 patients (group A1) suffered from single-segment spinal tuberculosis, and 9 patients, (group A2) had multi-segment spinal tuberculosis...
2017: PloS One
https://www.readbyqxmd.com/read/28401159/management-of-hepple-stage-v-osteochondral-lesion-of-the-talus-with-a-platelet-rich-plasma-scaffold
#11
Wenqi Gu, Tanzhu Li, Zhongmin Shi, Guohua Mei, Jianfeng Xue, Jian Zou, Xiaokang Wang, Haotong Zhang, Hongwei Xu
There has been no consensus on the treatment or prognosis of Hepple stage V osteochondral lesions of the talus (OLTs), especially for lesions greater than 1.5 cm(2) in size. The objective of this study was to investigate the clinical outcomes achieved upon application of a platelet-rich plasma (PRP) scaffold with a cancellous bone autograft for Hepple stage V OLTs. Fourteen patients (mean age, 39 years) were treated with a cancellous bone graft and a PRP scaffold between 2013 and 2015. The mean time to surgical treatment was 23...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28393820/comparison-of-gray-values-of-cone-beam-computed-tomography-with-hounsfield-units-of-multislice-computed-tomography-an-in-vitro-study
#12
Sanjana Patrick, N Praveen Birur, Keerthi Gurushanth, A Shubhasini Raghavan, Shubha Gurudath
PURPOSE: Hounsfield unit (HU) provides a quantitative evaluation of bone density. The assessment of bone density is essential for successful treatment plan. Although, multislice computed tomography (MSCT) is considered as gold standard in evaluating bone density, cone-beam computed tomography (CBCT) is frequently used in dentomaxillofacial imaging due to lower radiation dose, less complex device, and images with satisfactory resolution. AIMS AND OBJECTIVES: The aim of this study is to determine and compare the gray value and HU value of hypodense and hyperdense structures on CBCT and MSCT, respectively...
January 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28391431/sclerostin-antibody-increases-callus-size-and-strength-but-does-not-improve-fracture-union-in-a-challenged-open-rat-fracture-model
#13
Alyson Morse, Michelle M McDonald, Aaron Schindeler, Lauren Peacock, Kathy Mikulec, Tegan L Cheng, Min Liu, Hua Zhu Ke, David G Little
Open fractures remain a challenge in orthopedics. Current strategies to intervene are often inadequate, particularly in severe fractures or when treatment is delayed. Sclerostin is a negative regulator of bone growth and sclerostin-neutralizing antibodies (Scl-Ab) can increase bone mass and strength. The application of these antibodies to improve orthopedic repair has shown varied results, and may be dependent on the location and severity of the bony injury. We examined Scl-Ab treatment within an established rat osteotomy model with periosteal stripping analogous to open fracture repair...
April 8, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28391383/percutaneous-radiofrequency-ablation-for-spinal-osteoid-osteoma-and-osteoblastoma
#14
Ben Wang, Song Bo Han, Liang Jiang, Hui Shu Yuan, Chen Liu, Bin Zhu, Zhong Jun Liu, Xiao Guang Liu
PURPOSES: We sought to verify the efficacy and safety of RFA in spinal OO and osteoblastomas (OB) (Enneking Stage 2, S2). METHODS: We retrospectively reviewed patients treated in our hospital. Surgical resection was indicated for Enneking Stage 3 OB. RFA indications for spinal OO and OB (S2) were no neurological deficits, complete bone cortex around the lesion on computed tomography (CT), and cerebrospinal fluid between a lesion and the spinal cord/nerve root on magnetic resonance imaging...
April 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28390010/vitamin-d-supplementation-in-the-prevention-and-management-of-major-chronic-diseases-not-related-to-mineral-homeostasis-in-adults-research-for-evidence-and-a-scientific-statement-from-the-european-society-for-clinical-and-economic-aspects-of-osteoporosis-and
#15
Luisella Cianferotti, Francesco Bertoldo, Heike A Bischoff-Ferrari, Olivier Bruyere, Cyrus Cooper, Maurizio Cutolo, John A Kanis, Jean-Marc Kaufman, Jean-Yves Reginster, Rene Rizzoli, Maria Luisa Brandi
INTRODUCTION: Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided indirect and some direct evidence for possible extraskeletal vitamin D-related effects. PURPOSE AND METHODS: Members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis have reviewed the main evidence for possible proven benefits of vitamin D supplementation in adults at risk of or with overt chronic extra-skeletal diseases, providing recommendations and guidelines for future studies in this field...
April 7, 2017: Endocrine
https://www.readbyqxmd.com/read/28385445/a-combined-digital-and-stereophotogrammetric-technique-for-rehabilitation-with-immediate-loading-of-complete-arch-implant-supported-prostheses-a-randomized-controlled-pilot-clinical-trial
#16
María Peñarrocha-Diago, José Carlos Balaguer-Martí, David Peñarrocha-Oltra, José Francisco Balaguer-Martínez, Miguel Peñarrocha-Diago, Rubén Agustín-Panadero
STATEMENT OF PROBLEM: Traditional impressions for complete-arch restorations are complex and time-consuming, and they can be uncomfortable for the patient. New digital techniques such as stereophotogrammetry may mitigate this. PURPOSE: The purpose of this randomized controlled pilot clinical trial was to compare the patient and dentist satisfaction and work times of traditional impressions (control group) and digital impressions with stereophotogrammetry in complete-arch, implant-supported prostheses...
April 3, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28383423/treating-osteoporotic-vertebral-compression-fractures-with-intraosseous-vacuum-phenomena-using-high-viscosity-bone-cement-via-bilateral-percutaneous-vertebroplasty
#17
Dan Guo, Jun Cai, Shengfei Zhang, Liang Zhang, Xinmin Feng
Osteoporotic vertebral compression fractures with intraosseous vacuum phenomena could cause persistent back pains in patients, even after receiving conservative treatment. The aim of this study was to evaluate the efficacy of using high-viscosity bone cement via bilateral percutaneous vertebroplasty in treating patients who have osteoporotic vertebral compression fractures with intraosseous vacuum phenomena.Twenty osteoporotic vertebral compression fracture patients with intraosseous vacuum phenomena, who received at least 2 months of conservative treatment, were further treated by injecting high-viscosity bone cement via bilateral percutaneous vertebroplasty due to failure of conservative treatment...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28380670/improved-regeneration-and-de-novo-bone-formation-in-a-diabetic-zebrafish-model-treated-with-paricalcitol-and-cinacalcet
#18
Filipe R Carvalho, Ana R Fernandes, M Leonor Cancela, Paulo J Gavaia
Bone changes related to diabetes have been well stablished, but few strategies have been developed to prevent this growing health problem. In our work we propose to investigate the effects of calcitriol as well as of a vitamin D analog (paricalcitol) and a calcimimetic (cinacalcet), in fin regeneration and de novo mineralization in a zebrafish model of diabetes. Following exposure of diabetic transgenic Tg(ins:nfsb-mCherry) zebrafish to calcitriol, paricalcitol and cinacalcet, caudal fins were amputated to assess their effects on tissue regeneration...
April 5, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28377862/arthrodesis-rate-and-patient-reported-outcomes-after-anterior-lumbar-interbody-fusion-utilizing-a-plasma-sprayed-titanium-coated-peek-interbody-implant-a-retrospective-observational-analysis
#19
Joseph A Sclafani, Sophea R Bergen, Miranda Staples, Kevin Liang, Ramin Raiszadeh
BACKGROUND: Anterior lumbar interbody fusion (ALIF) is utilized in symptomatic spinal disc destabilization due to degenerative lumbar disc disease, isthmic and degenerative spondylolisthesis, internal disc disruption, or pseudarthrosis after non-operative treatments fail. The addition of a plasma-sprayed titanium coating (PTC) to polyether ether ketone spacers (PEEK) may reduce the rate of implant subsidence or non-union secondary to poor osseous-integration of non-coated PEEK or metal interbody systems...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28376262/the-effects-of-iterative-reconstruction-and-kernel-selection-on-quantitative-computed-tomography-measures-of-lung-density
#20
Alfonso Rodriguez, Frank N Ranallo, Philip F Judy, Sean B Fain
PURPOSE: To determine the effects of iterative reconstruction (IR) and high frequency kernels on quantitative computed tomography (qCT) density measures at reduced X-ray dose. MATERIALS AND METHODS: The COPDGene 2 Phantom (CTP 698, The Phantom Laboratory, Salem, NY) with four embedded lung mimicking foam densities (12lb, 20lb, and 4lb), as well as water, air, and acrylic reference inserts was imaged using a GE 64 slice CT750 HD scanner in helical mode with four current-time products ranging from 12-100 mAs...
April 4, 2017: Medical Physics
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