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calcified plaque models

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https://www.readbyqxmd.com/read/29753765/maximization-of-the-usage-of-coronary-cta-derived-plaque-information-using-a-machine-learning-based-algorithm-to-improve-risk-stratification-insights-from-the-confirm-registry
#1
Alexander R van Rosendael, Gabriel Maliakal, Kranthi K Kolli, Ashley Beecy, Subhi J Al'Aref, Aeshita Dwivedi, Gurpreet Singh, Mohit Panday, Amit Kumar, Xiaoyue Ma, Stephan Achenbach, Mouaz H Al-Mallah, Daniele Andreini, Jeroen J Bax, Daniel S Berman, Matthew J Budoff, Filippo Cademartiri, Tracy Q Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J W Chow, Ricardo C Cury, Augustin DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A Kaufmann, Yong-Jin Kim, Jonathon A Leipsic, Erica Maffei, Hugo Marques, Gianluca Pontone, Gilbert L Raff, Ronen Rubinshtein, Leslee J Shaw, Todd C Villines, Heidi Gransar, Yao Lu, Erica C Jones, Jessica M Peña, Fay Y Lin, James K Min
INTRODUCTION: Machine learning (ML) is a field in computer science that demonstrated to effectively integrate clinical and imaging data for the creation of prognostic scores. The current study investigated whether a ML score, incorporating only the 16 segment coronary tree information derived from coronary computed tomography angiography (CCTA), provides enhanced risk stratification compared with current CCTA based risk scores. METHODS: From the multi-center CONFIRM registry, patients were included with complete CCTA risk score information and ≥3 year follow-up for myocardial infarction and death (primary endpoint)...
April 30, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29751802/associations-of-coronary-artery-calcified-plaque-density-with-mortality-in-type-2-diabetes-the-diabetes-heart-study
#2
Laura M Raffield, Amanda J Cox, Michael H Criqui, Fang-Chi Hsu, James G Terry, Jianzhao Xu, Barry I Freedman, J Jeffrey Carr, Donald W Bowden
BACKGROUND: Coronary artery calcified plaque (CAC) is strongly predictive of cardiovascular disease (CVD) events and mortality, both in general populations and individuals with type 2 diabetes at high risk for CVD. CAC is typically reported as an Agatston score, which is weighted for increased plaque density. However, the role of CAC density in CVD risk prediction, independently and with CAC volume, remains unclear. METHODS: We examined the role of CAC density in individuals with type 2 diabetes from the family-based Diabetes Heart Study and the African American-Diabetes Heart Study...
May 11, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29696936/relationship-of-calcification-in-the-carotid-or-coronary-arteries-and-osteoporosis-in-the-elderly
#3
Jie Zhu, Feng Guo, Jie Zhang, Chunli Mu
BACKGROUND: To investigate the correlation between senile osteoporosis and calcified plaques in the arteries and to study the common potential risk factors for loss of bone mass and calcified plaques in the arteries. METHODS: Eligible patients (≥60 years old) who received treatment in our hospital from January 2016 to December2016 were included in this study. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA). Multivariate regression model was used to analyze the correlation of osteoporosis and loss of bone mass with the risk of calcified plaques in the carotid and coronary arteries...
April 24, 2018: Minerva Medica
https://www.readbyqxmd.com/read/29627372/psoas-and-paraspinous-muscle-index-as-a-predictor-of-mortality-in-african-american-men-with-type-2-diabetes-mellitus
#4
Mariana Murea, Leon Lenchik, Thomas C Register, Gregory B Russell, Jianzhao Xu, S Carrie Smith, Donald W Bowden, Jasmin Divers, Barry I Freedman
AIM: Recent studies revealed a correlation between skeletal muscle mass index and density with longevity; these studies largely evaluated appendicular skeletal muscles in older Caucasians. This retrospective cohort study assessed the association between axial skeletal muscles size and density with survival in African Americans with type 2 diabetes mellitus. METHODS: Psoas and paraspinous muscle mass index (cross sectional area/height2 ) and radiographic density (in Hounsfield Units) were measured using computed tomography in African American-Diabetes Heart Study participants, 314 women and 256 men, with median (25th, 75th quartile) age 55...
March 19, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29607444/oct-based-three-dimensional-modeling-of-stent-deployment
#5
Pengfei Dong, David Prabhu, David L Wilson, Hiram G Bezerra, Linxia Gu
Stent deployment has been widely used to treat narrowed coronary artery. Its acute outcome in terms of stent under expansion and malapposition depends on the extent and shape of calcifications. However, no clear understanding as to how to quantify or categorize the impact of calcification. We have conducted ex vivo stenting characterized by the optical coherence tomography (OCT). The goal of this work is to capture the ex vivo stent deployment and quantify the effect of calcium morphology on the stenting. A three dimensional model of calcified plaque was reconstructed from ex vivo OCT images...
November 2017: International Mechanical Engineering Congress and Exposition: [proceedings]
https://www.readbyqxmd.com/read/29519676/statin-use-is-associated-with-carotid-plaque-composition-the-rotterdam-study
#6
Blerim Mujaj, Daniel Bos, Mariana Selwaness, Maarten J G Leening, Maryam Kavousi, Jolanda J Wentzel, Aad van der Lugt, Albert Hofman, Bruno H Stricker, Meike W Vernooij, Oscar H Franco
BACKGROUND: Statins represent a key treatment for cardiovascular disease. Nevertheless, the direct effects of statin treatment on the composition of atherosclerotic plaques remain elusive. OBJECTIVES: We aimed to investigate the association of statin treatment with the presence of different plaque components located in the carotid arteries within a population-based setting. METHODS: From the population-based Rotterdam Study, 1740 participants with carotid atherosclerosis (mean age 72...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29407881/combination-of-biomarkers-of-vascular-calcification-and-stweak-to-predict-cardiovascular-events-in-chronic-kidney-disease
#7
Milica Bozic, Nerea Méndez-Barbero, Carmen Gutiérrez-Muñoz, Angels Betriu, Jesús Egido, Elvira Fernández, Jose L Martín-Ventura, Jose M Valdivielso, Luis M Blanco-Colio
BACKGROUND AND AIMS: Vascular calcification (VC) and atherosclerosis are associated with an increased cardiovascular morbimortality in chronic kidney disease (CKD). Osteoprotegerin (OPG) and osteopontin (OPN) are involved in both VC and CKD. Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) has been related to cardiovascular disease. We hypothesized that OPG, OPN and sTWEAK levels may be associated with a higher prevalence of cardiovascular outcomes in patients with CKD...
March 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29397334/optimized-energy-of-spectral-coronary-ct-angiography-for-coronary-plaque-detection-and-quantification
#8
Rolf Symons, Younhee Choi, Tyler E Cork, Mark A Ahlman, Marissa Mallek, David A Bluemke, Veit Sandfort
BACKGROUND: To optimize spectral coronary computed tomography angiography (CTA) for quantification of coronary artery plaque components. MATERIALS AND METHODS: Fifty-one subjects were prospectively enrolled (88.2% male) (NCT02740699). Dual energy coronary CTA was performed at 90/Sn150 kVp using a 3rd generation dual-source CT scanner (SOMATOM Force, Siemens Healthcare). Dual energy images were reconstructed with a) linear mixed blending of 90 and Sn150 kVp data, b) virtual monoenergetic algorithm from 40 to 150 keV (at 10- keV intervals), and c) noise-optimized virtual monoenergetic algorithm from 40 to 150 keV...
March 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29376102/quantification-of-uncertainty-in-the-assessment-of-coronary-plaque-in-ccta-through-a-dynamic-cardiac-phantom-and-3d-printed-plaque-model
#9
Taylor Richards, Gregory M Sturgeon, Juan Carlos Ramirez-Giraldo, Geoffrey D Rubin, Lynne Hurwitz Koweek, William Paul Segars, Ehsan Samei
The purpose of this study was to develop a dynamic physical cardiac phantom with a realistic coronary plaque to investigate stenosis measurement accuracy under clinically relevant heart-rates. The coronary plaque model (5 mm diameter, 50% stenosis, and 32 mm long) was designed and 3D-printed with tissue equivalent materials (calcified plaque with iodine-enhanced lumen). Realistic cardiac motion was modeled by converting computational cardiac motion vectors into compression and rotation profiles executed by a commercial base cardiac phantom...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29356018/the-evolving-view-of-coronary-artery-calcium-and-cardiovascular-disease-risk
#10
REVIEW
Isac C Thomas, Nketi I Forbang, Michael H Criqui
Calcification of the coronary artery is a complex pathophysiologic process that is intimately associated with atherosclerosis. Extensive investigation has demonstrated the value of identifying and quantifying coronary artery calcium (CAC) in atherosclerotic cardiovascular disease (CVD) prognostication. However, over the last several years, an increasing body of evidence has suggested that CAC has underappreciated aspects that modulate, and at times attenuate, future CVD risk. The most commonly used measure of CAC, the Agatston unit, effectively models both higher density and higher area of CAC as risk factors for future CVD events...
January 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29352380/integrated-prediction-of-lesion-specific-ischaemia-from-quantitative-coronary-ct-angiography-using-machine-learning-a-multicentre-study
#11
Damini Dey, Sara Gaur, Kristian A Ovrehus, Piotr J Slomka, Julian Betancur, Markus Goeller, Michaela M Hell, Heidi Gransar, Daniel S Berman, Stephan Achenbach, Hans Erik Botker, Jesper Moller Jensen, Jens Flensted Lassen, Bjarne Linde Norgaard
OBJECTIVES: We aimed to investigate if lesion-specific ischaemia by invasive fractional flow reserve (FFR) can be predicted by an integrated machine learning (ML) ischaemia risk score from quantitative plaque measures from coronary computed tomography angiography (CTA). METHODS: In a multicentre trial of 254 patients, CTA and invasive coronary angiography were performed, with FFR in 484 vessels. CTA data sets were analysed by semi-automated software to quantify stenosis and non-calcified (NCP), low-density NCP (LD-NCP, < 30 HU), calcified and total plaque volumes, contrast density difference (CDD, maximum difference in luminal attenuation per unit area) and plaque length...
January 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29205743/rotational-atherectomy-and-new-generation-drug-eluting-stent-implantation
#12
Daisuke Hachinohe, Yoshifumi Kashima, Daitaro Kanno, Ken Kobayashi, Takuro Sugie, Umihiko Kaneko, Yutaka Tadano, Tomohiko Watanabe, Hidemasa Shitan, Tsutomu Fujita
OBJECTIVES: The aim of this study was to evaluate the clinical outcomes of rotational atherectomy (RA) followed by new-generation drug-eluting stent (DES) implantation in patients with an extensive amount of calcified and fibrotic plaque. BACKGROUND: RA followed by new-generation DES implantation for complex lesions has not been thoroughly evaluated. METHODS: A total of 744 consecutive patients (770 lesions) treated with new-generation DES implantation following RA for de novo lesions between January 2013 and November 2015 were retrospectively identified using our institutional database...
December 5, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29184766/an-investigation-of-correlation-between-left-coronary-bifurcation-angle-and-hemodynamic-changes-in-coronary-stenosis-by-coronary-computed-tomography-angiography-derived-computational-fluid-dynamics
#13
Zhonghua Sun, Thanapong Chaichana
Background: To investigate the correlation between left coronary bifurcation angle and coronary stenosis as assessed by coronary computed tomography angiography (CCTA)-generated computational fluid dynamics (CFD) analysis when compared to the CCTA analysis of coronary lumen stenosis and plaque lesion length with invasive coronary angiography (ICA) as the reference method. Methods: Thirty patients (22 males, mean age: 59±6.9 years) with calcified plaques at the left coronary artery were included in the study with all patients undergoing CCTA and ICA examinations...
October 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29180327/-a-probability-model-for-analyzing-speckles-in-intravascular-ultrasound-images-to-facilitate-image-segmentation
#14
Wu-Yi Chai, Feng Yang, Shao-Feng Yuan, Shu-Jun Liang, Jing Huang
Ultrasonic image speckles result from the interference of the reflected signals by the scatters in the detected tissue. The physical characteristics of the speckles are closely correlated with the structures of the biological tissues, and the probability distribution of these speckles differs across different tissues. Based on the probability characteristics of intravascular ultrasound (IVUS) speckles, a Gamma mixture model and Gaussian mixture model are proposed to describe the calcified plaque, soft plaque and normal vascular regions on IVUS images...
November 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29158070/assessment-of-carotid-calcifications-on-digital-panoramic-radiographs-retrospective-analysis-and-review-of-the-literature
#15
I A Monteiro, C Ibrahim, R Albuquerque, N Donaldson, F Salazar, L Monteiro
OBJECTIVES: To assess the validity of digital panoramic radiographs as an effective means of diagnosis for atherosclerosis and as a potential aid in the early detection of the disease. STUDY DESIGN: We reviewed 2014 digital panoramic radiographs taken throughout 2012 and 2013 to identify the presence of calcified atherosclerotic plaques of both female and male patients all aged over 18 years. In addition the medical records of these patients were reviewed in order to establish if there were any predisposing risk factors for atherosclerosis...
November 20, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29113983/fgf23-concentration-and-apol1-genotype-are-novel-predictors-of-mortality-in-african-americans-with-type-2-diabetes
#16
Gary C Chan, Jasmin Divers, Gregory B Russell, Carl D Langefeld, Lynne E Wagenknecht, Fang-Chi Hsu, Jianzhao Xu, S Carrie Smith, Nicholette D Palmer, Pamela J Hicks, Donald W Bowden, Thomas C Register, Lijun Ma, J Jeffrey Carr, Barry I Freedman
OBJECTIVE: Cardiovascular and renal complications contribute to higher mortality in patients with diabetes. We assessed novel and conventional predictors of mortality in African American-Diabetes Heart Study (AA-DHS) participants. RESEARCH DESIGN AND METHODS: Associations between mortality and subclinical atherosclerosis, urine albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), plasma fibroblast growth factor 23 (FGF23) concentration, African ancestry proportion, and apolipoprotein L1 genotypes ( APOL1 ) were assessed in 513 African Americans with type 2 diabetes; analyses were performed using Cox proportional hazards models...
January 2018: Diabetes Care
https://www.readbyqxmd.com/read/29017805/atherosclerotic-plaque-characteristics-are-not-associated-with-future-cardiovascular-events-in-patients-undergoing-iliofemoral-endarterectomy
#17
Steven T W van Haelst, Saskia Haitjema, Wouter Derksen, Ian van Koeverden, Jean-Paul P M de Vries, Frans L Moll, Hester M den Ruijter, Gerard Pasterkamp, Gert J de Borst
BACKGROUND: Plaque characteristics such as intraplaque hemorrhage (IPH) have been associated with secondary cardiovascular events (CVE) in patients undergoing carotid endarterectomy. In addition, carotid plaques containing macrophage infiltration or a large lipid core size were associated with less restenosis. It is currently unknown whether iliofemoral plaque histopathologic characteristics are predictive for secondary CVE in patients with peripheral arterial disease undergoing iliofemoral endarterectomy...
March 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28867375/calcified-plaque-modification-alters-local-drug-delivery-in-the-treatment-of-peripheral-atherosclerosis
#18
Abraham R Tzafriri, Fernando Garcia-Polite, Brett Zani, James Stanley, Benny Muraj, Jennifer Knutson, Robert Kohler, Peter Markham, Alexander Nikanorov, Elazer R Edelman
BACKGROUND: Calcific atherosclerosis is a major challenge to intraluminal drug delivery in peripheral artery disease (PAD). OBJECTIVES: We evaluated the effects of orbital atherectomy on intraluminal paclitaxel delivery to human peripheral arteries with substantial calcified plaque. METHODS: Diagnostic angiography and 3-D rotational imaging of five fresh human lower limbs revealed calcification in all main arteries. The proximal or distal segment of each artery was treated using an orbital atherectomy system (OAS) under simulated blood flow and fluoroscopy...
October 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28838637/calcification-volume-reduces-stretch-capability-and-predisposes-plaque-to-rupture-in-an-in%C3%A2-vitro-model-of-carotid-artery-stenting
#19
H E Barrett, E M Cunnane, H Hidayat, J M O Brien, E G Kavanagh, M T Walsh
OBJECTIVE/BACKGROUND: Carotid artery stenting (CAS) in calcified arteries carries a higher peri-operative risk. This study investigates the relationship between the stretching limits of carotid plaque samples and calcification in order to determine a stretch tolerance criterion for endovascular intervention. METHODS: Seventeen carotid plaque samples were acquired from standard endarterectomy procedures. The maximum stretch capability of the global plaque was determined by circumferentially extending the tissue to complete failure...
October 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28826570/effect-of-longitudinal-anatomical-mismatch-of-stenting-on-the-mechanical-environment-in-human-carotid-artery-with-atherosclerotic-plaques
#20
Zhenmin Fan, Xiao Liu, Anqiang Sun, Nan Zhang, Zhanming Fan, Yubo Fan, Xiaoyan Deng
Longitudinal anatomic mismatch (LAM) of stenting (i.e., a stenotic artery segment is not fully covered by a deployed stent) worsens the mechanical environment in the treated artery, which most likely is the cause for the associated high risks of restenosis, myocardial infarction and stent thrombosis. To probe the possibility, we constructed a patient-specific carotid model with two components of plaques (lipid and calcified plaque) based on MRI images; we numerically compared three different stenting scenarios in terms of von Mises stress (VMS) distribution in the treated arteries, namely, the short stenting (LAM), the medium stenting and the long stenting...
August 17, 2017: Medical Engineering & Physics
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