Lena Rühl, Joji B Kuramatsu, Jochen A Sembill, Bernd Kallmünzer, Dominik Madzar, Stefan T Gerner, Antje Giede-Jeppe, Stefanie Balk, Tamara Mueller, Jakob Jäger, Stefan Schwab, Hagen B Huttner, Maximilian I Sprügel
OBJECTIVE: This study determined the effect of amantadine treatment on consciousness in patients with non-traumatic brain injury. METHODS: We pooled individual patient data of five single-centre observational studies to determine the effect of amantadine treatment among patients with ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, community-acquired bacterial meningitis and status epilepticus, admitted between January 2012 and December 2015 and ventilated ≥7 days...
June 2022: Journal of Neurology, Neurosurgery, and Psychiatry