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malnutrition leucocytes t

Bingna Cai, Hua Chen, Han Sun, Peng Wan, Huili Sun, Jianyu Pan
Chemotherapy is generally accompanied by undesirable side effects, such as immunosuppression and malnutrition, which reduce tolerance to cancer therapies. Prior studies have shown that immunonutrition improves the clinical outcomes of cancer patients. In this study, immunoregulatory polysaccharides from Crassostrea hongkongensis were included in a nutrition formula that was administered to S180 tumor-bearing mice in combination with 5-fluorouracil (5-FU) treatment. The C30-60% fraction of the polysaccharides was characterized as a branched polysaccharide, with a high amount of d-glucose (96...
January 2016: Food & Function
Régia F Martins, Patrícia M Martinelli, Paulo M M Guedes, Bruno da Cruz Pádua, Fabiana M Dos Santos, Marcelo Eustáquio Silva, Maria T Bahia, Andre Talvani
OBJECTIVE: Chagas heart disease is developed as a result of the infection with Trypanosoma cruzi. Protein malnutrition contributes to secondary immunodeficiency. The aim of this study was to investigate the role of a low protein diet on the production of endothelin-1 and CX3CL1 in blood and cardiac tissue samples in an experimental model with T. cruzi infection. METHODS: Fisher rats were submitted to low protein (6%) and normal protein (15%) diets and then infected with the Y strain of T...
April 2013: Tropical Medicine & International Health: TM & IH
J Sultan, S M Griffin, F Di Franco, J A Kirby, B K Shenton, C J Seal, P Davis, Y K S Viswanath, S R Preston, N Hayes
BACKGROUND: Oesophagogastric cancer surgery is immunosuppressive. This may be modulated by omega-3 fatty acids (O-3FAs). The aim of this study was to assess the effect of perioperative O-3FAs on clinical outcome and immune function after oesophagogastric cancer surgery. METHODS: Patients undergoing subtotal oesophagectomy and total gastrectomy were recruited and allocated randomly to an O-3FA enteral immunoenhancing diet (IED) or standard enteral nutrition (SEN) for 7 days before and after surgery, or to postoperative supplementation alone (control group)...
March 2012: British Journal of Surgery
Peng Li, Yu-Long Yin, Defa Li, Sung Woo Kim, Guoyao Wu
A deficiency of dietary protein or amino acids has long been known to impair immune function and increase the susceptibility of animals and humans to infectious disease. However, only in the past 15 years have the underlying cellular and molecular mechanisms begun to unfold. Protein malnutrition reduces concentrations of most amino acids in plasma. Findings from recent studies indicate an important role for amino acids in immune responses by regulating: (1) the activation of T lymphocytes, B lymphocytes, natural killer cells and macrophages; (2) cellular redox state, gene expression and lymphocyte proliferation; and (3) the production of antibodies, cytokines and other cytotoxic substances...
August 2007: British Journal of Nutrition
M Hildebrandt, M Rose, C Mayr, C Schüler, W Reutter, A Salama, B F Klapp
The notion that patients with eating disorders maintain a functional immunosurveillance in spite of severe malnutrition has attracted researchers for years. Dipeptidyl peptidase IV (DPP IV), a serine protease with broad tissue distribution and known activity in serum, operates in the cascade of immune responses. Membrane-bound DPP IV expressed on lymphocytes, also known as the leucocyte antigen CD26, is considered to participate in T-cell activation. We hypothesized that the activity of DPP IV in serum and expression of CD26 in lymphocytes may be altered in patients with eating disorders...
November 1999: Scandinavian Journal of Immunology
B T Akingbemi, P V Rao, T A Aire
Some aspects of the toxicity of gossypol were investigated in ethanol-fed, gossypol-treated Sprague-Dawley rats, with and without protein malnutrition. Serum creatine phosphokinase activity was depressed in all gossypol-treated rats and gossypol caused greater decreases than ethanol in those animals that were fed the normal diet. Even though the adrenal glands were enlarged in all gossypol-treated rats, this was accompanied by depressed serum cortisol levels. Histopathological findings, including vacuolar degeneration of hepatocytes and dilation of the sinusoids in the liver, atrophy and leucocytic infiltration of cardiac myofibres, vacuolation of the renal glomerulus and cellular depletion of the spleen and thymus, were most severe in the protein-malnourished, gossypol-treated rats; these were generally absent in the other groups...
September 1996: Journal of Applied Toxicology: JAT
H Fouad, N Afifi, A Fatt-Hi, N El-Sheemy, I Iskander, M N Abou Saif
Cellular immunity was studied in patients with atrophic rhinitis using the in vitro leucocyte migration and the spontaneous rosette tests. Cellular hypersensitivity to crude nasal homogenate was detected in 90 per cent of our cases as shown by inhibition of the leucocyte migration. The spontaneous rosette test showed a reduction in the number of T-cells forming rosettes which reflects a decrease in the absolute number of T-lymphocytes. This altered cellular reactivity or loss of tolerance to nasal tissues may be precipitated primarily by virus infection, malnutrition and/or immuno-deficiency which trigger a destructive auto-immune process with the release of antigen(s) of nasal mucosa into the circulation...
May 1980: Journal of Laryngology and Otology
L M Vanella, A M González Lascano, V M Míguez
The aim of this study was to evaluate the capability of Levamisole to stimulate delayed tuberculin cutaneous hypersensitivity in malnourished and eutrophic infants who in spite of having been given BCG at birth, repeatedly failed to react to Mantoux intradermo-reaction. Leucocyte, lymphocyte and RFC counts, and blast cell transformation tests with PHA, BCG and AT were carried out at the beginning of the study, and every 4 weeks over a 4 month period. Tuberculin conversion occurred in 60% of the well-nourished and in 58% of the malnourished infants...
March 1981: Allergologia et Immunopathologia
Z Spirer, G Hauzer, V Zakuth, S Diamant, A Golander
The immune functions were evaluated in 30 children, aged one year to 9 8/12 years, who had suffered during their early infancy from protein-calorie malnutrition (PCM) as the result of intractable diarrhea. Twelve healthy children matched for age and sex served as controls. All 42 children responded normally to intradermal injections of tuberculin and candida antigens. The reduction of nitrous blue tetrazolium (NBT) by the polymorphonuclear leucocytes (PMN) was normal. Apart from the lower concentrations of IgM in the post-PCM group--145 +/- 67 mg % as compared to 212...
September 1981: Journal of Clinical & Laboratory Immunology
T Yoshida, J Metcoff, S Frenk, C De la Pena
No abstract text is available yet for this article.
April 29, 1967: Nature
L T Uĭen, F T Lĭen, D K Lĭen, Kh V Tĭen, Z V Tin', P K Lĭen
It is shown that addition of zinc into the ration of pigs suffering from protein calorie deficiency leads to increased food consumption and its utilization in the body attended by a rise of the protein and fat absorption coefficient and by diminution of food expenditure for body mass increment. Immune processes are intensified which is expressed in the growth of the leucocyte count, phagocytic coefficient and blood neutrophil index. The nutrition improvement is manifested by the increase of body mass increment, red blood cell number and hemoglobin level in the blood, and by the shift of the leucocytic formula to the left; skin lesions disappear...
March 1987: Voprosy Pitaniia
M J Farthing
Review of animal and human studies concerning the impact of iron deficiency on immune function in vivo indicates that in many instances there is no firm consensus of opinion as to the relationship between iron status and immunity. One major problem with almost all human studies is that other micro- and macronutrient deficiencies are inadequately controlled for and thus it is often unclear as to whether reported abnormalities of immune function can be attributed specifically to iron deficiency. Even when abnormalities of immune function have been detected it is often uncertain as to the biological and clinical relevance that these may have for the host...
1989: Acta Paediatrica Scandinavica. Supplement
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