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Radiotherapy for Breast cancer

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https://www.readbyqxmd.com/read/29332358/a-study-on-basic-demographic-and-disease-characteristics-of-cancer-diagnosed-syrian-refugees-treated-in-the-border-city-of-turkey-sanliurfa-a-hospital-based-retrospective-case-series-study
#1
Yasemin Bakkal Temi, Ali Murat Sedef, Serkan Gokcay, Hatice Coskun, Sedenay Oskeroglu Kaplan, Ozlem Ozkul, Huseyin Mertsoylu, Fatih Kose
PURPOSE: Turkey hosts around 3 million Syrian refugees which is more than any other country in the world. Along with some other adaptation issues like cultural, language, and economic difficulties, significant problems in managing medical problems, chronic diseases like cancer in particular, have to be fixed. However, there are few studies which explore main patient and clinicopathological characteristics in Syrian refugees with cancer. The purpose of this study was to highlight the aforementioned characteristics along with management issues after cancer diagnosis of these patients...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29331262/can-interrogation-of-tumour-characteristics-lead-us-to-safely-omit-adjuvant-radiotherapy-in-patients-with-early-breast-cancer
#2
I S Bhattacharya, A M Kirby, J M Bliss, C E Coles
Adjuvant radiotherapy after breast-conserving surgery has been an important component of the standard of care for early breast cancer. Improvements in breast cancer care have resulted in a substantial reduction in local relapse rates over recent decades. Although the proportional benefits of adjuvant radiotherapy are similar for different prognostic risk groups of patients, the absolute benefits depend on the risk of relapse and therefore vary considerably between prognostic groups. Radiotherapy is not without risk and for some patients at very low risk of relapse the risks of radiotherapy may outweigh the benefit, leading to potential overtreatment...
January 10, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29330268/pelvic-and-buttock-hypoplasia-reconstructed-with-anatomical-breast-implants
#3
Felicity Page, Ayad Harb, Garth Titley
Radiation therapy is used in the management of a number of childhood cancers and can have significant effects on skeletal growth. We present the case of a 35-year-old woman who developed a hypoplastic pelvis and buttocks following radiotherapy for rhabdomyosarcoma of the vagina at the age of 2. At the age of 25, the patient underwent bilateral buttock augmentation with a two-stage reconstruction using tissue expansion followed by definitive augmentation with anatomical breast implant insertion. The patient continues to have a satisfactory outcome 10 years following reconstruction, having undergone a single uplift procedure and exchange of implants through the original incision 9 years postoperatively...
January 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29328488/synthesis-and-application-of-131i-fulvestrant-as-a-targeted-radiation-drug-for-endocrine-therapy-in-human-breast-cancer
#4
Guobing Yin, Bin Zeng, Zhiping Peng, Ying Liu, Lu Sun, Changan Liu
The aim of this study was to label fulvestrant (an endocrine therapy drug for breast cancer) with radioiodine and to evaluate the effect of 131I-fulvestrant on inhibiting the growth of human breast cancer and its influence on major organs in nude mice. Fulvestrant was labeled with radioiodine using a modified chloramine T method, and its chemical properties were assessed using traditional methods. The binding affinity of 131I-fulvestrant was measured by radioligand binding assays, and its antiproliferative activity was determined by MTT assays...
January 11, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29324933/brachytherapy-in-soft-tissue-tumours-an-interdisciplinary-challenge
#5
Silvanie Volz, Konstantinos Kalousis, Jung In Song, Tobias Kisch, Eike Wenzel, Peter Mailänder
OBJECTIVE: Interdisciplinary work including surgery and additive radiotherapy is often needed for the therapy of tumours. Beneath this, brachytherapy is an important part of the radiotherapy. It was first used over 100 years ago and is in regular use after the development of afterload technology in the early 1970s. Today it is often used in different tumour therapies, for example in soft tissue sarcoma or breast tumours, in order to decrease the risk of local recurrence. Concerning its benefits, higher doses could be used because of the localized effect with equivalent local control rate and less toxicity of treatment...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29322827/hypofractionated-volumetric-modulated-arc-therapy-in-ductal-carcinoma-in-situ-toxicity-and-cosmetic-outcome-from-a-prospective-series
#6
Fiorenza De Rose, Antonella Fogliata, Davide Franceschini, Cristina Iftode, Rosalba Torrisi, Giovanna Masci, Andrea Sagona, Corrado Tinterri, Alberto Testori, Wolfgang Gatzemeier, Bethania Fernandes, Daoud Rahal, Luca Cozzi, Armando Santoro, Marta Scorsetti
OBJECTIVE: Hypofractionated radiotherapy in early stage breast cancer is an effective adjuvant treatment, but there is a lack of randomized data for patients with ductal carcinoma in situ (DCIS). Aim of this study is the evaluation of skin toxicity and cosmesis, and early clinical outcome of DCIS patients enrolled in an institutional phase II trial of hypofractionated breast irradiation. METHODS: One hundred thirty-seven DCIS patients were enrolled in the trial...
January 11, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29322287/metaplastic-breast-cancer-practice-patterns-outcomes-and-the-role-of-radiotherapy
#7
Waqar Haque, Vivek Verma, Nilan Naik, E Brian Butler, Bin S Teh
PURPOSE: Metaplastic breast cancer (MBC) is a rare, aggressive form of breast cancer with limited data to guide management. This study of a large, contemporary US database described national practice patterns and addressed the impact of radiotherapy (RT) on survival. METHODS: The National Cancer Data Base was queried (2004-2013) for women with non-metastatic MBC. Multivariable logistic regression ascertained factors associated with RT administration. Kaplan-Meier analysis evaluated overall survival (OS) between patients treated with either lumpectomy or mastectomy with or without RT, while substratifying patients into pT1-2N0 and pT3-4/N+ subcohorts...
January 10, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29320921/benefits-and-risks-with-acellular-dermal-matrix-adm-and-mesh-support-in-immediate-breast-reconstruction-a-systematic-review-and-meta-analysis
#8
Håkan Hallberg, Svanheidur Rafnsdottir, Gennaro Selvaggi, Annika Strandell, Ola Samuelsson, Ida Stadig, Therese Svanberg, Emma Hansson, Richard Lewin
In modern implant-based immediate breast reconstruction, it has become common to use biological acellular dermal and synthetic matrices in combination with a tissue expander or an implant. The aim of this systematic review was to examine differences in recurrence of cancer, impact on oncological treatment, health related quality of life, complications and aesthetic outcome between matrix and no matrix in immediate breast reconstruction. Systematic searches, data extraction and assessment of methodological quality were performed according to predetermined criteria...
January 10, 2018: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/29306555/outcome-of-postmastectomy-radiotherapy-after-primary-systemic-treatment-in-patients-with-clinical-t1-2n1-breast-cancer
#9
L Cao, D Ou, K-W Shen, G Cai, R Cai, F Xu, S-G Zhao, C Xu, N Grellier Adedjouma, Y M Kirova, J-Y Chen
PURPOSE: The role of postmastectomy radiotherapy following primary systemic treatment in patients with clinical T1-2N1 breast cancer remains a controversial issue. The purpose of this study was to evaluate the benefit of postmastectomy radiotherapy following primary systemic treatment. PATIENTS AND METHODS: Between 2005 and 2012, in two independent institutions, female patients with T1-2N1 breast cancer receiving primary systemic treatment followed by mastectomy and lymph node dissection because bad response, then treated with or without chest wall and regional lymph node irradiation have been studied retrospectively...
January 3, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29305748/production-of-human-single-chain-fragment-antibody-scfv-against-human-epidermal-growth-factor-receptor-2-her-2-by-phage-display-technology
#10
Saeideh Foroumadi, Masoumeh Rajabibazl, Azam Rahimpour, Solmaz Shahidi, Walead Ebrahimizadeh, Maral Yarahmadi, Shirin Rajabi, Azam Daraei
Breast cancer with more than 1.7 million diagnoses per year has been known as one of the most prevalent cancers among women worldwide. Despite the availability of advanced treatment options, cancer progression and metastasis is observed in 20% of patients. Human epidermal growth factor receptor-2 (HER-2) is considered as an important prognostic and diagnostic tumor marker for breast cancer. While HER-2 is expressed on the surface of normal cells, its overexpression occurs in 20-25% on breast cancer tumor cells...
January 5, 2018: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29302485/21-gene-recurrence-assay-in-patients-receiving-intraoperative-radiotherapy-are-favorable-characteristics-a-surrogate-for-low-recurrence
#11
Bridget A Oppong, Surupa Sen Gupta, Monique Gary, Patricia Wehner, Mihriye Mete, Danjing Zhao, Sulakshana Seevaratnam, Sonali Rudra, Shawna C Willey
Background: Intraoperative radiotherapy (IORT) has gained momentum for early stage and favorable breast cancers (BC). The 21-gene recurrence assay guides treatment of hormone positive and node-negative BC. Methods: Analysis of 82 invasive BC treated with breast conservation surgery (BCS) and IORT 2013-2015. Data collection included patient demographics, tumor characteristics, nodal status, recurrence test (RS) and adjuvant therapy. Results: The mean age was 68 years...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29302482/conservative-mastectomy-versus-nipple-sparing-mastectomy-preliminary-considerations-of-oncological-safety-on-30-patients-not-receiving-intra-operative-radiotherapy
#12
Tito Brambullo, Erica Dalla Venezia, Stefano Martella, Vincenzo Vindigni, Franco Bassetto, Alessandra Gottardi, Visnu Lohsiriwat, Jean-Yves Petit, Paolo Veronesi, Mario Rietjens
Background: For several years, there has been broad consensus that nipple-sparing mastectomy is a safe surgical treatment for breast cancer. However, the technique is associated with a relatively high risk of local recurrence (LR) behind the nipple-areola complex (NAC). It is for this reason that some years ago we introduced intraoperative radiotherapy with electrons (ELIOT) targeted specifically to the NAC to reduce the probability of recurrence there. However, in some cases we preferred to avoid ELIOT when the NAC appears to have a poor blood supply to ensuring the best chance of NAC survival...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29301945/modulation-of-glutathione-promotes-apoptosis-in-triple-negative-breast-cancer-cells
#13
Tara Miran, Andreas T J Vogg, Natascha Drude, Felix M Mottaghy, Agnieszka Morgenroth
Triple-negative breast cancer has an extremely high rate of relapse. This is particularly due to the existence and survival of cancer stem cells (CSCs) characterized by increased amounts of glutathione (GSH). In this study, we evaluated the potential of pharmacological GSH depletion to sensitize CSCs to ionizing radiotherapy with an I-125-labeled nucleoside analog, 5-iodo-4'-thio-2'-deoxyuridine (ITdU). CSCs were isolated using CD24-- and CD44+-specific microbeads. GSH and reactive oxygen species (ROS) were evaluated by fluorescence-activated cell sorting...
January 4, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29299946/a-new-approach-for-modeling-patient-overall-radiosensitivity-and-predicting-multiple-toxicity-endpoints-for-breast-cancer-patients
#14
Chamberlain Mbah, Kim De Ruyck, Silke De Schrijver, Charlotte De Sutter, Kimberly Schiettecatte, Chris Monten, Leen Paelinck, Wilfried De Neve, Hubert Thierens, Catharine West, Gustavo Amorim, Olivier Thas, Liv Veldeman
INTRODUCTION: Evaluation of patient characteristics inducing toxicity in breast radiotherapy, using simultaneous modeling of multiple endpoints. METHODS AND MATERIALS: In 269 early-stage breast cancer patients treated with whole-breast irradiation (WBI) after breast-conserving surgery, toxicity was scored, based on five dichotomized endpoints. Five logistic regression models were fitted, one for each endpoint and the effect sizes of all variables were estimated using maximum likelihood (MLE)...
January 4, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29298280/complete-objective-response-stable-for-5-years-with-the-di-bella-method-of-multiple-metastatic-carcinoma-of-the-breast
#15
Giuseppe Di Bella, Biagio Colori, Rosilde Toscano
Breast cancer is the most common cancer and the leading cause of cancer death among women. Despite all efforts, about 11,939 deaths and 50,000 new diagnoses for breast cancer were estimated among Italian women in 2016. Therefore new approaches are needed to improve the survival and higher remission rates. We present a case of a woman with carcinoma of the breast and multiple metastases after right mastectomy, axillary dissection, repeated cycles of chemo and radiotherapy, and estrogen block. Biological method formulated by Prof...
December 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29296037/estimating-second-malignancy-risk-in-intensity-modulated-radiotherapy-and-volumetric-modulated-arc-therapy-using-a-mechanistic-radiobiological-model-in-radiotherapy-for-carcinoma-of-left-breast
#16
Vasanthan Sakthivel, Ganesh Kadirampatti Mani, Sunil Mani, Raghavendiran Boopathy, Jothybasu Selvaraj
Objectives: The aim of this study is to estimate second cancer risk (SCR) in intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) using a mechanistic radiobiological model. The model also takes into account patient age at exposure and the gender-specific correction factors of SCR. Materials and Methods: Fifty IMRT and VMAT plans were selected for the study. Monte Carlo-based dose calculation engine was used for dose calculation. Appropriate model parameters were taken from the literature for the mechanistic model to calculate excess absolute risk (EAR), lifetime attributable risk, integral dose and relative risk (RR) for lungs, contralateral breast, heart, and spinal cord...
October 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/29289334/does-preoperative-axillary-staging-lead-to-overtreatment-of-women-with-screen-detected-breast-cancer
#17
M G Wallis, F Kilburn-Toppin, S Taylor-Phillips
AIM: To determine the impact of preoperative axillary ultrasound staging in a screen-detected breast cancer population. MATERIALS AND METHODS: Ultrasound and needle biopsy staging results alongside reference standard sentinel lymph node biopsy and axillary lymph node dissection were extracted retrospectively from the unit's computer records between 1 April 2008 and 31 March 2015. Axillary staging was compared with final histopathology and treatment. RESULTS: Of the 215,661 screening examinations performed, 780 invasive cancers were diagnosed, which had preoperative axillary staging data, of which 162 (20...
December 27, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29286157/hsa-mir-212-modulates-the-radiosensitivity-of-glioma-cells-by-targeting-brca1
#18
Xin He, Saijun Fan
Radioresistance remains a major challenge in the treatment of glioma, and the response of patients to radio-therapy varies considerably. MicroRNAs (miRNAs) are involved in various biological processes. The purpose of the present study was to investigate miRNAs involved in the response to radiation in glioma cell lines. Total RNA was isolated from human glioma U251 cells 30 min after γ-ray exposure and hybridized to an miRNA chip array. miRNA expression profiles were analyzed by quantitative real-time PCR...
December 15, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29285037/interactions-of-family-history-of-breast-cancer-with-radiotherapy-in-relation-to-the-risk-of-breast-cancer-recurrence
#19
Danmeng Li, Volker Mai, Travis Gerke, Susan Mengel Pinney, Lusine Yaghjyan
Purpose: We examined associations between a family history of breast cancer and the risk of breast cancer recurrence in women who received or did not receive radiotherapy. Methods: Our study included 2,440 women enrolled in the Breast Cancer Registry of Greater Cincinnati. Information on breast cancer risk factors, including detailed family history of breast cancer, characteristics of the primary tumor, treatment received, and recurrence status was collected at baseline and via updates...
December 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29284000/oestrogen-receptor-negative-early-operable-primary-breast-cancer-in-older-women-biological-characteristics-and-long-term-clinical-outcome
#20
Binafsha Manzoor Syed, Dal Morgan, Tulassi Setty, Andrew R Green, Emma C Paish, Ian O Ellis, K L Cheung
BACKGROUND: Older women are at the greatest risk of breast cancer development and a considerable number present with comorbidities. Although the majority of breast cancers in this age group express oestrogen receptor (ER), which makes endocrine therapy (primary or adjuvant) feasible, given the huge size of the elderly population, there remains a significant number of patients, in absolute term, whose tumours do not express ER and their management is challenging. METHODS: Of a consecutive series of 1,758 older (≥70 years) women with early operable primary breast cancer managed in a dedicated service from 1973-2010, 252(14...
2017: PloS One
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