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https://www.readbyqxmd.com/read/28346767/hormone-replacement-therapy-for-chronic-tinnitus-in-menopausal-women-our-experience-with-13-cases
#1
Jen-Tsung Lai, Chiung-Lin Liu, Tien-Chen Liu
Tinnitus is a common complaint among patients visiting an ENT clinic. It can cause severe annoyance and distress to some patients. Many treatment modalities are available for the management of tinnitus, with different degrees of effectiveness. This article is protected by copyright. All rights reserved.
March 27, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28346293/comparison-of-experts-and-residents-performing-a-complex-procedure-in-a-temporal-bone-surgery-simulator
#2
Ioanna Ioannou, Yun Zhou, Sudanthi Wijewickrema, Patorn Piromchai, Bridget Copson, Gregor Kennedy, Stephen O'Leary
OBJECTIVE: To investigate the use of automated metrics from a virtual reality (VR) temporal bone surgery simulator to determine how the performance of experts and trainees differs when performing a complex otological procedure (mastoidectomy with posterior tympanotomy and cochleostomy). STUDY DESIGN: Cohort study. METHODS: Using the University of Melbourne VR temporal bone surgery simulator, seven ENT consultants and seven ENT residents performed two trials of the surgical approach to cochlear implantation on a virtual temporal bone...
March 24, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28345194/decay-of-the-glycolytic-pathway-and-adaptation-to-intranuclear-parasitism-within-enterocytozoonidae-microsporidia
#3
Dominic Wiredu Boakye, Pattana Jaroenlak, Anuphap Prachumwat, Tom A Williams, Kelly S Bateman, Ornchuma Itsathitphaisarn, Kallaya Sritunyalucksana, Konrad H Paszkiewicz, Karen A Moore, Grant D Stentiford, Bryony A P Williams
Glycolysis and oxidative phosphorylation are the fundamental pathways of ATP generation in eukaryotes. Yet in microsporidia, endoparasitic fungi living at the limits of cellular streamlining, oxidative phosphorylation has been lost: energy is obtained directly from the host or, during the dispersive spore stage, via glycolysis. It was therefore surprising when the first genome from the Enterocytozoonidae - a major family of human and animal-infecting microsporidians - appeared to have lost glycolysis. Here we sequence and analyse genomes from four additional members of this family, shedding new light on their unusual biology...
March 26, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28344079/nasal-foreign-bodies-in-children-in-a-pediatric-hospital-in-senegal-a-three-year-assessment
#4
P-E-J Regonne, M Ndiaye, A Sy, Y Diandy, A-D Diop, B-K Diallo
OBJECTIVES: Nasal foreign bodies (NFB) constitute a common domestic accident in children. The objectives of the present study were to report the particularities of NFBs in children presenting at a pediatric hospital in Senegal, and to describe our therapeutic attitude. MATERIAL AND METHODS: A retrospective descriptive study included all under-15 year-olds presenting with NFB in the ENT department of the National Children's Hospital Center of Diamniadio, Senegal, between January 1, 2013 and December 31, 2015...
March 23, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28343805/the-reported-incidence-and-nature-of-voice-disorders-in-the-private-healthcare-context-of-gauteng
#5
Kayla Fourie, Maeve Richardson, Jeannie van der Linde, Shabnam Abdoola, Renata Mosca
OBJECTIVES: The study aimed to determine the incidence and nature of voice disorders, as reported by ear, nose, and throat specialists (ENTs), in the Gauteng private healthcare context. STUDY DESIGN: This is a cross-sectional survey design. METHODS: The respondents had to be certified ENTs working in the private healthcare context in Gauteng. The survey was sent out electronically to all 94 ENTs, registered with the ENT Society, working in the private healthcare context; thus, no additional requirements had to be met...
March 23, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28339881/genetic-aspects-and-environmental-sources-of-microsporidia-that-infect-the-human-gastrointestinal-tract
#6
Martin F Heyworth
Enterocytozoon bieneusi and Encephalitozoon intestinalis are microsporidia that infect the human gastrointestinal (GI) tract. Each of these microsporidia has been shown to infect various non-human hosts (mammalian and avian), raising the possibility of inter-species transmission, for example, from such hosts to human subjects via waterborne dispersal of microsporidian spores. During the past two decades, genome sequencing has delineated more than 90 genotypes of Ent. bieneusi, and has led to the conclusion that not all the genotypes of this organism infect human subjects...
February 27, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28339364/clinical-and-prognostic-features-of-korean-patients-with-mpo-anca-pr3-anca-and-anca-negative-vasculitis
#7
Juyoung Yoo, Ho Jae Kim, Sung Soo Ahn, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
OBJECTIVES: We reclassified Korean patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) into 3 categories of AAV including MPO-ANCA, PR3-ANCA and ANCA negative vasculitis, and investigated clinical and prognostic features. METHODS: We reviewed the medical records of 133 patients with microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic GPA (EGPA), who had having either myeloperoxidase (MPO)-ANCA, proteinase 3 (PR3)-ANCA or no ANCA, and who had ever achieved the first remission...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28337333/efficient-semisynthesis-of-pseudoirroratin-a-from-flexicaulin-a-and-assessment-of-their-antitumor-activities
#8
Lei Guo, Siu Wai Tsang, Tong-Xin Zhang, Kang-Lun Liu, Yi-Fu Guan, Bo Wang, Han-Dong Sun, Hong-Jie Zhang, Man Shing Wong
Accumulating evidence indicates that natural ent-kaurane diterpenoids show great potential for medical treatment of different pathological conditions including cytotoxicity, antibacterial, and anti-inflammatory activity. Among a variety of diterpenoids tested, (-)-pseudoirroratin A displayed a promising antitumor property in vitro and in vivo. However, this diterpenoid could merely be isolated in a limited amount from a rare source of Isodon pseudoirrorata. To overcome such scanty source, we developed a novel, facile, and efficient semisynthetic strategy to prepare (-)-pseudoirroratin A from natural (-)-flexicaulin A, which can be expediently obtained from I...
March 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28316944/human-amnion-membrane-potential-applications-in-oral-and-periodontal-field
#9
REVIEW
Ranjana Mohan, Aashima Bajaj, Mohan Gundappa
Human amniotic membrane (HAM) is derived from the fetal membranes which consist of the inner amniotic membrane made of single layer of amnion cells fixed to collagen-rich mesenchyme attached to chorion. HAM has low immunogenicity, anti-inflammatory properties and their cells can be isolated without the sacrifice of human embryos. Amniotic membrane has biological properties which are important for the experimental and clinical applications in managing patients of various medical specialties. Abundant, natural and wonderful biomembrane not only protects the foetus but also has various clinical applications in the field of dermatology, ophthalmology, ENT surgery, orthopedics and dental surgery...
January 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28302454/craniofacial-fibrous-dysplasia-a-10-case-series
#10
A Couturier, O Aumaître, L Gilain, B Jean, T Mom, M André
OBJECTIVES: Fibrous dysplasia of bone is a rare sporadic benign congenital condition in which normal cancellous bone is replaced by fibro-osseous tissue with immature osteogenesis. Sarcomatous transformation is exceptional. Lesions may involve one bone (monostotic) or several (polyostotic). Fibrous dysplasia may be associated with café-au-lait skin macules and endocrinopathy in McCune-Albright syndrome, or with myxoma in Mazabraud's syndrome. METHODS: We report ten cases of patients followed up for craniofacial fibrous dysplasia in our center between 2010 and 2015...
March 14, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28301961/current-management-of-necrotising-otitis-externa-in-the-uk-survey-of-221-uk-otolaryngologists
#11
Gaurav Chawdhary, Miran Pankhania, Susan Douglas, Ian Bottrill
INTRODUCTION: Necrotising otitis externa (NOE) is a rare infection causing skull base osteomyelitis. The evidence regarding NOE consists mostly of case series. Hence, there is a limited evidence base to guide decision-making. This survey aims to report the experience of 221 otolaryngologists in this condition. MATERIALS AND METHODS: Internet survey administered to the membership of the British Association of Otorhinolaryngology - Head and Neck Surgery (ENT UK). RESULTS: Respondents' detailed replies on diagnosis, treatment and follow up are presented...
March 16, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28300699/monomeric-and-dimeric-ent-kauranoid-type-diterpenoids-from-rabdosia-japonica-and-their-cytotoxicity-and-anti-hbv-activities
#12
Hong-Chuan Liu, Zhao-Bao Xiang, Qiang Wang, Bo-Yan Li, Yong-Sheng Jin, Hai-Sheng Chen
Two new ent-kauranoid-type diterpenoids (1 and 2) and one new rare dimer of ent-kauranoids (3) with a cyclobutane ring by a [2+2] cycloaddition, together with nine known diterpenoids (4-12) were obtained from the aerial parts of Rabdosia japonica. Their chemical structures were established by 1D and 2D NMR techniques and mass spectrometry and by comparison with spectroscopic data reported. All ent-kauranoids were test for their cytotoxic effects against A549, HCT116, CCRF-CEM and HL-60 tumor cell lines. Compounds 1, 2, 4, 5, 7, 10 and 12 showed potent and selective cytotoxicity...
March 12, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28296244/-watchful-observation-follow-up-scheme-after-endoscopic-co2-laser-treatment-for-small-glottic-carcinomas-a-retrospective-study-of-93-cases
#13
Patrice Gallet, Cécile Rumeau, Duc Trung Nguyen, Pedro Augusto Teixeira, Cédric Baumann, Bruno Toussaint
OBJECTIVES: Evaluate the clinical outcome of patients treated with CO2-laser surgery for early-stage glottic carcinomas followed-up with 3 month laryngoscopy regardless of tumor grade and margins. DESIGN: Case series. SETTING: Retrospective review of the clinical records of patients treated at the ENT department of a tertiary university hospital. PARTICIPANTS AND METHOD: Clinical records from patients with early-stage glottic carcinomas (Tis-T2) treated with curative intent by CO2-laser surgery in a ten year period were evaluated...
March 10, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28296145/synthesis-and-opioid-activity-of-tyr1-z-cf-ch-gly2-and-tyr1-s-r-cf3ch-nh-gly2-leu-enkephalin-fluorinated-pep-tidomimetics
#14
Somnath N Karad, Mohan Pal, Thomas E Prisinzano, Rachel Saylor Crowley, Ryan A Altman
We describe the design, synthesis, and opioid activity of fluoroalkene (Tyr1-ψ[(Z)CF=CH]-Gly2) and trifluoroethylamine (Tyr1-ψ[(S)/(R)-CF3CH-NH]-Gly2) analogs of the endogenous opioid neuropeptide, Leu-enkephalin. The fluoroalkene peptidomimetic exihibited low nanomolar functional activity (5.0 ± 2 nM and 60 ± 15 nM for δ- and μ-opioid receptors, respectively) with a μ/δ-selectivity ratio that mimicked the natural peptide. However, the trifluoroethyl-amine peptidomimetics, irrespective of stereochemistry, did not activate the opioid receptors, which suggest that bulky CF3 substitu-ents are not tolerated at this position...
March 14, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28292363/tonsillar-surface-micro-flora-does-it-truly-represent-pathological-tonsillar-flora
#15
Syed Nadeem Ul Haq, Zeeshan Ayub, Azeema Ahmed
OBJECTIVE: To determine the best method of identifying core tonsillar flora. STUDY DESIGN: Quasi-experimental study. PLACE AND DURATION OF STUDY: ENT Department, Combined Military Hospital, Lahore, from September 2013 to October 2015. METHODOLOGY: Eighty-seven patients of recurrent tonsillitis undergoing tonsillectomy were included. All the patients, after being anaesthetised, had surface swabs taken from the tonsillar surface followed by tonsillar aspiration with a 5cc syringe...
January 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28290230/cilia-and-ear
#16
Gioia Piatti, Maria Margherita De Santi, Sara Torretta, Lorenzo Pignataro, Daniela Soi, Umberto Ambrosetti
OBJECTIVE: To investigate the prevalence of otological complications derived from primary ciliary dyskinesia (PCD) in adulthood. METHODS: Twenty-three patients with diagnosed PCD underwent medical history aimed at recording the presence of ear, nose, and throat manifestations (ENT) and any surgical treatments. The ENT objectivity was annotated, and then patients were subjected to audiometric test, tympanometry, registration of otoacoustic emission, and vestibular evaluation...
April 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28287049/impact-of-processing-conditions-on-the-phytoprostanes-profile-of-three-types-of-nut-kernels
#17
Ana María Carrasco-Del Amor, Encarna Aguayo, Jacinta Collado-González, Alexandre Guy, Jean-Marie Galano, Thierry Durand, Ángel Gil-Izquierdo
The goal of this work was the identification and quantification of phytoprostanes (PhytoPs) in three types of nuts: "Walnut", "Macadamia", and "Pecan". This study represents a first approach to the relationship between the quantitative and qualitative PhytoP profiles in the "Macadamia" and "Pecan" nuts subjected to fried salt or fried honey processing. The kernels were found to contain 9-F1t-PhytoP, 9-epi-9-F1t-PhytoP, 16-B1-PhytoP, ent-16-B1-PhytoP, 9-L1-PhytoP, and ent-9-L1-PhytoP. "Macadamia" fried salt nuts were the only ones that produced 9-epi-9-D1-PhytoP and 9-D1-PhytoP...
February 2017: Free Radical Research
https://www.readbyqxmd.com/read/28283399/dietary-intake-and-lipid-profile-in-children-and-adolescents-with-cystic-fibrosis
#18
Janna W Woestenenk, Dorothea A Schulkes, Henk S Schipper, Cornelis K van der Ent, Roderick H J Houwen
BACKGROUND: Cystic fibrosis (CF) patients are advised to derive 35% of their daily energy intake from dietary fat. Whether this high fat intake is associated with dyslipidaemia is unknown. We described the lipid profile and dietary intake in paediatric patients with CF. METHODS: 110 fasting lipid concentrations of 110 Dutch patients with CF were studied, along with 86 measurements of dietary intake. For the total group and for boys and girls separately, the lipid profile and the dietary intake were investigated...
March 7, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28279631/drug-induced-sleep-endoscopy-a-new-gold-standard-for-evaluating-osas-part-i-technique
#19
M Blumen, E Bequignon, F Chabolle
Surgical results in obstructive sleep apnea syndrome (OSAS) vary greatly, whatever the surgical technique or site treated. Most authors agree that rigorous patient selection is logical and mandatory. Drug-induced sleep endoscopy (DISE) was introduced in 1991 and has been rediscovered and used extensively since the 2000s. It mimics sleep in order to observe the upper airway on flexible endoscopy. A review of the DISE literature was performed, and is reported in two parts. The present first part describes the technique: drugs, practical anesthesiologic and ENT modalities, reproducibility, and limitations...
March 6, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28279524/two-residues-determine-the-product-profile-of-the-class-ii-diterpene-synthases-tps14-and-tps21-of-tripterygium-wilfordii
#20
Nikolaj L Hansen, Jakob N Nissen, Björn Hamberger
The medicinal plant Tripterygium wilfordii (Celastraceae) contains a pair of class II diterpene synthases (diTPS) of specialized labdane-type metabolism that, despite remarkably close homology, form strikingly different products. TwTPS21 catalyzes bicyclization of the linear C20 precursor geranylgeranyl diphosphate to ent-copal-8-ol diphosphate, while TwTPS14 forms kolavenyl diphosphate. To determine the amino acid signature controlling the functional divergence of the homologues, we modeled their structures based on an existing crystal structure of the Arabidopsis ent-copalyl diphosphate synthase, archetypal of diTPSs in general metabolism of gibberellin phytohormones...
March 6, 2017: Phytochemistry
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