Read by QxMD icon Read


Xunian Zhou, Cyanne Ye Cao, Angel Tsz-Yau Wan, Grace Gar-Lee Yue, Frankie Hin-Fai Kwok, Kwok-Pui Fung, Handong Sun, Clara Bik-San Lau, Pema-Tenzin Puno, Stephen Kwok-Wing Tsui
BACKGROUND: Eriocalyxin B (EriB) is a natural ent-kaurane diterpenoid obtained from Isodon eriocalyx var. laxiflora (family Lamiaceae), which has multiple biological activities (e.g. anti-tumor and anti-inflammatory) via the alteration of gene expression and signaling transduction. Recently, RNA sequencing (RNA-seq) has been developed as a dynamic transcriptome approach to analyze the transcriptional profile and in addition use such gene expression profiles to identify novel candidate genes in a zebrafish model...
April 20, 2018: Molecular omics
Devina Maru, Ghada-Al Malky
OBJECTIVE: Effective management of patients diagnosed with ototoxicity is needed to reduce hearing and balance damage which affects communication and life quality. Despite widespread recommendations to monitor and manage ototoxicity in an early and effective manner, there is limited evidence to support the actual implementation of these recommendations for affected patient groups in healthcare services across the UK with limited publications available. In this study, an online questionnaire analysed the current practice of ototoxicity management and patient pathways across the UK once the diagnosis of ototoxicity was confirmed, targeting Audiologists, ENTs/AVPs and GPs...
April 20, 2018: International Journal of Audiology
Nicole Powell-Dunford, Charles Reese, Alaistair Bushby, Berit H Munkeby, Sébastien Coste, Višnja Livajić Pezer, Lars Rosenkvist
INTRODUCTION: Allergic rhinitis is a prevalent condition warranting special aeromedical consideration due to its potential for acute and painful manifestations involving the middle ear or paranasal sinuses during rapid barometric pressure changes. Although second generation antihistamines and intranasal steroids are safe and effective treatments for this common condition, aeromedical management varies. METHODS: An aeromedical policy review of 14 public access civil and military data repositories was undertaken...
May 1, 2018: Aerospace Medicine and Human Performance
Shengjie Li, Mingxi Shao, Danhui Li, Binghua Tang, Wenjun Cao, Xinghuai Sun
PURPOSE: It has been hypothesised that uric acid (UA) has a protective effect against oxidative damage in the central nervous system. Therefore, we investigated serum UA concentrations in patients with primary open-angle glaucoma (POAG) and explored the relationship between serum UA concentration and glaucoma severity. METHODS: This prospective, cross-sectional, case-control study was conducted in 163 POAG patients and 103 normal controls. Clinical and demographic information was obtained from the medical data platform of the Eye & ENT Hospital of Fudan University, Shanghai, China...
April 19, 2018: Acta Ophthalmologica
Karolina M Griffiths, Hélène Savini, Philippe Brouqui, Fabrice Simon, Philippe Parola, Philippe Gautret
Background: With increasing international travel and historically high numbers of residents visiting friends and relatives overseas, travel-associated illnesses are frequent in Marseille, France. We report the changing epidemiology of travel-related illnesses over a 12-year period. Methods: A single site GeoSentinel surveillance analysis was undertaken for 3460 ill returned travellers presenting to two public hospitals in Marseille, France from March 2003 to October 2015, with travel-related illnesses...
January 1, 2018: Journal of Travel Medicine
Baiyu Jian, Hao Zhang, Jicheng Liu
Diterpenoids are the focus of natural product drug discovery because of their great structural diversity and pronounced biological activities. Euphorbia fischeriana Steud is a Chinese traditional medicinal herb for curing edema, ascites, and cancer. This plant contains rich diterpenoids. Based on the carbon skeleton and substituents, it can be classified into thirteen subtypes: ent -abietane, daphnane, tigliane, ingenane, ent -atisane, ent -rosane, ent -kaurene, ent -kaurane, secotigliane, lathyrane, ent-pimarene, isopimarene and dimeric...
April 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Victoria I Holden, Meredith S Wright, Sébastien Houle, Abigail Collingwood, Charles M Dozois, Mark D Adams, Michael A Bachman
Klebsiella pneumoniae is rapidly acquiring resistance to all known antibiotics, including carbapenems. Multilocus sequence type ST258 (sequence type 258), carrying a gene encoding the K. pneumoniae carbapenemase ( bla KPC ) on a transmissible plasmid, is the most prevalent carbapenem-resistant Enterobacteriaceae (CRE) in the United States and has disseminated worldwide. Previously, whole-genome sequencing identified core genome single nucleotide variants that divide ST258 into two distinct clades, ST258a and ST258b...
April 25, 2018: MSphere
Alexandre B Todeschini, Mostafa Shahein, Alaa S Montaser, Douglas Hardesty, Bradley A Otto, Ricardo L Carrau, Daniel M Prevedello
A 42-yr-old female presented with an olfactory groove meningioma causing progressive vision loss and anosmia. Given the size of the tumor, we opted for a 2-stage surgery: endoscopic endonasal approach (EEA) followed by a craniotomy. Stage I surgery was a transcribriform transplanum EEA using a binostril 4-hand/2 surgeons (ENT and neuro) technique, with the patient positioned supine with the head slightly turned to the right side and tilted to the left, fixed in a 3-pin head clamp, under imaging guidance, in which we drilled out all the affected skull base bone, devascularized and debulked the tumor...
April 16, 2018: Operative Neurosurgery (Hagerstown, Md.)
Guowei Chen, Hongguang Pan, Lan Li, Jumei Wang, Delun Zhang, Zebin Wu
Young children with olfactory disturbance are sometimes encountered in ENT clinics. We investigated the clinical applicability of olfactory testing to the pediatric population in China.One hundred and ninety-three healthy children aged 6 to 17 years were enrolled. All participants were asked for demographic information (age, sex, body mass index [BMI], and rating of olfactory function) in a structured questionnaire and underwent olfactory testing including T&T Olfactometer (T&T), odor discrimination (OD), and odor identification (OI) tests of Sniffin' Sticks...
April 2018: Medicine (Baltimore)
Bin Cheng, Lin-Fen Ding, Tong Yan, Zhang-Qiao Xie, Zhi-Jun Zhang, Liu-Dong Song, Xing-De Wu, Qin-Shi Zhao
Twelve new ent-labdane diterpenoids, hypofolins A-F (1-6) and hypofolins G-L (7a/7b, 8a/8b, and 9a/9b), were isolated from the roots of Hypoestes phyllostachya "Pink Splash". Their structures were elucidated by extensive 1D and 2D NMR spectroscopic and HRMS data. The absolute configurations of 1, 2, 5, and 7a/7b were determined by single crystal X-ray diffraction and ECD analysis, as well as chemical transformations. Compounds 7a/7b, 8a/8b, and 9a/9b were isolated as three pairs of interconverting mixture of two isomers between ketone and hemiketal types...
April 18, 2018: Chemistry & Biodiversity
Sheng-Nan Zhang, Jin Zeng, Ya-Nan Tan, Rui-Jing Ma, Gui-Jie Zhang, Heng-Shan Wang, Qin-Gang Tan
A new natural product, 3α,19-dihydroxyl-ent-pimara-8(14),15-diene (1), which possesses an α-orientation hydroxymethyl at C-4 and ∆8,14 groups, as well as eight known compounds, was isolated from the rhizomes of Ricinus communis. The structure of 1 was elucidated by extensive spectroscopic methods and its absolute configurations were confirmed by X-ray crystallographic analysis. The inhibitory rate of 1 against protein tyrosine phosphatase 1B (PTP1B) was 49.49% at the concentration of 6.58 × 10-5  mol/L...
April 18, 2018: Journal of Asian Natural Products Research
Sanghee Yun, Ryan P Reynolds, Iraklis Petrof, Alicia White, Phillip D Rivera, Amir Segev, Adam D Gibson, Maiko Suarez, Matthew J DeSalle, Naoki Ito, Shibani Mukherjee, Devon R Richardson, Catherine E Kang, Rebecca C Ahrens-Nicklas, Ivan Soler, Dane M Chetkovich, Saïd Kourrich, Douglas A Coulter, Amelia J Eisch
Major depressive disorder (MDD) is considered a 'circuitopathy', and brain stimulation therapies hold promise for ameliorating MDD symptoms, including hippocampal dysfunction. It is unknown whether stimulation of upstream hippocampal circuitry, such as the entorhinal cortex (Ent), is antidepressive, although Ent stimulation improves learning and memory in mice and humans. Here we show that molecular targeting (Ent-specific knockdown of a psychosocial stress-induced protein) and chemogenetic stimulation of Ent neurons induce antidepressive-like effects in mice...
April 16, 2018: Nature Medicine
Hannah M Kansen, Thuy-My Le, Yolanda Meijer, Bertine M J Flokstra-de Blok, Paco M J Welsing, Cornelis K van der Ent, André C Knulst, Francine C van Erp
BACKGROUND: Food allergy significantly impairs health-related quality of life (HRQL). Currently, it is still unknown whether diagnostic interventions for food allergy improve HRQL. We aim to assess the impact of diagnostic interventions for food allergy on HRQL. METHODS: A systematic search was performed in MEDLINE, Embase, Cochrane Library and CINAHL focused on patients with a (suspected) food allergy who underwent diagnostic interventions (i.e. skin prick test, specific IgE or oral food challenges (OFC)), and in whom HRQL was assessed...
April 16, 2018: Pediatric Allergy and Immunology
Chenning Zhang, Caibin Qin, Guangyi Yang, Fadia Boughaba, Yue He, Weidong Ma, Yonghong Zhang, Song Gao
Maoecrystal A (MC-A) is an ent-kaurane-type diterpene isolated from Rabdosia eriocalyx (Dunn) Hara. MC-A has been reported to show different types of pharmacological activities, including anticancer, anti-inflammatory and bacteriostatic functions. However, bioanalysis of MC-A has not been reported. The purpose of this study is to develop an UPLC-MS/MS method to quantify MC-A in plasma and determine its pharmacokinetic properties using an animal model. The separation was performed using a Waters HSS T3 column (50 mm × 2...
April 10, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Seyyed Mustafa Hashemi, Nezamoddin Berjis, Hamidreza Ebrahimi
Background: Damage to ethmoid skull base (ESB) and lateral lamella (LL) during endoscopic sinus surgery (ESS) causes penetration into the brain. This study is aimed to determine the relationship between the height of ESB and length of LL by sectional coronal computed tomography (CT) scans before ESS. Materials and Methods: In a cross-sectional study, 100 patients admitted to ENT clinic of Al-Zahra Hospital, filled the consents regarding the use of CT scan stereotype...
2018: Advanced Biomedical Research
N D McNiven, J P Pracy, B A McGrath, A K Robson
In October 2016 an editorial was published jointly in Clinical Otolaryngology and the British Journal of Anaesthesia concerning the appropriate management of the difficult airway in a situation of 'Can't Intubate Can't Oxygenate' (CICO).1 It highlighted the importance of joint working between surgeons and anaesthetists and also made a case for the wider use of the scalpel-bougie cricothyroidotomy technique in securing a Front of Neck Airway (FONA), especially in an emergency. This article is protected by copyright...
April 15, 2018: Clinical Otolaryngology
Siwen Li, Huanmin Niu, Yanan Qiao, Rongxiu Zhu, Yong Sun, Zhaojie Ren, Huiqing Yuan, Yun Gao, Yi Li, Wang Chen, Jinchuan Zhou, Hongxiang Lou
Five new terpenoids (1-5) including two dollabellane-type, one ent-kaurane-type diterpenoids and two sesquiterpenoids were isolated from the Chinese liverwort Lepidozia reptans (L.) Dumort., together with nine known terpenoids (6-14). Their structures were determined on the basis of analysis of MS and NMR spectroscopic data, single-crystal X-ray diffraction and electronic circular dichroism calculations. The selected compounds 1, 2, 6, 7, 9 and 14 were screened for anti-inflammatory activities by the model of LPS-induced nitric oxide (NO) production with macrophage cells, and the mechanism of the active compounds 1 and 2 were further explored...
March 27, 2018: Bioorganic & Medicinal Chemistry
Yue Liu, Shan Lu, Liang Zhao, Xin Dong, Zhenyu Zhu, Yongsheng Jin, Haisheng Chen, Feng Lu, Zhanying Hong, Yifeng Chai
Studies have documented the potential antitumor activities of glaucocalyxin A (GLA), an ent-kaurene diterpenoid isolated from Rabdosia japonica. However, the metabolic mechanism underlying the antitumor activity of GLA remains largely unknown. The effects of GLA on the metabolome of human liver cancer cells using GC/MS- and LC/MS-based metabolic profiling have been investigated. An untargeted metabolomics approach in conjunction with orthogonal projection to latent structures-discriminant analysis (OPLS-DA) has been developed to characterize the metabolic modifications induced by GLA treatment in human hepatoma cell line SMMC7721...
April 13, 2018: Analytical and Bioanalytical Chemistry
Miha Zabret, Irena Hočevar Boltežar, Maja Šereg Bahar
Introduction: The voice represents a basic working tool for carrying out certain occupations. Hoarseness, as a consequence of vocal fold lesions, presents an important cause of work-related absences for voice professionals. Methods: Our study was designed as a retrospective cohort one. Data on gender, workplace, vocal load and exposure to risk factors for voice disorders of the patients who had surgery in the 2014-2015 period at the tertiary centre due to benign vocal fold lesions were collected from their clinical records...
March 2018: Zdravstveno Varstvo
(no author information available yet)
No abstract text is available yet for this article.
April 13, 2018: British Dental Journal
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"