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https://www.readbyqxmd.com/read/29055085/current-use-of-baseline-medical-treatment-in-chronic-rhinosinusitis-data-from-the-national-chronic-rhinosinusitis-epidemiology-study-cres
#1
Carl Philpott, Sally Erskine, Rupert Smith, Claire Hopkins, Naveed Kara, Amir Farboud, Mahmoud Salam, Alasdair Robertson, Rob Almeyda, B Nirmal Kumar, Shahram Anari, Jaydip Ray, Russell Cathcart, Sean Carrie, Shahzada Ahmed, Hisham Khalil, Allan Clark, Mike Thomas
OBJECTIVES: According to clinical and comissioning guidelines for chronic rhinosinusitis (CRS), patients being referred to secondary care should have failed primary medical treatment with nasal douching (ND) and intranasal corticosteroids (INCS). The study objectives were to identify the rate of specific medical therapy in CRS patients and establish any differences in medication use, for both CRS and associated medical conditions, between CRS phenotypes. DESIGN AND SETTING: Case-control study in a secondary care setting...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29055025/contribution-of-equilibrative-nucleoside-transporter-s-to-intestinal-basolateral-and-apical-transports-of-anticancer-trifluridine
#2
Koichi Takahashi, Kunihiro Yoshisue, Masato Chiba, Takeo Nakanishi, Ikumi Tamai
Trifluridine (FTD) exhibits anticancer activities after its oral administration despite its hydrophilic nature. We previously reported that concentrative nucleoside transporter (CNT) 1 mediates the apical uptake of FTD in human small intestinal epithelial cells (HIECs). In the present study, FTD was also identified as a substrate for equilibrative nucleoside transporter (ENT) 1 and ENT2 in transporter gene-transfected cells. An immunocytochemical analysis revealed that ENT1 was expressed at the basolateral and apical membranes of HIECs...
October 20, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29054752/esophageal-lesions-following-button-battery-ingestion-in-children-analysis-of-causes-and-proposals-for-preventive-measures
#3
J Lahmar, C Célérier, E N Garabédian, V Couloigner, N Leboulanger, F Denoyelle
OBJECTIVES: To study recent cases of esophageal injury due to button-battery ingestion in children presenting in pediatric ENT emergency departments of the Paris area of France (Île-de-France region), in order to propose appropriate preventive measures. MATERIAL AND METHOD: A retrospective descriptive single-center study included all children under 15 years of age, presenting in pediatric ENT emergency departments between January 2008 and April 2014 for button-battery ingestion with esophageal impaction requiring emergency removal...
October 17, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29051621/vector-independent-transmembrane-transport-of-oligodeoxyribonucleotides-involves-p38-mitogen-activated-protein-kinase-phosphorylation
#4
Minyuan Peng, Yanming Li, Jian Zhang, Yong Wu, Xiaoyang Yang, Ye Lei, Mao Ye, Jing Liu, Xu Han, Yijin Kuang, Xielan Zhao, Fangping Chen
The main roles of equilibrative nucleoside transporters (ENTs) and concentrative nucleoside transporters (CNTs) are to transfer single nucleosides and analogues for the nucleic acid salvage pathway. Oligodeoxyribonucleotides (ODNs) can be transported into the cytoplasm or nucleus of cells under certain conditions. Among ODNs composed of a single type of nucleotide, the transport efficiency differs with the length and nucleotide composition of the ODNs and varies in different types of leukaemia cells; among the 5 tested random sequence ODNs and 3 aptamers with varying sequences, the data showed that some sequences were associated with significantly higher transport efficiency than others...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051398/relationship-between-postoperative-complications-and-survival-after-gastrectomy-for-cancer
#5
Paolo Del Rio, Emiliano Bernuzzi, Elisa Bertocchi, Lorenzo Viani, Federico Cozzani, Chiara Montana
BACKGROUND: Surgical resection remains the main curative treatment for gastric cancer but is still affected by high postoperative morbidity and mortality rates, especially in Western countries. MATERIALS AND METHODS: We've analyzed patients treated for gastric cancer at our Operative Unit of ent, extent of lymphadenectomy and survival. General Surgery and Organ Transplantation of the University Hospital of Parma from January 2006 till December 2010, relating the occurrence of eventual complications to sex, age at diagnosis, definitive histological examination, type and duration of surgical treatment...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29050548/does-intranasal-steroid-spray-technique-affect-side-effects-and-compliance-results-of-a-patient-survey
#6
V Ganesh, A Banigo, A E L McMurran, M Shakeel, B Ram
BACKGROUND: Intranasal steroid sprays are fundamental in the medical management of inflammatory rhinological conditions. Side effects are common, but these may be related to the method of application rather than the medication itself. METHODS: A survey was distributed to patients using intranasal steroid sprays at the ENT out-patient clinic at Aberdeen Royal Infirmary over three months. This evaluated the spray technique used, side effects and compliance. RESULTS: Of 103 patients, 22 patients (21...
October 20, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29048158/efficient-energy-transfer-ent-in-pyrene-and-porphyrin-based-mixed-ligand-metal-organic-frameworks
#7
Kyoung Chul Park, Changwon Seo, Gajendra Gupta, Jeongyong Kim, Chang Yeon Lee
Designing and synthesizing the ordered light-harvesting systems, possessing complementary absorption and energy transfer process between the chromophores, are essential steps to accomplish successful mimicking of the natural photosynthetic systems. Metal-organic frameworks (MOFs) can be considered as an ideal system to achieve this due to their highly ordered structure, superior synthetic versatility and tailorable functionality. Herein, we have synthesized the new light-harvesting mixed-ligand MOFs (MLMs, MLM-1-3) via solvothermal reactions between a Zr6 cluster and mixture of an appropriate ratio of 1,3,6,8-tetrakis(p-benzoic acid)pyrene (H4TBAPy) and [5,10,15,20-tetrakis(4-carboxy-phenyl)porphyrinato]-Zn(II) (Zn-TCPP) ligands...
October 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29047167/the-association-between-an-genetic-risk-score-for-allergy-and-the-risk-of-developing-allergies-in-childhood-results-of-the-whistler-cohort
#8
Ali Arabkhazaeli, Fariba Ahmadizar, Maarten Leusink, Hubertus G M Arets, Jan A M Raaijmakers, Cuno S Uiterwaal, Cornelis K van der Ent, Anke-Hilse Maitland-van der Zee, Susanne J H Vijverberg
BACKGROUND: Several genetic variants have been associated with the susceptibility to allergic disease in adults, but it remains unclear whether these genetic variants are also associated with the onset of allergic disease early in life. The aim of this study was to develop a genetic risk score (GRS) for allergy based on findings in adults and study its predictive capacity for allergy in children. METHODS: A GRS was constructed based on 10 SNPs previously associated with allergies in adults...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29040487/pedunculated-liposarcoma-of-the-esophagus
#9
G B Salis, J C Albertengo, M Bruno, G Palau, R González Villaveirán, D Lombardo, V Villafañe, C Zorraquín, M Ghigliani
Polypoid tumours of the esophagus present diagnostic and therapeutic problems. Liposarcomas are infrequent among them. We report a recent case. A 73-year-old male patient was seen in May 1995 in the Ear, Nose and Throat (ENT) Department, Clinica Modelo de Morón, with intermittent dysphagia and dyspnoea due to recurrent vomiting. A laryngeal lineal tomography showed a subglottic obstruction due to extrinsic compression. The patient was referred to the Gastroenterology Department, where an upper gastrointestinal (upper GI) series demonstrated mega-esophagus with abundant retained food...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29038660/genetic-regulation-of-ga-metabolism-during-vernalization-floral-bud-initiation-and-development-in-pak-choi-brassica-rapa-ssp-chinensis-makino
#10
Mengya Shang, Xueting Wang, Jing Zhang, Xianhui Qi, Amin Ping, Leiping Hou, Guoming Xing, Gaizhen Li, Meilan Li
Pak choi (Brassica rapa ssp. chinensis Makino) is a representative seed vernalization vegetable and premature bolting in spring can cause significant economic loss. Thus, it is critical to elucidate the mechanism of molecular regulation of vernalization and floral bud initiation to prevent premature bolting. Gibberellin (GA) is the key plant hormone involved in regulating plant development. To gain a better understanding of GA metabolism in pak choi, the content of GA in pak choi was measured at different stages of plant development using enzyme-linked immunosorbent assay...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29038080/a-stent-retrieving-into-an-aspiration-catheter-with-proximal-balloon-asap-technique-a-technique-of-mechanical-thrombectomy
#11
Shunsaku Goto, Tomotaka Ohshima, Kojiro Ishikawa, Taiki Yamamoto, Shinji Shimato, Toshihisa Nishizawa, Kyozo Kato
PURPOSE: The best technique for the first attempt at mechanical thrombectomy for acute ischemic stroke is a still matter of debate. In this study, we evaluated the efficacy of a stent-retrieving into an aspiration catheter with proximal balloon (ASAP) technique that employs a series of thrombus extraction by withdrawing the stent retriever into the aspiration catheter, and continuous aspiration from the aspiration catheter in the first attempt. METHODS: We performed a retrospective analysis of 42 consecutive patients with acute ischemic stroke caused by occlusions in the anterior circulation, who were treated with the ASAP technique at our institution...
October 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29036583/characterization-of-moss-ent-kaurene-oxidase-cyp701b1-using-a-highly-purified-preparation
#12
Chisato Noguchi, Sho Miyazaki, Hiroshi Kawaide, Osamu Gotoh, Yuzo Yoshida, Yuri Aoyama
CYP701B1 of the moss, Physcomitrella patents, might be a unique cytochrome P450 having the ent-kaurene oxidase (KO) activity occurring in nonvascular plant. Phylogenetic analysis suggested that the gene encoding CYP701B1 was diverged from a common ancestral gene encoding KO of vascular plants. CYP701B1 expressed in Phichia yeast microsomes was purified and characterized. The purified CYP701B1 catalyzed the oxidation of ent-kaurene to ent-kaurenoic acid through three successive monooxygenations, and the rate-limiting step of this oxidation might be the initial step that forms ent-kaurenol...
September 27, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29034967/evaluation-of-a-method-for-isocapnic-hyperventilation-a-clinical-pilot-trial
#13
K Hallén, P Jildenstål, O Stenqvist, S-E Ricksten, S Lindgren
BACKGROUND: Isocapnic hyperventilation (IHV) is a method that shortens time to extubation after inhalation anaesthesia using hyperventilation (HV) without lowering airway CO2 . In a clinical trial on patients undergoing long-duration sevoflurane anaesthesia for major ear-nose-throat (ENT) surgery, we evaluated the utility of a technique for CO2 delivery (DCO2 ) to the inspiratory limb of a closed breathing circuit, during HV, to achieve isocapnia. METHODS: Fifteen adult ASA 1-3 patients were included...
October 16, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29033123/diagnosis-and-treatment-of-otitis-media-with-effusion-codepeh-recommendations
#14
Faustino Núñez-Batalla, Carmen Jáudenes-Casaubón, Jose Miguel Sequí-Canet, Ana Vivanco-Allende, Jose Zubicaray-Ugarteche
The incidence and the prevalence rates of otitis media with effusion (OME) are high. However, there is evidence that only a minority of professionals follow the recommendations provided in clinical practice guidelines. For the purpose of improving diagnosis and treatment of OME in children to prevent and/or reduce its impact on children's development, the Commission for the Early Detection of Deafness (CODEPEH) has deeply reviewed the scientific literature on this field and has drafted a document of recommendations for a correct clinical reaction to of OME, including diagnosis and medical and surgical treatment methodology...
October 13, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/29031536/extraction-of-carboxylic-acid-containing-diterpenoids-from-dodonaea-viscosa-via-pressurised-hot-water-extraction
#15
Bianca J Deans, Wesley J Olivier, David Girbino, Alex C Bissember, Jason A Smith
Pressurised hot water extraction (PHWE) was employed to effect the extraction of two carboxylic acid-containing ent-labdane diterpenoids from Dodonaea viscosa. The different extraction profile provided by PHWE in this case suggests that this recently developed method also has applications as a complementary tool for natural products extraction.
October 11, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29024833/health-of-vlbw-infants-in-germany-at-five-years-of-age-what-do-parents-describe
#16
Juliane Spiegler, Guido Stichtenoth, Inke R König, Egbert Herting, Wolfgang Göpel
BACKGROUND: There are only few data on medical problems and utilization of health services of former very low birth weight (VLBW) children at preschool age. STUDY DESIGN: At five years of age parents of a cohort of VLBW children (N=862) received questionnaires, a medical interview and examination. The results were compared to the KIGGS cohort (Deutscher-Kinder-und Jugendgesundheitssurvey, N=777). RESULTS: Parents of the VLBW and KIGGS cohort reported a very good or good health in 95% in their children...
October 9, 2017: Early Human Development
https://www.readbyqxmd.com/read/29018891/-depression-and-anxiety-prevalence-among-ent%C3%A2-outpatients
#17
D Kleemann, A Kresin, H Kleemann
BACKGROUND: Few data exist on the prevalence of comorbid mental disorders among ENT patients. This investigation aimed to assess the prevalence of two disorders frequent in our society, namely depression and anxiety, in patients of an ENT outpatient clinic. PATIENTS AND METHODS: During a 2‑week period, 101 consecutive patients were interviewed with the Beck Depression Inventory-II (BDI II) and Beck Anxiety Inventory (BAI) screening aids. RESULTS: Of 97 evaluated tests, 38% contained indications of a psychiatric problem or mental comorbidity...
October 10, 2017: HNO
https://www.readbyqxmd.com/read/29016590/endoscopic-endonasal-transsphenoidal-approach-to-pituitary-adenoma-a-multi-disciplinary-approach
#18
Deepak Regmi, Amit Thapa, Bidur Kc, Bikram Shakya
BACKGROUND: The excellent visualization and minimally invasive approach employed in endoscopic endonasal procedures has now revolutionized the pituitary surgery, replacing the transnasal microscopic technique worldwide. However, it involves major shift in hand-eye co-ordination from static 3 dimensional images of microscope to 2 dimensional endoscopic images hence demands training and inter-disciplinary approach. Here we present our experiences in learning and developing a safe endonasal transsphenoidal endoscopic approach to resect pituitary adenomas...
September 8, 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/29016581/bacteriological-study-of-otitis-media-and-its-antibiotic-susceptibility-pattern
#19
Rabina Basnet, Sudarshan Sharma, Jid Chani Rana, Pradeep Kumar Shah
BACKGROUND: Otitis Media is a prevailing and notorious infection in developing countries causing serious local damage and threating complication. Mainly in developing countries like Nepal, Otitis Media results because of illiteracy, poverty and poor hygiene. The aim of this study was to determine the profile of Otitis Media, its causative agents and their antibiotic susceptibility pattern. METHODS: The study included 263 pus samples from 240 patients attending ENT department of Bharatpur hospital from May 2015 to January 2016...
September 8, 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28994153/x-ray-elemental-mapping-techniques-for-elucidating-the-ecophysiology-of-hyperaccumulator-plants
#20
REVIEW
Antony van der Ent, Wojciech J Przybyłowicz, Martin D de Jonge, Hugh H Harris, Chris G Ryan, Grzegorz Tylko, David J Paterson, Alban D Barnabas, Peter M Kopittke, Jolanta Mesjasz-Przybyłowicz
Contents I. II. III. IV. V. VI. References SUMMARY: Hyperaccumulators are attractive models for studying metal(loid) homeostasis, and probing the spatial distribution and coordination chemistry of metal(loid)s in their tissues is important for advancing our understanding of their ecophysiology. X-ray elemental mapping techniques are unique in providing in situ information, and with appropriate sample preparation offer results true to biological conditions of the living plant. The common platform of these techniques is a reliance on characteristic X-rays of elements present in a sample, excited either by electrons (scanning/transmission electron microscopy), protons (proton-induced X-ray emission) or X-rays (X-ray fluorescence microscopy)...
October 10, 2017: New Phytologist
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