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https://www.readbyqxmd.com/read/28649564/primary-ciliary-dyskinesia-an-update-on-clinical-aspects-genetics-diagnosis-and-future-treatment-strategies
#1
REVIEW
Virginia Mirra, Claudius Werner, Francesca Santamaria
Primary ciliary dyskinesia (PCD) is an orphan disease (MIM 244400), autosomal recessive inherited, characterized by motile ciliary dysfunction. The estimated prevalence of PCD is 1:10,000 to 1:20,000 live-born children, but true prevalence could be even higher. PCD is characterized by chronic upper and lower respiratory tract disease, infertility/ectopic pregnancy, and situs anomalies, that occur in ≈50% of PCD patients (Kartagener syndrome), and these may be associated with congenital heart abnormalities...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28644410/enhanced-antibacterial-activity-of-ent-labdane-derivatives-of-salvic-acid-7%C3%AE-hydroxy-8-17-ent-labden-15-oic-acid-effect-of-lipophilicity-and-the-hydrogen-bonding-role-in-bacterial-membrane-interaction
#2
Javier Echeverría, Alejandro Urzúa, Loreto Sanhueza, Marcela Wilkens
In the present study, the antibacterial activity of several ent-labdane derivatives of salvic acid (7α-hydroxy-8(17)-ent-labden-15-oic acid) was evaluated in vitro against the Gram-negative bacterium Escherichia coli and the Gram-positive bacteria Staphylococcus aureus and Bacillus cereus. For all of the compounds, the antibacterial activity was expressed as the minimum inhibitory concentration (MIC) in liquid media and minimum inhibitory amount (MIA) in solid media. Structure activity relationships (SAR) were employed to correlate the effect of the calculated lipophilicity parameters (logPow) on the inhibitory activity...
June 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28641459/a-new-ent-kaurane-diterpene-derivative-from-the-stems-of-eurya-chinensis-r-br
#3
Jia-Ling Song, Yao Yuan, Ling-Hui Nie, Bai-Lin Li, Xu-Bing Qin, Yan Li, Jie-Wei Wu, Sheng-Xiang Qiu
One new ent-kaurane diterpene derivative (1), along with four known diterpenes, was isolated from the stems of Eurya chinensis R.Br. The structure of the new compound was established by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. Compound 1 showed moderate anti-inflammatory activities with IC50 value of 8.12 μM. This is the first example of diterpenoids with 4-hydroxy-4-(2-hydroxyethyl)-1-hydroxyl-cyclohexanoyl substituent.
June 23, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28641356/-tracheal-surgery
#4
Jan Volmerig, Erich Hecker
Surgery of the trachea is a specialised field in which many disciplines work jointly due to the variety of indications and the extended topography. Not only because of its particular functional importance, but also because of its complex morphology, anatomy and physiology, this organ represents a special therapeutic challenge. A variety of diseases require surgical procedures of the trachea; the therapeutic strategy is influenced both by the disease itself as well as patient-dependent parameters. Regardless of the nature of the underlying disorder, good results require a high level of expertise in airway management, a careful diagnosis and interventional planning as well as an experienced surgical team that masters extended operative techniques...
June 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28631673/-the-problems-associated-with-the-treatment-of-stenosing-laryngotracheitis-in-the-children-the-results-of-the-35-year-long-experience
#5
L A Safronenko, A P Davydova, V V Karpov, M G Lukashevich, V A Novikov
Stenosing laryngotracheitis (SLT) affecting the children is considered to be an emergency pediatric condition associated with ENT pathology. Its treatment presents a serious challenge for otolaryngologists, pediatricians, specialists in communicable diseases, allergologists, etc. We have undertaken a retrospective analysis of the available data with a view to summarizing the tendencies in the evolution of SLT morbidity. The results of the 35 year-long experience with the use of the currently available therapeutic strategies for the treatment of the children suffering from stenosing laryngotracheitis are presented...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28627377/mikania-glomerata-sprengel-extract-and-its-major-compound-ent-kaurenoic-acid-display-activity-against-bacteria-present-in-endodontic-infections
#6
Dora Lúcia Carrara Moreti, Luís Fernando Leandro, Thaís da Silva Moraes, Monique Rodrigues Moreira, Rodrigo Cassio Sola Veneziani, Sergio Ricardo Ambrosio, Brenda Paula Figueiredo Almeida Gomes, Carlos Henrique Gomes Martins
The search for new, effective and safe antimicrobial compounds from plant sources has continued to play an important role in the maintenance of human health since ancient times. Such compounds can be used to help to eradicate microorganisms from the root canal system, preventing/healing periapical diseases. Mikania glomerata (Spreng.), commonly known as "guaco," is a native climbing plant from Brazil that displays a wide range of pharmacological properties. Many of its activities have been attributed to its phytochemical composition, which is mainly composed of diterpenes, such as ent-kaurenoic acid (KA)...
June 13, 2017: Anaerobe
https://www.readbyqxmd.com/read/28624597/suppressive-effect-of-kamebakaurin-on-acetaminophen-induced-hepatotoxicity-by-inhibiting-lipid-peroxidation-and-inflammatory-response-in-mice
#7
Hiroki Yoshioka, Yutaka Aoyagi, Nobuyuki Fukuishi, Ming-Yu Gui, Yong-Ri Jin, Xu-Wen Li, Yoshiyuki Adachi, Naohito Ohno, Koichi Takeya, Yukio Hitotsuyanagi, Nobuhiko Miura, Tsunemasa Nonogaki
BACKGROUND: Kamebakaurin (KA) is an ent-kaurane diterpenoid known to have anti-inflammatory potential. In the current study, we investigated whether pretreatment with KA could ameliorate acetaminophen (APAP)-induced hepatotoxicity by inhibiting the anti-inflammatory response in mice. METHODS: Seven-week-old C57BL/6J mice were orally administered KA or olive oil emulsion for seven days. Twenty-four hours after the last KA or olive oil administration, the mice were intraperitoneally injected with 400mg/kg APAP or saline under feed deprived condition...
April 12, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28623244/it-s-a-cod-finding-nemo-impacted-fishbone-in-the-emergency-department
#8
Aileen McCabe, Andrew Patton, Nigel Salter
A 23-year-old woman presented to the emergency department (ED) with a sensation of a 'fish bone' stuck in her throat after eating cod. On physical examination, while she reported an uncomfortable sensation in her throat, no airway compromise was evident. Clinical examination, including ear, nose and throat (ENT) and oropharyngeal assessment, was unremarkable. A linear opacity consistent with a fishbone was visualised on a soft tissue lateral neck X-ray anterior to the vertebral body of C4-6. One attempt to visualise the fishbone on direct laryngoscopy failed in the ED...
June 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28621966/rosenbluth-separation-of-the-%C3%AF-0-electroproduction-cross-section-off-the-neutron
#9
M Mazouz, Z Ahmed, H Albataineh, K Allada, K A Aniol, V Bellini, M Benali, W Boeglin, P Bertin, M Brossard, A Camsonne, M Canan, S Chandavar, C Chen, J-P Chen, M Defurne, C W de Jager, R de Leo, C Desnault, A Deur, L El Fassi, R Ent, D Flay, M Friend, E Fuchey, S Frullani, F Garibaldi, D Gaskell, A Giusa, O Glamazdin, S Golge, J Gomez, O Hansen, D Higinbotham, T Holmstrom, T Horn, J Huang, M Huang, G M Huber, C E Hyde, S Iqbal, F Itard, Ho Kang, Hy Kang, A Kelleher, C Keppel, S Koirala, I Korover, J J LeRose, R Lindgren, E Long, M Magne, J Mammei, D J Margaziotis, P Markowitz, A Martí Jiménez-Argüello, F Meddi, D Meekins, R Michaels, M Mihovilovic, N Muangma, C Muñoz Camacho, P Nadel-Turonski, N Nuruzzaman, R Paremuzyan, A Puckett, V Punjabi, Y Qiang, A Rakhman, M N H Rashad, S Riordan, J Roche, G Russo, F Sabatié, K Saenboonruang, A Saha, B Sawatzky, L Selvy, A Shahinyan, S Sirca, P Solvignon, M L Sperduto, R Subedi, V Sulkosky, C Sutera, W A Tobias, G M Urciuoli, D Wang, B Wojtsekhowski, H Yao, Z Ye, L Zana, X Zhan, J Zhang, B Zhao, Z Zhao, X Zheng, P Zhu
We report the first longitudinal-transverse separation of the deeply virtual exclusive π^{0} electroproduction cross section off the neutron and coherent deuteron. The corresponding four structure functions dσ_{L}/dt, dσ_{T}/dt, dσ_{LT}/dt, and dσ_{TT}/dt are extracted as a function of the momentum transfer to the recoil system at Q^{2}=1.75  GeV^{2} and x_{B}=0.36. The ed→edπ^{0} cross sections are found compatible with the small values expected from theoretical models. The en→enπ^{0} cross sections show a dominance from the response to transversely polarized photons, and are in good agreement with calculations based on the transversity generalized parton distributions of the nucleon...
June 2, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28621782/stereodivergent-synthesis-of-all-the-four-stereoisomers-of-antidepressant-reboxetine
#10
Cheng Liu, Zhi-Wei Lin, Zhao-Hui Zhou, Hong-Bin Chen
Chiral amino alcohol-copper(ii) catalysts Cu-L1c and Cu-ent-L1c were utilized to promote the diastereoselective nitroaldol reactions of chiral aldehydes (S)-3 or (R)-3 with nitromethane, which respectively led to the preferential formation of certain stereoisomer for nitro diol derivatives 4. Using this catalytic protocol, all the four stereoisomers of the antidepressant reboxetine were divergently prepared. The highest overall yield of this synthetic route reached up to 30.5% from aldehyde (S)-3.
June 16, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28620761/medicinal-chemistry-of-%C3%AF-1-receptor-ligands-pharmacophore-models-synthesis-structure-affinity-relationships-and-pharmacological-applications
#11
Frauke Weber, Bernhard Wünsch
In the first part of this chapter, we summarize the various pharmacophore models for σ1 receptor ligands. Common to all of them is a basic amine flanked by two hydrophobic regions, representing the pharmacophoric elements. The development of computer-based models like the 3D homology model is described as well as the first crystal structure of the σ1 receptor. The second part focuses on the synthesis and biological properties of different σ1 receptor ligands, identified as 1-9. Monocyclic piperazines 1 and bicyclic piperazines 2 and 3 were developed as cytotoxic compounds, thus the IC50 values of cell growth and survival inhibition studies are given for all derivatives...
June 16, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28616774/-molecular-component-resolved-allergy-diagnostics-in-ent
#12
REVIEW
L Klimek, S Becker
Molecular component-resolved diagnostics (CRD) are, in addition to its research applications, being increasingly used in daily allergological routine. CRD offers improved diagnostic accuracy via a better understanding of the underlying allergen causing symptoms and helps to distinguish between true sensitization and cross reactions in polysensitized patients, thereby providing an approach for individual personalized therapy. Particularly in food allergies and anaphylaxis, CRD can stratify risks for the recurrence of reactions and their severity...
June 14, 2017: HNO
https://www.readbyqxmd.com/read/28613902/nickel-catalyzed-c-h-silylation-of-arenes-with-vinylsilanes-rapid-and-reversible-%C3%AE-si-elimination
#13
Matthew R Elsby, Samuel A Johnson
The reaction of C6F5H and H2C═CHSiMe3 with catalytic [(i)Pr2Im]Ni(η(2)-H2C═CHSiMe3)2 (1b) exclusively forms the C-H silylation product C6F5SiMe3 with ethylene as a byproduct ([(i)Pr2Im] = 1,3-di(isopropyl)imidazole-2-ylidene). Catalytic C-H bond silylation is facile with partially fluorinated aromatic substrates containing two ortho fluorine substituents adjacent to the C-H bond and 1,2,3,4-tetrafluorobenzene. Less fluorinated substrates react slower. Under the same reaction conditions, catalytic [IPr]Ni(η(2)-H2C═CHSiMe3)2 (1a) ([IPr] = 1,3-bis[2,6-diisopropylphenyl]-1,3-dihydro-2H-imidazol-2-ylidene) provided only the alkene hydroarylation product C6F5CH2CH2SiMe3...
June 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28611799/endophytic-paecilomyces-formosus-lhl10-augments-glycine-max-l-adaptation-to-ni-contamination-through-affecting-endogenous-phytohormones-and-oxidative-stress
#14
Saqib Bilal, Abdul L Khan, Raheem Shahzad, Sajjad Asaf, Sang-Mo Kang, In-Jung Lee
This study investigated the Ni-removal efficiency of phytohormone-producing endophytic fungi Penicillium janthinellum, Paecilomyces formosus, Exophiala sp., and Preussia sp. Among four different endophytes, P. formosus LHL10 was able to tolerate up to 1 mM Ni in contaminated media as compared to copper and cadmium. P. formosus LHL10 was further assessed for its potential to enhance the phytoremediation of Glycine max (soybean) in response to dose-dependent increases in soil Ni (0.5, 1.0, and 5.0 mM). Inoculation with P...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28608188/-hiv-associated-plasmablastic-lymphoma-of-the-paranasal-sinuses-an-incidental-finding
#15
V Weber, K Helling, C Matthias
A 48-year-old female patient presented to the ENT department of the University Medical Center of the Johannes Gutenberg University Mainz with subfebrile temperatures, one-sided nasal obstruction, and left-sided cephalgia. Clinical examination and CT scans showed a mass occupying the left nasal cavity and left paranasal sinuses. Further diagnosis and histopathological examination showed an HIV-associated plasmablastic lymphoma of the left paranasal sinuses. This case report with literature review discusses the diagnosis and treatment of this rare nasal tumor...
June 12, 2017: HNO
https://www.readbyqxmd.com/read/28607898/a-study-of-clinicopathological-profile-of-patients-of-hoarseness-of-voice-presenting-to-tertiary-care-hospital
#16
Smita Soni, Sanchay Chouksey
Hoarseness is subjective term used to describe abnormal voice quality which may occur due to many causes because it is just a symptom. Proper knowledge and clinicopathological profile is important to treat the underlying pathology. This prospective study was carried out in 100 patients presented in Department of ENT, Gandhi Medical College, Bhopal from April 2013 to September 2014 with complaint of hoarseness of voice for more than 15 days. Objective of this study is to study incidence, duration and sex predilection for hoarseness of voice...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28607887/odontogenic-tumours-of-jaw-a-prospective-study-on-clinico-pathological-profile-and-their-management
#17
Dwaipayan Mukherjee, Chiranjib Das, Pritam Chatterjee
Odontogenic tumours are a group of heterogeneous diseases that range from hamartomatous or non-neoplastic tissue proliferations to benign neoplasms to malignant tumours with metastatic potential. They are rare, comprising about <2-3% of all oral and maxillofacial biopsy specimens. The aim of the present study was to determine the clinico-pathological presentation of this heterogeneous group of lesions and review of literature. The present study was conducted in the ENT department of a Government Medical College and Hospital, West Bengal, India, over the period of 5 years from January 2011 to December 2015...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28607880/role-of-autologous-versus-homologous-cartilage-in-ossicular-reconstruction-a-comparative-study
#18
Karan Sharma, Pratibha Gururani, Archana Arora, Gagandeep Singh
Ossicular discontinuity is the most common cause of conductive hearing loss. The use of ossicular graft material in ossicular chain reconstruction significantly improves the result in hearing. This study was conducted to compare and analyze the outcome of ossicular reconstruction using autologous conchal cartilage and homologous septal cartilage in terms of hearing results and graft uptake rates. Study design Randomized clinical trial. Study included 100 patients visiting the ENT department of government medical college...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28606263/-three-dimensional-vector-analysis-after-decompression-surgery-in-thyroid-associated-ophthalmopathy
#19
J Guo, J Qian, X F Li, F X Meng, R Q Ma
Objective: To analyze the change of globe position after different orbital decompression in thyroid-associated ophthalmopathy (TAO). Methods: It was a retrosective case series study. Twenty-nine TAO patients (33 eyes) underwent orbital decompression were collected between October 2014 and December 2016 at Eye & ENT Hospital of Fudan University. There were 17 males and 12 females, and the average age was 46 years (ranging from 21 to 66 years). Fifteen patients (17 eyes) underwent balanced decompression, 11 patients (11 eyes) underwent deep lateral decompression, and 4 patients (5 eyes) underwent medial decompression...
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28605817/-handling-and-reprocessing-of-semicritical-medical-devices-in-the-ent-a-prospective-study
#20
Roland Hülse, Angela Wenzel, J Ulrich Sommer, Manfred Hülse, Karl Hörmann
Numerous laws, guidelines and recommendations govern the handling and reprocessing of semi-critical medical devices in the field of ENT. Although mechanically reprocessing is characterized as a preferential, manual reprocessing is still conducted in most ENT clinics and medical practices for reasons of cost and practicability. In the presented study, we developed an optimized hygienic concept for reprocessing of medical products in the field of ENT.A demand analysis of rigid endoscopes and of ENT equipment was carried out based on hypothesis that only mechanical reprocessing was performed for the entire instrumentation...
June 12, 2017: Laryngo- Rhino- Otologie
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