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https://www.readbyqxmd.com/read/29223623/gene-indexed-mutations-in-maize-zea-mays
#1
Xiaoduo Lu, Jisheng Liu, Wen Ren, Qun Yang, Zhenguang Chai, Rumei Chen, Lei Wang, Jun Zhao, Zhihong Lang, Haiyang Wang, Yunliu Fan, Jiuran Zhao, Chunyi Zhang
The availability of the B73 inbred reference genome sets the stage for high- throughput functional characterisation of maize genes on a whole-genome scale. Among the 39,324 protein-coding genes predicted, the vast majority has been untapped due to the lack of suitable high throughput reverse genetic resources. We have generated a gene-indexed maize mutant collection through ethyl methanesulfonate (EMS) mutagenesis and detected the mutations by combining exome capture and next-generation sequencing. A total of 1,086 mutated M1 plants were sequenced and 195,268 CG>TA-type point mutations, including stop gain/loss, missplice, start gain/loss, and various non-synonymous protein mutations as well as 4,610 InDel mutations, were identified...
December 6, 2017: Molecular Plant
https://www.readbyqxmd.com/read/29223159/factors-beyond-enolase-2-and-mitochondrial-lysyl-trna-synthetase-precursor-are-required-for-trna-import-into-yeast-mitochondria
#2
M V Baleva, M Meyer, N Entelis, I Tarassov, P Kamenski, B Masquida
In yeast, the import of tRNALys with CUU anticodon (tRK1) relies on a complex mechanism where interaction with enolase 2 (Eno2p) dictates a deep conformational change of the tRNA. This event is believed to mask the tRNA from the cytosolic translational machinery to re-direct it towards the mitochondria. Once near the mitochondrial outer membrane, the precursor of the mitochondrial lysyl-tRNA synthetase (preMsk1p) takes over enolase to carry the tRNA within the mitochondrial matrix, where it is supposed to participate in translation following correct refolding...
November 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29213222/antiplasmodial-compounds-from-leaves-of-dodonaea-angustifolia
#3
Yadessa Melaku, Tefera Worku, Yemane Tadesse, Yalemtsehay Mekonnen, Juergen Schmidt, Norbert Arnold, Ermias Dagne
Background: Dodonaea angustifolia is used in Ethiopian traditional medicine to treat malaria. The objective of this work was to conduct bioassay guided fractionation of the leaves of D. angustifolia using Plasmodium berghei infected mice. Method: The antiplasmodial activity of the extracts and pure compounds was evaluated using the standard Peter's four-day suppressive method. The structures of isolated compounds were elucidated using chemi-cal and spectroscopic methods...
September 2017: Current Bioactive Compounds
https://www.readbyqxmd.com/read/29210182/topical-ofloxacin-use-in-g6pd-deficiency-safe-or-unsafe
#4
Natalie Watson, Manuel Gomez Serrano, David Selvadurai
we have recently treated a paediatric patient with known glucose-6-phosphate dehydrogenase (G6PD) deficiency and wished to communicate to the clinical ENT community the controversies around the use of fluoroquinolone (FQ) antibiotic drops in this patient cohort. This article is protected by copyright. All rights reserved.
December 6, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29208244/role-of-nucleoside-transporters-in-transplacental-pharmacokinetics-of-nucleoside-reverse-transcriptase-inhibitors-zidovudine-and-emtricitabine
#5
S Karbanova, L Cerveny, M Ceckova, Z Ptackova, L Jiraskova, S Greenwood, F Staud
INTRODUCTION: Zidovudine (AZT) and emtricitabine (FTC) are effective and well tolerated antiretroviral drugs, routinely used in the prevention of perinatal HIV transmission. However, precise mechanism(s) involved in their transfer from mother to fetus are not fully elucidated. Since both drugs are nucleoside analogues, we hypothesized that the mechanisms of their transplacental passage might include equilibrative nucleoside transporters, ENT1 and/or ENT2. METHODS: To address this issue, we performed in vitro accumulation assays in the BeWo placental trophoblast cell line, ex vivo uptake studies in fresh villous fragments isolated from human placenta and in situ dually perfused rat term placenta experiments...
December 2017: Placenta
https://www.readbyqxmd.com/read/29205726/total-synthesis-of-maoecrystal-p-the-application-of-a-strained-bicyclic-synthon
#6
Fan Su, Yandong Lu, Lingran Kong, Jingjing Liu, Tuoping Luo
A new strategy was devised for the total syntheses of highly oxidized ent-kauranoids. A highly regio- and diastereoselective intermolecular Diels-Alder cycloaddition involving a diene embedded in a substituted bicyclo[4.1.0] skeleton was used to assemble all but the C17 carbon of the target molecule at the early stage of the synthesis. The subsequent synthetic steps including redox manipulations, SmI2-mediated cyclization and isomerizations afforded the anti-tumor natural product, maoecrystal P.
December 3, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29202490/-metastasation-of-cutaneous-squamous-cell-carcinoma-in-the-ent-area
#7
Alexander Dellweg, Thomas Mantei
Objectives Our aim was to investigate the metastasis behavior and its prognostic Factor for Survival, with our clinical data. Materials and methods This retrospective study included 29 Caucasians, with a squamous cell carcinoma of the skin in the head and neck region, at our tertiary clinic between 2004 and 2016. All Patients received a Tumorresection and Neckdissection. We used either Ultrasound or Computer-Tomography (conventional or PET-CT) for our preoperative Staging and the Follow-up. The Patients were classified according to metastatic behavior and the corresponding survival rates were determined...
December 4, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29197966/aetiological-profile-and-treatment-outcomes-of-epistaxis-at-a-major-teaching-hospital-a-review-of-721-cases
#8
Brian Carey, Patrick Sheahan
BACKGROUND: Epistaxis is the most prevalent ENT emergency and a significant burden on ENT services. Our objective was to study the incidence and outcomes of patients presenting with epistaxis at a major teaching hospital. METHODS: A retrospective descriptive study of 721 patients, who presented with epistaxis over a 1-year period, was carried out. Data collected was analysed using SPSS software version 20. RESULTS: Of the 721 patients, initial treatment consisted of nasal cautery (298), nasal packing (200), or no treatment (223)...
December 2, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29194024/adapting-the-mullen-scales-of-early-learning-for-a-standardized-measure-of-development-in-children-with-rett-syndrome
#9
Tessa Clarkson, Jocelyn LeBlanc, Geneva DeGregorio, Vanessa Vogel-Farley, Katherine Barnes, Walter E Kaufmann, Charles A Nelson
Rett Syndrome (RTT) is characterized by severe impairment in fine motor (FM) and expressive language (EL) function, making accurate evaluations of development difficult with standardized assessm ents. In this study, the administration and scoring of the Mullen Scales of Early Learning (MSEL) were adapted to eliminate the confounding effects of FM and EL impairments in assessing development. Forty-seven girls with RTT were assessed with the Adapted-MSEL (MSEL-A), a subset (n = 30) was also assessed using the Vineland Adaptive Behavior Scales-Second Edition (Vineland-II) and a further subset (n = 17) was assessed using an eye-tracking version of the MSEL (MSEL-ET)...
December 2017: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/29187760/the-exit-ex-utero-intrapartum-treatment-procedure-from-the-paediatric-ent-perspective
#10
B Pucher, J Szydlowski, K Jonczyk-Potoczna, J Sroczynski
The main principle of the EXIT procedure is to maintain uteroplacental circulation with neonatal anaesthesia by controlled uterine hypotonia. This enables securing the foetal airways and decompress or resect large neck and mediastinal foetal masses. The authors present their experience with use of the EXIT procedure in 7 foetuses in whom evaluation and management of the airways were performed. In 4 patients, the neck mass was surgically removed in the neonatal period, in 1 the propranolol treatment was introduced...
November 30, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29187193/paediatric-case-mix-in-a-rural-clinical-school-is-relevant-to-future-practice
#11
Helen M Wright, Moira A L Maley, Denese E Playford, Pam Nicol, Sharon F Evans
BACKGROUND: Exposure to a representative case mix is essential for clinical learning, with logbooks established as a way of demonstrating patient contacts. Few studies have reported the paediatric case mix available to geographically distributed students within the same medical school. Given international interest in expanding medical teaching locations to rural contexts, equitable case exposure in rural relative to urban settings is topical. The Rural Clinical School of Western Australia locates students up to 3500 km from the urban university for an academic year...
November 29, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29186749/-microvascular-reconstruction-of-the-larynx-following-total-laryngectomy
#12
Stephan Hackenberg, Norbert Kleinsasser, Agmal Scherzad, Fabian Kraus, Rudolf Hagen
Total laryngectomy still is a standard procedure for the treatment of advanced laryngeal or hypopharyngeal carcinoma. The unavoidable loss of voice may lead to serious impairments in quality of life. The most common technique of voice restoration is the tracheal-esophageal puncture combined with the application of a voice prosthesis. Laryngeal reconstruction with a radial forearm flap represents a possible surgical method of voice restoration. This study is a mono-center retrospective analysis of patients receiving a so-called laryngoplasty after total laryngectomy between 2006 and 2015, focusing on long-term functional outcome and complications...
November 29, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29179884/mortality-pattern-in-otorhinolaryngology-ward-a-5-years%C3%A2-retrospective-study-at-an-urban-tertiary-health-care-center-in-india
#13
Vivek Kumar, Satish Kumar, Naresh Chandra Sharma, Badal Kumar
BACKGROUND: To recognize deaths in the otorhinolaryngology indoor wards, determine the reason behind the mortalities and recommend modifications for betterment of patient care and surgical outcomes. METHOD: Data was collected from the mortality register, operation theatre registers, ward registers and case notes of patients declared dead at an urban tertiary health care center in India for a period of 5 years; from January 2012 to December 2016. The data included date of admission, age, sex, educational status, residence, and clinical diagnosis, course of hospital stay and medical cause of death...
October 2017: Biomedical Journal
https://www.readbyqxmd.com/read/29166865/king-s-health-partners-prostate-cancer-biobank-khp-pcabb
#14
S R Saifuddin, W Devlies, A Santaolalla, F Cahill, G George, D Enting, S Rudman, P Cathcart, B Challacombe, P Dasgupta, C Galustian, A Chandra, S Chowdhury, C Gillett, M Van Hemelrijck
The KHP PCaBB was established in 2013 and recruits donors from the Urology or Oncology Departments at Guy's Hospital in London (UK). Prostate cancer patients may be approached to give their consent for biobanking at any point in their treatment pathway, which allows residual material from their earlier diagnosis to be transferred and used by the Biobank. Currently, patients are specifically asked to donate samples of blood and surplus prostate tissue as well as permitting access to their clinical and pathological data that continues to be added throughout the course of their disease...
November 22, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29166424/the-future-in-rhinology-from-local-treatment-to-monoclonals-and-influencing-the-microbiome
#15
W J Fokkens
Over the last few decades, rhinology has been one of the most dynamic and progressive areas of ENT. We have not experienced such an intense period of development since the introduction of nasal corticosteroids in the 1970s.
November 22, 2017: Rhinology
https://www.readbyqxmd.com/read/29166422/intranasal-bevacizumab-in-the-treatment-of-hht-related-epistaxis-a-systematic-review
#16
P Stokes, J Rimmer
BACKGROUND: Hereditary haemorrhagic telangiectasia (HHT) remains a difficult disease for the ENT specialist to manage. Affected patients often report recurrent epistaxis as the most debilitating symptom. The pathogenesis of the disease is due to genetic mutations affecting angiogenesis. For this reason, the anti-angiogenic therapy bevacizumab has gained popularity in the local treatment of epistaxis in patients with HHT. OBJECTIVE: A systematic review of the efficacy of bevacizumab in local treatment of epistaxis in patients with HHT based on epistaxis duration, frequency, severity and impact on quality of life...
November 22, 2017: Rhinology
https://www.readbyqxmd.com/read/29165436/cochlear-implant-in-prelingually-deafened-oralist-adults-speech-perception-outcomes-subjective-benefits-and-quality-of-life-improvement
#17
F Forli, G Turchetti, G Giuntini, S Bellelli, S Fortunato, L Bruschini, M R Barillari, S Berrettini
The aim of this study is to report our results in a group of prelingually deafened adults, who followed an oralist rehabilitation programme, and submitted to cochlear implant at our institution. We evaluated 30 prelingually deafened adult patients, 18 males and 12 females, median age 35 years, of a group of 36 prelingually deafened adult patients consecutively submitted to unilateral cochlear implantation at the ENT Unit of the University of Pisa. After implantation, patients achieved significant benefits in terms of speech perception skills, including the ability to have telephone conversations in some cases, quality of life and their own perception of disability...
October 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29165214/fecal-contamination-on-produce-from-wholesale-and-retail-food-markets-in-dhaka-bangladesh
#18
Angela R Harris, Mohammad Aminul Islam, Leanne Unicomb, Alexandria B Boehm, Stephen Luby, Jennifer Davis, Amy J Pickering
Fresh produce items can become contaminated with enteric pathogens along the supply chain at the preharvest (e.g., irrigation water, soil, fertilizer) or postharvest (e.g., vendor handling or consumer handling) stages. This study assesses the concentrations of fecal indicator bacteria Escherichia coli, enterococci (ENT), and Bacteriodales on surfaces of carrots, eggplants, red amaranth leaves, and tomatoes obtained from both a wholesale market (recently harvested) and neighborhood retail markets in Dhaka, Bangladesh...
November 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29163996/lymphangiomatous-polyp-presenting-as-tonsillar-mass
#19
Ashish Dhakal, Sameer Karmacharya, Sandhya Shrestha
A 19-year-old female presented to ENT OPD of Dhulikhel Hospital, Kathmandu University Hospital, with history of foreign body sensation in throat for 2 weeks and mass in left tonsil for 1 week. There is no history of difficulty swallowing or recurrent throat infection. Physical examination revealed a pedunculated mass arising from upper pole of left tonsil. Bilateral tonsillectomy was done under general anaesthesia. Grossly, 2.5 × 1.5 × 1 cm polypoidal mass, soft in consistency, was found to be attached to left tonsil...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29160150/electrocardiogram-screening-in-children-with-congenital-sensorineural-hearing-loss-prevalence-and-follow-up-of-abnormalities
#20
Zainab Farzal, Jonathan Walsh, Faisal I Ahmad, Jason Roberts, Sunita J Ferns, And Carlton J Zdanski
Objective The purpose is to determine the prevalence of electrocardiogram (ECG) abnormalities, including borderline and prolonged QT, among screened children with sensorineural hearing loss (SNHL) and to analyze their subsequent medical workup. Study Design Institutional Review Board-approved case series with chart review. Setting Tertiary academic center. Subjects and Methods Cases from 1996 to 2014 involving pediatric patients (N = 1994) with SNHL were analyzed. Abnormal ECGs were categorized as borderline/prolonged QT or other...
November 1, 2017: Otolaryngology—Head and Neck Surgery
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