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https://www.readbyqxmd.com/read/28426518/pathophysiologic-insight-into-mesoamerican-nephropathy
#1
Magdalena Madero, Fernando E García-Arroyo, Laura-Gabriela Sánchez-Lozada
PURPOSE OF REVIEW: Mesoamerican nephropathy (MeN) is an emerging pathophysiological entity of Chronic kidney desease (CKD) not related to traditional risk factors (diabetes and hypertension) that have caused thousands of deaths in Central America, mainly in sugarcane workers. The focus of this review is to discuss the risk factors and probable mechanisms involved in the initiation and progression of this devastating disease. RECENT FINDINGS: Frequent episodes of subclinical Acute kidney injury caused by repetitive heat stress, dehydration, and strenuous work have been regarded as the main risk factors for MeN...
April 19, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28424997/changing-places-changing-plates-a-binational-comparison-of-barriers-and-facilitators-to-healthful-eating-among-central-american-communities
#2
Melissa Fuster, Uriyoán Colón-Ramos
To understand the process by which immigrants adopt dietary practices, this study offers a binational comparison of factors that predispose, enable, and reinforce healthful eating in the sending and receiving countries. Data are from two qualitative studies that examined barriers and facilitators to healthful eating in El Salvador (four focus groups, n = 28 adults) and in the US (30 in-depth interviews n = 15 mothers recently migrated from Central America). There was a strong emphasis on hygiene and vitamin-content of foods among participants in El Salvador...
April 19, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28420332/genetic-diversity-of-elaeis-oleifera-hbk-cortes-populations-using-cross-species-ssrs-implication-s-for-germplasm-utilization-and-conservation
#3
Maizura Ithnin, Chee-Keng Teh, Wickneswari Ratnam
BACKGROUND: The Elaeis oleifera genetic materials were assembled from its center of diversity in South and Central America. These materials are currently being preserved in Malaysia as ex situ living collections. Maintaining such collections is expensive and requires sizable land. Information on the genetic diversity of these collections can help achieve efficient conservation via maintenance of core collection. For this purpose, we have applied fourteen unlinked microsatellite markers to evaluate 532 E...
April 19, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28419347/evolutionary-trade-offs-between-drought-resistance-mechanisms-across-a-precipitation-gradient-in-a-seasonally-dry-tropical-oak-quercus-oleoides
#4
Jose A Ramírez-Valiente, Jeannine Cavender-Bares
In seasonally dry tropical forest regions, drought avoidance during the dry season coupled with high assimilation rates in the wet season is hypothesized to be an advantageous strategy for forest trees in regions with severe and long dry seasons. In contrast, where dry seasons are milder, drought tolerance coupled with a conservative resource-use strategy is expected to maximize carbon assimilation throughout the year. Tests of this hypothesis, particularly at the intraspecific level, have been seldom conducted...
April 13, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28414993/chikungunya-virus-infections-time-to-act-time-to-treat
#5
REVIEW
Rana Abdelnabi, Johan Neyts, Leen Delang
Chikungunya virus (CHIKV) is a re-emerging alphavirus that caused massive outbreaks of Chikungunya fever in several countries and regions in Africa, Asia and more recently in Central and South America. An acute CHIKV infection is usually associated with fever and arthritis and it is rarely fatal. However, 15-60% of patients suffer from chronic polyarthralgia for weeks, months or even for several years after the acute infection. There are currently no vaccines or antivirals available for the prevention or treatment of CHIKV infections...
April 14, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28414672/a-strong-and-fortuitous-case-of-dyspnea
#6
R Hammer, M Sciaudone
CASE: A 48 year-old man with no past medical history was sent to our emergency department (ED); from a primary care clinic for hypertensive urgency of 200/130. The man reported an intermittent non-productive cough of approximately one year's duration and worsening dyspnea on exertion and orthopnea over the last month with lower extremity swelling. Of note, he emigrated from Honduras twenty years ago. Blood pressure normalized with administration of Lasix in the ED. Physical exam revealed rales in lung bases bilaterally, jugular venous distension, lower extremity pitting edema with serpiginous patches of erythema and excoriation, and a cardiac gallop...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28414633/genome-wide-analysis-provides-evidence-on-the-genetic-relatedness-of-the-emergent-xylella-fastidiosa-genotype-in-italy-to-isolates-from-central-america
#7
Annalisa Giampetruzzi, Maria Saponari, Giuliana Loconsole, Donato Boscia, Vito Nicola Savino, Rodrigo Almeida, Stefania Zicca, Blanca Landa, Carlos Chacon Diaz, Pasquale Saldarelli
Xylella fastidiosa is a plant pathogenic bacterium recently introduced in Europe that is causing decline in olive trees in the South of Italy. Genetic studies have consistently shown that the bacterial genotype recovered from infected olive trees belongs to the sequence type ST53 within subspecies pauca. This genotype, ST53, has also been reported to occur in Costa Rica. The ancestry of ST53 was recently clarified, showing it contains alleles which are monophyletic with those of subsp. pauca in South America...
April 17, 2017: Phytopathology
https://www.readbyqxmd.com/read/28413847/greenhouse-gas-emissions-from-tropical-forest-degradation-an-underestimated-source
#8
Timothy R H Pearson, Sandra Brown, Lara Murray, Gabriel Sidman
BACKGROUND: The degradation of forests in developing countries, particularly those within tropical and subtropical latitudes, is perceived to be an important contributor to global greenhouse gas emissions. However, the impacts of forest degradation are understudied and poorly understood, largely because international emission reduction programs have focused on deforestation, which is easier to detect and thus more readily monitored. To better understand and seize opportunities for addressing climate change it will be essential to improve knowledge of greenhouse gas emissions from forest degradation...
December 2017: Carbon Balance and Management
https://www.readbyqxmd.com/read/28413829/prioritizing-us-cervical-cancer-prevention-with-results-from-a-geospatial-model
#9
Jonathan K Kish, Alicia I Rolin, Zhaohui Zou, James E Cucinelli, Zaria Tatalovich, Mona Saraiya, Sean F Altekruse
PURPOSE: To determine if differences in screening and vaccination patterns across the population may accentuate ethnic and geographic variation in future burden of disease. METHODS: Using Cancer in North America data provided by the North American Association of Central Cancer Registries, county cervical cancer incidence trends from 1995 to 2009 were modeled for the entire United States using ecologic covariates. Rates for health service areas were also modeled by ethnicity...
October 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28413745/seven-cases-of-zika-virus-infection-in-south-florida
#10
Waqaar Khawar, Romina Bromberg, Molly Moor, Natalya Lyubynska, Hilda Mahmoudi
INTRODUCTION: Zika virus, an arbovirus of the Flaviviridae family, is a mosquito-borne virus known to cause microcephaly through vertical transmission. Infection presents with mild, self-limiting symptoms. Currently, a Zika virus outbreak has spread across most of South and Central America. Travel-related and sexually transmitted cases have been reported across the United States. However, the vector-borne transmission has been limited to Florida and Texas. We present seven cases of Zika virus infection that presented at a single institution in South Florida...
March 16, 2017: Curēus
https://www.readbyqxmd.com/read/28413726/gb4gv-a-genome-browser-for-geminivirus
#11
Eric S Ho, Catherine M Newsom-Stewart, Lysa Diarra, Caroline S McCauley
BACKGROUND: Geminiviruses (family Geminiviridae) are prevalent plant viruses that imperil agriculture globally, causing serious damage to the livelihood of farmers, particularly in developing countries. The virus evolves rapidly, attributing to its single-stranded genome propensity, resulting in worldwide circulation of diverse and viable genomes. Genomics is a prominent approach taken by researchers in elucidating the infectious mechanism of the virus. Currently, the NCBI Viral Genome website is a popular repository of viral genomes that conveniently provides researchers a centralized data source of genomic information...
2017: PeerJ
https://www.readbyqxmd.com/read/28411872/induction-therapy-with-the-selective-interleukin-23-inhibitor-risankizumab-in-patients-with-moderate-to-severe-crohn-s-disease-a-randomised-double-blind-placebo-controlled-phase-2-study
#12
Brian G Feagan, William J Sandborn, Geert D'Haens, Julián Panés, Arthur Kaser, Marc Ferrante, Edouard Louis, Denis Franchimont, Olivier Dewit, Ursula Seidler, Kyung-Jo Kim, Markus F Neurath, Stefan Schreiber, Paul Scholl, Chandrasena Pamulapati, Bojan Lalovic, Sudha Visvanathan, Steven J Padula, Ivona Herichova, Adina Soaita, David B Hall, Wulf O Böcher
BACKGROUND: The interleukin-23 pathway is implicated genetically and biologically in the pathogenesis of Crohn's disease. We aimed to assess the efficacy and safety of risankizumab (BI 655066, Boehringer Ingelheim, Ingelheim, Germany), a humanised monoclonal antibody targeting the p19 subunit of interleukin-23, in patients with moderately-to-severely active Crohn's disease. METHODS: In this randomised, double-blind, placebo-controlled phase 2 study, we enrolled patients at 36 referral sites in North America, Europe, and southeast Asia...
April 12, 2017: Lancet
https://www.readbyqxmd.com/read/28410591/eurasian-golden-jackal-as-host-of-canine-vector-borne-protists
#13
Barbora Mitková, Kristýna Hrazdilová, Gianluca D'Amico, Georg Gerhard Duscher, Franz Suchentrunk, Pavel Forejtek, Călin Mircea Gherman, Ioana Adriana Matei, Angela Monica Ionică, Aikaterini Alexandra Daskalaki, Andrei Daniel Mihalca, Jan Votýpka, Pavel Hulva, David Modrý
BACKGROUND: Jackals are medium-sized canids from the wolf-like clade, exhibiting a unique combination of ancestral morphotypes, broad trophic niches, and close phylogenetic relationships with the wolf and dog. Thus, they represent a potential host of several pathogens with diverse transmission routes. Recently, populations of the Eurasian golden jackal Canis aureus have expanded into the Western Palaearctic, including most of Europe. The aim of our study was to examine Eurasian golden jackals from Romania, Czech Republic and Austria for a wide spectrum of vector-borne protists and to evaluate the role of this species as a reservoir of disease for domestic dogs and/or humans...
April 14, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28410010/phylogeny-and-diversity-of-fomitiporella-hymenochaetales-basidiomycota
#14
Xiao-Hong Ji, Josef Vlasák, Li-Wei Zhou, Fang Wu, Yu-Cheng Dai
Fomitiporella accommodates polypores producing annual to perennial basidiocarps with an indistinct subiculum (very thin to almost lacking), mostly a dimitic hyphal structure, lacking any kind of setae, with brownish, thick-walled basidiospores, and causing a white rot. Previously, only a few samples of Fomitiporella were studied on the basis of morphological and nuc 28S rDNA (28S)-based phylogenetic analyses. In this study, we made a comprehensive study on Fomitiporella on the basis of collections from Central America, USA, Europe, and China...
March 15, 2017: Mycologia
https://www.readbyqxmd.com/read/28407135/pro-heat-stress-as-a-potential-etiology-of-mesoamerican-and-sri-lankan-nephropathy-a-late-night-consult-with-sherlock-holmes
#15
Richard J Johnson
Epidemics of chronic kidney disease are now recognized in Central America, Mexico, India and Sri Lanka, and there is also some evidence that similar epidemics may be occurring in the USA, Thailand and elsewhere. A common denominator for each location is manually working outside in extremely hot environments. Here we review the evidence that the primary etiology may be heat stress related to repeated subclinical or clinical acute kidney injury that eventually manifests as chronic kidney disease. In some aspects, the disease may manifest as subclinical heat stroke, subclinical rhabdomyolysis or a subclinical tumor lysis syndrome...
April 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28407133/con-mesoamerican-nephropathy-is-the-problem-dehydration-or-rehydration
#16
Vito M Campese
In recent years, an increasing number of inhabitants of Central America have developed a form of chronic kidney disease, now named Mesoamerican nephropathy. This disease is characterized by minimal proteinuria, hyperuricemia, hypokalemia and reduced glomerular filtration rate. Histologically the kidneys manifest tubulointerstitial nephritis. The cause(s) of this disease remain unknown. Some have proposed that dehydration, in combination with hyperuricemia, may be primarily responsible for Mesoamerican nephropathy...
April 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28407132/causal-mechanism-and-component-causes-in-mesoamerican-sri-lankan-nephropathy-the-moderator-s-view
#17
Carmine Zoccali
Inspired by Conan Doyle's novels, the pro contender of this Polar View undertakes an elegant exercise in territory common to epidemiology and police investigation and concludes that cyclic episodes of dehydration in individuals exposed to heavy work in very hot climates is the cause of Mesoamerican and Sri Lankan nephropathy. The contender in the opposite camp accepts the idea that dehydration may play a key role in this condition but highlights a different explanation, that it is contaminated water used for rehydration that is the eventual cause of the disease...
April 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28406873/investigation-of-the-anxiolytic-and-antidepressant-effects-of-curcumin-a-compound-from-turmeric-curcuma-longa-in-the-adult-male-sprague-dawley-rat
#18
Tomás Eduardo Ceremuga, Katie Helmrick, Zachary Kufahl, Jesse Kelley, Brian Keller, Fabiola Philippe, James Golder, Gina Padrón
As the use of herbal medications continues to increase in America, the potential interaction between herbal and prescription medications necessitates the discovery of their mechanisms of action. The purpose of this study was to investigate the anxiolytic and antidepressant effects of curcumin, a compound from turmeric (Curcuma longa), and its effects on the benzodiazepine site of the γ-aminobutyric acid receptor A (GABAA) receptor. Utilizing a prospective, between-subjects group design, 55 male Sprague-Dawley rats were randomly assigned to 1 of the 5 intraperitoneally injected treatment groups: vehicle, curcumin, curcumin + flumazenil, midazolam, and midazolam + curcumin...
May 2017: Holistic Nursing Practice
https://www.readbyqxmd.com/read/28405632/evidence-of-intercontinental-spread-and-uncommon-variants-of-low-pathogenicity-avian-influenza-viruses-in-ducks-overwintering-in-guatemala
#19
Ana S Gonzalez-Reiche, Martha I Nelson, Mathew Angel, Maria L Müller, Lucia Ortiz, Jayeeta Dutta, Harm van Bakel, Celia Cordon-Rosales, Daniel R Perez
Over a hundred species of aquatic birds overwinter in Central America's wetlands, providing opportunities for the transmission of influenza A viruses (IAVs). To date, limited IAV surveillance in Central America hinders our understanding of the evolution and ecology of IAVs in migratory hosts within the Western Hemisphere. To address this gap, we sequenced the genomes of 68 virus isolates obtained from ducks overwintering along Guatemala's Pacific Coast during 2010 to 2013. High genetic diversity was observed, including 9 hemagglutinin (HA) subtypes, 7 neuraminidase (NA) subtypes, and multiple avian IAV lineages that have been detected at low levels (<1%) in North America...
March 2017: MSphere
https://www.readbyqxmd.com/read/28399298/an-early-holocene-record-of-cimex-hemiptera-cimicidae-from-western-north-america
#20
Martin E Adams, Dennis L Jenkins
The subfossil remains of 14 cimicids (Hemiptera: Cimicidae) were recovered during archaeological investigations of the Paisley Five Mile Point Cave site (35LK3400), an exceptionally well-dated (n = 229 radiocarbon dates) late Pleistocene-early Holocene rock shelter site in south-central Oregon. Nine of the specimens have been assigned to three modern species of Nearctic Cimicidae-Cimex antennatus Usinger & Ueshima, Cimex latipennis Usinger & Ueshima, and Cimex pilosellus (Horváth)-whereas the remaining five individuals were too fragmentary to positively identify...
April 4, 2017: Journal of Medical Entomology
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