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Carlo Maida, Antonino Tuttolomondo, Domenico Di Raimondo, Mario Daidone, Antonio Pinto
BACKGROUND: Stroke represent one of the most devastating of all neurological diseases, affecting about 15 million people per year and is an important cause of morbidity and mortality worldwide and currently the leading cause of adult disability in developed countries. Blood pressure and heart rate may undergo several modifications in patients with both ischemic and hemorrhagic stroke in fact raised blood pressure levels may lead to cerebral edema, hematoma expansion or hemorrhagic transformation and in contrast low blood pressure can lead to increased cerebral infarction or perihematomal ischemia...
2017: Current Pharmaceutical Design
Vladan Vukomanovic, Marijana Tadic, Jelena Suzic-Lazic, Vesna Kocijancic, Vera Celic
The aim of this study was to investigate heart rate variability (HRV) and left ventricular (LV) remodeling in uncomplicated diabetic patients. Furthermore, we sought to investigate the association between HRV indices and LV structural, functional and mechanical parameters. This cross-sectional study included 50 uncomplicated patients with type 2 diabetes and 40 healthy controls without cardiovascular risk factors. All study subjects underwent 24-h Holter monitoring, laboratory analyses and complete two-dimensional echocardiography examination (2DE)...
April 2017: International Journal of Cardiovascular Imaging
Ricardo Ribeiro Dias, José Augusto Duncan, Diego Sarty Vianna, Leandro Batisti de Faria, Fábio Fernandes, Félix José Álvares Ramirez, Charles Mady, Fábio Biscegli Jatene
OBJECTIVE: Report initial experience with the Frozen Elephant Trunk technique. METHODS: From July 2009 to October 2013, Frozen Elephant Trunk technique was performed in 21 patients (66% male, mean age 56 ± 11 years). They had type A aortic dissection (acute 9.6%, chronic 57.3%), type B (14.3%, all chronic) and complex aneurysms (19%). It was 9.5% of reoperations and 38% of associated procedures (25.3% miocardial revascularization, 25.3% replacement of aortic valve and 49...
March 2015: Revista Brasileira de Cirurgia Cardiovascular
S Pascual-Gil, E Garbayo, P Díaz-Herráez, F Prosper, M J Blanco-Prieto
Myocardial infarction causes almost 7.3 million deaths each year worldwide. However, current treatments are more palliative than curative. Presently, cell and protein therapies are considered the most promising alternative treatments. Clinical trials performed until now have demonstrated that these therapies are limited by protein short half-life and by low transplanted cell survival rate, prompting the development of novel cell and protein delivery systems able to overcome such limitations. In this review we discuss the advances made in the last 10years in the emerging field of cardiac repair using biomaterial-based delivery systems with focus on the progress made on preclinical in vivo studies...
April 10, 2015: Journal of Controlled Release: Official Journal of the Controlled Release Society
Mauro Ferrante, Giovanni De Luca, Giovanna Fantaci, Sebastiano Pollina Addario, Salvatore Scondotto
OBJECTIVES: to analyse the effect of distance between the Municipality of residence and the nearest hospital on out-of-hospital mortality rate of patients died for acute myocardial infarction (AMI). DESIGN: analysis of out-of-hospital mortality using a record linkage database. SETTING AND PARTICIPANTS: Sicilian Municipalities; 4,999 deaths with acute myocardial infarction as primary cause of death, by excluding patients hospitalised within the 15 days before the death event...
November 2014: Epidemiologia e Prevenzione
I E Karpova, L E Samoĭlenko, G N Soboleva, V B Sergienko, Iu A Karpov, I E Chernysheva, D G Ioseliani
PURPOSE: To assess diagnostic potential of (99m)Tc-MIBI-single-photon emission computed tomography (SPECT) with intravenous adenosine triphosphate (ATP) infusion in comparison with exercise stress (EX) SPECT in patients with microvascular angina. MATERIAL AND METHODS: Patients with angina, positive exercise test and normal coronary angiogram (n=25) were included in the study. Patients underwent a three-phase (99m)Tc-MIBI-SPECT scan: at rest, exercise stress test and pharmacological stress with ATP infusion...
2014: Kardiologiia
Bruno Lorenção de Almeida, Antonio Massamitsu Kambara, Fabio Henrique Rossi, Samuel Martins Moreira, Eduardo Silva Jordao de Oliveira, Frederico Augusto de Carvalho Linhares Filho, Patrick Bastos Metzger, Aldo Zampieri Passalacqua
INTRODUCTION: The subclavian steal syndrome is characterized by the vertebral artery flow inversion, due to a stenotic lesion in the origin of the subclavian artery. The Coronary-subclavian Steal Syndrome is a variation of the Subclavian Steal Syndrome and is characterized by inversion of flow in the Internal Thracic artery that has been used as conduct in a myocardial revascularization. Its diagnosis must be suspected in patients with difference in pulse and arterial pressure in the upper limbs, that present with angina pectoris and that have done a myocardial revascularization...
April 2014: Revista Brasileira de Cirurgia Cardiovascular
Vf Sagach, Tv Shimanskaya, Yu Goshovska, Av Kotsjuruba
Hydrogen sulfide is enzymaticaly synthesized by three enzymes - cystathionine gama-lyase (CSE), cystathionine beta-lyase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST). After physical training of rats (4 weeks swimming course) we observed in myocardium the increased of these enzymes expression (in 1,5; 2,5 and 5 times accordingly), which accompanied with increased H2S content in myocardium (31,65±1.29 vs 12,6±0,31 nmol/mg protein in control), in miocardial mitochondria (10,55±1,2 vs 4,2±1,1 nmol/mg protein in control) and in plasma (3,75±0,22 vs 2,48±0,08 nmol/mg protein in control)...
July 15, 2014: Cardiovascular Research
T V Zaval's'ka
The modern cardiology pays much attention to research of myocardial ischemia, especially painless myocardial ischemia as the problem of sudden coronary death. Findings from the current study suggest that antianginal therapy which includes antiaggregant and anticoagulant is effective because of decreasing general myocardial ischemia and its painless form.
March 2013: Likars'ka Sprava
Zh A Zheltysheva
The article presents data of the research aimed at the study of obesity in elderly women and interrelations of obesity, its type and severity with changes in the structure and function of the myocardium. The results showed that more than half of elderly women had obesity, mostly mild with a redistribution of adipose tissue in the region of the anterior abdominal wall. Significant left ventricular remodeling and diastolic dysfunction often develop in the patients with obesity than in non-obese ones and depend on the obesity severity and type...
2011: Advances in Gerontology, Uspekhi Gerontologii
Angela Bento, João Vasconcelos, Carlos Aguiar, Agostinho Caeiro, António Jara
The development of troponins dramatically changed the diagnosis of cardiac injury. Cardiac troponins are the most sensitive and specific biochemical markers of myocardial damage. In 2000. it was elaborated the new definition of miocardial infarction that reflected the importance of that biomarker. The rationale of including troponin assay in the diagnosis pathway was based on the assumption that myocardial necrosis, regardless of its magnitude, should be characterized as myocardial infarction. However, if the patient's clinical picture do no match an elevated troponin result we shoud suspect a false positive value caused by analytical interferences...
September 2010: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Nicoletta Biglia, Silvia Maffei, Stefano Lello, Rossella E Nappi
AIM: To critically discuss the use of tibolone (T), in light of a series of very recent double-blind placebo (PL) controlled trials (LISA, LIFT, OPAL, THEBES, LIBERATE) conducted worldwide in a large number of postmenopausal women (PMW). METHODS: The most relevant publications on T therapy in PMW were considered with emphasis on menopausal symptoms, quality of life, sexuality, bone, cardiovascular system (CVS) and oncologic risk. RESULTS: T significantly relieves climacteric symptoms and improves mood and sexual well-being (LISA)...
November 2010: Gynecological Endocrinology
Cecilia Mihalcea, G I Pandele
UNLABELLED: Chronic myocardial infarction represents one of the most important problems of actual clinical medicine because their incidence is growing especially at young adults (< 45 years) and their mortality with no treatment is high in first month after acute myocardial infarction (50%). When cardiovascular disease is associated with diabetes mellitus, evolution of patients is more serious. AIM: To compare the disease evolution for two groups of patients--one with patients who have purely chronic myocardial infarction and other with patients who have chronic myocardial infarction associated with glycoregulation disturbances (diabetes mellitus, impaired glucose tolerance or impaired fasting glucose)...
July 2009: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
E Vizzardi, I Bonadei, G Zanini, C Fiorina, R Raddino, L Dei Cas
Several studies and recent patents have demonstrated that hyperhomocysteinemia (HHCY) is an independent risk factor for congestive heart failure (CHF); it is also correlated to the severity of the disease. In literature there are some data about effects of HHCY on myocardial structure and function in animal models. These studies indicate a direct effect of HCY in promoting reactive myocardial fibrosis and systolic dysfunction, promoting miocardial redox state, endothelial and mithocondryal dysfunction, negative inotropic effect...
October 2009: Minerva Medica
S A Talanov, A V Kotsiuruba, Iu P Korkach, V F Sahach
The physiological significance of cardiac mitochondrial reactive oxygen species (ROS) regulation is unknown. In the current study, mitochondrial ROS (O2- and OH) generation, stable H2O2 and lipids peroxidation marker (malonic dialdehyde, MDA) pools, as well as pools of potent antioxidants--urea and uric acid--were determined in rat heart, miocardial mitochondria and in blood plasma and erytrocytes at low (44%) and high (96%) levels of cerebral dopamine-synthesis neurons destruction (by 6-hydroxidopamine treatment)...
2009: Fiziolohichnyĭ Zhurnal
G V Abuladze, M I Nevieridze, R I Abashidze, L V Gabarashvili, A A Kvirkveliia
Sudden cardiac death (SCD) - this natural death caused by cardiac reasons and which is characterized by sudden loss of consciousness within first hour after revealing of sharp clinical symptoms. A primary factor of SCD is not traumatic. It occurs suddenly and unexpectedly. The high risk of development of sudden cardiac death is basically associated with ventricular arrhythmias. Electrophysiological anomalies in cells lead to development of ventricular ectopic activity or ventricular tachycardia which comes to the end with fibrillation...
March 2009: Georgian Medical News
Predrag Stojanović, Branislava Kocić, Gordana Randelović, Vojislav Cirić
INTRODUCTION: According to the results of different investigations, the opinion that isolate of coagulase-negative staphylococci by bloodcultures represents the blood infection in 10-12% patient. The aim of the work was to determine the number of patients with blood infection-sepsa induced coagulase-negative staphylococci isolated by bloodcultures. MATERIAL AND METHODS: The research was done at the Institute for Public Health in Nis. The basic group consisted of 56 patients and coagulase-negative staphylococci were segregated form their bloodcultures...
May 2008: Medicinski Pregled
Marcello Gasparrini, Andrea Liverani, Valeria Catracchia, Stefano Conte, Giacomo Leonardo, Graziella Marino, Andrea Milillo, Francesco Saverio Mari, Massimo Pezzatini, Francesco Favi
Gallstone ileus is a rare complication of gallstone disease, accounting for 1-4% of all bowel obstructions. The phisiopathology is related to the presence of a bilio-enteric fistula. Cholecistoenteric fistulae occur in fewer than 1% of patients with gallstone. We present the case of an 83-years-old woman, complaining of acute abdominal pain, vomiting and mechanical obstruction at admission. She reported a past history of hypertension, recent miocardial ischaemia, diverticular disease and cholelithiasis. A CT scan revealed aerobilia, gastric and duodenal dilatation and a gallstone impacted just beyond the duodeno-jejunal junction...
September 2008: Chirurgia Italiana
M Piqué-Gilart, J Torres-Puig-Gros, B Balsera-Garrido, I Tarruella-Vidal, J Loscos-Solé, E Pueo-Crespo, M Almirall-Egerique, G Amat-Camats, S Barranco-Tomàs, M Maria Bretcha-Vivó, J Cabré-Ollé, C Cardona-Cabasés, M Galán-Seuma, J M Guiu-Bardají, J M Lara-Nieto, M Tersa-Alcobé, T Vilá-Parrot
OBJECTIVE: A preliminary evaluation of the impact of a training program on pre-hospitalization care of acute coronary syndrome (ACS). DESIGN: A cross-sectional study. SETTING: Lleida Health Service area. PATIENTS: A total of 661 ACS cases were observed in the Intensive Medical Care Unit from January 1st 2002 to December 31st 2004. INTERVENTIONS: A training program for primary health care medical staff on the pre-hospitalization management of ACS from July 2003 to December 2006 in 29 health care centers was conducted...
January 2008: Medicina Intensiva
Nikhil Sikri, Amit Bardia
A serendipitous discovery by William Smith Tillett in 1933, followed by many years of work with his student Sol Sherry, laid a sound foundation for the use of streptokinase as a thrombolytic agent in the treatment of acute myocardial infarction. The drug found initial clinical application in combating fibrinous pleural exudates, hemothorax, and tuberculous meningitis. In 1958, Sherry and others started using streptokinase in patients with acute myocardial infarction and changed the focus of treatment from palliation to "cure...
2007: Texas Heart Institute Journal
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