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Ocd cerebellum

Matilde M Vaghi, Petra E Vértes, Manfred G Kitzbichler, Annemieke M Apergis-Schoute, Febe E van der Flier, Naomi A Fineberg, Akeem Sule, Rashid Zaman, Valerie Voon, Prantik Kundu, Edward T Bullmore, Trevor W Robbins
BACKGROUND: A recent hypothesis has suggested that core deficits in goal-directed behavior in obsessive-compulsive disorder (OCD) are caused by impaired frontostriatal function. We tested this hypothesis in OCD patients and control subjects by relating measures of goal-directed planning and cognitive flexibility to underlying resting-state functional connectivity. METHODS: Multiecho resting-state acquisition, combined with micromovement correction by blood oxygen level-dependent sensitive independent component analysis, was used to obtain in vivo measures of functional connectivity in 44 OCD patients and 43 healthy comparison subjects...
August 11, 2016: Biological Psychiatry
Janardhanan C Narayanaswamy, Dania Jose, Sunil V Kalmady, Sri Mahavir Agarwal, Ganesan Venkatasubramanian, Y C Janardhan Reddy
Even though conventional neurobiological models of obsessive compulsive disorder (OCD) commonly demonstrate abnormalities involving fronto-striatal circuits, there is emerging evidence regarding the role of posterior brain structures such as cerebellum. In this study, we examined the cerebellar regional volume in a large sample of medication-naïve OCD patients compared to matched healthy controls (HC). In 49 medication naïve right handed OCD patients and 39 age and sex matched HC, sub-region wise volume of cerebellum was extracted from the T1 weighted images using Spatially Unbiased Infra tentorial Template (SUIT) toolbox and compared using hypothesis driven, region of interest approach after clinical assessment with standard scales...
August 30, 2016: Psychiatry Research
Wenxin Tang, Qifeng Zhu, Xiangyang Gong, Cheng Zhu, Yiquan Wang, Shulin Chen
The primary aim of this study was to identify structural and functional abnormalities in the brains of obsessive-compulsive disorder (OCD) patients. Another aim was to assess the effect of serotonin selective reuptake inhibitors (SSRIs) on brain structure of OCD patients. All subjects underwent brain magnetic resonance imaging (MRI) and resting functional MRI (fMRI). High-resolution three-dimensional images were processed using the voxel-based morphometry (VBM) method. The final analysis included 18 OCD patients and 16 healthy controls...
October 15, 2016: Behavioural Brain Research
E Real, M Subirà, P Alonso, C Segalàs, J Labad, C Orfila, C López-Solà, I Martínez-Zalacaín, E Via, N Cardoner, S Jiménez-Murcia, C Soriano-Mas, J M Menchón
Objectives There is growing evidence supporting a role for stressful life events (SLEs) at obsessive-compulsive disorder (OCD) onset, but neurobiological correlates of such effect are not known. We evaluated regional grey matter (GM) changes associated with the presence/absence of SLEs at OCD onset. Methods One hundred and twenty-four OCD patients and 112 healthy controls were recruited. Patients were split into two groups according to the presence (n = 56) or absence (n = 68) of SLEs at disorder's onset...
August 2016: World Journal of Biological Psychiatry
Xinyu Hu, Qi Liu, Bin Li, Wanjie Tang, Huaiqiang Sun, Fei Li, Yanchun Yang, Qiyong Gong, Xiaoqi Huang
Magnetic resonance imaging (MRI) studies have revealed brain structural abnormalities in obsessive-compulsive disorder (OCD) patients, involving both gray matter (GM) and white matter (WM). However, the results of previous publications were based on average differences between groups, which limited their usages in clinical practice. Therefore, the aim of this study was to examine whether the application of multivariate pattern analysis (MVPA) to high-dimensional structural images would allow accurate discrimination between OCD patients and healthy control subjects (HCS)...
February 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Lin Tian, Chun Meng, Ying Jiang, Qunfeng Tang, Shuai Wang, Xiyao Xie, Xiangshuai Fu, Chunhui Jin, Fuquan Zhang, Jidong Wang
OBJECTIVE: Abnormal brain networks have been observed in patients with obsessive-compulsive disorder (OCD). However, detailed network hub and connectivity changes remained unclear in treatment-naive patients with OCD. Here, we sought to determine whether patients show hub-related connectivity changes in their whole-brain functional networks. METHODS: We used resting-state functional magnetic resonance imaging data and voxel-based graph-theoretic analysis to investigate functional connectivity strength and hubs of whole-brain networks in 29 treatment-naive patients with OCD and 29 age- and gender-matched healthy controls...
April 3, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
Tue Hartmann, Sanne Vandborg, Raben Rosenberg, Leif Sørensen, Poul Videbech
BACKGROUND: Previous morphology and diffusion-imaging studies have suggested that structural changes in white matter is an important part of the pathophysiology of obsessive-compulsive disorder (OCD). However, different methodological approaches and the heterogeneity of patient samples question the validity of the findings. Materials and methods In total, 30 patients were matched for age and sex with 30 healthy controls. All participants underwent T1-weighted magnetic resonance imaging, diffusion tensor imaging and T2 fluid-attenuated inversion recovery...
June 2016: Acta Neuropsychiatrica
Emily V Ho, Summer L Thompson, William R Katzka, Mitra F Sharifi, James A Knowles, Stephanie C Dulawa
RATIONALE: Serotonin-1B receptor (5-HT1BR) agonist treatment induces obsessive-compulsive disorder (OCD)-like behaviors including locomotor stereotypy, prepulse inhibition deficits, and delayed alternation disruptions, which are selectively prevented by clinically effective OCD treatment. However, the role of 5-HT1BRs in modulating other repetitive behaviors or OCD-like patterns of brain activation remains unclear. OBJECTIVES: We assessed the effects of 5-HT1BR agonism on digging, grooming, and open field behaviors in mice...
January 2016: Psychopharmacology
Xiang-Yun Yang, Jing Sun, Jia Luo, Zhao-Xi Zhong, Ping Li, Shu-Min Yao, Hong-Fang Xiong, Fang-Fang Huang, Zhan-Jiang Li
BACKGROUND: Cognitive behavioural therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD). Several neuroimaging studies have explored alterations of brain function in OCD patients as they performed tasks after CBT. However, the effects of CBT on the neural activityin OCD during rest remain unknown. Therefore, we investigated changes in regional homogeneity (ReHo) in OCD patients before and after CBT. METHODS: Twenty-two OCD patients and 22 well-matched healthy controls participated in the resting-state functional magnetic resonance imaging scans...
December 1, 2015: Journal of Affective Disorders
Bochao Cheng, Xiaoqi Huang, Shiguang Li, Xinyu Hu, Ya Luo, Xiuli Wang, Xun Yang, Changjian Qiu, Yanchun Yang, Wei Zhang, Feng Bi, Neil Roberts, Qiyong Gong
Post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and social anxiety disorder (SAD) all bear the core symptom of anxiety and are separately classified in the new DSM-5 system. The aim of the present study is to obtain evidence for neuroanatomical difference for these disorders. We applied voxel-based morphometry (VBM) with Diffeomorphic Anatomical Registration Through Exponentiated Lie to compare gray matter volume (GMV) in magnetic resonance images obtained for 30 patients with PTSD, 29 patients with OCD, 20 patients with SAD, and 30 healthy controls...
2015: Frontiers in Behavioral Neuroscience
Goi Khia Eng, Kang Sim, Shen-Hsing Annabel Chen
Obsessive-compulsive disorder (OCD) is a debilitating disorder. However, existing neuroimaging findings involving executive function and structural abnormalities in OCD have been mixed. Here we conducted meta-analyses to investigate differences in OCD samples and controls in: Study 1 - grey matter structure; Study 2 - executive function task-related activations during (i) response inhibition, (ii) interference, and (iii) switching tasks; and Study 3 - white matter diffusivity. Results showed grey matter differences in the frontal, striatal, thalamus, parietal and cerebellar regions; task domain-specific neural differences in similar regions; and abnormal diffusivity in major white matter regions in OCD samples compared to controls...
May 2015: Neuroscience and Biobehavioral Reviews
Kayo Okada, Tomohiro Nakao, Hirokuni Sanematsu, Keitaro Murayama, Shinichi Honda, Mayumi Tomita, Osamu Togao, Takashi Yoshiura, Shigenobu Kanba
AIM: Although many neuroimaging studies of obsessive-compulsive disorder (OCD) have reported broad abnormalities in gray matter (GM), their results remain inconsistent. One reason for this inconsistency could be the heterogeneity of OCD. In the present study, we aimed to classify alterations in brain anatomy by OCD subtype. METHODS: Magnetic resonance imaging examinations of 37 OCD patients and 37 matched healthy controls were conducted using a 3.0-Tesla scanner...
July 2015: Psychiatry and Clinical Neurosciences
Luisa Lázaro, Anna Calvo, Ana G Ortiz, Ana E Ortiz, Astrid Morer, Elena Moreno, Rosa Calvo, Núria Bargallo
BACKGROUND: The aims of this study were to determine white matter (WM) microstructure abnormalities in obsessive-compulsive disorder (OCD) using diffusion tensor imaging, and to investigate whether these abnormalities differ according to OCD symptom dimensions. METHODS: Sixty-three child and adolescent OCD patients (11-18 years old) and 37 healthy subjects matched for gender, age, and estimated intelligence quotient were assessed by means of psychopathology scales and diffusion tensor magnetic resonance imaging...
December 2014: Depression and Anxiety
Zoya Marinova, Camelia-Maria Monoranu, Sonja Fetz, Susanne Walitza, Edna Grünblatt
AIMS: The serotonin 2A receptor (HTR2A) is widely expressed in the brain and involved in the modulation of fear, mood, anxiety and other symptoms. HTR2A and HTR2A gene variations are implicated in depression, schizophrenia, anxiety and obsessive-compulsive disorder. To understand HTR2A signalling changes in psychiatric or neurodegenerative disorders, its normal pattern of brain expression and region specificity during development and ageing needs to be clarified. The aim of the present study was to assess HTR2A expression through developmental and ageing stages in six brain regions in post mortem human brain samples from individuals with no clinical or neuropathological evidence of neuropsychiatric disorders and to investigate the interaction with the rs6311 HTR2A promoter polymorphism...
June 2015: Neuropathology and Applied Neurobiology
Jing-Ming Hou, Ming Zhao, Wei Zhang, Ling-Heng Song, Wen-Jing Wu, Jian Wang, Dai-Quan Zhou, Bing Xie, Mei He, Jun-Wei Guo, Wei Qu, Hai-Tao Li
BACKGROUND: Obsessive-compulsive disorder (OCD) is a common, heritable neuropsychiatric disorder, hypothetically underpinned by dysfunction of brain cortical-striatal-thalamic-cortical (CSTC) circuits; however, the extent of brain functional abnormalities in individuals with OCD is unclear, and the genetic basis of this disorder is poorly understood. We determined the whole brain functional connectivity patterns in patients with OCD and their healthy first-degree relatives. METHODS: We used resting-state fMRI to measure functional connectivity strength in patients with OCD, their healthy first-degree relatives and healthy controls...
September 2014: Journal of Psychiatry & Neuroscience: JPN
Matteo Tonna, Rebecca Ottoni, Paolo Ossola, Chiara De Panfilis, Carlo Marchesi
The onset of obsessive-compulsive disorder (OCD) after age 50 is rare and generally related to an organic etiology. An involvement of fronto-striatal circuits has been strongly suggested, whereas cerebellum remains so far scarcely explored. We present here the description of a "pure" late-onset OCD associated with a cerebellar lesion, neither comorbid with other mental disorders nor with neurological syndromes. To our knowledge, this condition was not previously described in literature. The patient is a 62-year-old woman who developed a late-onset OCD associated with a left cerebellar lesion due to an arachnoid cyst in the left posterior fossa...
August 2014: Cerebellum
Kristin Suetens, Bart Nuttin, Loes Gabriëls, Koen Van Laere
UNLABELLED: Around 7%-10% of patients with obsessive-compulsive disorder (OCD) are refractory to first-line treatment. Neurosurgical approaches are available such as capsulotomy or deep-brain stimulation (DBS). There is strong evidence for central involvement of the corticostriatopallidothalamocortical (CSPTC) circuit in OCD, but the exact mechanism through which these interventions lead to clinical improvement and potential differences in network modulation are not fully understood. METHODS: In total, 13 capsulotomy patients (aged 29-59 y, 10 men and 3 women) and 16 DBS patients (aged 25-56 y, 6 men and 10 women) were prospectively included...
June 2014: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Talma Hendler, Tal Gonen, Eiran V Harel, Haggai Sharon
No abstract text is available yet for this article.
April 15, 2014: Biological Psychiatry
G J Harris, R Hoehn-Saric, R Lewis, G D Pearlson, C Streeter
Locations of cerebral perfusion abnormalities in obsessive-compulsive disorder (OCD) were mapped with single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). This report is a new, more thorough analysis of a previous study of these subjects that used region-of-interest methods. Ten obsessive-compulsive patients and seven age- and sex-matched control subjects were studied. Image sets were converted into stereotaxic space, normalized to each subject's mean cerebral value, then group averaged...
1994: Human Brain Mapping
Birgitte Bertelsen, Linea Melchior, Lars R Jensen, Camilla Groth, Birte Glenthøj, Renata Rizzo, Nanette Mol Debes, Liselotte Skov, Karen Brøndum-Nielsen, Peristera Paschou, Asli Silahtaroglu, Zeynep Tümer
Tourette syndrome is a neurodevelopmental disorder characterized by multiple motor and vocal tics, and the disorder is often accompanied by comorbidities such as attention-deficit hyperactivity-disorder and obsessive compulsive disorder. Tourette syndrome has a complex etiology, but the underlying environmental and genetic factors are largely unknown. IMMP2L (inner mitochondrial membrane peptidase, subunit 2) located on chromosome 7q31 is one of the genes suggested as a susceptibility factor in disease pathogenesis...
November 2014: European Journal of Human Genetics: EJHG
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