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https://www.readbyqxmd.com/read/29142406/biological-activity-and-isolation-of-compounds-from-stem-bark-of-plumeria-acutifolia
#1
Ghadah A Alhozaimy, Ebtesam Saad Al-Sheddi, Taghreed A Ibrahim
Background: Plumeria acutifolia (Apocynaceae) is an ornamental plant, used in the traditional medicine and known to have a variety of constituents as alkaloids, flavonoids, and iridoids. Extracts of this plant were proved to have antimicrobial and anticancer activities. Objectives: This research was conducted for the evaluation of the biological activities of P. acutifolia stem bark and isolation and structural elucidation of various chemical compounds from the biologically active fractions...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29099264/co-targeting-pi3k-mtor-and-igf1r-with-small-molecule-inhibitors-for-treating-undifferentiated-pleomorphic-sarcoma
#2
Caitlin D May, Sharon M Landers, Svetlana Bolshakov, XiaoYan Ma, Davis R Ingram, Christine M Kivlin, Kelsey L Watson, Ghadah A Al Sannaa, Angela D Bhalla, Wei-Lien Wang, Alexander J Lazar, Keila E Torres
Undifferentiated pleomorphic sarcomas (UPSs) are aggressive mesenchymal malignancies with no definitive cell of origin or specific recurrent genetic hallmarks. These tumors are largely chemoresistant; thus, identification of potential therapeutic targets is necessary to improve patient outcome. Previous studies demonstrated that high expression of activated protein kinase B (AKT) in patients with UPS corresponds to poor disease-specific survival. Here, we demonstrate that inhibiting phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR) signaling using a small molecule inhibitor reduced UPS cell proliferation and motility and xenograft growth; however, increased phosphorylation of insulin-like growth factor 1 receptor (IGF1R) indicated the potential for adaptive resistance following treatment through compensatory receptor activation...
October 3, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29038900/correction-to-dietary-interventions-and-multiple-sclerosis
#3
Ghadah Altowaijri, Allison Fryman, Vijayshree Yadav
The original version of this article contains an error in the second sentence of the second paragraph of the Paleolithic Diet section.
October 17, 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29038712/prevalence-of-diabetes-and-its-relation-with-age-and-sex-in-turaif-city-northern-saudi-arabia-in-2016-2017
#4
Nour Homoud Alanazi, Mahmoud Mohammed Alsharif, Ghazala Rasool, Ahmed Bin Hashash Alruwaili, Asem Matrouk Zayed Alrowaili, Ahmed Saud Aldaghmi, Mohammad Khalil Dughaieum Al Shkra, Fatimah Awadh Alrasheedi, Ghadah Saleem Alenezi, Mona Theyab Alanazi
BACKGROUND: The prevalence of diabetes in Saudi Arabia has increased dramatically during the last decades. This increase has been attributed to significant changes in cultural and socio-economic factors. OBJECTIVE: The aim of this study was to determine prevalence of diabetes and its relation with age and sex in Turaif city, northern Saudi Arabia. METHODS: This was a cross-sectional study carried out during the academic year 2016-2017 over a period of 6 months (October 01, 2016 to March 30, 2017)...
September 2017: Electronic Physician
https://www.readbyqxmd.com/read/29033731/ultrasound-guided-continuous-spinal-anesthesia-for-cesarean-section-in-a-parturient-with-scoliosis-corrected-with-harrington-s-rod-surgery
#5
Amer Majeed, Iftikhar Ahmed, Ghadah Jamaan Alkahtani, Nasser Abdullah Altahtam
With rapid improvement in healthcare in Saudi Arabia, increasing number of women with surgically corrected kyphoscoliosis are likely to present for cesarean section (CS) or vaginal delivery requiring anesthesia or analgesia. Despite the surgical correction, these patients have poor cardiopulmonary reserves which increase the risks associated with general anesthesia. Whereas altered vertebral anatomy from previous surgery and the presence of metal work in spine make performing of regional anesthesia (RA) difficult and unpredictable, we report anesthetic management of such a patient who underwent CS using continuous spinal anesthesia technique...
October 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28954789/web-based-self-management-support-for-people-with-type-2-diabetes-help-diabetes-randomised-controlled-trial-in-english-primary-care
#6
Elizabeth Murray, Michael Sweeting, Charlotte Dack, Kingshuk Pal, Kerstin Modrow, Mohammed Hudda, Jinshuo Li, Jamie Ross, Ghadah Alkhaldi, Maria Barnard, Andrew Farmer, Susan Michie, Lucy Yardley, Carl May, Steve Parrott, Fiona Stevenson, Malcolm Knox, David Patterson
OBJECTIVE: To determine the effectiveness of a web-based self-management programme for people with type 2 diabetes in improving glycaemic control and reducing diabetes-related distress. METHODS AND DESIGN: Individually randomised two-arm controlled trial. SETTING: 21 general practices in England. PARTICIPANTS: Adults aged 18 or over with a diagnosis of type 2 diabetes registered with participating general practices. INTERVENTION AND COMPARATOR: Usual care plus either Healthy Living for People with Diabetes (HeLP-Diabetes), an interactive, theoretically informed, web-based self-management programme or a simple, text-based website containing basic information only...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28885122/clinicopathological-variables-of-sporadic-schwannomas-of-peripheral-nerve-in-291-patients-and-expression-of-biologically-relevant-markers
#7
Eric D Young, Davis Ingram, William Metcalf-Doetsch, Dilshad Khan, Ghadah Al Sannaa, Francois Le Loarer, Alexander J F Lazar, John Slopis, Keila E Torres, Dina Lev, Raphael E Pollock, Ian E McCutcheon
OBJECTIVE While sporadic peripheral schwannomas (SPSs) are generally well treated with surgery, their biology is not well understood. Consequently, treatment options are limited. The aim of this study was to provide a comprehensive description of SPS. The authors describe clinicopathological features and treatment outcomes of patients harboring these tumors, and they assess expression of biomarkers using a clinically annotated tissue microarray. Together, these data give new insight into the biology and management of SPS...
September 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28829328/promoting-engagement-with-a-digital-health-intervention-help-diabetes-using-email-and-text-message-prompts-mixed-methods-study
#8
Ghadah Alkhaldi, Kerstin Modrow, Fiona Hamilton, Kingshuk Pal, Jamie Ross, Elizabeth Murray
BACKGROUND: Engagement with digital health interventions (DHIs) may be regarded as a prerequisite for the intervention to achieve positive health or behavior change outcomes. One method employed to promote engagement is the use of prompts such as emails and text messages. However, little is known about the characteristics of prompts that promote engagement. This study explored the association between the content and delivery mode of prompts and the users' engagement with HeLP-Diabetes (Healthy Living for People with type 2 Diabetes), a DHI that aimed to promote self-management in adults with type 2 diabetes...
August 22, 2017: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/28817317/living-outside-the-gender-box-in-mexico-testimony-of-transgender-mexican-asylum-seekers
#9
Marshall K Cheney, Mary J Gowin, E Laurette Taylor, Melissa Frey, Jamie Dunnington, Ghadah Alshuwaiyer, J Kathleen Huber, Mary Camero Garcia, Grady C Wray
OBJECTIVES: To explore preimmigration experiences of violence and postimmigration health status in male-to-female transgender individuals (n = 45) from Mexico applying for asylum in the United States. METHODS: We used a document review process to examine asylum declarations and psychological evaluations of transgender Mexican asylum seekers in the United States from 2012. We coded documents in 2013 and 2014 using NVivo, a multidisciplinary team reviewed them, and then we analyzed them for themes...
October 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28776179/frequency-and-nature-of-medication-errors-and-adverse-drug-events-in-mental-health-hospitals-a-systematic-review
#10
REVIEW
Ghadah H Alshehri, Richard N Keers, Darren M Ashcroft
INTRODUCTION: Little is known about the frequency and nature of medication errors (MEs) and adverse drug events (ADEs) that occur in mental health hospitals. OBJECTIVES: This systematic review aims to provide an up-to-date and critical appraisal of the epidemiology and nature of MEs and ADEs in this setting. METHOD: Ten electronic databases were searched, including MEDLINE, Embase, CINAHL, International Pharmaceutical Abstracts, PsycINFO, Scopus, British Nursing Index, ASSIA, Web of Science, and Cochrane Database of Systematic Reviews (1999 to October 2016)...
October 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28616003/development-and-validation-of-arabic-version-of-the-postoperative-quality-of-recovery-40-questionnaire
#11
Abdullah Sulieman Terkawi, Paul S Myles, Waleed Riad, Sumaya Nemer Nassar, Maissa Mahmoud, Ghadah Jumaan AlKahtani, Fatima Jaina Sala, Anas Abdulrahman, Khaled S Doais, Rayan Suliman Terkawi, Siny Tsang
INTRODUCTION: The postoperative quality of recovery-40 (QoR-40) is one of the most frequently used tools to assess the quality of recovery after surgery. The aim of the current study was to translate, culturally adapt, and validate the QoR-40 questionnaire in Arabic. METHODS: A systematic translation process was used to translate the original English QoR-40 into Arabic. After the pilot study, the translated version was validated among patients who underwent different types of surgeries...
May 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28616001/development-and-validation-of-arabic-version-of-the-postoperative-quality-of-recovery-scale
#12
Abdullah Sulieman Terkawi, Siny Tsang, Waleed Riad, Sumaya Nemer Nassar, Maissa Mahmoud, Ghadah Jumaan AlKahtani, Hanin Hussain Alsharif, Khalid S Doais, Fatima Jaina Sala, Anas Abdulrahman, Colin F Royse
INTRODUCTION: The postoperative quality of recovery scale (PostopQRS) is a widely used tool to assess the postoperative quality of recovery. Our aim was to translate, culturally adapt, and validate the PostopQRS questionnaire in Arabic. METHODOLOGY: A systematic translation process was used to translate the original English PostopQRS into Arabic. After the pilot study, the translated version was validated among patients who underwent different types of surgeries...
May 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28616000/development-and-validation-of-arabic-version-of-the-hospital-anxiety-and-depression-scale
#13
Abdullah Sulieman Terkawi, Siny Tsang, Ghadah Jumaan AlKahtani, Sumaya Hussain Al-Mousa, Salma Al Musaed, Usama Saleh AlZoraigi, Esraa M Alasfar, Khalid S Doais, Anas Abdulrahman, Khaild Ali Altirkawi
INTRODUCTION: The Hospital Anxiety and Depression Scale (HADS) is widely used to predict and diagnose hospital anxiety and depression. It has been translated and validated in many languages, but the existing Arabic version was not validated in hospitalized patients. The aim was to translate, culturally adapt, and validate the HADS Questionnaire into Arabic language for in-patient use, especially for surgical wards. METHODS: A systematic translation process was used to translate the original English HADS into Arabic...
May 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28578447/maternal-and-neonatal-outcomes-in-twin-and-triplet-gestations-in-western-saudi-arabia
#14
Samera F AlBasri, Ghadah M Shouib, Osama S Bajouh, Hasan A Nasrat, Ejaz Ahmad, Fahad M AlGreisi
Tocompare maternal and neonatal complications in twin and triplet gestations at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Methods: Retrospective medical records of 165 women with 144 twin and 21 triplet pregnancies from 2004 to 2011 were analyzed. Comparisons were carried out for maternal complications, gestational age at birth, neonatal birth weight, and neonatal intensive care admission. Results: Most common complications were preterm birth (49%), gestational diabetes mellitus (13.3%), and premature rupture of membrane (4...
June 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28324226/tobacco-cessation-counseling-attitudes-and-practices-among-yemeni-dental-professionals
#15
Sadeq Ali Al-Maweri, Walid A Al-Soneidar, Amer AlMaqtari, Abdulrahman Hunaish, Ghadah Al-Sufyani, Esam Halboub
Tobacco use is a significant health problem in Yemen and worldwide. Dental practitioners can play a pivotal role in educating their patients on the risk of smoking and motivating them to quit. This study aimed to assess the attitudes towards and practices of tobacco cessation counseling (TCC) among Yemeni dental professionals and to evaluate whether such attitudes and practices are associated with gender, smoking status, and years since graduation. In this cross-sectional study, a self-administered questionnaire containing questions regarding the practice and attitudes towards TCC in dental clinic was used...
March 21, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28317084/dietary-interventions-and-multiple-sclerosis
#16
REVIEW
Ghadah Altowaijri, Allison Fryman, Vijayshree Yadav
Multiple Sclerosis (MS) is a chronic, disabling neurologic disease that has its onset in young adulthood. While the knowledge about underlying pathogenesis of MS has improved significantly over the last few decades, the exact cause still eludes us. Despite the availability of several United States Food and Drug Administration-approved disease-modifying therapies (DMT) for MS in the last two decades, the disease remains disabling for many. DMT use is limited by its partial effectiveness, significant side effects in many cases, and high cost that leads people with MS (PwMS) to look for alternative management options...
March 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28187690/needs-of-a-silent-minority-mexican-transgender-asylum-seekers
#17
Mary Gowin, E Laurette Taylor, Jamie Dunnington, Ghadah Alshuwaiyer, Marshall K Cheney
Mexican male to female transgender asylum seekers in the United States suffer from serious health issues that can be attributed to stressors related to their transgender, ethnic minority, and socioeconomic status. This study explored these stressors, the resulting health issues, and the needs of this particularly vulnerable population. Asylum seekers' (n = 45) sworn declarations and psychological evaluations were examined by a multidisciplinary research team using a systematic document review process. The review identified stressors that occurred both in Mexico and the United States: verbal, physical, and sexual assaults; unstable environments; fear for safety/security; hiding undocumented status; and economic insecurity...
May 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28153002/access-and-utilisation-of-primary-health-care-services-comparing-urban-and-rural-areas-of-riyadh-providence-kingdom-of-saudi-arabia
#18
COMPARATIVE STUDY
Ghadah Alfaqeeh, Erica J Cook, Gurch Randhawa, Nasreen Ali
BACKGROUND: The Kingdom of Saudi Arabia (KSA) has seen an increase in chronic diseases. International evidence suggests that early intervention is the best approach to reduce the burden of chronic disease. However, the limited research available suggests that health care access remains unequal, with rural populations having the poorest access to and utilisation of primary health care centres and, consequently, the poorest health outcomes. This study aimed to examine the factors influencing the access to and utilisation of primary health care centres in urban and rural areas of Riyadh province of the KSA...
February 2, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/27965492/antibacterial-activity-of-two-chemomechanical-caries-removal-gels-on-carious-dentin-of-primary-teeth-an-in-vitro-study
#19
COMPARATIVE STUDY
Shabnam Gulzar, Ruchi Arora, Altaf H Shah, Bhupendra Bhardwaj, Ghadah Abusalim, Hesham S Khalil, Amjad H Wyne
INTRODUCTION: Chemomechanical caries removal (CMCR) is an effective method of caries removal especially for primary teeth as they cause less discomfort when compared with conventional caries removal. The most significant thing about caries removal is the elimination of cariogenic bacteria. This study compares the antibacterial activity of two CMCR gels. MATERIALS AND METHODS: A total of 40 primary molar teeth with carious dentin were split along the long axis in a laboratory...
December 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27806843/an-isolated-inflammatory-myofibroblastic-tumor-of-adrenal-gland
#20
Ghadah Al Sannaa, Jana L Wimmer, Alberto G Ayala, Jae Y Ro
Inflammatory myofibroblastic tumor (IMT) is an uncommon lesion that shows a wide range of anatomic distribution. The adrenal gland, however, is a distinctly rare site of occurrence. To date, only a few cases of IMT arising in the adrenal gland have been reported in the English literature. Here, we report another case of isolated adrenal IMT. A 34-year-old man presented to the emergency department with a complaint of a sudden severe right-sided back pain. Subsequent computed tomographic scan imaging studies demonstrated a large right adrenal mass associated with a hematoma...
December 2016: Annals of Diagnostic Pathology
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