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https://www.readbyqxmd.com/read/27806843/an-isolated-inflammatory-myofibroblastic-tumor-of-adrenal-gland
#1
Ghadah Al Sannaa, Jana L Wimmer, Alberto G Ayala, Jae Y Ro
Inflammatory myofibroblastic tumor (IMT) is an uncommon lesion that shows a wide range of anatomic distribution. The adrenal gland, however, is a distinctly rare site of occurrence. To date, only a few cases of IMT arising in the adrenal gland have been reported in the English literature. Here, we report another case of isolated adrenal IMT. A 34-year-old man presented to the emergency department with a complaint of a sudden severe right-sided back pain. Subsequent computed tomographic scan imaging studies demonstrated a large right adrenal mass associated with a hematoma...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27805645/self-assembly-of-predesigned-optical-materials-in-nematic-codispersions-of-plasmonic-nanorods
#2
Ghadah H Sheetah, Qingkun Liu, Ivan I Smalyukh
Optical metamaterials and other nanostructured metal-dielectric composites hold great potential for designing and practically realizing novel types of light-matter interactions. Here we develop an approach to fabricate composites with tunable pre-engineered properties via self-assembly of anisotropic nanoparticles codispersed in a nematic liquid crystal host. Orientations of plasmonic nanorods of varying aspect ratios are controlled to align parallel or perpendicular to the nematic director and retain this relative orientation during a facile electric switching...
November 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27646022/sarcoma-brain-metastases-28%C3%A2-years-of-experience-at-a-single-institution
#3
Ghadah Al Sannaa, Kelsey L Watson, Adriana Olar, Wei-Lien Wang, Gregory N Fuller, Ian McCutcheon, Keila E Torres, Alexander J Lazar
BACKGROUND: Brain metastasis from sarcoma is rare, thus limited information is available. We examined sarcoma brain metastases diagnosed at our institution over a period of 28 years. METHODS: This is a retrospective study of 112 cases. Clinical records were reviewed and clinical, pathological, and survival data were tabulated. RESULTS: Undifferentiated sarcoma was the most common source. In 50 % of cases, the primary sarcoma was in the extremities...
September 19, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27597768/respiratory-rate-variability-in-sleeping-adults-without-obstructive-sleep-apnea
#4
Guillermo Gutierrez, Jeffrey Williams, Ghadah A Alrehaili, Anna McLean, Ramin Pirouz, Richard Amdur, Vivek Jain, Jalil Ahari, Amandeep Bawa, Shawn Kimbro
Characterizing respiratory rate variability (RRV) in humans during sleep is challenging, since it requires the analysis of respiratory signals over a period of several hours. These signals are easily distorted by movement and volitional inputs. We applied the method of spectral analysis to the nasal pressure transducer signal in 38 adults with no obstructive sleep apnea, defined by an apnea-hypopnea index <5, who underwent all-night polysomnography (PSG). Our aim was to detect and quantitate RRV during the various sleep stages, including wakefulness...
September 2016: Physiological Reports
https://www.readbyqxmd.com/read/27580826/investigating-the-epidemiology-of-medication-errors-and-error-related-adverse-drug-events-ades-in-primary-care-ambulatory-care-and-home-settings-a-systematic-review-protocol
#5
Ghadah Asaad Assiri, Liz Grant, Hisham Aljadhey, Aziz Sheikh
INTRODUCTION: There is a need to better understand the epidemiology of medication errors and error-related adverse events in community care contexts. METHODS AND ANALYSIS: We will systematically search the following databases: Cumulative Index to Nursing and Allied Health Literature (CINAHL), EMBASE, Eastern Mediterranean Regional Office of the WHO (EMRO), MEDLINE, PsycINFO and Web of Science. In addition, we will search Google Scholar and contact an international panel of experts to search for unpublished and in progress work...
2016: BMJ Open
https://www.readbyqxmd.com/read/27573709/loss-of-h3k27-tri-methylation-is-a-diagnostic-marker-for-malignant-peripheral-nerve-sheath-tumors-and-an-indicator-for-an-inferior-survival
#6
Arjen Hg Cleven, Ghadah A Al Sannaa, Inge Briaire-de Bruijn, Davis R Ingram, Matt van de Rijn, Brian P Rubin, Maurits W de Vries, Kelsey L Watson, Kelia E Torres, Wei-Lien Wang, Sjoerd G van Duinen, Pancras Cw Hogendoorn, Alexander J Lazar, Judith Vmg Bovée
No abstract text is available yet for this article.
September 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27362662/the-prevalence-of-allergic-rhinitis-and-atopic-markers-in-obstructive-sleep-apnea
#7
Ghadah Gadi, Siraj Wali, Emad Koshak, Mohammad Albar, Abdulkareem Fida, Muntasir Abdelaziz, Khaled Alnoury, Nabil Alama
Allergic rhinitis (AR) related inflammation might worsen the severity of obstructive sleep apnea (OSA), however, the relationship between the two disorders remains controversial. Our aim was to determine the prevalence of AR and atopic markers in OSA. This cross-sectional study recruited participants with sleep-related complaints referred to a sleep center from February 2013 to June 2014. The diagnosis of OSA was based on the Berlin questionnaire (BQ) followed by confirmatory polysomnography (PSG). The diagnosis of AR was made via focused history and clinical examination and was confirmed by measuring atopic markers...
June 27, 2016: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/27035165/patterns-of-recurrence-and-survival-in-sporadic-neurofibromatosis-type-1-associated-and-radiation-associated-malignant-peripheral-nerve-sheath-tumors
#8
Kelsey L Watson, Ghadah A Al Sannaa, Christine M Kivlin, Davis R Ingram, Sharon M Landers, Christina L Roland, Janice N Cormier, Kelly K Hunt, Barry W Feig, B Ashleigh Guadagnolo, Andrew J Bishop, Wei-Lien Wang, John M Slopis, Ian E McCutcheon, Alexandar J Lazar, Keila E Torres
OBJECTIVE Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive group of soft tissue sarcomas that can arise sporadically, in the context of neurofibromatosis Type 1 (NF1) or at a site of prior irradiation. Large series profiling the features and outcomes of sporadic, NF1-associated, and radiation-associated MPNSTs are limited. The goal of this study was to elucidate differences between MPNST etiologies in a large single-institution retrospective study. METHODS Patients (n = 317) were identified through the tumor registry of The University of Texas MD Anderson Cancer Center...
April 1, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/26990975/loss-of-h3k27-tri-methylation-is-a-diagnostic-marker-for-malignant-peripheral-nerve-sheath-tumors-and-an-indicator-for-an-inferior-survival
#9
Arjen H G Cleven, Ghadah A Al Sannaa, Inge Briaire-de Bruijn, Davis R Ingram, Matt van de Rijn, Brian P Rubin, Maurits W de Vries, Kelsey L Watson, Kelia E Torres, Wei-Lien Wang, Sjoerd G van Duinen, Pancras C W Hogendoorn, Alexander J Lazar, Judith V M G Bovée
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that can show overlapping features with benign neurofibromas as well as high-grade sarcomas. Additional diagnostic markers are needed to aid in this often challenging differential diagnosis. Recently mutations in two critical components of the polycomb repressor 2 (PRC2) complex, SUZ12 and EED, were reported to occur specifically in MPNSTs while such mutations are absent in neurofibromas, both in the setting of neurofibromatosis (NF) and sporadic cases...
June 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/26847678/analysis-of-clinical-and-molecular-factors-impacting-oncologic-outcomes-in-undifferentiated-pleomorphic-sarcoma
#10
Christina L Roland, Caitlin D May, Kelsey L Watson, Ghadah A Al Sannaa, Sean P Dineen, Rachel Feig, Sharon Landers, Davis R Ingram, Wei-Lien Wang, B Ashleigh Guadagnolo, Barry Feig, Kelly K Hunt, Janice N Cormier, Alexander J Lazar, Keila E Torres
BACKGROUND: Undifferentiated pleomorphic sarcomas (UPS) present a diagnostic and therapeutic challenge. Identification of prognostic molecular markers is required for the discovery of novel treatment approaches. The purpose of this study was to correlate clinicopathologic variables, expression of tyrosine kinase receptors, and markers of cell cycle progression and survival with oncologic outcomes. METHODS: A tissue microarray containing 208 primary UPS samples was analyzed by immunohistochemistry for protein markers and in situ hybridization for microRNA...
July 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26747176/the-effectiveness-of-prompts-to-promote-engagement-with-digital-interventions-a-systematic-review
#11
REVIEW
Ghadah Alkhaldi, Fiona L Hamilton, Rosa Lau, Rosie Webster, Susan Michie, Elizabeth Murray
BACKGROUND: Digital interventions have been effective in improving numerous health outcomes and health behaviors; furthermore, they are increasingly being used in different health care areas, including self-management of long-term conditions, mental health, and health promotion. The full potential of digital interventions is hindered by a lack of user engagement. There is an urgent need to develop effective strategies that can promote users' engagement with digital interventions. One potential method is the use of technology-based reminders or prompts...
2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/26656900/molecular-characterization-of-novel-splice-site-mutation-causing-protein-c-deficiency
#12
Mohamed H Al-Hamed, Fatma AlBatniji, Ghadah A AlDakheel, Huda El-Faraidi, Azzah Al-Zahrani, Fahed Al-Abbass, Faiqa Imtiaz
Congenital protein C deficiency is an inherited coagulation disorder associated with an elevated risk of venous thromboembolism. A Saudi Arabian male from a consanguineous family was admitted to neonatal intensive care unit in his first days of life because of transient tachypnea and hematuria. Laboratory investigations determined low platelet and protein C deficiency. Direct sequencing of PROC gene and RNA analysis were performed. Analysis of factor V Leiden (G1691A) and factor II (G20210A) mutations was also done...
July 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/26650448/poly-adp-ribose-polymerase-inhibition-a-potential-treatment-of-malignant-peripheral-nerve-sheath-tumor
#13
Christine M Kivlin, Kelsey L Watson, Ghadah A Al Sannaa, Roman Belousov, Davis R Ingram, Kai-Lieh Huang, Caitlin D May, Svetlana Bolshakov, Sharon M Landers, Azad Abul Kalam, John M Slopis, Ian E McCutcheon, Raphael E Pollock, Dina Lev, Alexander J Lazar, Keila E Torres
Poly (ADP) ribose polymerase (PARP) inhibitors, first evaluated nearly a decade ago, are primarily used in malignancies with known defects in DNA repair genes, such as alterations in breast cancer, early onset 1/2 (BRCA1/2). While no specific mutations in BRCA1/2 have been reported in malignant peripheral nerve sheath tumors (MPNSTs), MPNST cells could be effectively targeted with a PARP inhibitor to drive cells to synthetic lethality due to their complex karyotype and high level of inherent genomic instability...
2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/26629783/clinical-observations-and-molecular-variables-of-primary-vascular-leiomyosarcoma
#14
Christina L Roland, Genevieve M Boland, Elizabeth G Demicco, Kristelle Lusby, Davis Ingram, Caitlin D May, Christine M Kivlin, Kelsey Watson, Ghadah A Al Sannaa, Wei-Lien Wang, Vinod Ravi, Raphael E Pollock, Dina Lev, Janice N Cormier, Kelly K Hunt, Barry W Feig, Alexander J Lazar, Keila E Torres
IMPORTANCE: Vascular leiomyosarcomas are a rare subtype of leiomyosarcomas that most commonly affect the inferior vena cava and account for 5% of all leiomyosarcomas. These tumors are aggressive malignant tumors for which adjuvant modalities have not shown increased efficacy compared with surgery. OBJECTIVES: To evaluate the outcomes of patients with vascular leiomyosarcoma and the association between vascular leiomyosarcomas and immunohistochemical molecular markers, to determine their potential prognostic and therapeutic utility...
April 2016: JAMA Surgery
https://www.readbyqxmd.com/read/26559867/effect-of-horizontal-strabismus-surgery-on-the-refractive-status
#15
Elham Al-Tamimi, Ghadah Al-Nosair, Sanaa Yassin
PURPOSE: To evaluate the effects of horizontal strabismus surgery on the refractive and astigmatic status of eyes following horizontal muscle surgery using double-angle vector analysis. MATERIALS AND METHODS: This was a retrospective analysis of 137 patients (250 eyes) conducted between February 1997 and October 2010 in patients who had unilateral or bilateral recession or monocular recession and/or underwent resection of horizontal muscles by a single surgeon. Refraction data were obtained at 1-2 weeks preoperative and at 4-6 weeks and 4-6 months postoperative...
2015: Strabismus
https://www.readbyqxmd.com/read/26349011/targeting-the-notch-pathway-a-potential-therapeutic-approach-for-desmoid-tumors
#16
Hui Shang, Danielle Braggio, Ya-Jung Lee, Ghadah A Al Sannaa, Chad J Creighton, Svetlana Bolshakov, Alexander J F Lazar, Dina Lev, Raphael E Pollock
BACKGROUND: Desmoid tumors (DTs) are rare mesenchymal lesions that can recur repeatedly. When it is feasible, DTs are surgically resected; however, this often results in high recurrence rates. Recently, treatment with PF-03084014, a potent γ-secretase inhibitor, has been shown to have antitumor activity in several tumor types by affecting the WNT/β-catenin pathway. Consequently, Notch pathway inhibition by PF-03084014 might be a promising approach for DT treatment. METHODS: The expression of Notch pathway components was analyzed in DT tissues and cell strains with immunohistochemistry and Western blotting, respectively...
November 15, 2015: Cancer
https://www.readbyqxmd.com/read/26193637/increased-h3k9me3-drives-dedifferentiated-phenotype-via-klf6-repression-in-liposarcoma
#17
Emily Z Keung, Kadir C Akdemir, Ghadah A Al Sannaa, Jeannine Garnett, Dina Lev, Keila E Torres, Alexander J Lazar, Kunal Rai, Lynda Chin
Liposarcoma (LPS) can be divided into 4 different subtypes, of which well-differentiated LPS (WDLPS) and dedifferentiated LPS (DDLPS) are the most common. WDLPS is typically low grade, whereas DDLPS is high grade, aggressive, and carries a worse prognosis. WDLPS and DDLPS frequently co-occur in patients. However, it is not clear whether DDLPS arises independently from WDLPS, or whether epigenomic alterations underly the histopathological differences of these subtypes. Here, we profiled 9 epigenetic marks in tumor samples from 151 patients with LPS and showed elevated trimethylation of histone H3 at Lys9 (H3K9me3) levels in DDLPS tumors...
August 3, 2015: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/26163629/myiasis-associated-with-oral-squamous-cell-carcinoma-a-literature-review
#18
Sadeq Ali Al-Maweri, Ghadah A Al-Sufyani, Bassel Tarakji, Saleem Abdulrab
Advanced oral squamous cell carcinoma (SCC) is a possible risk factor for myiasis, a parasitic infestation of vital tissue of humans or other mammals by dipterous larvae (maggots). Oral myiasis is a rare entity, and is mostly associated with various medical and anatomical conditions, such as neglected mandibular fracture, lip incompetence, cerebral palsy, poor oral hygiene, suppurative lesions, and cancerous wounds. Larvae cause itching and irritation due to their crawling movements and can destroy vital tissues, inducing serious or even life-threating hemorrhage...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26155347/lip-and-oral-lesions-in-children-with-down-syndrome-a-controlled-study
#19
Sadeq-Ali Al-Maweri, Bassel Tarakji, Ghadah A Al-Sufyani, Hashem M Al-Shamiri, Giath Gazal
BACKGROUND: Down syndrome (DS) is the most common chromosomal abnormality affecting numerous organs, including the orofacial region. The objective of the present study was to assess the prevalence of lip and oral soft tissue lesions, with particular emphasize on the incidence of fissured tongue, lip fissures and angular cheilitis, among individuals with DS in Yemen. MATERIAL AND METHODS: This controlled cross-sectional study included 50 children with DS (6-18 years), and 50 age-and gender-matched healthy controls...
April 2015: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/26142520/generation-of-recombinant-bioluminescent-escherichia-coli-for-quantitative-determination-of-bacterial-adhesion
#20
Khalid Abdul Rahman AlLuhaybi, Ghadah Yazeed Alghaith, Nayera Ahmed Moneib, Mahmoud Abdul Magead Yassien
Bacterial adhesion to urinary catheter was evaluated by measuring the light emitted from a recombinant bioluminescent glycocalyx producer Escherichia coli strain. Generation of the bioluminescent strain was carried out by transforming the bacterial cells with pUCP18-GFP plasmid that contains a green fluorescence gene. Light emission measurement was closely correlated with the number of the adherent cells, giving a detectable signal from 1.2 X 10² cells. The efficiency of this assay was confirmed by testing the antiadherent effect of subinhibitory concentrations of ciprofloxacin with the aid of a model for in-vitro catheter colonization...
July 2015: Pakistan Journal of Pharmaceutical Sciences
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