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https://www.readbyqxmd.com/read/29776018/voxel-based-morphometry-in-creative-writers-gray-matter-increase-in-a-prefronto-thalamic-cerebellar-network
#1
Nicola Neumann, Martin Domin, Katharina Erhard, Martin Lotze
Continuous practice modulates those features of brain anatomy specifically associated with requirements of the respective training task. The current study aimed to highlight brain structural changes going along with long-term experience in creative writing. To this end, we investigated the gray-matter volume of 23 expert writers with voxel-based morphometry and compared it to 28 matched non-expert controls. Expert writers had higher gray-matter volume in the right superior frontal and middle frontal gyri (BA 9,10) as well as left middle frontal gyrus (BA 9, 10, 46), the bilateral medial dorsal nuclei of the thalamus and left posterior cerebellum...
May 18, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29776009/dependence-receptors-the-dark-side-awakens
#2
REVIEW
Ana-Maria Negulescu, Patrick Mehlen
Transmembrane receptors are usually seen as on and off switch: when the specific ligand is bound, the receptor is on and transduces a downstream signal, while when the ligand is absent, the receptor is off. Over the last two decades several reports have argued from an alternative view where some receptors, depending on the context, will be active both in the presence and in the absence of ligand, being sort of onA and onB switch rather than on and off. These receptors have been named Dependence Receptors (DR) and they share the ability to actively trigger cell death when unbound by their respective ligands...
May 18, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29775992/from-breaking-point-to-breakthrough-during-the-icu-stay-a-qualitative-study-of-family-members-experiences-of-long-term-intensive-care-patients-pathways-towards-survival
#3
Hege S Haugdahl, Regina Eide, Ingeborg Alexandersen, Tove Engan Paulsby, Berit Stjern, Stine Borgen Lund, Gørill Haugan
AIMS AND OBJECTIVES: To explore family members' experiences of long-term intensive care unit (ICU) patients' pathways towards survival and to highlight family members' efforts to promote the patient's health during the ICU stay. BACKGROUND: Although considerable research has been devoted to the substantial burden of long-term ICU patients, less attention has been paid to health promoting factors that facilitate patients' health and survival during ICU stays. Support from family members can improve patient outcome...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29775991/redefining-perinatal-experience-a-philosophical-exploration-of-a-hypothetical-case-of-gender-diversity-in-labour-and-birth
#4
Brianna Richardson, Sheri Price, Marsha Campbell-Yeo
OBJECTIVE AND AIMS: Using a queer phenomenological approach, the objective of this philosophical analysis is to explore the transgender experience in highly gendered clinical areas, such as the birth unit, and make recommendations on how to provide perinatal care that is inclusive of gender diversity within these areas. This paper aims to describes a hypothetical clinical experience to provide insight on the institutional barriers that currently exist and to provide nurses and midwives with pragmatic strategies to enhance gender-diverse care in general and gendered clinical areas...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29775970/anti-inflammatory-flavanones-and-flavanols-from-the-roots-of-pongamia-pinnata
#5
Ran Wen, Haining Lv, Yong Jiang, Pengfei Tu
A phytochemical study of the roots of Pongamia pinnata afforded 29 flavanones and flavanols, including 7 previously undescribed compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and mass spectroscopy data. The absolute configurations of the compounds were assigned via analysis of the specific rotations and electronic circular dichroism spectra, application of Mosher's method, and by comparing the calculated and experimental electronic circular dichroism spectra. The isolates were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells...
May 18, 2018: Planta Medica
https://www.readbyqxmd.com/read/29775960/strategies-to-decrease-oxidative-stress-biomarker-levels-in-human-medical-conditions-a-meta-analysis-on-8-iso-prostaglandin-f-2%C3%AE
#6
Thomas J van 't Erve
The widespread detection of elevated oxidative stress levels in many medical conditions has led to numerous efforts to design interventions to reduce its effects. Efforts have been wide-ranging, from dietary changes to administration of antioxidants, supplements, e.g., omega-3-fatty acids, and many medications. However, there is still no systemic assessment of the efficacy of treatments for oxidative stress reduction across a variety of medical conditions. The goal of this meta-analysis is, by combining multiple studies, to quantitate the change in the levels of the popular oxidative stress biomarker 8-iso-prostaglandin F2α (8-iso-PGF2α ) after a variety of treatment strategies in human populations...
May 9, 2018: Redox Biology
https://www.readbyqxmd.com/read/29775958/a-systematic-review-of-community-based-interventions-to-improve-oral-chronic-disease-medication-regimen-adherence-among-individuals-with-substance-use-disorder
#7
REVIEW
Karen M Clements, Tasmina Hydery, Mark A Tesell, Bonnie C Greenwood, Michael C Angelini
BACKGROUND: Poor medication adherence has been shown to cause medical complications, death, and increased healthcare costs and may be of particular importance in patients with substance use disorder (SUD). Concerns regarding adherence in this population may influence a healthcare provider's decision to prescribe a medication requiring high adherence. Guidance defining best practices that promote adherence among individuals with SUD is lacking. METHODS: A review of English articles in Medline and PsycINFO databases, published between October 1, 1994 and October 31, 2017, was conducted in order to identify studies of interventions intended to improve adherence to oral chronic disease medication regimens among patients with SUD...
May 1, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29775954/a-new-methodology-based-on-functional-principal-component-analysis-to-study-postural-stability-post-stroke
#8
M Luz Sánchez-Sánchez, Juan-Manuel Belda-Lois, Silvia Mena-Del Horno, Enrique Viosca-Herrero, Celedonia Igual-Camacho, Beatriz Gisbert-Morant
BACKGROUND: A major goal in stroke rehabilitation is the establishment of more effective physical therapy techniques to recover postural stability. Functional Principal Component Analysis provides greater insight into recovery trends. However, when missing values exist, obtaining functional data presents some difficulties. The purpose of this study was to reveal an alternative technique for obtaining the Functional Principal Components without requiring the conversion to functional data beforehand and to investigate this methodology to determine the effect of specific physical therapy techniques in balance recovery trends in elderly subjects with hemiplegia post-stroke...
May 5, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29775952/molecular-simulation-and-experimental-validation-of-resorcinol-adsorption-on-ordered-mesoporous-carbon-omc
#9
Zaki Uddin Ahmad, Bing Chao, Mas Iwan Konggidinata, Qiyu Lian, Mark E Zappi, Daniel Dianchen Gang
Numerous research works have been devoted in the adsorption area using experimental approaches. All these approaches are based on trial and error process and extremely time consuming. Molecular simulation technique is a new tool that can be used to design and predict the performance of an adsorbent. This research proposed a simulation technique that can greatly reduce the time in designing the adsorbent. In this study, a new Rhombic ordered mesoporous carbon (OMC) model is proposed and constructed with various pore sizes and oxygen contents using Materials Visualizer Module to optimize the structure of OMC for resorcinol adsorption...
April 27, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29775931/a-nanocomposite-optosensor-containing-carboxylic-functionalized-multiwall-carbon-nanotubes-and-quantum-dots-incorporated-into-a-molecularly-imprinted-polymer-for-highly-selective-and-sensitive-detection-of-ciprofloxacin
#10
Naphat Yuphintharakun, Piyaluk Nurerk, Kochaporn Chullasat, Proespichaya Kanatharana, Frank Davis, Dhassida Sooksawat, Opas Bunkoed
A nanocomposite optosensor consisting of carboxylic acid functionalized multiwall carbon nanotubes and CdTe quantum dots embedded inside a molecularly imprinted polymer (COOH@MWCNT-MIP-QDs) was developed for trace ciprofloxacin detection. The COOH@MWCNT-MIP-QDs were synthesized through a facile sol-gel process using ciprofloxacin as a template molecule, 3-aminopropylethoxysilane as a functional monomer and tetraethoxysilane as a cross-linker at a molar ratio of 1:8:20. The synthesized nanocomposite optosensor had high sensitivity, excellent specificity and high binding affinity to ciprofloxacin...
May 10, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29775910/hip-and-patellofemoral-joint-loading-during-gait-are-increased-in-children-with-idiopathic-torsional-deformities
#11
Elyse Passmore, H Kerr Graham, Marcus G Pandy, Morgan Sangeux
BACKGROUND: Torsional deformities of the femur and tibia are associated with gait impairments and joint pain. Several studies have investigated these gait deviations in children with cerebral palsy. However, relatively little is known about gait deviations in children with idiopathic torsion and debate ensues about the management of these patients. RESEARCH QUESTION: What are the effects of idiopathic increased femoral neck anteversion and external tibial torsion on lower-limb kinematics, kinetics and joint loading during gait in children and adolescents...
May 9, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29775905/kinetic-modelling-of-methane-production-during-bio-electrolysis-from-anaerobic-co-digestion-of-sewage-sludge-and-food-waste
#12
Kalp Bhusan Prajapati, Rajesh Singh
In present study batch tests were performed to investigate the enhancement in methane production under bio-electrolysis anaerobic co-digestion of sewage sludge and food waste. The bio-electrolysis reactor system (B-EL) yield more methane 148.5 ml/g COD in comparison to reactor system without bio-electrolysis (B-CONT) 125.1 ml/g COD. Whereas bio-electrolysis reactor system (C-EL) Iron Scraps amended yield lesser methane (51.2 ml/g COD) in comparison to control bio-electrolysis reactor system without Iron scraps (C-CONT - 114...
May 10, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29775902/type-1-diabetes-through-the-lens-of-human-genome-and-metagenome-interplay
#13
REVIEW
Sepideh Zununi Vahed, Hakimeh Moghaddas Sani, Yalda Rahbar Saadat, Abolfazl Barzegari, Yadollah Omidi
Diabetes is a genetic- and epigenetic-related disease from which a large population worldwide suffers. Some genetic factors along with various mutations related to the immune system for disease mechanism(s) have contrastively been determined. However, sometimes mechanisms have not been fully managed for the clarification of the initiation and/or progression of diseases to help patients. In the recent years, due to familiarity with the role of gut microbiota in the health, it has been found that the changes of the microbial balance in the industrialized societies can cause a battery of modern diseases, for which we have no specific definition of how they emerge...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29775901/tricine-co-ligand-improved-the-efficacy-of-99m-tc-hynic-ser-3-j18-peptide-for-targeting-and-imaging-of-non-small-cell-lung-cancer
#14
Zahra Shaghaghi, Seyed Mohammad Abedi, Seyed Jalal Hosseinimehr
The early diagnosis of non-small cell lung cancer (NSCLC) is important for increasing survival rate and improving quality life of patients. The aim of this study was to investigate 99m  Tc-(tricine)-HYNIC-(Ser)3 -J18 for targeting and imaging of NSCLC in A-549 xenografted nude mice. The (Ser)3 -J18 peptide was conjugated with HYNIC and labeled with 99m  Tc using tricine as a co-ligand. The radiolabeled peptide was evaluated for its radiochemical purity, stability, receptor binding and internalization in vitro...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29775896/dysregulated-network-of-mirnas-involved-in-the-pathogenesis-of-multiple-sclerosis
#15
REVIEW
Sanam Dolati, Faroogh Marofi, Zohreh Babaloo, Leili Aghebati-Maleki, Leila Roshangar, Majid Ahmadi, Reza Rikhtegar, Mehdi Yousefi
Multiple sclerosis (MS) is a chronic and organ-specific autoimmune disease in which immune cells act against the myelin sheath, resulting in central nervous system (CNS) damage. It has been revealed that miRNAs can play significant role in the pathogenesis of MS. These regulatory molecules lead to the activation of different signaling pathways, regulation of several transcriptional factors, influencing the differentiation of Th17 cells, development of Tregs and alteration from Th2 to Th1 response in MS. New studies have discovered that dysregulation of miRNAs may trigger abnormal immune responses leading consequently in the emergence of autoimmunity...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29775894/positive-effects-of-antitumor-drugs-in-combination-with-propolis-on-canine-osteosarcoma-cells-spos-2-and-mesenchymal-stem-cells
#16
Pedro Negri Bernardino, Paulo Ricardo Oliveira Bersano, João Ferreira Lima Neto, José Maurício Sforcin
The combination of lower concentrations of antitumor drugs (carboplatin - CARB, doxorubicin - DOX, and methotrexate - MET) with propolis was investigated against canine osteosarcoma (spOS-2) and mesenchymal stem cells (MSC) in vitro. The mechanism of action in the combinations was analyzed. spOS-2 cells were incubated up to 72 h with propolis (50 μg/ml) alone or in combination with CARB (10-400 μmol/l), DOX (0.5-2 μmol/l) or MET (50-200 μmol/l). Cell viability was assessed by MTT assay, apoptosis/necrosis by flow cytometry, and MSC was incubated with the optimum combination...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29775887/gender-and-age-varying-associations-of-sensation-seeking-and-substance-use-across-young-adulthood
#17
Rebecca J Evans-Polce, Megan S Schuler, John E Schulenberg, Megan E Patrick
INTRODUCTION: Sensation seeking is associated with elevated risk for substance use among adolescents and young adults. However, whether these associations vary across age for young men and women is not well characterized. METHODS: Using data from the Monitoring the Future (MTF) panel study, we examine the age-varying associations of sensation seeking and three types of substance use behavior (binge drinking, cigarette use, and marijuana use) across ages 18 to 30 using time-varying effect modeling...
May 4, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29775875/the-reduced-level-of-growth-factors-in-an-animal-model-of-depression-is-accompanied-by-regulated-necrosis-in-the-frontal-cortex-but-not-in-the-hippocampus
#18
Mateusz Kucharczyk, Anna Kurek, Bartosz Pomierny, Jan Detka, Mariusz Papp, Katarzyna Tota, Bogusława Budziszewska
In the present study, we asked if the different types of stress alter neuronal plasticity markers distinctively in the frontal cortex (FCx) and in the hippocampus (Hp). To do so, we implemented various stress regimens to analyze changes evoked in these rat brain structures. We utilized several molecular techniques, including western blot, ELISA, quantitative RT-PCR, and various biochemical assays, to examine a range of proteins and subjected rats to behavioral tests to evaluate potential maladaptive alterations...
May 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29775871/associations-between-abuse-neglect-and-adhd-from-childhood-to-young-adulthood-a-prospective-nationally-representative-twin-study
#19
Adi Stern, Jessica Agnew-Blais, Andrea Danese, Helen L Fisher, Sara R Jaffee, Timothy Matthews, Guilherme V Polanczyk, Louise Arseneault
Child maltreatment has consistently been found to be associated with attention deficit/hyperactivity disorder (ADHD). However, the robustness of this association and the direction of the link between maltreatment and ADHD remain unclear. We used data from the Environmental Risk (E-Risk) Longitudinal Twin Study, a cohort of 2232 British twins, to investigate the associations between exposure to abuse/neglect and ADHD in childhood and in young adulthood, and to test their robustness and specificity. We also aimed to test longitudinal associations between abuse/neglect and ADHD from childhood to young adulthood, controlling for confounders...
May 15, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29775869/mathematics-intervention-for-children-with-fetal-alcohol-spectrum-disorder-a-replication-and-extension-of-the-math-interactive-learning-experience-mile-program
#20
Katrina Kully-Martens, Jacqueline Pei, Julie Kable, Claire D Coles, Gail Andrew, Carmen Rasmussen
BACKGROUND: Individuals with fetal alcohol spectrum disorders (FASD) experience deficits in behavior, cognition, and academic functioning resulting from prenatal alcohol exposure (PAE). Although receiving intervention for developmental disabilities is a strong protective factor against negative outcomes in FASD, intervention research in this population is in its infancy. AIMS: The purpose of this study was to replicate and extend a mathematics intervention, the Math Interactive Learning Experience (MILE) program, which was developed in the USA specifically for children with FASD...
May 15, 2018: Research in Developmental Disabilities
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