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https://www.readbyqxmd.com/read/29677683/application-of-solid-phase-microextraction-followed-by-liquid-chromatography-mass-spectrometry-in-the-determination-of-antibiotic-drugs-and-their-metabolites-in-human-whole-blood-and-tissue-samples
#1
Malgorzata Szultka-Mlynska, Pawel Pomastowski, Boguslaw Buszewski
A sensitive, rapid and specific analytical method using high performance liquid chromatography coupled with mass spectrometry (HPLC-QqQ-MS) was developed to determine selected antibiotic drugs and their metabolites (amoxicillin, cefotaxime, ciprofloxacin, clindamycin and metronidazole; amoxycilloic acid, 4-hydroxyphenyl glycyl amoxicillin, desacetyl cefotaxime, 3-desacetyl cefotaxime lactone, ciprofloxacin N-oxide, N-demethylclindamycin, clindamycin sulfoxide, and hydroxy metronidazole) in human whole blood and vascularized tissue after single oral administration...
April 12, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29677678/%C3%AE-glucosidase-enzyme-inhibitory-effects-and-ursolic-and-oleanolic-acid-contents-of-fourteen-anatolian-salvia-species
#2
Zeynep Kalaycıoğlu, Sesil Uzaşçı, Tuncay Dirmenci, F Bedia Erim
During the last decade, ursolic and oleanolic acids have been of considerable interest because of their α-glucosidase inhibitory activities and potential effects for treatment of type 2 diabetes. A simple and sensitive reversed-phase HPLC method was developed for the simultaneous determination of ursolic acid and oleanolic acid. The optimal mobile phase was selected as 85% acetonitrile solution. The limit of detection of the method for ursolic acid and oleanolic acid were 14 ng mL-1 and 13 ng mL-1 , respectively...
April 11, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29677651/occurrence-distribution-and-ecological-risk-assessment-of-the-herbicide-simazine-a-case-study
#3
Linlin Li, Yizhang Zhang, Lei Zheng, Shaoyong Lu, Zhenguang Yan, Junhong Ling
The occurrence and distributions of simazine, and its environmental behaviors were studied in Taizi River, China. Results showed that concentration of simazine in surface water and suspended solids (SS) were in the range of 35-1150 ng L-1 and 0.00-1075 ng g-1 with mean value of 240.26 ng L-1 and 311.68 ng g-1 , respectively. A significant correlation between the concentrations of simazine and organic carbon was observed in both surface water and SS (r1  = 0.82, n1  = 15, r2  = 0...
April 5, 2018: Chemosphere
https://www.readbyqxmd.com/read/29677642/diagnostic-value-of-18-f-fluordesoxyglucose-positron-emission-tomography-for-patients-with-brain-metastasis-from-unknown-primary-site
#4
Fabian Wolpert, Michael Weller, Anna Sophie Berghoff, Elisabeth Rushing, Lisa Michaela Füreder, Gregory Petyt, Henning Leske, Nicolaus Andratschke, Luca Regli, Marian Christoph Neidert, Roger Stupp, Rolf Stahel, Reinhard Dummer, Thomas Frauenfelder, Patrick Roth, Nicolas Reyns, Philipp Antonio Kaufmann, Matthias Preusser, Emilie Le Rhun
BACKGROUND: In 30% of patients with brain metastasis (BM), neurological symptoms are the first clinical manifestation of systemic malignancy, referred to as BM from cancer of unknown primary site (BM-CUPS). Here, we define the diagnostic value of 18 F-fluordesoxyglucose positron emission tomography (FDG-PET/CT) in the workup of BM-CUPS. METHODS: We screened 565 patients operated for BM at the University Hospital Zurich and identified 64 patients with BM-CUPS with data on both FDG-PET/CT and contrast-enhanced chest/abdomen computed tomography (CT) available at BM diagnosis...
April 17, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29677636/aunp-rf-sensor-an-innovative-application-of-rf-technology-for-sensing-pathogens-electrically-in-liquids-spel-within-the-food-supply-chain
#5
Leann Lerie Matta, Saranraj Karuppuswami, Premjeet Chahal, Evangelyn C Alocilja
Rapid detection techniques of pathogenic bacteria in the liquid food supply chain are of significant research interest due to their pivotal role in preventing foodborne outbreaks, and in maintaining high standards of public health and safety. Milk and dairy products are of particular interest due to their widespread consumption across the globe. In this paper, a biosensor for detecting pathogenic bacteria in milk using dextrin-capped gold nanoparticles (d-AuNP) as labels decoded at microwave frequencies is presented...
April 11, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29677626/positive-alcohol-use-expectancies-moderate-the-association-between-anxiety-sensitivity-and-alcohol-use-across-adolescence
#6
Allison M Borges, Carl W Lejuez, Julia W Felton
Anxiety sensitivity (AS), or the fear of anxious symptoms and the belief that these symptoms may have negative physical, social, and cognitive consequences, is one personality trait that emerges in early adolescence and may be linked to alcohol use. However, findings are equivocal as to whether elevated AS during adolescence directly predicts alcohol use. Adolescents do report increases in positive alcohol use expectancies during this developmental period, and these expectancies have been found to be significantly associated with alcohol use...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29677616/in-situ-synthesis-of-molybdenum-sulfide-reduced-graphene-oxide-porous-film-as-robust-counter-electrode-for-dye-sensitized-solar-cells
#7
Junliang Chen, Dapeng Wu, Hongju Wang, Fujuan Wang, Yixin Wang, Zhiyong Gao, Fang Xu, Kai Jiang
Molybdenum sulfide/reduced graphene oxide (MoS2 /RGO) porous film was in-situ deposited on fluorine-doped tin oxide (FTO) substrates via a one-pot hydrothermal method. Due to the oxygen-containing groups distributing on graphene oxide (GO) surface, the MoS2 sheets could nucleate and grow taking GO as substrates and the MoS2 /RGO film can be strongly linked to the FTO. Based on the electrochemical investigations, the enhanced cell performance could be ascribed to the improved electrical conductivity, catalytic active sites and electrolyte diffusion rate, which finally contribute to the high catalytic performance on the reduction of I- /I3 - couples in the electrolyte...
April 11, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29677610/a-new-electrochemical-sensor-for-highly-sensitive-and-selective-detection-of-nitrite-in-food-samples-based-on-sonochemical-synthesized-calcium-ferrite-cafe-2-o-4-clusters-modified-screen-printed-carbon-electrode
#8
Paramasivam Balasubramanian, Ramki Settu, Shen-Ming Chen, Tse-Wei Chen, Ganapathi Sharmila
Herein, we report a novel, disposable electrochemical sensor for the detection of nitrite ions in food samples based on the sonochemical synthesized orthorhombic CaFe2 O4 (CFO) clusters modified screen printed electrode. As synthesized CFO clusters were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transformer infrared spectroscopy (FT-IR), Thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and amperometry (i-t)...
April 11, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29677601/indirect-detection-of-10-b-i-3-overtone-nmr-at-very-fast-magic-angle-spinning
#9
Nghia Tuan Duong, Ilya Kuprov, Yusuke Nishiyama
The application of overtone nuclear magnetic resonance (OT NMR) to symmetric spin transitions of integer quadrupolar nuclei is of considerable interest since this transition is immune to the first-order quadrupolar interaction, thus resulting in narrow NMR lines. Owing to its roles in nature and its high natural abundance, 14 N (I = 1) OT NMR has been explored, in which the indirect and/or direct acquisitions of 14 N OT were experimentally demonstrated. However, other than 14 N nucleus, no OT NMR observation of other integer quadrupolar nuclei has been reported in the literature...
April 11, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29677587/effects-of-chronic-exposure-to-cadmium-and-temperature-alone-or-combined-on-the-threespine-stickleback-gasterosteus-aculeatus-interest-of-digestive-enzymes-as-biomarkers
#10
Younes Mohamed Ismail Hani, Cyril Turies, Olivier Palluel, Laurence Delahaut, Véronique Gaillet, Anne Bado-Nilles, Jean-Marc Porcher, Alain Geffard, Odile Dedourge-Geffard
The development of predictive, sensitive and reliable biomarkers is of crucial importance for aquatic biomonitoring to assess the effects of chemical substances on aquatic organisms, especially when it comes to combined effects with other stressors (e.g. temperature). The first purpose of the present study was to evaluate the single and combined effects of 90 days of exposure to an environmental cadmium concentration (0.5 μg L-1 ) and two water temperatures (16 and 21 °C) on different parameters. These parameters are involved in (i) the antioxidant system (superoxide dismutase activity -SOD- and total glutathione levels -GSH-), (ii) the energy metabolism, i...
April 12, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29677584/the-effect-of-copayments-on-the-utilization-of-the-gp-service-in-norway
#11
Mari Magnussen Landsem, Jon Magnussen
We examine the effect of copayment on the utilization of the GP service in Norway. We use a regression discontinuity design to study two key aspects of the policy. First, we examine the overall effect of copayments on total utilization of the GP service. Second, we look at how this effect varies across different patient groups according to medical necessity. Data consists of 5,5 million GP visits for youths aged 10-20 over the 6 year period 2009-2014. We find that the introduction of a co-payment leads to an overall reduction of GP visits of 10-15%...
March 23, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29677560/effective-discovery-of-rare-variants-by-pooled-target-capture-sequencing-a-comparative-analysis-with-individually-indexed-target-capture-sequencing
#12
Seungjin Ryu, Jeehae Han, Trina M Norden-Krichmar, Nicholas J Schork, Yousin Suh
Identification of all genetic variants associated with complex traits is one of the most important goals in modern human genetics. Genome-wide association studies (GWAS) have been successfully applied to identify common variants, which thus far explain only small portion of heritability. Interests in rare variants have been increasingly growing as an answer for this missing heritability. While next-generation sequencing allows detection of rare variants, its cost is still prohibitively high to sequence a large number of human DNA samples required for rare variant association studies...
March 30, 2018: Mutation Research
https://www.readbyqxmd.com/read/29677553/developmental-change-in-tone-perception-in-mandarin-monolingual-english-monolingual-and-mandarin-english-bilingual-infants-divergences-between-monolingual-and-bilingual-learners
#13
Leher Singh, Charlene S L Fu, Xian Hui Seet, Ashley P Y Tong, Joelle L Wang, Catherine T Best
Most languages use lexical tone to discriminate the meanings of words. There has been recent interest in tracking the development of tone categories during infancy. These studies have focused largely on monolingual infants learning either a tone language or a non-tone language. It remains to be seen how bilingual infants learning one tone language (e.g., Mandarin) and one non-tone language (e.g., English) discriminate tones. Here, we examined infants' discrimination of two Mandarin tones pairs: one salient and one subtle...
April 17, 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29677531/synthesis-of-nanowire-bundle-like-wo-3-w-18-o-49-heterostructures-for-highly-sensitive-nh-3-sensor-application
#14
Ya Xiong, Zongye Zhu, Tianchao Guo, Hui Li, Qingzhong Xue
Heterojunctions are very promising structures due to their hybrid properties, which are usually obtained via a multistep growth process. However, in this paper, WO3 -W18 O49 heterostructures are synthesized via a novel one-step approach by using isopropanol as reaction media and are applied in NH3 gas detection for the first time. The obtained WO3 -W18 O49 heterostructures with loose nanowire bundle-like morphology show a response value of 23.3 toward 500 ppm NH3 at 250 °C, which is 5.63 times higher than that of pristine W18 O49 ...
April 14, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29677520/stable-black-phosphorus-bi-2-o-3-heterostructures-for-synergistic-cancer-radiotherapy
#15
Hao Huang, Lizhen He, Wenhua Zhou, Guangbo Qu, Jiahong Wang, Na Yang, Jie Gao, Tianfeng Chen, Paul K Chu, Xue-Feng Yu
X-ray induced photodynamic therapy (X-ray-PDT) is a promising approach for synergistic cancer radiotherapy and development of suitable radiosensitizers is highly desired. In this paper, we propose black phosphorus/Bi2 O3 (BP/Bi2 O3 ) heterostructures as efficient and biocompatible radiosensitizers for synergistic cancer radiotherapy. The heterostructures are synthesized by growth of ultrasmall Bi2 O3 nanoparticles onto BP nanosheets. The Bi2 O3 decoration inhibits the rapid degradation of BP nanosheets by occupation of the defect sites, and the synergistic effects of BP and Bi2 O3 enable 1 O2 overproduction under X-ray irradiation...
April 13, 2018: Biomaterials
https://www.readbyqxmd.com/read/29677511/an-integrated-genome-wide-crispra-approach-to-functionalize-lncrnas-in-drug-resistance
#16
Assaf C Bester, Jonathan D Lee, Alejandro Chavez, Yu-Ru Lee, Daphna Nachmani, Suhani Vora, Joshua Victor, Martin Sauvageau, Emanuele Monteleone, John L Rinn, Paolo Provero, George M Church, John G Clohessy, Pier Paolo Pandolfi
Resistance to chemotherapy plays a significant role in cancer mortality. To identify genetic units affecting sensitivity to cytarabine, the mainstay of treatment for acute myeloid leukemia (AML), we developed a comprehensive and integrated genome-wide platform based on a dual protein-coding and non-coding integrated CRISPRa screening (DICaS). Putative resistance genes were initially identified using pharmacogenetic data from 760 human pan-cancer cell lines. Subsequently, genome scale functional characterization of both coding and long non-coding RNA (lncRNA) genes by CRISPR activation was performed...
April 19, 2018: Cell
https://www.readbyqxmd.com/read/29677500/raman-spectral-analysis-for-rapid-screening-of-dengue-infection
#17
T Mahmood, H Nawaz, A Ditta, M I Majeed, M A Hanif, N Rashid, H N Bhatti, H F Nargis, M Saleem, F Bonnier, H J Byrne
Infection with the dengue virus is currently clinically detected according to different biomarkers in human blood plasma, commonly measured by enzyme linked immunosorbent assays, including non-structural proteins (Ns1), immunoglobulin M (IgM) and immunoglobulin G (IgG). However, there is little or no mutual correlation between the biomarkers, as demonstrated in this study by a comparison of their levels in samples from 17 patients. As an alternative, the label free, rapid screening technique, Raman spectroscopy has been used for the characterisation/diagnosis of healthy and dengue infected human blood plasma samples...
April 11, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29677498/dye-sensitized-solar-cells-using-catalytically-active-cuo-zno-nanocomposite-synthesized-by-single-step-method
#18
Nelsa Abraham, Alex Rufus, C Unni, Daizy Philip
In the present paper we report a low cost, single step preparation method for the synthesis of CuO-ZnO nanocomposite through simple co-precipitation technique using oxalic acid. To have a better idea about the deviations brought about by the inclusion of CuO in ZnO lattice, pure ZnO nanoparticles synthesized from 0.1M solutions were also investigated. X-ray diffraction studies showed that the composite contains only hexagonal wurtzite ZnO and monoclinic CuO structures. The magnetic studies of CuO-ZnO heterostructures were also conducted in order to elucidate the source of the ferromagnetism observed at room temperature...
April 10, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29677466/measuring-electric-fields-in-biological-matter-using-the-vibrational-stark-effect-of-nitrile-probes
#19
Joshua D Slocum, Lauren J Webb
Measurement of the electrostatic interactions that give rise to biological functions has been a longstanding challenge in biophysics. Advances in spectroscopic techniques over the past two decades have allowed for the direct measurement of electric fields in a wide variety of biological molecules and systems via the vibrational Stark effect (VSE). The frequency of the nitrile stretching oscillation has received much attention as an electric field reporter because of its sensitivity to electric fields and its occurrence in a relatively transparent region of the infrared spectrum...
April 20, 2018: Annual Review of Physical Chemistry
https://www.readbyqxmd.com/read/29677462/ondansetron-blocks-wildtype-and-p-f503l-variant-small-conductance-calcium-activated-potassium-channels
#20
Jum-Suk Ko, Shuai Guo, Jonathan Hassel, Patricia Celestino-Soper, Ty C Lynnes, James E Tisdale, James J Zheng, Stanley E Taylor, Tatiana Foroud, Michael D Murray, Richard J Kovacs, Xiaochun Li, Shien-Fong Lin, Zhenhui Chen, Matteo Vatta, Peng-Sheng Chen, Michael Rubart
The apamin-sensitive, small conductance, calcium-activated potassium (SK) current ( IKAS ) is encoded by KCNN genes. IKAS importantly contributes to cardiac repolarization in conditions associated with reduced repolarization reserve. To test the hypothesis that IKAS inhibition contributes to drug-induced long QT (diLQT) syndrome, we (1) screened for KCNN variants among patients with diLQT, (2) determined the properties of heterologously expressed wildtype and variant KCNN channels, and (3) determined if the 5-HT3 receptor antagonist ondansetron blocks IKAS ...
April 20, 2018: American Journal of Physiology. Heart and Circulatory Physiology
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