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Arya Das, Sk Musharaf Ali
Tri-isoamyl phosphate (TiAP) has been proposed to be an alternative for tri-butyl phosphate (TBP) in the Plutonium Uranium Extraction (PUREX) process. Recently, we have successfully calibrated and tested all-atom optimized potentials for liquid simulations using Mulliken partial charges for pure TiAP, TBP, and dodecane by performing molecular dynamics (MD) simulation. It is of immense importance to extend this potential for the various molecular properties of TiAP and TiAP/n-dodecane binary mixtures using MD simulation...
February 21, 2018: Journal of Chemical Physics
Georgios Polychronidis, Roland Hennes, Cosima Engerer, Phillip Knebel, Daniel Schultze, Thomas Bruckner, Beat P Müller-Stich, Lars Fischer
BACKGROUND: Insertion of a Totally Implantable Access Port (TIAP) can be performed either via Central Vein Puncture (CVP) or Brachiocephalic Vein Cut-down (venous section-VS). The primary success rate of TIAP implantation using VS rarely ever achieves 100%. The objective of this study was to describe a modified VS approach using a hydrophilic coated wire (TVS). METHODS: From 01.01.2015 to 31.12.2015, all patients receiving TIAP implantations were screened. During this time, all patients in whom the primary VS procedure was found to be unsuccessful were analysed...
December 7, 2017: BMC Surgery
Diego S Buarque, Cícera M Gomes, Ricardo N Araújo, Marcos H Pereira, Roberta C Ferreira, Alessandra A Guarneri, Aparecida S Tanaka
The Reduviid Triatoma infestans is a vector for the protozoan Trypanosoma cruzi, the etiological agent of Chagas disease. The parasite must address the defense molecules and microbiota that colonize the anterior midgut of T. infestans. To obtain insight into T. cruzi - microbiota interactions in triatomine insects, we characterized a new antimicrobial product from the anterior midgut of T. infestans (TiAP) that may be involved in these relationships. The TiAP DNA fragment was cloned and expressed in a bacterial system, and the effect of the protein on bacteria and T...
April 2016: Biochimie
Michela Piredda, Valentina Biagioli, Diana Giannarelli, Daniele Incletoli, Francesca Grieco, Massimiliano Carassiti, Maria Grazia De Marinis
PURPOSE: Providing patients with written information about totally implantable access ports (TIAPs) is recommended during the pre-implantation period to reduce anxiety and to help recalling information. No study tested the effectiveness of information about TIAP neither with oral communication nor with booklets. This study aimed at evaluating the effectiveness of an information booklet, alone or together with answers to clarification questions, both in improving patients' short- and long-time knowledge about TIAP and in decreasing patients' physiological indicators of anxiety immediately after TIAP implantation...
February 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Gian Domenico Arzu, Federico Coccolini, Michele Rossi, Fabio Longaretti, Andrea Costanzi, Stefano Senatore, Angelo Miranda, Dario Maggioni
Percutaneous central vascular venous access to allow positioning of a totally implantable access port (TIAP) is a widely employed procedure. An open issue is the need to find an ionizing radiation free technique which allows a safe and correct positioning of the device. Echo-guided vein puncture is currently accepted as the best method for decreasing major immediate complications. We describe an entirely echo-based method for the insertion and assessment of correct placement of the totally implantable access ports (TIAP)...
June 2014: Indian Journal of Surgery
James B Jaquith
The Inhibitor of Apoptosis Proteins (IAPs) play a critical role in the regulation of cellular apoptosis and cytokine signaling. IAP family members include XIAP, cIAP1, cIAP2, NAIP, survivin, Apollon/Bruce, ML-IAP/livin and TIAP. The IAPs have been targeted using both antisense oligonucleotides and small molecule inhibitors. Several research teams have advanced compounds that bind the highly conserved BIR3 domains of the IAPs into clinical trials, as single agents and in combination with standard of care. This patent review highlights the medicinal chemistry strategies that have been applied to the development of clinical compounds...
May 2014: Pharmaceutical Patent Analyst
Emine Ince, Pelin Oğuzkurt, Abdulkerim Temiz, Semire Serin Ezer, Hasan Özkan Gezer, Nalan Yazici, Akgün Hiçsönmez
BACKGROUND: Totally, implantable access ports (TIAPs) are used for long standing venous catheterization. This study was designed to present our experiences of the TIAPs applications and efficacy of Taurolidine-citrate lock solution (TCLS) against catheter-related infections. MATERIALS AND METHODS: We evaluated records of the 108 patients implanted with 112 TIAPs, which had been performed using heparin solution or TCLS between 2005 and 2013. RESULTS: Duration of exposure to TIAPs was 17-2051 days (median: 411 days)...
April 2014: African Journal of Paediatric Surgery: AJPS
Jianzhong Miao, Lijun Ji, Jianjun Lu, Jianqing Chen
The aim of this randomized controlled study was to compare ultrasound-guided procedure with the Seldinger's technique for placement of implantable venous ports. A total of 214 patients were randomized to receive TIAP placement by either ultrasound-guided procedure or the Seldinger's technique. Complications and pain perception were compared between these two groups. No severe perioperative or periinterventional complication occurred. Significantly (P < 0.05) lower pain perception was observed in the ultrasound-guided group...
September 2014: Cell Biochemistry and Biophysics
Hung-Wei Cheng, Chien-Kun Ting, Ya-Chun Chu, Wen-Kuei Chang, Kwok-Hon Chan, Pin-Tarng Chen
BACKGROUND: Totally implantable access ports (TIAPs) are alternatives to central venous catheters for patients requiring chemotherapy. Since January 2003, we have used a central approach two-point incision technique to insert TIAPs. Following advances in ultrasound technique and clinical experience for tunneled dialysis catheter placement, we modified the central approach to a low-approach technique. METHODS: From January 2009 to June 2010, patients consulted for TIAP insertion in our department were enrolled in our study...
May 2014: Journal of the Chinese Medical Association: JCMA
Yoshinobu Nagasawa, Tomoharu Shimizu, Hiromichi Sonoda, Eiji Mekata, Masato Wakabayashi, Hiroyuki Ohta, Satoshi Murata, Tsuyoshi Mori, Shigeyuki Naka, Tohru Tani
Totally implantable access ports (TIAPs) are generally used in oncology. Few studies have addressed complications associated with the insertion site. A total of 233 consecutive oncology patients were enrolled to receive TIAP inserts via internal jugular vein (IJV) or subclavian vein (SV). Data on clinicopathologic parameters and early/late complications were retrospectively collected. No differences were found early and late complication rates. Catheter injury was observed more frequently in the IJV group (2...
March 2014: International Surgery
Yoshinobu Nagasawa, Tomoharu Shimizu, Hiromichi Sonoda, Hirotomi Chou, Eiji Mekata, Tohru Tani
Catheter rupture after totally implantable access port (TIAP) implantation via the right internal jugular vein is thought to be very rare. We report a case of catheter rupture found 682 days after TIAP surgery in a 52-year-old woman with recurrent right breast cancer. It is possible that chronic stress at the flexure of the catheter induced by neck movements caused the catheter to rupture. Therefore, when inserting a TIAP via the right internal jugular vein, the site of venous puncture should be decided on carefully...
July 2014: Surgery Today
Hideki Osawa, Junichi Hasegawa, Kazuma Yamakawa, Nobuki Matsunami, Shoki Mikata, Junzo Shimizu, Yong Kook Kim, Hirotaka Morishima, Masaki Hirota, Yoshihito Souma, Ho Min Kim, Genta Sawada, Riichiro Nezu
PURPOSE: Pinch-off syndrome (POS) is a serious complication encountered during the long-term management of totally implantable access ports (TIAPs). The aim of this study was to examine the effect of ultrasound-guided infraclavicular axillary vein puncture to avoid POS in patients with long-term use of a TIAP. METHODS: This was a retrospective review of 207 consecutive TIAPs: one hundred devices implanted using an anatomical landmark technique were used as historical controls (Landmark group), while 107 devices were implanted using an ultrasound (US)-guided puncture method (US group)...
July 2013: Surgery Today
Ariane F Cardoso, Lucimara Moreli, Fernanda T M M Braga, Christiane I Vasques, Claudia B Santos, Emilia C Carvalho
BACKGROUND: Handling Totally Implantable Access Ports (TIAP) is a nursing procedure that requires skill and knowledge to avoid adverse events. No studies addressing this procedure with undergraduate students were identified prior to this study. Communication technologies, such as videos, have been increasingly adopted in the teaching of nursing and have contributed to the acquisition of competencies for clinical performance. OBJECTIVE: To evaluate the effect of a video on the puncture and heparinization of TIAP in the development of cognitive and technical competencies of undergraduate nursing students...
August 2012: Nurse Education Today
Phillip Knebel, Ruben Lopez-Benitez, Lars Fischer, Boris A Radeleff, Ulrike Stampfl, Thomas Bruckner, Roland Hennes, Meinhard Kieser, Hans-Ulrich Kauczor, Markus W Büchler, Christoph M Seiler
OBJECTIVE: Comparison of two different insertion techniques for implantation of totally implantable access ports (TIAP). BACKGROUND: TIAP are introduced through different open and closed cannulation strategies and by various medical experts. The aim of this expertise-based randomized trial was to compare venous cutdown approach with puncture of subclavian vein. METHODS: One hundred and ten patients scheduled for primary implantation of a TIAP were randomly assigned to either open insertion technique performed by surgeons or puncture of the subclavian vein under fluoroscopic guidance by radiologists at an outpatient single university center...
June 2011: Annals of Surgery
Alberto Dal Molin, Laura Rasero, Linda Guerretta, Elisa Perfetti, Mario Clerico
PURPOSE: The principal aim of this study is to analyze the incidence of late complications in oncologic patients with totally implanted central venous access ports. METHODS: A prospective multicenter observational study was conducted in 26 Italian oncologic outpatient clinics. 1076 cancer patients with Totally Implanted Central Venous Access Ports (TIAP) were observed. 515 devices were observed in patients under treatment and 561 in patients who went to the outpatient clinic only for flushing...
December 2011: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
Yi-Chang Lin, Chi-Hong Chu, Kuang-Wen Ou, De-Chuan Chan, Chung-Bao Hsieh, Teng-Wei Chen, Huan-Ming Hsu, Jyh-Cherng Yu
BACKGROUND: We report our experience of using a totally implantable access port (TIAP) through the external jugular vein (EJV) when the cephalic vein (CV) approach is not feasible. METHODS: We reviewed 197 cases involving TIAP implantation through the EJV in a single medical center between January 1995 and January 2009. All the ports were implanted after the CV approach was found unfeasible. Patient characteristics, operating time, and early and late complications were recorded...
February 2011: Annals of Vascular Surgery
Roberto Biffi, Franco Orsi, Simonetta Pozzi, Andrea Maldifassi, Davide Radice, Nicole Rotmensz, Maria Giulia Zampino, Nicola Fazio, Giulia Peruzzotti, Florence Didier
PURPOSE: Though totally implantable access ports (TIAP) are extensively used, information from randomized trials about the impact of insertion site on patient's quality of life (QoL) and psychological distress is unavailable. PATIENTS AND METHODS: Four hundred and three patients eligible for receiving intravenous chemotherapy for solid tumours were randomly assigned to implantation of a single type of TIAP, either through a percutaneous landmark access to the internal jugular or an ultrasound-guided access to the subclavian or a surgical cut-down access through the cephalic vein at the deltoid-pectoralis groove...
October 2011: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Cédric Plumhans, Andreas H Mahnken, Christina Ocklenburg, Sebastian Keil, Florian F Behrendt, Rolf W Günther, Felix Schoth
PURPOSE: To determine the safest and most tolerable method for totally implantable access ports (TIAPs) particularly in regard to patient's pain perception and catheter-related complications. MATERIALS AND METHODS: From January 2007 to October 2008 a subcutaneous TIAP (Bardport, Bard Access System, UT, USA) was implanted in 138 oncological patients (60 male, 78 female; 18-85 years old; mean age of 56 ± 6 years) by experienced interventional radiologists. 94 TIAP were implanted through the subclavian vein (subclavian group) and 44 TIAP were implanted through the internal jugular vein (jugular group)...
September 2011: European Journal of Radiology
So-Hyun Nam, Dae-Yeon Kim, Seong-Chul Kim, In-Koo Kim
BACKGROUND: Totally implantable access ports (TIAPs) are widely used in pediatric hematology-oncology patients. We investigated the incidence of complications, causes of TIAP removal, and risk factors for infection. PROCEDURE: We retrospectively analyzed the clinical, demographic, and surgical characteristics in 225 pediatric hematology-oncology patients implanted with 238 TIAPs between January 2004 and December 2005. RESULTS: Except for 20 patients lost to follow-up, the mean maintenance period was 724...
April 2010: Pediatric Blood & Cancer
Makoto Sonobe, Fengshi Chen, Takuji Fujinaga, Kiyoshi Sato, Tsuyoshi Shoji, Hiroaki Sakai, Ryo Miyahara, Toru Bando, Kenichi Okubo, Toshiki Hirata, Hiroshi Date
BACKGROUND: For patients with a thoracic malignancy whose peripheral veins are not suitable for blood access for chemotherapy, we evaluated a totally implantable central venous access port, in which the port is implanted in the ulnar side of the arm and the catheter is introduced via the basilic vein into the superior vena cava (TIAP-BV). METHODS: Twenty-five patients (21 with lung cancer, 2 with malignant pleural mesothelioma, and 2 with thymoma) receiving TIAP-BV were included...
June 2009: International Journal of Clinical Oncology
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