keyword
MENU ▼
Read by QxMD icon Read
search

Pupillometry

keyword
https://www.readbyqxmd.com/read/27928748/pupillary-response-to-complex-interdependent-tasks-a-cognitive-load-theory-perspective
#1
Ritayan Mitra, Karen S McNeal, Howard D Bondell
Pupil dilation is known to indicate cognitive load. In this study, we looked at the average pupillary responses of a cohort of 29 undergraduate students during graphical problem solving. Three questions were asked, based on the same graphical input. The questions were interdependent and comprised multiple steps. We propose a novel way of analyzing pupillometry data for such tasks on the basis of eye fixations, a commonly used eyetracking parameter. We found that pupil diameter increased during the solution process...
December 7, 2016: Behavior Research Methods
https://www.readbyqxmd.com/read/27924440/is-pupillary-response-a-reliable-index-of-word-recognition-evidence-from-a-delayed-lexical-decision-task
#2
Juan Haro, Marc Guasch, Blanca Vallès, Pilar Ferré
Previous word recognition studies have shown that the pupillary response is sensitive to a word's frequency. However, such a pupillary effect may be due to the process of executing a response, instead of being an index of word processing. With the aim of exploring this possibility, we recorded the pupillary responses in two experiments involving a lexical decision task (LDT). In the first experiment, participants completed a standard LDT, whereas in the second they performed a delayed LDT. The delay in the response allowed us to compare pupil dilations with and without the response execution component...
December 6, 2016: Behavior Research Methods
https://www.readbyqxmd.com/read/27915119/neural-correlates-of-pupil-dilation-during-human-fear-learning
#3
Laura Leuchs, Max Schneider, Michael Czisch, Victor I Spoormaker
BACKGROUND: Fear conditioning and extinction are prevailing experimental and etiological models for normal and pathological anxiety. Pupil dilations in response to conditioned stimuli are increasingly used as a robust psychophysiological readout of fear learning, but their neural correlates remain unknown. We aimed at identifying the neural correlates of pupil responses to threat and safety cues during a fear learning task. METHODS: Thirty-four healthy subjects underwent a fear conditioning and extinction paradigm with simultaneous functional magnetic resonance imaging (fMRI) and pupillometry...
December 1, 2016: NeuroImage
https://www.readbyqxmd.com/read/27858935/multiethnic-involvement-in-autosomal-dominant-optic-atrophy-in-singapore
#4
J L Loo, S Singhal, A V Rukmini, S Tow, P Amati-Bonneau, V Procaccio, D Bonneau, J J Gooley, P Reynier, M Ferré, D Milea
PurposeAutosomal-dominant optic atrophy (ADOA), often associated with mutations in the OPA1 gene (chromosome 3q28-q29) is rarely reported in Asia. Our aim was to identify and describe this condition in an Asian population in Singapore.Patients and methodsPreliminary cross-sectional study at the Singapore National Eye Centre, including patients with clinical suspicion of ADOA, who subsequently underwent genetic testing by direct sequencing of the OPA1 gene.ResultsAmong 12 patients (10 families) with clinically suspected ADOA, 7 patients (5 families) from 3 different ethnic origins (Chinese, Indian, and Malay) carried a heterozygous pathogenic variant in the OPA1 gene...
November 18, 2016: Eye
https://www.readbyqxmd.com/read/27843292/topography-modified-refraction-tmr-adjustment-of-treated-cylinder-amount-and-axis-to-the-topography-versus-standard-clinical-refraction-in-myopic-topography-guided-lasik
#5
Anastasios John Kanellopoulos
PURPOSE: To evaluate the safety, efficacy, and contralateral eye comparison of topography-guided myopic LASIK with two different refraction treatment strategies. SETTING: Private clinical ophthalmology practice. PATIENTS AND METHODS: A total of 100 eyes (50 patients) in consecutive cases of myopic topography-guided LASIK procedures with the same refractive platform (FS200 femtosecond and EX500 excimer lasers) were randomized for treatment as follows: one eye with the standard clinical refraction (group A) and the contralateral eye with the topographic astigmatic power and axis (topography-modified treatment refraction; group B)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27821359/pupillary-response-abnormalities-in-depressive-disorders
#6
Scott A Laurenzo, Randy Kardon, Johannes Ledolter, Pieter Poolman, Ashley M Schumacher, James B Potash, Jan M Full, Olivia Rice, Anna Ketcham, Cole Starkey, Jess G Fiedorowicz
Depressive disorders lack objective physiological measurements to characterize the affected population and facilitate study of relevant mechanisms. The melanopsin-mediated light signaling pathway may contribute to seasonal variation and can be measured non-invasively by pupillometry. We prospectively studied changes in melanopsin-mediated pupillary constriction in 19 participants with major depressive disorder (MDD) and 10 control across the summer and winter solstices. The melanopsin-mediated response, as measured by the pupil's sustained constriction six s after a high intensity blue light stimulus, was marginally attenuated in those with MDD relative to controls (p=0...
October 21, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27787677/measuring-physician-cognitive-load-validity-evidence-for-a-physiologic-and-a-psychometric-tool
#7
Adam Szulewski, Andreas Gegenfurtner, Daniel W Howes, Marco L A Sivilotti, Jeroen J G van Merriënboer
In general, researchers attempt to quantify cognitive load using physiologic and psychometric measures. Although the construct measured by both of these metrics is thought to represent overall cognitive load, there is a paucity of studies that compares these techniques to one another. The authors compared data obtained from one physiologic tool (pupillometry) to one psychometric tool (Paas scale) to explore whether they actually measured the construct of cognitive load as purported. Thirty-two participants with a range of resuscitation medicine experience and expertise completed resuscitation-medicine based multiple-choice-questions as well as arithmetic questions...
October 27, 2016: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/27753579/objective-pupillary-correlates-of-photosensitivity-in-the-normal-and-mild-traumatic-brain-injury-populations
#8
James Q Truong, Kenneth J Ciuffreda
OBJECTIVE: No objective vision biomarker for photosensitivity currently exists. The present study sought to uncover potential biomarkers for photosensitivity within the pupillary light reflex. METHODS: The pupillary light reflex was evaluated in those with mild traumatic brain injury (mTBI) and in normal individuals, with and without photosensitivity, under a range of test conditions. The Neuroptics DP-2000, infrared, binocular pupillometer was used for both binocular stimulation and recording...
October 2016: Military Medicine
https://www.readbyqxmd.com/read/27731503/pupillometry-reveals-changes-in-physiological-arousal-during-a-sustained-listening-task
#9
Ronan McGarrigle, Piers Dawes, Andrew J Stewart, Stefanie E Kuchinsky, Kevin J Munro
Hearing loss is associated with anecdotal reports of fatigue during periods of sustained listening. However, few studies have attempted to measure changes in arousal, as a potential marker of fatigue, over the course of a sustained listening task. The present study aimed to examine subjective, behavioral, and physiological indices of listening-related fatigue. Twenty-four normal-hearing young adults performed a speech-picture verification task in different signal-to-noise ratios (SNRs) while their pupil size was monitored and response times recorded...
October 12, 2016: Psychophysiology
https://www.readbyqxmd.com/read/27712127/quantifying-pupillary-asymmetry-through-objective-binocular-pupillometry-in-the-normal-and-mild-traumatic-brain-injury-mtbi-populations
#10
James Q Truong, Kenneth J Ciuffreda
INTRODUCTION: Little is known about human inter-ocular pupillary asymmetry (IOPA). Thus, the purpose of the present investigation was to assess objectively static and dynamic IOPA in normals and in individuals with mild traumatic brain injury (mTBI). METHODS: The pupillary light reflex (PLR) was assessed in an adult population of normals and in those with mTBI using the Neuroptics DP-2000 binocular pupillometer. Four stimulus conditions were used to optimize the assessment...
August 11, 2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27712047/coupling-between-spontaneous-pupillary-fluctuations-and-brain-activity-relates-to-inattentiveness
#11
A L Breeden, G J Siegle, M E Norr, E M Gordon, C J Vaidya
Autonomic activity in neurological and psychiatric disorders is often dysregulated, particularly in the context of attentional behaviors. This suggests that interplay between the autonomic nervous system and aspects of the central nervous system subserving attention may be disrupted in these conditions. Better understanding these interactions and their relationship to individual variation in attentional behaviors could facilitate development of mechanistic biomarkers. We identified brain regions defined by trait-sensitive central-autonomic coupling as a first step in this process...
October 6, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27705959/neural-mechanisms-underlying-catastrophic-failure-in-human-machine-interaction-during-aerial-navigation
#12
Sameer Saproo, Victor Shih, David C Jangraw, Paul Sajda
OBJECTIVE: We investigated the neural correlates of workload buildup in a fine visuomotor task called the boundary avoidance task (BAT). The BAT has been known to induce naturally occurring failures of human-machine coupling in high performance aircraft that can potentially lead to a crash-these failures are termed pilot induced oscillations (PIOs). APPROACH: We recorded EEG and pupillometry data from human subjects engaged in a flight BAT simulated within a virtual 3D environment...
December 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27692796/pupillometry-registers-toddlers-sensitivity-to-degrees-of-mispronunciation
#13
Katalin Tamási, Cristina McKean, Adamantios Gafos, Tom Fritzsche, Barbara Höhle
This study introduces a method ideally suited for investigating toddlers' ability to detect mispronunciations in lexical representations: pupillometry. Previous research has established that the magnitude of pupil dilation reflects differing levels of cognitive effort. Building on those findings, we use pupil dilation to study the level of detail encoded in lexical representations with 30-month-old children whose lexicons allow for a featurally balanced stimulus set. In each trial, we present a picture followed by a corresponding auditory label...
January 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/27669664/oral-human-abuse-potential-of-oxycodone-deterx-%C3%A2-xtampza-%C3%A2-er
#14
Ernest A Kopecky, Alison B Fleming, Naama Levy-Cooperman, Melinda O'Connor, Edward Sellers
Oxycodone DETERx(®) (Collegium Pharmaceutical Inc, Canton, MA) is an extended-release, microsphere-in-capsule, abuse-deterrent formulation designed to retain its extended-release properties after tampering (eg, chewing/crushing). This randomized, double-blind, placebo-controlled, triple-dummy study evaluated the oral abuse potential of intact and chewed oxycodone DETERx capsules compared with crushed immediate-release oxycodone. Subjects with a history of recreational opioid use who were nondependent/nontolerant to opioids were enrolled...
September 27, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27651514/oral-abuse-potential-pharmacokinetics-and-safety-of-once-daily-single-entity-extended-release-hydrocodone-hyd-in-recreational-opioid-users
#15
Stephen C Harris, Alessandra Cipriano, Ram P Kapil, Naama Levy-Cooperman, Salvatore V Colucci, Pierre Geoffroy, Talar Hopyan
OBJECTIVES:  A once-daily, extended-release hydrocodone bitartrate tablet with abuse-deterrent properties (Hysingla ER [HYD]) is available for the treatment of chronic pain in appropriate patients. This study evaluated the oral abuse potential and pharmacokinetics (PK) of HYD intact, chewed, or milled to fine particles in comparison with hydrocodone solution or placebo. DESIGN:  Single-center, double-blind, randomized, five-period, five-treatment crossover study...
September 19, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27647873/abuse-potential-and-pharmacodynamic-characteristics-of-oral-and-intranasal-eluxadoline-a-mixed-%C3%AE-and-%C3%AE%C2%BA-opioid-receptor-agonist-and-%C3%AE-opioid-receptor-antagonist
#16
Naama Levy-Cooperman, Gail McIntyre, Laura Bonifacio, Michael McDonnell, J Michael Davenport, Paul S Covington, Leonard S Dove, Edward M Sellers
Drugs with μ-opioid receptor (OR) activity can be associated with abuse and misuse. The peripherally acting mixed μ-OR and κ-OR agonist and δ-OR antagonist, eluxadoline, is approved in the US for the treatment of irritable bowel syndrome with diarrhea. In two separate crossover studies, we evaluated the oral and intranasal abuse potential of eluxadoline versus placebo and the active control oxycodone. Healthy recreational opioid users received eluxadoline 100, 300, and 1000 mg, oxycodone 30 and 60 mg, and placebo (oral study), or eluxadoline 100 and 200 mg, oxycodone 15 and 30 mg, and placebos matched to eluxadoline and oxycodone (intranasal study)...
September 19, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27622679/quadrant-field-pupillometry-detects-melanopsin-dysfunction-in-glaucoma-suspects-and-early-glaucoma
#17
Prakash Adhikari, Andrew J Zele, Ravi Thomas, Beatrix Feigl
It is difficult to detect visual function deficits in patients at risk for glaucoma (glaucoma suspects) and at early disease stages with conventional ophthalmic tests such as perimetry. To this end, we introduce a novel quadrant field measure of the melanopsin retinal ganglion cell mediated pupil light response corresponding with typical glaucomatous arcuate visual field defects. The melanopsin-mediated post-illumination pupil response (PIPR) was measured in 46 patients with different stages of glaucoma including glaucoma suspects and compared to a healthy group of 21 participants with no disease...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27579158/others-emotions-teach-but-not-in-autism-an-eye-tracking-pupillometry-study
#18
Heather J Nuske, Giacomo Vivanti, Cheryl Dissanayake
BACKGROUND: Much research has investigated deficit in emotional reactivity to others in people with autism, but scant attention has been paid to how this deficit affects their own reactions to features of their environment (objects, events, practices, etc.). The present study presents a preliminary analysis on whether calibrating one's own emotional reactions to others' emotional reactions about features of the world, a process we term social-emotional calibration, is disrupted in autism...
2016: Molecular Autism
https://www.readbyqxmd.com/read/27560455/pupillometer-based-neurofeedback-cognitive-training-to-improve-processing-speed-and-social-functioning-in-individuals-at-clinical-high-risk-for-psychosis
#19
Jimmy Choi, Cheryl M Corcoran, Joanna M Fiszdon, Michael Stevens, Daniel C Javitt, Melissa Deasy, Lawrence C Haber, Michael J Dewberry, Godfrey D Pearlson
Objective: Among individuals at clinical high risk (CHR) for psychosis, processing speed (PS) has been related to social and role functioning regardless of conversion to schizophrenia. This information processing dysfunction is a gateway to broader behavioral deficits such as difficulty executing social behaviors. We examined the feasibility of improving information processing relevant to social situations in CHR, including its sustainability at 2-month follow-up, and its association with concurrent social function...
August 25, 2016: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/27439493/effects-of-azelnidipine-and-amlodipine-on-exercise-induced-sympathoexcitation-assessed-by-pupillometry-in-hypertensive-patients
#20
Yumi Koike, Tetsuya Kawabe, Kanami Nishihara, Naomi Iwane, Takuzo Hano
The pupil is a suitable end organ for studying autonomic function because both sympathetic and parasympathetic nerve activity can be evaluated independently using a light stimulus. Sympathetic response elicited by physical stress is augmented in hypertensive patients compared with normotensive subjects, which increases the risk of cardiovascular events. We used pupillometry to evaluate the effects of the calcium channel blockers azelnidipine (AZ) and amlodipine (AM) on changes in autonomic nervous activity induced by isometric exercise in patients with hypertension...
July 21, 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
keyword
keyword
5438
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"